MTOR SIGNALING PATHWAY (PW:0000180)

View Ontology Report

Description

The mTOR signaling pathway responds to and integrates a range of environmental cues and is known for its role in the control of protein translation and ribosome biogenesis, autophagy, cytoskeleton, and metabolism. The highly conserved Ser/Thr mTOR kinase is found in two distinct complexes: the rapamycin-sensitive mTORC1 and the largely rapamycin-insensitive mTORC2. Rapamycin (sirolimus) - a macrolide produced by Streptomyces hygroscopicus, in complex with Fkbp1a (the 12-kDa FK506-binding

Pathway Diagram:

Elsevier Inc. translation initiation pathway TSC complex Akt1s1 Gatsl3 insulin signaling pathway mTORC1 complex GF leucine ribosome biogenesis pathway translation pathway nuclear factor, erythroid 2 like 2 signaling pathway autophagy pathway phosphatidylinositol 3-kinase-Akt signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Irs1 Rheb Rrag members rapamycin Flcn-Flip mTORC2 complex Gator2 complex Ragulator complex Gator1 complex Rrag members ---> mTORC1 complex phosphatidylinositol 3-kinase-Akt signaling pathway ---| Tsc2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---| Tsc2 Tsc1 Tsc2 Rheb --+> mTORC1 complex insulin signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway insulin signaling pathway --+> phosphatidylinositol 3-kinase-Akt signaling pathway environmental cues Rrag members --+> mTORC1 complex mTORC2 complex --+> cytoskeletal rearrangements cytoskeletal rearrangements Flcn-Flip --+> Rrag members Gator2 complex ---| Gator1 complex Ragulator complex --+> Rrag members Gator2 complex ---- Sesn2 Sesn2 ---| Gator2 complex Gator2 complex ---- Gatsl2 Gator2 complex ---- Gatsl3 Gatsl3 ---| Gator2 complex Gatsl2 ---| Gator2 complex Rps6kb1 ---| Irs1 leucine ---- Sesn2 Rps6kb1 Rps6kb1 --+> translation initiation pathway Eif4ebp1 ---| translation initiation pathway mTORC1 complex --+> Rps6kb1 translation initiation pathway ---> ribosome biogenesis pathway Eif4ebp1 mTORC1 complex ---| Eif4ebp1 mTORC1 complex ---| autophagy pathway mTORC1 complex --+> nuclear factor, erythroid 2 like 2 signaling pathway Sesn2 leucine ---| Sesn2 arginine ---| Gatsl3 environmental cues --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway GF --+> mTORC2 complex mTORC2 complex --+> phosphatidylinositol 3-kinase-Akt signaling pathway Gator1 complex ---| Rrag members phosphatidylinositol 3-kinase-Akt signaling pathway ---| Akt1s1 adenosine monophosphate-activated protein kinase (AMPK) signaling pathway --+> Tsc2 Tsc2 ---| Rheb Akt1s1 ---| mTORC1 complex adenosine monophosphate-activated protein kinase (AMPK) signaling pathway ---| mTORC1 complex Fkbp1a ---- rapamycin rapamycin ---| mTORC1 complex arginine arginine ---- Gatsl3 Gatsl2 Gatsl2 ---- Gatsl3 Fkbp1a
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Genes in Pathway:

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mTOR signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
RGD:6907045
G Akt1s1 AKT1 substrate 1 JBrowse link 1 100,845,443 100,851,961 RGD:2308795
RGD:11535033
RGD:6484113
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:6484113
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:6484113
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6484113
RGD:6907045
G Cab39 calcium binding protein 39 JBrowse link 9 92,834,327 92,895,778 RGD:6907045
G Cab39l calcium binding protein 39-like JBrowse link 15 39,745,124 39,849,022 RGD:6907045
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 JBrowse link 14 84,447,552 84,457,396 RGD:11535047
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 JBrowse link 12 25,595,800 25,638,806 RGD:11535047
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6484113
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6484113
G Clip1 CAP-GLY domain containing linker protein 1 JBrowse link 12 38,345,203 38,452,650 RGD:6484113
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6484113
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6484113
RGD:6907045
G Depdc5 DEP domain containing 5 JBrowse link 14 83,089,000 83,219,576 RGD:11535043
G Deptor DEP domain containing MTOR-interacting protein JBrowse link 7 94,795,161 95,000,750 RGD:6484113
RGD:11535033
G Eef2 eukaryotic translation elongation factor 2 JBrowse link 7 11,401,501 11,406,771 RGD:6484113
G Eef2k eukaryotic elongation factor-2 kinase JBrowse link 1 190,780,211 190,839,926 RGD:6484113
G Eif4a1 eukaryotic translation initiation factor 4A1 JBrowse link 10 56,271,257 56,276,764 RGD:6484113
G Eif4b eukaryotic translation initiation factor 4B JBrowse link 7 143,679,656 143,701,452 RGD:6484113
RGD:6907045
G Eif4e eukaryotic translation initiation factor 4E JBrowse link 2 243,819,616 243,853,987 RGD:6484113
RGD:6907045
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 JBrowse link 9 94,310,476 94,325,445 RGD:6907045
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:1625616
RGD:6907045
RGD:6484113
RGD:2308795
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:6484113
G Fkbp1a FK506 binding protein 1a JBrowse link 3 147,042,944 147,062,725 RGD:11535033
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:11535042
G Fnip1 folliculin interacting protein 1 JBrowse link 10 39,786,687 39,870,188 RGD:11535042
G Fnip2 folliculin interacting protein 2 JBrowse link 2 178,223,561 178,334,925 RGD:11535042
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6484113
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6484113
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 JBrowse link 1 166,991,474 166,997,045 RGD:11535043
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 JBrowse link 2 187,911,530 187,914,930 RGD:11535043
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 JBrowse link 2 243,160,821 243,173,057 RGD:11535043
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 JBrowse link 12 19,573,909 19,577,625 RGD:11535043
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 JBrowse link 2 210,034,095 210,039,451 RGD:11535043
G Lpin1 lipin 1 JBrowse link 6 41,796,214 41,905,149 RGD:1641823
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6484113
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
RGD:6907045
G Mapkap1 mitogen-activated protein kinase associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:2308795
RGD:11535033
RGD:6484113
G Mios meiosis regulator for oocyte development JBrowse link 4 34,238,370 34,264,015 RGD:11535043
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:1626104
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1625611
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
RGD:2307383
RGD:1625616
G Nprl2 NPR2-like, GATOR1 complex subunit JBrowse link 8 116,297,950 116,301,123 RGD:11535043
G Nprl3 NPR3-like, GATOR1 complex subunit JBrowse link 10 15,620,824 15,661,332 RGD:11535043
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6484113
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
RGD:6907045
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:6484113
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:6484113
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:6484113
G Poldip3 DNA polymerase delta interacting protein 3 JBrowse link 7 123,992,167 124,020,596 RGD:6484113
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6484113
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6907045
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6484113
G Prr5 proline rich 5 JBrowse link 7 125,569,791 125,609,340 RGD:6484113
RGD:11535033
G Prr5l proline rich 5 like JBrowse link 3 91,290,207 91,461,208 RGD:11535033
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6484113
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6484113
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6484113
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:6484113
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:1625606
RGD:11535034
RGD:6907045
RGD:6484113
RGD:2308795
RGD:1625616
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:1625616
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
RGD:2307383
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6907045
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:6484113
RGD:6907045
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:6907045
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:6907045
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:6907045
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:1625616
RGD:6907045
RGD:6484113
RGD:2308795
RGD:1626103
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:1625616
RGD:6907045
RGD:2308795
RGD:1626103
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:1625616
RGD:11535033
RGD:6907045
RGD:6484113
RGD:2308795
RGD:2307383
G Rraga Ras-related GTP binding A JBrowse link 5 104,941,067 104,942,662 RGD:2308795
RGD:11535043
RGD:6484113
G RragB Ras-related GTP binding B JBrowse link X 19,085,913 19,135,049 RGD:2308795
RGD:11535043
RGD:6484113
G Rragb_v1 Ras-related GTP binding B, variant 1 RGD:2308795
G Rragc Ras-related GTP binding C JBrowse link 5 141,572,536 141,590,784 RGD:2308795
RGD:11535043
RGD:6484113
G Rragd Ras-related GTP binding D JBrowse link 5 48,224,994 48,260,691 RGD:2308795
RGD:11535043
RGD:6484113
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor JBrowse link 10 3,170,387 3,214,648 RGD:6484113
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:11535042
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6484113
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6484113
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6907045
G Strada STE20-related kinase adaptor alpha JBrowse link 10 94,355,369 94,384,404 RGD:6907045
G Tbc1d7 TBC1 domain family, member 7 JBrowse link 17 23,774,793 23,792,389 RGD:11535034
G Telo2 telomere maintenance 2 JBrowse link 10 14,461,581 14,476,812 RGD:11535033
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:1625616
RGD:11535034
RGD:6907045
RGD:6484113
RGD:2308795
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580520
RGD:11535034
RGD:6907045
RGD:6484113
RGD:2308795
RGD:1625616
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:1625616
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:1625616
G Tti1 TELO2 interacting protein 1 JBrowse link 3 154,463,108 154,506,955 RGD:11535033
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:6484113
RGD:6907045
G Ulk2 unc-51 like autophagy activating kinase 2 JBrowse link 10 48,050,079 48,129,377 RGD:6484113
RGD:6907045
G Ulk3 unc-51 like kinase 3 JBrowse link 8 62,368,548 62,375,229 RGD:6907045
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Wdr24 WD repeat domain 24 JBrowse link 10 15,191,078 15,195,860 RGD:11535043
G Wdr59 WD repeat domain 59 JBrowse link 19 43,651,686 43,714,391 RGD:11535043
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta JBrowse link 3 160,391,108 160,399,931 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6484113
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:6484113
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6484113
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6484113
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupRrag membersA protein family that mediates mTorc1 activation
ComplexmTORC1 complexmTOR complex 1
ComplexmTORC2 complexmTOR complex 2

Pathway Gene Annotations

Disease Annotations Associated with Genes in the mTOR signaling pathway
Disease TermsGene Symbols
abdominal obesity-metabolic syndromePpargc1a
Aberrant Crypt FociMapk1 , Mapk3
Abnormalities, Drug-InducedRhoa
Abortion, SpontaneousIgf1 , Pgf
acneIgf1
acoustic neuromaIgf1 , Vegfa
acromegalyIgf1
acute chest syndromeVegfa
Acute HepatitisTsc2
acute kidney failureHif1a , Igf1 , Ins2 , Mtor , Ppargc1a , Vegfa
Acute Liver FailureIns1 , Ins2
Acute Lung InjuryPrkaa1 , Vegfa
acute myeloid leukemiaEif4ebp1 , Hras , Nras , Sgk1 , Tsc2 , Vegfa
acute promyelocytic leukemiaAkt1 , Nras , Pml
Acute Recurrent Myoglobinuria, Autosomal RecessiveLpin1
Acute-Phase ReactionHif1a
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaEef2 , Mtor , Pik3ca , Stk11 , Vegfa
adenoid cystic carcinomaHras , Map2k2 , Pik3ca
adenomaIgf1 , Ins2
adrenal carcinomaBraf , Nras , Pik3ca
adrenocortical carcinomaBraf , Nras , Pik3ca
adult T-cell leukemiaNras
adult-onset Still's diseaseVegfa
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS Dementia ComplexIrs1
AIDS-Associated NephropathyMtor
AlbuminuriaIgf1 , Ins2 , Ppargc1a
Alcoholic Liver DiseasesHif1a
alcoholic neuropathyIgf1
allergic contact dermatitisVegfa
alopeciaIgf1
Alzheimer's diseaseAkt1 , Eef2 , Eef2k , Hif1a , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Irs1 , Pik3r1 , Ppargc1a , Tsc2 , Vegfa
amblyopiaPpargc1a
ameloblastomaBraf
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Pgf , Ppargc1a , Vegfa
amyotrophic lateral sclerosis type 1Vegfa
AnaplasiaHif1a
angiomyolipomaTsc2
angiosarcomaHras , Vegfa , Vegfc
Animal Disease ModelsAkt1 , Mapk1 , Mapk3 , Rhoa
ankylosing spondylitisPgf
ANTERIOR SEGMENT DYSGENESIS 7Pxn
Aortic Valve, Calcification ofAkt1
Arterial InjuryPdcd4
Arterial ThrombosisHif1a
arteriosclerosisIgf1
Arteriovenous FistulaVegfa
arteriovenous malformations of the brainVegfa
AsphyxiaHif1a
asthmaHif1a , Pgf , Rhoa , Vegfa
Asthma, OccupationalPrkca
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Hif1a , Hras , Tsc1
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Pgf , Vegfa , Vegfc
atrial fibrillationHif1a , Vegfa
AtrophyMapk3 , Rps6kb1
attention deficit hyperactivity disorderVegfa
autism spectrum disorderEif4b , Mapk3 , Tsc1 , Tsc2
autistic disorderEif4e , Hras , Igf1 , Mapk1 , Tsc1 , Tsc2
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Nras
autosomal dominant mental retardation 48Rac1
autosomal dominant polycystic kidney diseaseMtor , Rps6kb1
autosomal recessive Alport syndromeHras
autosomal recessive polycystic kidney diseaseAkt1 , Mtor , Pik3ca , Tsc1
B-cell lymphomaNras
bacterial pneumoniaPgf
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeAkt3
Barth syndromeFkbp1a
basal cell carcinomaPik3ca
Behcet's diseaseVegfa
benign epilepsy with centrotemporal spikesDepdc5 , Strada
bipolar disorderAkt1 , Ins2
Birt-Hogg-Dube syndromeFlcn
bladder carcinomaHras
bladder diseaseIns2
bladder neck obstructionHif1a
bladder urothelial carcinomaAkt1 , Braf , Hras , Map2k1 , Nras , Pik3ca
blindnessVegfa
bone development diseaseRps6ka3
Bowen's DiseaseCcne1 , Ppargc1a
brain diseaseTsc1 , Tsc2
brain edemaVegfa
Brain InjuriesAkt1 , Igf1 , Ppargc1a , Rhoa , Vegfa , Vegfb
brain ischemiaAkt1 , Cycs , Hif1a , Igf1 , Map2k1 , Mapk1 , Mapk3 , Pgf , Prkca , Ywhab
Brain NeoplasmsBraf , Hras , Nras , Pik3ca , Pik3r1 , Tsc2 , Vegfa
breast adenocarcinomaAkt1 , Pik3ca , Rb1cc1
breast cancerAkt1 , Braf , Hras , Mtor , Pik3ca , Rb1cc1 , Rhoa
Breast Cancer, FamilialPik3r3
breast carcinomaStk11
breast ductal carcinomaPml
Breast NeoplasmsAkt1 , Akt2 , Braf , Ccne1 , Cdk2 , Eef2 , Hif1a , Hras , Igf1 , Ikbkb , Lamtor5 , Map2k1 , Map2k2 , Mapk1 , Mtor , Pdpk1 , Pgf , Pik3ca , Pik3r1 , Prkaa1 , Prkca , Raf1 , Rb1cc1 , Rhoa , Rps6 , Rps6kb2 , Stk11 , Tsc1 , Tsc2 , Vegfa , Vegfb , Vegfc
Bronchitis, ChronicVegfa
Bronchopulmonary DysplasiaHif1a
Bruton-type agammaglobulinemiaPik3r1
bullous pemphigoidVegfa
Burkitt lymphomaPik3r1
BurnsHif1a , Igf1 , Mtor , Rps6kb1
CachexiaLpin1
cannabis abuseAkt1
capillary hemangiomaAkt3
CarcinogenesisBraf
carcinomaHif1a , Hras , Pik3r1 , Rhoa , Sgk1 , Ywhaz
cardiac arrestAkt1 , Ins2
cardiofaciocutaneous syndromeBraf , Hras , Map2k1 , Map2k2
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Hif1a , Igf1 , Mapk1 , Mtor , Pld1 , Pld2 , Ppargc1a , Prkaa2 , Prkca , Rac1 , Raf1 , Rhoa , Rps6kb1 , Stk11 , Yy1
cardiomyopathyAkt1 , Mapk1 , Mapk3 , Ppargc1a , Prkaa2 , Vegfa , Ywhah
Cardiomyopathy, Hypertrophic, FamilialRaf1
CardiotoxicityRac1
Cardiovascular AbnormalitiesMap2k1
cardiovascular system diseasePpargc1a
carotid artery diseaseIgf1 , Pgf
Carotid Artery InjuriesIgf1 , Ppargc1a
cataractMap2k1
Cell Transformation, NeoplasticHras , Irs1 , Pdcd4 , Pxn , Rac1
Cerebral HemorrhageMtor , Vegfa
cervix uteri carcinoma in situCcne1 , Vegfa
Chemical and Drug Induced Liver InjuryIgf1 , Sesn2 , Vegfa
childhood absence epilepsyYwhaz
ChloracneCycs
cholangiocarcinomaCycs
cholestasisIgf1
cholesteatomaVegfa
cholesteatoma of middle earHif1a , Vegfa
chondrosarcomaMtor
Choroidal NeovascularizationIkbkb , Vegfa , Vegfb
Chromosome 17, Trisomy 17p11 2Flcn , Srebf1 , Ulk2
Chronic Allograft DysfunctionMtor
Chronic Cerebral HypoperfusionHif1a
Chronic Intermittent HypoxiaBnip3
chronic kidney diseasePpargc1a
chronic lymphocytic leukemiaBraf , Hras , Nras
Chronic Lymphocytic Leukemia, B-CellBraf , Hras , Nras
chronic myeloid leukemiaAkt1 , Braf , Nras , Vegfa
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseBnip3 , Ppargc1a , Vegfa
clear cell renal cell carcinomaVegfa
Cocaine-Related DisordersMapk1 , Mapk3
Cockayne syndromeIgf1
Coffin-Lowry syndromeRps6ka3
Cognition DisordersTsc1
cognitive disorderIns2
colitisIgf1 , Ikbkb , Pgf , Ppargc1a
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3 , Rac1
colon adenomaRac1
colon cancerAkt1 , Braf , Flcn , Nras , Pik3ca
colon carcinomaAkt1 , Braf , Flcn , Nras , Pik3ca
Colonic NeoplasmsAkt2 , Akt3 , Braf , Ccne1 , Hif1a , Ikbkb , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Prkaa1 , Vegfa , Vegfc
colorectal adenocarcinomaMapk1 , Mapk3 , Raf1
colorectal adenomaRaf1
colorectal cancerAkt1 , Braf , Flcn , Nras , Pik3ca , Rac1 , Rhoa
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Flcn , Hras , Map2k1 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Raf1 , Rhoa
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Mtor , Pik3ca
congenital diaphragmatic herniaIgf1
Congenital Disorder of Glycosylation Type 1AIgf1
congenital heart diseaseFkbp1a , Hif1a , Vegfa
congenital hypothyroidismIgf1 , Ppargc1a
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Congenital Myopathy, with Excess of Muscle SpindlesHras
congestive heart failureBnip3 , Hif1a , Igf1 , Ins2 , Mtor , Pdpk1 , Pgf , Pld2 , Ppargc1a , Prkca , Rac1 , Vegfa , Yy1
contact dermatitisVegfa
corneal diseaseIgf1
corneal neovascularizationVegfa
coronary artery diseaseAkt1 , Irs1 , Vegfa
Coronary DiseaseIgf1 , Irs1 , Vegfa
coronary restenosisMapk1
coronary stenosisIgf1
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Map2k1 , Map2k2
Cowden diseaseAkt1 , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1 , Pik3ca
craniopharyngiomaBraf
crescentic glomerulonephritisMtor
Crohn's diseaseIgf1 , Pgf , Vegfa
Cronkhite-Canada syndromeStk11
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1 , Braf , Flcn , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Rac1 , Raf1 , Stk11
cutaneous T cell lymphomaBraf , Rhoa
cystic fibrosisIgf1
cystic kidney diseaseIns2
CystsFlcn
DeafnessIgf1
decubitus ulcerHif1a , Vegfa
DehydrationYwhaz
demyelinating diseaseIgf1
dermatitisIkbkb
dermatitis herpetiformisVegfa
Developmental Cardiac Valvular DefectPld1
Developmental DisabilitiesAkt3 , Braf , Pik3r2 , Rps6ka3
Diabetes ComplicationsHif1a , Prkaa1 , Vegfa
diabetes mellitusIgf1 , Ins1 , Ins2 , Irs1 , Rac1
Diabetes Mellitus, New-Onset after TransplantationMtor
diabetic angiopathyVegfa
Diabetic CardiomyopathiesIgf1 , Ins2
Diabetic FootIgf1
diabetic ketoacidosisIns2
Diabetic NephropathiesCcne1 , Hif1a , Igf1 , Ins2 , Mapk1 , Mtor , Pgf , Ppargc1a , Srebf1 , Vegfa
diabetic neuropathyIgf1 , Pgf , Sgk1 , Srebf1 , Vegfa
diabetic retinopathyHif1a , Hras , Igf1 , Ins2 , Pgf , Ppargc1a , Vegfa
diffuse large B-cell lymphomaPdpk1 , Pik3ca , Pik3cb , Pik3cd , Rps6kb1
DiGeorge syndromeVegfa
dilated cardiomyopathyIgf1 , Pgf , Ppargc1a , Prkca , Rac1 , Raf1 , Rps6kb1
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationBraf , Hras , Map2k1 , Nras , Pik3ca , Pik3r1 , Stk11 , Vegfa , Yy1
disease of metabolismIns2 , Srebf1
Disease ProgressionCcne1 , Hras , Pik3ca , Rps6 , Vegfb , Yy1
Diseases of the AgedPpargc1a
Drug-Induced DyskinesiaMtor
Drug-Related Side Effects and Adverse ReactionsIgf1
Ductal CarcinomaHif1a
ductal carcinoma in situBnip3 , Hif1a , Prkca , Vegfa
duodenal ulcerVegfa
DwarfismIgf1
dysembryoplastic neuroepithelial tumorBraf
dysplastic nevus syndromeStk11
dystoniaIns2
EdemaIns2
end stage renal failureBnip3 , Igf1 , Irs1 , Lpin1 , Mtor , Pgf , Srebf1
endometrial cancerPik3cb , Pik3r1 , Stk11
endometrial carcinomaMlst8 , Pik3ca , Pik3r1 , Tsc2
Endometrial NeoplasmsAkt2 , Braf , Cdk2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Prkca , Sfn , Stk11 , Vegfa
Endometrioid CarcinomasAkt1 , Ccne1 , Cdk2 , Pik3r2
endometriosisIgf1 , Vegfa
EndotoxemiaIgf1 , Irs1 , Pgf , Prkaa1
EpendymomaDepdc5
epidermal nevusHras , Nras , Pik3ca
epilepsyAkt1 , Pgf , Strada , Tsc1 , Tsc2
EPILEPSY, FAMILIAL FOCAL, WITH VARIABLE FOCI 1Depdc5 , Nprl2 , Nprl3
EPILEPSY, FAMILIAL FOCAL, WITH VARIABLE FOCI 2Nprl2
EPILEPSY, FAMILIAL FOCAL, WITH VARIABLE FOCI 3Nprl3
erythema multiformeVegfa
esophageal carcinomaHras , Pik3ca , Rhoa
Esophageal NeoplasmsHras , Pik3ca , Rhoa , Sfn
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaFkbp1a , Hif1a , Sfn
Experimental ArthritisAkt1 , Hif1a , Igf1 , Ikbkb , Mtor , Nras , Pgf , Pik3cd , Vegfa
Experimental Autoimmune EncephalomyelitisIgf1 , Prkaa1 , Rhoa , Vegfa
Experimental Autoimmune MyocarditisRps6
Experimental Autoimmune NeuritisHif1a , Rhoa
Experimental ColitisVegfa
Experimental Diabetes MellitusAkt1 , Eef2 , Hif1a , Hras , Igf1 , Ikbkb , Irs1 , Lpin1 , Mapk1 , Mapk3 , Mtor , Pgf , Pik3r1 , Ppargc1a , Prkca , Rhoa , Srebf1 , Tsc2 , Vegfa , Vegfb , Ywhah
Experimental Liver CirrhosisCdk2 , Fkbp1a , Igf1 , Ins2 , Mtor , Pgf , Rhoa , Srebf1 , Vegfa , Ywhag , Ywhaz
Experimental NeoplasmsBraf , Hras , Nras , Vegfa
Experimental SarcomaNras
extrahepatic cholestasisMapk1 , Mapk3
extrinsic allergic alveolitisVegfa
Facial AsymmetryPik3ca
familial adenomatous polyposisAkt1
familial hyperlipidemiaIrs1
familial Mediterranean feverIgf1
familial partial lipodystrophyAkt2
fatty liver diseaseCycs , Ins2 , Ppargc1a , Prkaa1 , Srebf1
Female InfertilityMapk1 , Mapk3 , Tsc2
Female Urogenital DiseasesIgf1
fetal alcohol spectrum disorderIgf1
Fetal Growth RetardationIgf1 , Irs1 , Ppargc1a , Srebf1
Fetal MacrosomiaIgf1
FibrosisAkt1 , Rhoa
Focal Cortical Dysplasia of TaylorMtor , Tsc1 , Tsc2
folic acid deficiency anemiaIgf1
follicular lymphomaRragc
Follicular Thyroid CancerBraf , Hras , Nras
follicular thyroid carcinomaBraf , Hras , Nras
GABRIELE-DE VRIES SYNDROMEYy1
gastric adenocarcinomaAkt1 , Braf , Hras , Map2k1 , Map2k2 , Mtor , Nras , Pik3ca , Raf1 , Rhoa
gastric ulcerVegfa
Gastrointestinal NeoplasmsPik3ca
gastrointestinal stromal tumorBraf
genetic diseaseAkt2 , Akt3 , Braf , Depdc5 , Hras , Map2k1 , Mapk1 , Mtor , Pik3ca , Pik3r1 , Pik3r2 , Pld1 , Raf1 , Rhoa , Rictor , Rps6ka3 , Stk11 , Tsc1 , Tsc2 , Yy1
Germ Cell and Embryonal NeoplasmsCcne1 , Rhoa
germinomaBraf
gestational diabetesIns2
Giant Pigmented Hairy NevusHras , Nras
gingivitisVegfa
glaucomaEef2 , Vegfa
glioblastoma multiformeAkt1 , Akt3 , Braf , Hif1a , Hras , Mtor , Nras , Pgf , Pik3ca , Pik3r1 , Pml , Vegfa
gliosarcomaVegfa
GliosisMapk1 , Mapk3
glomerulonephritisMapk1 , Vegfa
Glomus Tympanicum TumorVegfa
glucose intoleranceIns2 , Ppargc1a , Prkaa1 , Prkaa2
glycogen storage disease VHif1a
glycogen storage disease VIIHif1a
Gonadal Dysgenesis, XX Type, with DeafnessBraf
Graft vs Host DiseaseVegfa
granulosa cell tumorSgk1 , Vegfa
Graves OphthalmopathyIgf1
Graves' diseaseIgf1 , Vegfa
Growth DisordersIgf1 , Pik3ca
Growth Restriction, Severe, with Distinctive FaciesIns1
hairy cell leukemiaMap2k1
HamartomaFlcn , Tsc2
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca , Vegfa
head and neck squamous cell carcinomaAkt1 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Rac1 , Rhoa
Head Injuries, ClosedIgf1
Hearing Loss, Noise-InducedHif1a , Igf1
Hearing Loss, SuddenIgf1
heart diseasePpargc1a , Vegfa
Helicobacter InfectionsPrkaa1
hemangioblastomaHif1a
hemangiomaTsc2
HemimegalencephalyMtor , Pik3ca , Rheb
HemorrhageBnip3
Henoch-Schoenlein purpuraIgf1
hepatic encephalopathyHif1a
HepatitisIns2
hepatocellular adenomaHras
hepatocellular carcinomaAkt1 , Akt2 , Braf , Ccne1 , Depdc5 , Hif1a , Hras , Irs1 , Mtor , Nras , Pik3ca , Rac1 , Rps6 , Rps6ka3 , Sfn , Srebf1 , Tsc1
HepatomegalySesn2
hereditary lymphedemaVegfc
Hereditary Neoplastic SyndromesFlcn , Fnip1 , Pik3ca , Stk11 , Tsc1 , Tsc2
Hernias, Diaphragmatic, CongenitalIgf1 , Rhoa , Vegfa
Hirschsprung Disease 1Tsc2
Hot FlashesHif1a
human immunodeficiency virus infectious diseaseEif4a1 , Eif4ebp1 , Yy1
Huntington's diseaseCycs , Igf1 , Ppargc1a , Prkaa1
HyperalgesiaHif1a , Igf1 , Mapk1 , Mapk3 , Mtor , Raf1
Hyperbilirubinemia, NeonatalIkbkb
HypercholesterolemiaSrebf1 , Vegfa
hyperglycemiaIns2 , Ppargc1a
hyperinsulinismIns2 , Irs1 , Rps6kb1
HyperkalemiaIns2
HyperoxiaBnip3 , Igf1
HyperphagiaIgf1
HyperplasiaAkt1 , Hif1a , Ikbkb , Pik3ca , Vegfa
HyperproinsulinemiaIns1 , Ins2
HypertelorismRps6ka3
hypertensionAkt1 , Akt2 , Ccne1 , Hif1a , Igf1 , Ikbkb , Ins2 , Mtor , Pgf , Pik3r1 , Prkca , Rhoa , Rps6kb1 , Sgk1 , Stk11 , Vegfa , Ywhaz
hyperthyroidismPpargc1a
HypertriglyceridemiaIns2 , Mtor
hypertrophic cardiomyopathyIgf1 , Ins2 , Raf1 , Yy1
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularMtor , Ppargc1a , Prkca , Rac1 , Rhoa , Rps6kb1 , Stk11
Hypertrophy, Right VentricularAkt1 , Igf1 , Mtor , Ppargc1a , Prkca
hyperuricemiaIns2
hypoglycemiaAkt2 , Ins2 , Pik3r1
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 7 with or without anosmiaNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypokalemiaIns2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypoproteinemiaRps6kb1
HypotensionIns2
hypothyroidismIgf1
HypoxiaPgf
Hypoxia-Ischemia, BrainHif1a , Igf1 , Vegfa
idiopathic interstitial pneumoniaMtor
idiopathic pulmonary fibrosisHif1a
Immunoblastic LymphadenopathyRhoa
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunodeficiency due to Defect in MAPBP-Interacting ProteinLamtor2
impotenceAkt1 , Vegfa
in situ carcinomaAkt1 , Sfn
infantile epileptic encephalopathy 56Ywhag
InfarctionHif1a
InflammationAkt1 , Eif4ebp1 , Mtor , Pgf , Tsc2 , Vegfa
inflammatory bowel diseaseIkbkb , Vegfa
Insulin ResistanceAkt2 , Ikbkb , Ins2 , Irs1 , Lpin1 , Pik3r1 , Ppargc1a , Prkaa1 , Prkaa2 , Srebf1 , Stk11 , Tsc1
Insulin-Like Growth Factor I DeficiencyIgf1
insulinomaIns2
intellectual disabilityRps6ka3 , Tsc1 , Tsc2 , Yy1
intermediate coronary syndromeAkt1
interstitial cystitisMtor
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1 , Igf1
Intestinal NeoplasmsMap2k1 , Map2k2 , Prkca
Intimal HyperplasiaCdk2
invasive ductal carcinomaAkt1 , Hif1a
Invasive Pulmonary AspergillosisVegfa
inverted papillomaVegfa
ischemiaAkt2 , Cycs , Prkca , Raf1
ischemic colitisVegfa
Joubert syndrome 9Braf
juvenile myelomonocytic leukemiaNras
juvenile rheumatoid arthritisMapk1
Kawasaki diseaseVegfa
Kearns-Sayre syndromePpargc1a
KeloidSfn
kidney angiomyolipomaMtor
kidney diseaseIgf1 , Mapk1 , Srebf1
kidney failureHif1a , Ins2 , Ppargc1a , Tsc1
Kidney NeoplasmsAkt1 , Braf , Eif4ebp1 , Mapk1 , Mapk3 , Ppargc1a , Raf1 , Tsc1 , Tsc2
Kidney Reperfusion InjuryBnip3 , Hif1a , Ikbkb , Ppargc1a
Klinefelter's syndromeNras
Kuhnt-Junius degenerationIgf1 , Vegfa
Language Development DisordersRps6ka3
large cell carcinomaPrkca
Laron syndromeIgf1
learning disabilityVegfa
left ventricular noncompactionYwhae
leiomyomaTsc2
LEOPARD syndromeBraf , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaDdit4 , Nras
Leukemia, ExperimentalNras
LeukocytosisNras
Lewy body dementiaIns2
Limb IschemiaHif1a , Vegfa
limited sclerodermaPgf
lipid storage diseaseSrebf1
lipodystrophyLpin1
liver cancerAkt1 , Hras , Nras , Pik3ca
liver cirrhosisPgf , Vegfa
liver diseaseRac1
Liver FailureRps6 , Vegfa
liver neoplasmBraf , Flcn , Hras , Raf1
Liver Neoplasms, ExperimentalHras , Map2k1 , Mapk1 , Mapk3 , Pml
long QT syndromeRheb
lung adenocarcinomaAkt1 , Braf , Hras , Map2k1 , Nras , Pik3ca , Pik3r1 , Raf1 , Rhoa , Sfn , Stk11
lung cancerBraf , Pik3ca
lung diseaseHif1a , Vegfa
Lung InjuryMtor
Lung NeoplasmsAkt1 , Braf , Eef2 , Hras , Mapk1 , Mapk3 , Mtor , Pdcd4 , Pik3ca , Raf1 , Stk11 , Tsc1
lung small cell carcinomaAkt1 , Pik3ca
lung squamous cell carcinomaAkt1 , Braf , Hras , Pik3ca , Stk11
lupus nephritisMtor
LymphangiectasisRaf1
lymphangioleiomyomatosisTsc1 , Tsc2 , Vegfd
Lymphatic MetastasisCcne1 , Pdpk1 , Pik3ca , Pik3cb , Rhoa , Sfn , Stk11 , Tsc2 , Vegfa , Vegfc , Vegfd
lymphedemaPgf
LYMPHEDEMA, HEREDITARY, IDVegfc
lymphomaNras
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3 , Rps6ka3 , Tbc1d7
macular degenerationPpargc1a , Vegfa
macular retinal edemaVegfa
major depressive disorderEif4b
Male Germ Cell TumorStk11
malignant fibroxanthomaPpargc1a
malignant gliomaAkt2 , Braf , Hras , Igf1 , Pik3ca , Raf1
malignant mesotheliomaRaf1 , Ulk2
MalocclusionIgf1
Mammary Neoplasms, AnimalHras , Pik3r1 , Sgk1 , Ywhaz
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Ccne1 , Cdk2 , Hif1a , Hras , Igf1 , Mtor , Pik3r1 , Sgk1 , Vegfa , Ywhaz
Mandibular NeoplasmsBraf
Manganese PoisoningBnip3
mantle cell lymphomaEif4e , Eif4ebp1 , Mtor , Pik3cd
maturity-onset diabetes of the youngIns1 , Ins2
maturity-onset diabetes of the young type 10Ins1 , Ins2
medulloblastomaCcne1 , Nras , Pik3ca , Strada , Tsc2
Megakaryoblastic Leukemia of Down SyndromeNras
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3 , Rps6ka3 , Tbc1d7
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Braf , Cdk2 , Flcn , Hras , Map2k1 , Map2k2 , Mtor , Nras , Pik3ca , Pik3r1 , Ppargc1a , Rac1 , Raf1 , Stk11 , Vegfa , Vegfc
Melanoma, ExperimentalIkbkb , Pxn
membranoproliferative glomerulonephritisCdk2
membranous glomerulonephritisRhoa
Memory DisordersHif1a , Ins2 , Vegfa
Meningeal NeoplasmsAkt1
meningiomaAkt1
Mental Retardation, X-Linked 19Rps6ka3
MesotheliomaMtor
Metabolic Bone DiseasesIgf1
Metabolic SyndromeIns2 , Irs1 , Ppargc1a , Vegfa
methylmalonic acidemiaCycs
microcephalyIgf1
MicrognathismRps6ka3
Micronuclei, Chromosome-DefectiveHif1a , Ins2
Microsatellite InstabilityBraf
Microvascular Complications of Diabetes, Susceptibility to, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 2Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 7Vegfa
middle cerebral artery infarctionBnip3 , Hif1a , Igf1 , Ikbkb , Mtor , Pld1
migraineMap2k2
Miller-Dieker lissencephaly syndromeYwhae
morbid obesityHif1a , Lpin1
mouth diseaseDdit4
Mouth NeoplasmsHras , Nras , Pik3ca , Sfn , Tsc1 , Tsc2
MPTP PoisoningIns2
mucinous cystadenocarcinomaSgk1
mucositisUlk1
Multiple AbnormalitiesMapk1 , Pik3r2 , Pld1
Multiple Hamartoma SyndromePik3ca
multiple myelomaBnip3 , Braf , Hras , Nras , Pik3ca , Vegfa
Multiple Organ FailureMapk1
multiple sclerosisRhoa , Vegfa
Muscle HypotoniaRps6ka3
muscular atrophyAkt1 , Igf1 , Ikbkb , Mtor , Rps6kb1
muscular diseaseIns2
Muscular Dystrophy, AnimalMtor , Ppargc1a
mycosis fungoidesHif1a
myelodysplastic syndromeHras , Nras
myeloid leukemiaVegfa
myeloid neoplasmNras
myocardial infarctionAkt1 , Bnip3 , Hif1a , Igf1 , Mapk1 , Mtor , Pgf , Ppargc1a , Rps6kb1 , Vegfa , Vegfb
Myocardial IschemiaEif4e , Eif4ebp1 , Hif1a , Igf1 , Pgf , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bnip3 , Hif1a , Mapk1 , Pld2 , Ppargc1a , Rhoa , Vegfa
myoglobinuriaLpin1
myopiaIgf1
Nasal PolypsIgf1 , Vegfa
Nasopharyngeal NeoplasmsHras , Nras , Pik3ca
nasopharynx carcinomaAkt2 , Pik3ca
Nematode InfectionsPik3r1
NeointimaIgf1 , Yy1
neonatal diabetes mellitusIns1 , Ins2
Neoplasm InvasivenessEef2 , Eif4e , Hif1a , Hras , Igf1 , Mapk1 , Mapk3 , Pdcd4 , Rhoa , Rps6ka3
Neoplasm MetastasisAkt2 , Braf , Ccne1 , Eef2 , Igf1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r3 , Pml , Pxn , Rac1 , Rhoa , Rps6ka3 , Vegfa , Ywhae
Neoplasm Recurrence, LocalVegfa , Ywhaz
Neoplasms, Second PrimaryPml
Neoplastic ProcessesHras
neovascular glaucomaVegfa
Neovascularization, PathologicVegfa
nephritisMtor
nephroblastomaHif1a , Vegfc
nephrogenic diabetes insipidusPrkca
nephrotic syndromePpargc1a
Nerve DegenerationDdit4 , Igf1 , Mapk1 , Mapk3 , Tsc2 , Vegfa
neural tube defectIns2
neuroblastomaHras , Nras , Pik3ca , Tsc2
Neurocutaneous MelanosisNras
neuroendocrine tumorBraf
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
neurofibrosarcomaNras , Vegfa
neuronal ceroid lipofuscinosisBraf
neuronal ceroid lipofuscinosis 1Ppargc1a , Rps6kb1
neuronal ceroid lipofuscinosis 6Braf , Mapk1 , Mapk3
NevusBraf
Nevus, PigmentedNras
newborn respiratory distress syndromeVegfa
non-Hodgkin lymphomaBraf , Map2k1 , Nras , Pik3ca , Rhoa
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Braf , Ccne1 , Hif1a , Hras , Map2k1 , Nras , Pdpk1 , Pik3ca , Pxn , Raf1 , Rheb , Stk11 , Vegfa
non-syndromic X-linked intellectual disabilityRps6ka3
nonalcoholic fatty liver diseaseIgf1 , Irs1 , Ppargc1a , Srebf1
nonpapillary renal cell carcinomaFlcn
Nonseminomatous Germ Cell TumorBraf
Noonan syndromeBraf , Hras , Igf1 , Map2k1 , Map2k2 , Nras , Raf1
Noonan syndrome 1Braf , Map2k1 , Nras
Noonan syndrome 3Hras , Raf1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 8Lamtor2
obesityAkt1 , Akt2 , Bnip3 , Cycs , Ikbkb , Ins2 , Irs1 , Mtor , Pgf , Pik3r1 , Ppargc1a , Rhoa , Rps6kb1 , Srebf1 , Stk11 , Tsc1
obsessive-compulsive disorderHras
olfactory neuroblastomaHif1a
Optic Nerve InjuriesCdk2 , Rhoa
Orthomyxoviridae InfectionsPld2
osteoarthritisEef2 , Hif1a , Igf1 , Ins2 , Mtor , Ywhaq
Osteoarthritis, ExperimentalUlk1
Osteoarthritis, KneeIgf1
osteochondrodysplasiaVegfa
OsteophyteIgf1
osteoporosisIgf1 , Irs1
Osteoporosis, PostmenopausalHif1a , Igf1
Osteoporotic FracturesIgf1
osteosarcomaAkt1 , Tsc2 , Vegfa
otitis mediaVegfa
Otitis Media with EffusionVegfa
ovarian cancerAkt1 , Pik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Ccne1 , Cdk2 , Hif1a , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Prkca , Rhoa , Sfn , Stk11 , Vegfa , Vegfc , Vegfd
ovarian serous cystadenocarcinomaBraf , Hras , Nras , Pik3ca
Oxygen-Induced RetinopathyHif1a , Igf1 , Vegfa
Paget's disease of bonePml
PainAkt1
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaHras , Map2k2 , Pik3ca
pancreatic cancerAkt1 , Akt2 , Akt3 , Braf , Cycs , Hif1a , Igf1 , Ins2 , Mtor , Stk11 , Tsc2 , Vegfb
pancreatic carcinomaMtor , Stk11 , Tsc1
pancreatic ductal carcinomaIgf1 , Ins2 , Stk11 , Tsc2 , Vegfa
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic NeoplasmsStk11
pancreatitisIkbkb , Ins2
panic disorderIns2
papillary carcinomaVegfc
Papillary Thyroid CancerBraf
papillary thyroid carcinomaBraf
papillomaHras
ParalysisIns2
paraplegiaAkt1
ParesthesiaIns2
Parkinson's diseaseAkt1 , Ddit4 , Ins2 , Ppargc1a , Rrn3
Parkinsonian DisordersFkbp1a , Mtor , Ppargc1a
PEHO SyndromeIgf1
penile neoplasmHras , Pik3ca
perinatal necrotizing enterocolitisBnip3
Periodontal AtrophyVegfa
peripheral nervous system diseaseIgf1
peripheral T-cell lymphomaRhoa
permanent neonatal diabetes mellitusIns1 , Ins2
Peutz-Jeghers syndromeStk11
phobic disorderHras
Phyllodes TumorHif1a
Pituitary NeoplasmsIgf1 , Prkca
placental insufficiencyPpargc1a
Plaque, AtheroscleroticIgf1
plasmacytomaBraf , Hras , Nras , Pik3ca
pleomorphic xanthoastrocytomaBraf , Castor2 , Cycs , Lamtor4 , Tsc1 , Ywhag
pleuropulmonary blastomaYy1
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaIkbkb
pneumothoraxFlcn
polyarteritis nodosaVegfa
Polycystic Kidney DiseasesHif1a , Mtor
polycystic ovary syndromeAkt2 , Igf1 , Ins2 , Vegfa
Polyhydramnios, Megalencephaly, and Symptomatic EpilepsyStrada
PolymicrogyriaAkt3
Polypoidal Choroidal VasculopathyVegfa
PolyuriaPrkca
portal hypertensionMtor , Pik3r1 , Vegfa
Potocki-Lupski syndromeFlcn
pre-eclampsiaPgf , Vegfa
pre-malignant neoplasmAkt1 , Eif4ebp1 , Hras , Irs1 , Prkaa1 , Tsc2 , Vegfa
precursor lymphoblastic lymphoma/leukemiaNras
precursor T-lymphoblastic lymphoma/leukemiaMtor
prediabetes syndromePpargc1a
Pregnancy in DiabeticsVegfa
Premature BirthPgf
primary biliary cirrhosisHif1a , Ppargc1a , Rps6kb1
primary spontaneous pneumothoraxFlcn
progeriaIgf1
progressive myoclonus epilepsyTsc1
proliferative diabetic retinopathyVegfa
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Raf1
prostate cancerAkt2 , Akt3 , Atg13 , Hif1a , Ikbkb , Ins2 , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Raf1 , Ulk2
prostate carcinomaAkt2
prostate carcinoma in situCcne1 , Igf1 , Stk11
Prostatic NeoplasmsAkt1 , Bnip3 , Braf , Ccne1 , Cdk2 , Hif1a , Hras , Igf1 , Ins2 , Irs1 , Map2k1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pml , Prkca , Vegfa
proteinuriaRhoa , Vegfa
Proteus syndromeAkt1
pseudoxanthoma elasticumVegfa
psoriasisHif1a , Igf1 , Ikbkb , Vegfa
Psychomotor DisordersRps6ka3
PTEN hamartoma tumor syndromePik3ca
pterygiumVegfa , Vegfc
Puberty, PrecociousIgf1
pulmonary edemaVegfa
pulmonary emphysemaPgf , Ppargc1a
pulmonary fibrosisIgf1
pulmonary hypertensionHif1a , Mtor , Pgf , Rhoa , Vegfb
pulmonary valve stenosisBraf , Hras
pycnodysostosisIgf1
pyelonephritisPgf
Radiation InjuriesHif1a
Radiation Injuries, ExperimentalHif1a , Mapk1 , Mapk3
RASopathiesBraf , Hras , Map2k1 , Map2k2 , Nras , Raf1
rectal neoplasmNras , Pik3ca , Pik3cb
RecurrenceCcne1 , Eef2 , Hras , Vegfc
renal carcinomaMtor , Nras , Pik3ca
renal cell carcinomaAkt1 , Akt3 , Ccne1 , Cdk2 , Eef2 , Flcn , Hif1a , Map2k1 , Mapk1 , Mtor , Nras , Pgf , Pik3ca , Pik3r1 , Pld2 , Rheb , Tsc1 , Tsc2 , Vegfa , Vegfc
renal fibrosisMapk1 , Ppargc1a
renal oncocytomaFlcn
Reperfusion InjuryAkt1 , Akt1s1 , Ccne1 , Eef2 , Hif1a , Igf1 , Pik3r1 , Pld2 , Prkca , Vegfc , Vegfd
Retina Reperfusion InjuryVegfa
retinal detachmentBnip3
retinal diseaseVegfa
retinal ischemiaHif1a , Vegfa
Retinal NeovascularizationHif1a , Mtor , Vegfa , Vegfb
retinal telangiectasiaVegfa
retinal vein occlusionVegfa , Vegfb
retinitis pigmentosaVegfa
retinopathy of prematurityIgf1 , Vegfa
RhabdomyolysisIns2
rhabdomyosarcomaVegfa
rheumatic heart diseaseIgf1
rheumatoid arthritisDdit4 , Hif1a , Pgf , Vegfa
rhinitisVegfa
RhinosinusitisIgf1
sarcomaPik3ca
SarcopeniaIgf1 , Ppargc1a
schizophreniaAkt1 , Eef2k , Lpin1 , Mapk3 , Mtor , Nprl2 , Pik3cb , Pml , Ppargc1a , Rb1cc1 , Rrn3 , Ywhah , Ywhaz
Schnyder corneal dystrophyMtor
sciatic neuropathyMtor , Ppargc1a
sclerosing cholangitisHif1a
Seasonal Allergic RhinitisVegfa
Sebaceous Nevus of JadassohnHras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Nras
seborrheic keratosisPik3ca
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
seminomaHras , Vegfa
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
SepsisEif4e , Irs1 , Mapk1 , Mapk3 , Mtor , Pgf , Ppargc1a
Septic PeritonitisPik3r1
serous cystadenocarcinomaSgk1
Sezary's diseaseBraf , Mapk1 , Rps6ka1
Shock, HemorrhagicMapk1 , Mtor
SHORT SyndromePik3r1
sickle cell anemiaPgf
Silver-Russell syndromeIns1
skin benign neoplasmHras
skin melanomaHif1a , Stk11
Skin NeoplasmsAkt1 , Hif1a , Hras , Igf1 , Vegfa
Skull FracturesIgf1
Sleep DeprivationEef2
Sleep Initiation and Maintenance DisordersPpargc1a
small cell carcinomaMtor
Small-For-Size SyndromeVegfa
Smith-Kingsmore SyndromeMtor
Smith-Magenis syndromeMap2k2 , Prkca , Rps6kb1 , Rptor , Srebf1 , Strada , Ulk2
spermatocytomaHras
Spinal Cord InjuriesAkt1 , Akt1s1 , Bnip3 , Ccne1 , Hif1a , Mtor , Ppargc1a , Ulk1 , Vegfa
spinocerebellar ataxia type 26Eef2
Splenic NeoplasmsHras
SplenomegalyNras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Hras , Mtor , Pik3ca , Rheb
squamous cell carcinomaAkt1 , Hras , Mapk1 , Mapk3 , Pik3ca , Sfn , Stk11 , Tsc1 , Tsc2 , Vegfa
status epilepticusMtor , Pgf , Vegfa
Stevens-Johnson syndromePml
stomach cancerPik3ca
Stomach NeoplasmsBnip3 , Hras , Mapk1 , Mapk3 , Nras , Pik3ca , Prkaa1 , Rhoa , Rps6
StrokeAkt1 , Igf1 , Pgf , Pik3ca , Prkaa2 , Vegfa
Subarachnoid HemorrhageBnip3 , Hif1a
substance-induced psychosisAkt1
sudden infant death syndromeVegfa
systemic lupus erythematosusPgf , Ywhab
systemic sclerodermaVegfa
T-Cell LymphomaAkt1 , Rhoa
TachycardiaIns2
Tachycardia, VentricularRaf1
Takotsubo CardiomyopathyPpargc1a
Telomeric 22q13 Monosomy SyndromeIns2
temporal lobe epilepsyMtor , Pgf , Vegfa
Temporomandibular Joint DisordersHif1a , Mtor
Testicular Germ Cell TumorStk11
Testis Reperfusion InjuryHif1a
ThinnessIgf1
thrombocytopeniaCycs
Thrombocytopenia 4Cycs
thrombosisPik3cb
Thrombotic MicroangiopathiesVegfa
thymomaHras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Hif1a , Hras , Nras , Pik3ca
Tibial FracturesPgf
Tobacco Use DisorderRptor
Tongue NeoplasmsHras , Igf1 , Vegfa , Vegfc
toxic encephalopathyMtor
transient cerebral ischemiaBnip3 , Cycs , Hif1a , Igf1 , Ikbkb , Rps6 , Sgk1
transitional cell carcinomaAkt1 , Braf , Hras , Map2k1 , Mapk1 , Mtor , Nras , Pik3ca , Rheb , Sfn
Transplant RejectionIkbkb
Trichilemmoma Hras
trigeminal neuralgiaMapk1 , Mapk3
tuberous sclerosisEif4ebp1 , Tsc1 , Tsc2
Tuberous Sclerosis 1Tsc1 , Tsc2
Tuberous Sclerosis 2Tsc2
Tumor Predisposition SyndromeFlcn , Stk11 , Tsc1 , Tsc2
Turner syndromeIgf1
Tympanic Membrane PerforationVegfa
type 1 diabetes mellitusIgf1 , Ins2 , Ppargc1a , Yy1
type 1 diabetes mellitus 2Ins1 , Ins2
type 2 diabetes mellitusAkt1 , Akt2 , Braf , Hif1a , Igf1 , Ikbkb , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3cb , Pik3r1 , Ppargc1a , Prkaa1 , Prkaa2 , Srebf1 , Vegfa
UlcerHif1a
ulcerative colitisVegfa
uremiaSgk1
ureteral obstructionAkt1 , Mtor
urethral obstructionMapk1
urinary bladder cancerAkt1 , Ccne1 , Hras , Igf1 , Mtor , Prkca , Rhoa , Sfn , Tsc1 , Vegfa , Vegfc , Vegfd
Urinary Bladder NeoplasmHras
Urinary IncontinenceMapk1
Urologic NeoplasmsHif1a , Rhoa , Vegfa
uterine carcinosarcomaHras , Pik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Ccne1 , Cdk2 , Hras , Mapk1 , Mtor , Nras , Pik3ca , Stk11 , Vegfa , Yy1
uterine fibroidTsc2
Uterine NeoplasmsBraf , Hras , Map2k1 , Mtor , Nras , Pik3ca , Pik3r1 , Rac1 , Rheb
uveal melanomaIgf1 , Vegfa
varicoceleHif1a
vascular dementiaEif4e , Igf1 , Mtor , Rps6
Vascular MalformationsPik3ca
velocardiofacial syndromeMapk1
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftIns2 , Rac1
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
ventricular septal defectBraf , Pgf
visual epilepsyIns2 , Pik3ca , Pld1 , Pld2 , Tsc1 , Tsc2 , Ywhab , Ywhaz
vitiligoPik3r1
Vulvar NeoplasmsSfn
Wallerian DegenerationPgf
Wegener's granulomatosisIgf1
Weight GainPik3ca
Weight LossIns2
Weissenbacher-Zweymuller syndromeMapk1
Werner syndromeHif1a
West syndromeTsc1 , Tsc2
withdrawal disorderMapk1 , Mapk3
Wolff-Parkinson-White syndromeFnip1
Wounds and InjuriesIgf1 , Vegfa
Wounds, PenetratingPgf
YOU-HOOVER-FONG SYNDROMETelo2
Zinc DeficiencyIgf1
Pathway Annotations Associated with Genes in the mTOR signaling pathway
Pathway TermsGene Symbols
activin signaling pathwayFkbp1a
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pml , Raf1 , Rps6kb1 , Rps6kb2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCab39 , Prkaa1 , Prkaa2 , Stk11 , Strada
adenosine signaling pathwayAkt1 , Braf , Hras , Ikbkb , Map2k2 , Mapk1 , Pdpk1 , Pik3ca , Rps6ka1
aldosterone signaling pathwayIgf1 , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Sfn , Sgk1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin signaling pathwayIns2
altered insulin-like growth factor signaling pathwayIgf1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
Alzheimer's disease pathwayCycs , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayCycs , Rac1
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Arf family mediated signaling pathwayPld2 , Rac1
autophagy pathwayAtg13 , Ins1 , Ins2 , Prkaa1 , Prkaa2 , Rb1cc1 , Ulk1 , Ulk2 , Ulk3
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1
bevacizumab pharmacodynamics pathwayVegfa
Bone morphogenetic proteins signaling pathwayMapk1
c-Jun N-terminal kinases MAPK signaling pathwayRac1
calcium signaling pathway via the calcium-sensing receptorRhoa
calcium/calcium-mediated signaling pathwayPrkca
cardiolipin metabolic pathwayCycs
cardiovascular system disease pathwayIgf1
cell cycle pathway, mitoticCcne1 , Cdk2 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Igf1 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pxn , Rac1 , Raf1 , Rhoa
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa
corticosteroid signaling pathwaySgk1
CRM1 export pathwayEif4e
cytokine mediated signaling pathwayVegfc , Vegfd
dilated cardiomyopathy pathwayIgf1
E-cadherin signaling pathwayAkt1 , Akt2 , Igf1 , Pik3ca , Pik3r1 , Rac1 , Rhoa
eicosanoid signaling pathwayAkt1 , Pik3r5 , Prkca , Rac1 , Rhoa
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
electron transport chain pathwayCycs
endocytosis pathwayHras , Pld1 , Pld2 , Pml , Rhoa
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkca , Rac1 , Raf1 , Rhoa
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca
ephrin - ephrin receptor bidirectional signaling axisHras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5 , Pxn , Rac1 , Rhoa
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1 , Rps6kb1 , Rps6kb2
erythropoietin signaling pathwayHras , Pik3r1
ether lipid metabolic pathwayPld1 , Pld2
ether lipid metabolic pathwayPld1 , Pld2
FasL mediated signaling pathwayAkt1 , Ikbkb , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Rac1 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pld2 , Prkca , Rac1 , Raf1 , Rps6kb1 , Rps6kb2
fibroblast growth factor signaling pathwayAkt1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Rps6ka1
forkhead class A signaling pathwayAkt1 , Ins2
G1/S DNA damage checkpoint pathwayCcne1
G1/S transition pathwayCcne1 , Cdk2
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
glutamate signaling pathwayMapk1 , Mapk3 , Pld1 , Pld2 , Prkca
glyburide pharmacodynamics pathwayIns2
glycerophospholipid metabolic pathwayPld1 , Pld2
glypican signaling pathwayVegfa
gonadotropin-releasing hormone signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pld1 , Pld2 , Prkca , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayHras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Ywhaz
Hedgehog signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Sspo
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
histone modification pathwayYwhaz
Huntington's disease pathwayCycs , Ppargc1a
hypertrophic cardiomyopathy pathwayIgf1 , Prkaa1 , Prkaa2
hypoxia inducible factor pathwayAkt1 , Bnip3 , Hif1a , Vegfa
influenza A pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pml , Prkca , Raf1
INO80 family mediated chromatin remodeling pathwayYy1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Ins2 , Rac1 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4e , Eif4e2 , Eif4ebp1 , Hras , Ikbkb , Ins1 , Ins2 , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Raf1 , Rheb , Rps6 , Rps6kb1 , Rps6kb2 , Rptor , Sgk1 , Srebf1 , Tsc1 , Tsc2
insulin-like growth factor signaling pathwayAkt1 , Hras , Igf1 , Irs1 , Pdpk1 , Pik3ca , Pik3r1 , Pxn , Raf1 , Rps6kb1 , Ywhae , Ywhaz
integrin mediated signaling pathwayPxn
interleukin-1 signaling pathwayIkbkb , Pik3ca , Pik3r1
interleukin-12 signaling pathwayMtor
interleukin-2 signaling pathwayCdk2 , Hras , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Rhoa
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1 , Ywhag , Ywhaz
interleukin-4 signaling pathwayAkt1 , Irs1 , Mtor , Pik3ca , Pik3r1 , Rps6kb1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pik3ca , Pik3r1 , Rac1
intrinsic apoptotic pathwayBnip3 , Cycs
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Leishmaniasis pathwayMapk1 , Mapk3
leptin system pathwayIrs1
long term depressionBraf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Raf1
long term potentiationBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6
maturity-onset diabetes of the young pathwayIns1 , Ins2
measles pathwayAkt1 , Akt2 , Akt3 , Ccne1 , Cdk2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitochondrial autophagy pathwayBnip3 , Ulk1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Rac1 , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
mTOR signaling pathwayAkt1 , Akt1s1 , Akt2 , Akt3 , Atg13 , Bnip3 , Braf , Cab39 , Cab39l , Castor1 , Castor2 , Ccne1 , Cdk2 , Clip1 , Cycs , Ddit4 , Depdc5 , Deptor , Eef2 , Eef2k , Eif4a1 , Eif4b , Eif4e , Eif4e2 , Eif4ebp1 , Fbxw11 , Fkbp1a , Flcn , Fnip1 , Fnip2 , Hif1a , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Irs1 , Lamtor1 , Lamtor2 , Lamtor3 , Lamtor4 , Lamtor5 , Lpin1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapkap1 , Mios , Mlst8 , Mtor , Nprl2 , Nprl3 , Nras , Pdcd4 , Pdpk1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pld2 , Pml , Poldip3 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Prr5 , Prr5l , Pxn , Rac1 , Raf1 , Rb1cc1 , Rheb , Rhoa , Rictor , Rps6 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Rps6kb1 , Rps6kb2 , Rptor , Rraga , RragB , Rragb_v1 , Rragc , Rragd , Rrn3 , Sesn2 , Sfn , Sgk1 , Srebf1 , Sspo , Stk11 , Strada , Tbc1d7 , Telo2 , Tsc1 , Tsc2 , Tsc2_v1 , Tsc2_v2 , Tti1 , Ulk1 , Ulk2 , Ulk3 , Vegfa , Vegfb , Vegfc , Vegfd , Wdr24 , Wdr59 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz , Yy1
myocarditis pathwayCycs , Rac1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Rac1 , Rhoa
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
NOD-like receptor signaling pathwayIkbkb , Mapk1 , Mapk3
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
Notch signaling pathwaySspo , Yy1
nuclear factor kappa B signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca , Sspo
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
p38 MAPK signaling pathwayRac1
p53 signaling pathwayAkt1 , Ccne1 , Cdk2 , Cycs , Igf1 , Sfn , Tsc2 , Yy1
p53-dependent G1/S DNA damage checkpoint pathwayCcne1
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Parkinson's disease pathwayCycs
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rhoa , Sgk1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Rictor , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Rac1 , Raf1 , Rhoa , Rps6ka3 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
potassium channel inhibitors pharmacodynamics pathwayIns2
prion disease pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Ccne1 , Cdk2 , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
protein kinase C (PKC) signaling pathwayPdpk1 , Prkca
Reelin signaling pathwayAkt1 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Flcn , Hif1a , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb
Rheb mediated signaling pathwayRheb
rheumatoid arthritis pathwayPgf , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayRac1 , Rhoa
RNA polymerase I transcription pathwayRrn3
RNA transport pathwayEif4a1 , Eif4b , Eif4e , Eif4e2 , Eif4ebp1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
sleeping sickness pathwayPrkca
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Ccne1 , Cdk2 , Cycs , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Irs1 , Mapk1 , Mapk3 , Rac1 , Rhoa , Vegfa
sterol regulatory element-binding protein signaling pathwaySrebf1
syndecan signaling pathwayHras , Mapk1 , Mapk3 , Prkca , Rac1 , Rhoa
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rhoa
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
thyroid cancer pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayFkbp1a , Pdpk1 , Pml , Rhoa , Rps6kb1 , Ywhae
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Rhoa , Rps6kb1 , Rps6kb2
translation elongation pathwayEef2
translation initiation pathwayEif4a1 , Eif4b , Eif4e
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Cycs , Mapk1 , Mapk3 , Raf1 , Rhoa
tumor necrosis factor mediated signaling pathwayIkbkb
type 1 diabetes mellitus pathwayIns1 , Ins2
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayFbxw11 , Pml
urinary bladder cancer pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Fbxw11 , Hif1a , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaa1 , Prkaa2 , Prkca , Pxn , Rac1 , Raf1 , Rhoa , Vegfa , Vegfb , Vegfc , Vegfd
Wnt signaling pathwayFbxw11 , Prkca , Rac1 , Rhoa
Wnt signaling, canonical pathwayTsc2
Wnt signaling, non-canonical pathwayRac1 , Rhoa
Wnt signaling, the planar cell polarity pathwayRac1 , Rhoa
Phenotype Annotations Associated with Genes in the mTOR signaling pathway

References Associated with the mTOR signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: