EPIDERMAL GROWTH FACTOR/NEUREGULIN SIGNALING PATHWAY (PW:0000170)

View Ontology Report

Description

The epidermal growth factor/neuregulin signaling pathway plays a central role in the regulation of cell growth, differentiation, proliferation and survival. At least eleven ligands bind to four receptors to activate downstream signaling pathways, primarily the Raf/Mek/Erk MAPK and the phosphatidylinositol 3-Akt cascades (reports point to activation of Stat proteins in certain cancer cell lines). The ligands are type 1 transmembrane proteins whose extracellular domain must be cleaved in order to

Pathway Diagram:

Ariadne Genomics Inc. Erbb3 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Erbb4 Erbb3 Sos1 Adams ---> Nrg ligands Adams ---> Egfr/Erbb4 ligands Adams ---> Egfr ligands Erbb4 ---- Nrg ligands Erbb3 ---- Nrg ligands Egfr/Erbb4 ligands ---- Erbb4 Egfr ---- Egfr/Erbb4 ligands Egfr ---- Egfr ligands the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell differentiation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell proliferation pro-growth phosphatidylinositol 3-kinase-Akt signaling pathway cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell survival the extracellular signal-regulated Raf/Mek/Erk signaling pathway Egfr ---- Shc1 Erbb4 ---- Grb2 Erbb2 ---- Shc1 Egfr ---- Grb2 Grb2 ---- Shc1 Grb2 ---- Sos2 Grb2 Grb2 ---- Sos1 Pik3r1 Shc1 Erbb4 ---- Shc1 Egfr cell differentiation cell survival Erbb2 Erbb3 ---- Pik3r1 Ptprj ---| Egfr Cbl Cbl ---| Egfr Egfr ligands Egfr/Erbb4 ligands Adams Ptprj Sos2 Nrg ligands
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Genes in Pathway:

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epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6907045
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:6907045
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:2317976
G Adam12 ADAM metallopeptidase domain 12 JBrowse link 1 205,951,840 206,286,294 RGD:2317976
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:2317976
G Adam19 ADAM metallopeptidase domain 19 JBrowse link 10 31,146,107 31,240,582 RGD:2317976
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:2317976
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:1578718
RGD:6907045
RGD:6484113
RGD:2317963
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Btc betacellulin JBrowse link 14 18,231,854 18,270,621 RGD:2317963
RGD:6907045
RGD:6484113
RGD:2324625
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6907045
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6907045
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:6907045
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:6907045
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:2317988
RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6907045
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1626483
RGD:6907045
RGD:6484113
RGD:2317963
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1581898
RGD:6907045
RGD:6484113
RGD:1581908
RGD:2317963
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Epgn epithelial mitogen JBrowse link 14 18,627,103 18,635,135 RGD:2317963
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:2317963
RGD:6907045
RGD:6484113
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:1642700
RGD:2289958
RGD:6907045
RGD:6484113
RGD:2317988
RGD:2317965
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:2317965
RGD:6907045
G Ereg epiregulin JBrowse link 14 18,577,620 18,591,395 RGD:2317963
RGD:6907045
RGD:6484113
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
RGD:6907045
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6484113
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:2317988
RGD:6907045
RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:6484113
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:2317963
RGD:6907045
RGD:6484113
RGD:1581908
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6484113
RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:6484113
RGD:6907045
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6484113
RGD:6907045
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:2317965
RGD:6907045
G Nrg2 neuregulin 2 JBrowse link 18 28,835,391 29,015,552 RGD:1304015
RGD:6907045
RGD:6484113
RGD:2317965
G Nrg3 neuregulin 3 JBrowse link 16 15,763,031 16,932,208 RGD:2317965
RGD:6907045
RGD:6484113
G Nrg4 neuregulin 4 JBrowse link 8 59,782,789 59,849,433 RGD:2317965
RGD:6907045
RGD:6484113
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6484113
RGD:6907045
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6907045
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:6907045
G Pak4 p21 (RAC1) activated kinase 4 JBrowse link 1 85,162,462 85,201,746 RGD:6907045
G Pak6 p21 (RAC1) activated kinase 6 JBrowse link 3 110,442,175 110,486,317 RGD:6907045
G Pak7 p21 (RAC1) activated kinase 7 JBrowse link 3 129,042,232 129,357,512 RGD:6907045
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1642700
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:2317988
RGD:6907045
RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma JBrowse link 7 11,267,207 11,294,291 RGD:6484113
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6484113
RGD:6907045
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642700
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:6907045
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6484113
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:6484113
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:2317988
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6484113
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6907045
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:6907045
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:2317988
RGD:6907045
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Shc3 SHC adaptor protein 3 JBrowse link 17 13,670,520 13,791,043 RGD:6907045
G Shc4 SHC adaptor protein 4 JBrowse link 3 117,897,738 117,990,289 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1581110
RGD:6907045
RGD:6484113
RGD:2317988
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:2317988
RGD:6907045
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1581134
RGD:6907045
RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6484113
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6907045
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:2317963
RGD:6907045
RGD:6484113
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:6484113
G Wasl Wiskott-Aldrich syndrome-like JBrowse link 4 51,677,722 51,726,212 RGD:6484113
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:5490965
RGD:5133242
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:5133243
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAdamsAdam members
Functional ClassEgfr ligandsepidermal growth factor receptor ligands
Functional ClassEgfr/Erbb4 ligandsligands for both epidermal growth factor receptor and Erbb4
Functional ClassNrg ligandsneuregulin ligands

Pathway Gene Annotations

Disease Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmMapk8
Aberrant Crypt FociGsk3b , Mapk1 , Mapk3 , Myc
acoustic neuromaCdkn1a
Acute Coronary SyndromeGsn
Acute ErythroleukemiaErbb3
acute kidney failureBad , Cdkn1b , Egf , Egfr , Gsk3b , Hbegf , Mtor , Myc , Tgfa
Acute Liver FailureMapk8
Acute Lung InjuryEgfr , Pak1
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesAbl1
acute myeloid leukemiaAbl1 , Cbl , Cdkn1b , Eif4ebp1 , Hras , Kras , Myc , Nras , Ptpn11 , Stat3
acute promyelocytic leukemiaAkt1 , Myc , Nras
Acute-Phase ReactionStat5b
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaAbl1 , Egf , Egfr , Erbb2 , Kras , Mtor , Myc , Pik3ca , Ptpn11 , Stat3 , Stat5a
adenoid cystic carcinomaHras , Kras , Map2k2 , Pik3ca , Stat3
adenomaKras
adrenal carcinomaBraf , Nras , Pik3ca
adrenocortical carcinomaBraf , Egfr , Nras , Pik3ca
adult T-cell leukemiaNras , Plcg1 , Prkcb , Stat3
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS-Associated NephropathyEgf , Mtor
AlbuminuriaNck1 , Nck2
Alzheimer's diseaseAbl1 , Akt1 , Bad , Camk2a , Egf , Egfr , Elk1 , Gsk3b , Hras , Hsp90aa1 , Mapk10 , Mapk8 , Mapk9 , Nrg1 , Pak1 , Pik3r1 , Plcg2 , Shc1 , Stat3
Alzheimer's disease 18Adam10
ameloblastomaBraf
amnestic disorderGnai1 , Gnai3
amphetamine abuseAkt1 , Nrg1
amyloidosisGsn
amyotrophic lateral sclerosisAkt1 , Bad , Gsk3b
amyotrophic lateral sclerosis type 1Shc1
amyotrophic lateral sclerosis type 19Erbb4
anaplastic large cell lymphomaHsp90aa1 , Stat3
anemiaKras
angiomyolipomaStat1 , Stat3
angiosarcomaHras , Jun , Kras , Myc , Plcg1 , Stat3
Animal Disease ModelsAkt1 , Erbb2 , Hbegf , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Prkcg , Stat3
aniridiaCamk2d
anti-basement membrane glomerulonephritisMapk8
aortic valve diseaseEgfr
aortic valve stenosisEgfr , Ptpn11
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arsenic PoisoningCdkn1a
arteriosclerosisMapk9
arteriovenous malformationRasa1
arteriovenous malformations of the brainEgfr , Kras
AsphyxiaJun
asthmaAreg , Egfr
Asthma, OccupationalPrkca
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Hras , Kras , Ptpn11
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Stat3
atopic dermatitisMapk8
atrial fibrillationCdkn1a
AtrophyMapk3 , Rps6kb1 , Stat3
Auriculo-Condylar SyndromeGnai3
autism spectrum disorderMapk3
autistic disorderEgf , Hras , Mapk1 , Prkcb , Stat3
Autoimmune Disease, Multisystem, Infantile-Onset, 1Stat3
Autoimmune DiseasesStat3
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Kras , Nras
Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-AssociatedPlcg2
autosomal dominant mental retardation 53Camk2a
autosomal dominant mental retardation 54Camk2b
autosomal dominant polycystic kidney diseaseCdkn1a , Mtor , Myc , Rps6kb1
autosomal recessive Alport syndromeHras
autosomal recessive nonsyndromic deafness 26Gab1
autosomal recessive polycystic kidney diseaseAkt1 , Egfr , Mtor , Myc , Pik3ca , Src
B-Cell LeukemiaMyc
B-cell lymphomaNras , Ptpn1
bacterial pneumoniaStat3
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeAkt3
Barrett's esophagusCdkn1a
basal cell carcinomaErbb2 , Pik3ca , Rasa1
Behcet's diseaseStat3
Bile Duct NeoplasmsEgfr
bipolar disorderAkt1 , Gsk3b
bladder carcinomaHras
bladder urothelial carcinomaAkt1 , Braf , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Nras , Pik3ca
BlisterAdam17
bone development diseaseAbl1
Bowen's DiseaseCdkn1a
Brain DeathMap2k4
Brain InjuriesAkt1 , Bad , Cdkn1a , Cdkn1b , Elk1 , Gsk3b , Gsn , Jun , Stat1 , Stat3
brain ischemiaAkt1 , Bad , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Pak1 , Prkca , Src , Stat3
Brain NeoplasmsBraf , Egfr , Hras , Nras , Pik3ca , Pik3r1 , Ptpn11
breast adenocarcinomaAkt1 , Kras , Pik3ca
breast cancerAkt1 , Braf , Erbb2 , Erbb3 , Grb2 , Hras , Kras , Mtor , Myc , Pik3ca , Stat1
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAbl1 , Adam10 , Akt1 , Akt2 , Areg , Bad , Braf , Cdkn1a , Cdkn1b , Crkl , Egf , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Hsp90aa1 , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mtor , Myc , Nrg1 , Pak1 , Pak2 , Pik3ca , Pik3r1 , Plcg1 , Prkca , Ptk2 , Raf1 , Rps6kb2 , Src , Stat1 , Stat3 , Stat5a
bronchiolo-alveolar adenocarcinomaEgfr , Kras
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaMyc , Pik3r1
BurnsBad , Gsk3b , Mtor , Rps6kb1
Cafe au lait Spots, MultipleSos1
calcinosisErbb2 , Ptpn6
Candidiasis, Familial, 6Stat1
cannabis abuseAkt1 , Camk2b
capillary hemangiomaAkt3
Capillary Malformation-Arteriovenous MalformationRasa1
CarcinogenesisAbl1 , Braf , Erbb2 , Kras
carcinomaCdkn1a , Egfr , Hras , Kras , Myc , Pik3r1 , Rasa1 , Stat3 , Stat5a
cardiac arrestAkt1
Cardiac ArrhythmiasMap2k4
Cardiac FibrosisPak1
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Gsk3b , Mapk1 , Mapk8 , Mtor , Myc , Pak1 , Prkca , Prkcb , Prkcz , Raf1 , Rps6kb1 , Shc1 , Src , Stat3
cardiomyopathyAkt1 , Kras , Mapk1 , Mapk3 , Stat3
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1 , Ptpn11
Carotid Artery InjuriesCbl , Myc
cataractMap2k1
Cecal NeoplasmsKras
Cell Transformation, NeoplasticEgf , Hras , Jun , Kras , Mapk8 , Myc , Nrg1 , Ptk2 , Stat3
Cerebral HemorrhageMtor
cervix uteri carcinoma in situAdam9 , Cdkn1a , Cdkn1b , Stat3
Charcot-Marie-Tooth diseaseNrg1
Chemical and Drug Induced Liver InjuryBad , Gsn , Rasa1 , Shc1 , Wasl
ChloracneCdkn1b , Egfr
cholangiocarcinomaEgfr , Erbb2 , Kras
cholesteatoma of middle earCdkn1a
Cholesteatoma, CongenitalCdkn1a
chondrosarcomaMtor
Choroidal NeovascularizationStat3
Chromosome BreakageMyc
Chronic Allograft DysfunctionMtor
chronic lymphocytic leukemiaBraf , Hras , Kras , Myc , Nras , Plcg2 , Ptpn11
Chronic Lymphocytic Leukemia, B-CellBraf , Cbl , Hras , Kras , Nras , Plcg2
chronic mucocutaneous candidiasisStat1
chronic myeloid leukemiaAbl1 , Abl2 , Akt1 , Braf , Cdkn1b , Crkl , Nras
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseEgfr , Erbb3 , Map2k4 , Mapk8
Churg-Strauss syndromeStat3
clear cell renal cell carcinomaMyc , Pak4 , Pak6
cleft lipMyc
cleft palateEgf , Myc
Cocaine-Related DisordersCamk2a , Camk2b , Mapk1 , Mapk3
Cognition DisordersGsk3b
Cognitive DysfunctionHsp90aa1
colitisAdam17 , Src
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3
colon cancerAkt1 , Braf , Nras , Pik3ca , Ptprj , Src
colon carcinomaAkt1 , Braf , Nras , Pik3ca , Ptprj
Colonic NeoplasmsAkt2 , Akt3 , Bad , Braf , Cdkn1a , Crkl , Egfr , Erbb2 , Erbb3 , Gsk3b , Jun , Kras , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Src , Stat3
colorectal adenocarcinomaCdkn1a , Gsk3b , Jun , Mapk1 , Mapk3 , Mapk8 , Raf1
colorectal adenomaJun , Mapk8 , Raf1
colorectal cancerAkt1 , Braf , Nras , Pik3ca , Ptprj , Src , Stat3
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Prkcb , Ptpn11 , Ptprj , Raf1 , Src
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Mtor , Pik3ca
cone-rod dystrophy 9Adam9
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPtpn11
congenital heart diseaseAbl1 , Adam19
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Congenital Myopathy, with Excess of Muscle SpindlesHras
congestive heart failureCbl , Erbb2 , Erbb4 , Gsk3b , Map2k7 , Mtor , Nrg1 , Prkca , Prkcb
contact dermatitisHsp90aa1 , Nrg1
Copper-Overload CirrhosisStat3
coronary artery diseaseAkt1
coronary restenosisMapk1 , Myc
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cowden diseaseAkt1 , Egfr , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1 , Pik3ca
Craniofacial AbnormalitiesEgfr
craniopharyngiomaBraf
crescentic glomerulonephritisMtor
Crohn's diseaseStat3
Cryopyrin-Associated Periodic SyndromesPlcg2
cryptorchidismCbl
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1 , Braf , Cbl , Erbb4 , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Raf1
cutaneous T cell lymphomaBraf , Plcg1 , Stat5b
Cytomegalovirus InfectionsStat1
degenerative disc diseaseCrk
dementiaEgfr , Nrg1
demyelinating diseaseMyc
dermatitisEgf , Egfr
Developmental DisabilitiesAkt3 , Braf , Cbl , Pik3r2
Diabetes Mellitus, New-Onset after TransplantationMtor
Diabetic CardiomyopathiesBad , Erbb2 , Erbb4 , Nrg1
Diabetic CystopathyBad
Diabetic NephropathiesCdkn1a , Cdkn1b , Egf , Mapk1 , Mtor , Prkcb , Stat3
diabetic neuropathyBad , Nrg1
diabetic retinopathyEgfr , Hras
diffuse large B-cell lymphomaPik3ca , Pik3cb , Pik3cd , Rps6kb1
DiGeorge syndromeCrkl
dilated cardiomyopathyEgfr , Erbb2 , Kras , Prkca , Prkcb , Ptpn11 , Raf1 , Rps6kb1
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationBraf , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Myc , Nras , Pik3ca , Pik3r1 , Src
disease of metabolismPtpn11
Disease ProgressionEgf , Egfr , Erbb2 , Erbb3 , Hras , Myc , Pik3ca , Stat1
Dowling-Degos diseaseAdam10
Drug-Induced DyskinesiaMtor
Ductal CarcinomaStat5a
ductal carcinoma in situCdkn1a , Erbb2 , Erbb3 , Erbb4 , Pak2 , Prkca , Ptk2 , Src , Stat5a
duodenal ulcerStat3
dysembryoplastic neuroepithelial tumorBraf
embryonal rhabdomyosarcomaPtpn11
end stage renal failureHbegf , Mtor
endometrial cancerEgf , Pik3cb , Pik3r1
endometrial carcinomaGsk3b , Kras , Pik3ca , Pik3r1
Endometrial HyperplasiaKras , Ptk2
Endometrial NeoplasmsAkt2 , Bad , Braf , Cdkn1a , Cdkn1b , Egf , Erbb2 , Erbb3 , Erbb4 , Grb2 , Gsk3b , Jun , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Prkca , Ptk2 , Stat3
Endometrioid CarcinomasAkt1 , Areg , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Kras , Pik3r2
endometriosisAreg , Egfr , Hbegf , Kras , Ptk2
EndotoxemiaStat5b
Epidermal HyperplasiaStat3
epidermal nevusHras , Kras , Nras , Pik3ca
epilepsyAkt1
epilepsy with generalized tonic-clonic seizuresHbegf
erythropoietic protoporphyriaAreg , Btc , Ereg
esophageal carcinomaEgfr , Erbb2 , Hras , Kras , Myc , Pik3ca
Esophageal NeoplasmsAbl1 , Cdkn1a , Egfr , Erbb2 , Hras , Kras , Myc , Pik3ca
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaCdkn1a , Egfr
Experimental ArthritisAkt1 , Cbl , Cblb , Egfr , Gsk3b , Mtor , Nras , Pik3cd , Stat1 , Stat3
Experimental Autoimmune EncephalomyelitisAdam17 , Cblb , Stat1 , Stat3
Experimental Autoimmune UveitisStat3
Experimental Autoimmune UveoretinitisStat3
Experimental Diabetes MellitusAkt1 , Bad , Btc , Cdkn1a , Egfr , Hras , Hsp90aa1 , Mapk1 , Mapk3 , Mtor , Myc , Pik3r1 , Plcg1 , Prkca , Prkcb , Stat1 , Stat3 , Stat5b
Experimental Liver CirrhosisAdam17 , Camk2d , Cdkn1a , Egf , Gsn , Mtor , Myc , Nrg1 , Prkcb , Ptk2 , Ptpn1
Experimental NeoplasmsAbl1 , Braf , Erbb2 , Hras , Kras , Nras
Experimental SarcomaKras , Nras
extrahepatic cholestasisJun , Mapk1 , Mapk3 , Mapk8 , Mapk9
Facial AsymmetryPik3ca
facioscapulohumeral muscular dystrophyCdkn1a
Failure to ThriveAbl1 , Ptpn11
Fallopian Tube NeoplasmsCdkn1b
familial adenomatous polyposisAkt1 , Egfr
Familial AmyloidosisGsn
familial cold autoinflammatory syndrome 3Plcg2
Familial ErythroleukemiaErbb3
familial hyperlipidemiaShc1
familial partial lipodystrophyAkt2
fatty liver diseaseMapk8 , Myc , Shc1
Female InfertilityMapk1 , Mapk3
Fetal DiseasesPrkcb
Fetal Growth RetardationElk1 , Ptpn11
FeverStat3
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Cdkn1b , Map2k7 , Stat3
Finnish type amyloidosisGsn
Focal Cortical Dysplasia of TaylorMtor
Follicular Thyroid CancerBraf , Hras , Nras
follicular thyroid carcinomaBraf , Hras , Kras , Nras
Frontotemporal Lobar DegenerationHsp90aa1
Fuchs' endothelial dystrophyCdkn1a
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Erbb3 , Erbb4 , Kras , Tgfa
gastric adenocarcinomaAkt1 , Braf , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Map2k2 , Mtor , Nras , Pik3ca , Ptpn11 , Raf1
gastric ulcerBad , Egf , Nrg1
gastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca
gastrointestinal stromal tumorBraf , Kras
Generalized EpilepsyMapk10
genetic diseaseAbl2 , Akt2 , Akt3 , Braf , Camk2b , Cbl , Erbb2 , Erbb4 , Hras , Kras , Map2k1 , Mapk1 , Mtor , Pak3 , Pik3ca , Pik3r1 , Pik3r2 , Plcg2 , Prkcg , Ptpn11 , Raf1 , Sos1 , Stat1 , Stat3
Genetic Predisposition to DiseaseEgf , Tgfa
Germ Cell and Embryonal NeoplasmsErbb2
germinomaBraf
Giant Pigmented Hairy NevusHras , Nras
gingival fibromatosisSos1
glaucomaBad , Cdkn1b
glioblastoma multiformeAkt1 , Akt3 , Braf , Egf , Egfr , Erbb2 , Hras , Mtor , Myc , Nras , Pik3ca , Pik3r1 , Ptk2
GliosisMapk1 , Mapk3
glomerulonephritisMapk1
GlucagonomaBtc
Gonadal Dysgenesis, XX Type, with DeafnessBraf
Granuloma, PyogenicStat3
Growth DisordersCbl , Pik3ca
growth hormone secreting pituitary adenomaCdkn1a , Ptpn11
hairy cell leukemiaMap2k1
Head and Neck NeoplasmsAreg , Egfr , Mapk1 , Mapk3 , Pik3ca , Tgfa
head and neck squamous cell carcinomaAkt1 , Braf , Egfr , Erbb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Stat3
Hearing LossStat1
Hearing Loss, Cisplatin-InducedCamk2a , Camk2b , Gsk3b
Hearing Loss, Noise-InducedCdkn1a
heart diseaseStat3
heart valve diseasePtpn6
Heat StrokeJun
Helicobacter InfectionsCdkn1b
HELLP syndromeErbb2
Hematologic NeoplasmsCbl
HemimegalencephalyMtor , Pik3ca
Hepatitis C, ChronicStat3
Hepatitis, ChronicShc1 , Stat3
hepatoblastomaTgfa
hepatocellular adenomaCdkn1b , Hras , Kras , Ptpn11
hepatocellular carcinomaAkt1 , Akt2 , Braf , Cdkn1a , Cdkn1b , Egf , Egfr , Hras , Jun , Kras , Mtor , Myc , Nras , Pik3ca , Ptk2 , Shc1 , Stat1 , Tgfa
HepatomegalyCamk2a
hereditary multiple exostosesPtpn11
Hereditary Neoplastic SyndromesCamk2a , Cdkn1b , Hbegf , Nrg2 , Pik3ca , Rasa1
Hernias, Diaphragmatic, CongenitalCbl , Stat3
Hirschsprung's diseaseErbb2 , Nrg1
Hodgkin's lymphomaJun , Ptpn1
human immunodeficiency virus infectious diseaseCdkn1a , Eif4ebp1 , Hsp90aa1
Human InfluenzaStat1
Huntington's diseaseEgfr , Elk1
Hyper-IgE Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaCamk2a , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nrg1 , Prkcb , Prkcg , Prkcz , Raf1 , Stat3
hyperglycemiaCbl , Prkcb , Prkcz , Shc1
hyperinsulinismPtpn1 , Rps6kb1
HyperoxiaCdkn1a
HyperparathyroidismMyc
Hyperphosphatasia with Mental Retardation Syndrome 2Tln1
HyperplasiaAkt1 , Cdkn1a , Egfr , Pik3ca
Hypersensitivity, ImmediateEgfr
hypertensionAkt1 , Akt2 , Bad , Egfr , Gnai3 , Gsk3b , Jun , Kras , Mapk8 , Mtor , Pik3r1 , Prkca , Prkcb , Ptk2 , Ptpn1 , Ptprj , Rps6kb1 , Src
Hypertensive NephropathyShc1
HypertriglyceridemiaMtor
hypertrophic cardiomyopathyMyc , Ptpn11 , Raf1
hypertrophic cardiomyopathy 4Braf
HypertrophyCdkn1a , Mapk1 , Mapk3
Hypertrophy, Left VentricularCdkn1b , Egfr , Hbegf , Mtor , Myc , Prkca , Prkcb , Prkcz , Ptk2 , Rasa1 , Rps6kb1 , Shc1
Hypertrophy, Right VentricularAkt1 , Mtor , Prkca , Ptk2 , Tgfa
hyperuricemiaStat3
hypoglycemiaAkt2 , Pik3r1
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 7 with or without anosmiaNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypoproteinemiaRps6kb1
hypothyroidismBad , Gsn
HypovolemiaCdkn1a
HypoxiaStat5b
idiopathic interstitial pneumoniaMtor
idiopathic pulmonary fibrosisStat3
immune system diseasePrkcb
Immunodeficiency 14Pik3cd
IMMUNODEFICIENCY 31AStat1
IMMUNODEFICIENCY 31BStat1
IMMUNODEFICIENCY 31CStat1
Immunodeficiency 36Pik3r1
impotenceAkt1 , Bad
in situ carcinomaAkt1
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaEgf
InflammationAkt1 , Camk2a , Egfr , Eif4ebp1 , Mtor , Ptpn1 , Stat3 , Tgfa
inflammatory bowel diseasePlcg2 , Stat3
Insulin ResistanceAkt2 , Bad , Cblb , Egfr , Pik3r1 , Prkcb , Prkcz , Ptpn1 , Shc1
insulinomaBtc , Tgfa
intellectual disabilityCamk2a , Camk2b , Camk2g , Kras , Prkcg
intermediate coronary syndromeAkt1
intermittent claudicationBad
interstitial cystitisMtor
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsCdkn1a , Cdkn1b , Gsk3b , Map2k1 , Map2k2 , Mapk8 , Prkca
Intestinal PolypsJun
intrahepatic cholangiocarcinomaKras
invasive ductal carcinomaAkt1 , Crkl , Erbb2 , Map2k4
invasive lobular carcinomaErbb2 , Stat5a
inverted papillomaCdkn1a
irritant dermatitisStat3
ischemiaAkt2 , Mapk9 , Prkca , Ptk2 , Raf1
Job's syndromeStat3
Joubert syndrome 9Braf
juvenile myelomonocytic leukemiaCbl , Kras , Nras , Ptpn11
juvenile rheumatoid arthritisAreg , Egf , Hbegf , Jun , Kras , Mapk1 , Nrg1 , Stat3
kidney angiomyolipomaMtor
kidney diseaseCdkn1a , Egf , Mapk1
Kidney NeoplasmsAkt1 , Braf , Cdkn1b , Eif4ebp1 , Erbb2 , Jun , Kras , Mapk1 , Mapk3 , Raf1
Kidney Reperfusion InjuryMyc , Src
Klinefelter's syndromeNras
Kuhnt-Junius degenerationMapk8
L-2-hydroxyglutaric aciduriaSos2
large cell carcinomaPrkca
Laron Syndrome Type 2Stat5b
Laryngeal NeoplasmsCdkn1a , Egfr
leiomyomaMyc , Ptk2
Lennox-Gastaut syndromeMapk10
LEOPARD syndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
lethal congenital contracture syndrome 1Erbb3
lethal congenital contracture syndrome 2Erbb3
lethal congenital contracture syndrome 3Pip5k1c
leukemiaBad , Nras , Prkcz , Ptpn11
Leukemia, Erythroblastic, AcuteErbb3
Leukemia, ExperimentalCbl , Nras
Leukemia, Myeloid, Chronic-PhaseAbl1
LeukocytosisKras , Nras
LeukoencephalopathiesCdkn1b
Lewy body dementiaElk1
Leydig cell tumorCdkn1b
Lip NeoplasmsCdkn1a
lipoid nephrosisCdkn1a
liver cancerAkt1 , Hras , Kras , Nras , Pik3ca
liver cirrhosisStat1 , Stat3
Liver InjuryMyc , Stat3
liver neoplasmAbl1 , Braf , Cdkn1a , Cdkn1b , Hras , Jun , Kras , Myc , Raf1 , Stat3 , Tgfa
Liver Neoplasms, ExperimentalCdkn1a , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Stat3 , Tgfa
Liver Reperfusion InjuryBad , Mapk8
localized sclerodermaCdkn1a
lung adenocarcinomaAkt1 , Braf , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Myc , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Rasa1 , Sos1
lung cancerBraf , Egfr , Erbb2 , Kras , Pik3ca
lung diseaseEgfr , Gsn
Lung InjuryMtor , Tgfa
Lung NeoplasmsAkt1 , Braf , Cdkn1a , Cdkn1b , Crkl , Egfr , Erbb2 , Erbb3 , Hras , Jun , Kras , Map2k7 , Mapk1 , Mapk3 , Mtor , Myc , Nrg1 , Pik3ca , Raf1 , Stat5a
Lung Reperfusion InjuryMyc
lung small cell carcinomaAkt1 , Cdkn1b , Egfr , Pik3ca
lung squamous cell carcinomaAkt1 , Braf , Egfr , Hras , Kras , Pik3ca , Ptpn11
lupus nephritisEgf , Mtor
LymphangiectasisRaf1
lymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisCdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Pik3ca , Pik3cb , Stat3
lymphomaKras , Nras
lymphopeniaCbl
lymphoproliferative syndromeStat3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular degenerationBad , Cdkn1a , Cdkn1b
male infertilityCbl
Malformations of Cortical Development, Group IIAdam19
malignant gliomaAkt2 , Areg , Bad , Braf , Egfr , Erbb2 , Hras , Pik3ca , Raf1
malignant mesotheliomaCdkn1a , Egfr , Raf1
Mammary Neoplasms, AnimalAreg , Cdkn1a , Egfr , Erbb2 , Hras , Pik3r1 , Rasa1 , Stat3 , Stat5a , Tgfa
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Areg , Bad , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Gsn , Hras , Map2k7 , Mtor , Myc , Pak4 , Pik3r1 , Ptk2 , Rasa1 , Stat1 , Stat3 , Stat5a , Tgfa
mammary Paget's diseaseErbb2
Mandibular NeoplasmsBraf
mantle cell lymphomaEif4ebp1 , Gsk3b , Mtor , Pik3cd
maxillary sinus neoplasmCdkn1a
median neuropathyErbb2 , Erbb3 , Erbb4 , Nrg1
Mediastinal NeoplasmsPtpn1
medulloblastomaErbb2 , Myc , Nras , Pik3ca , Stat3
Megakaryoblastic Leukemia of Down SyndromeNras
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Braf , Cbl , Cdkn1a , Erbb2 , Erbb4 , Hras , Kras , Map2k1 , Map2k2 , Mtor , Myc , Nras , Pik3ca , Pik3r1 , Raf1
membranoproliferative glomerulonephritisCdkn1b
membranous glomerulonephritisCdkn1b
Memory DisordersAbl1 , Stat3
Meningeal NeoplasmsAkt1
meningiomaAkt1
mental depressionGsk3b , Jun
Mental Retardation, X-Linked 47Pak3
Mercury Poisoning, Nervous SystemJun
Merkel cell carcinomaMyc
MesotheliomaCdkn1b , Egfr , Gsn , Mtor
MetachondromatosisPtpn11
MetaplasiaEgf
Microphthalmia, Syndromic 1Adam17
Microsatellite InstabilityBraf
middle cerebral artery infarctionBad , Camk2a , Mtor , Nrg1 , Prkcg , Stat3
migraineMap2k2
Mouth NeoplasmsErbb2 , Erbb3 , Hras , Kras , Nras , Pik3ca , Ptk2
movement diseaseNrg1
mucositisTgfa
Multiple AbnormalitiesGsk3b , Kras , Mapk1 , Pik3r2
Multiple Endocrine NeoplasiaCdkn1b
multiple endocrine neoplasia type 4Cdkn1b
Multiple Hamartoma SyndromePik3ca
multiple myelomaBraf , Cbl , Hras , Kras , Nras , Pik3ca , Ptpn11
Multiple Organ FailureMapk1
multiple sclerosisCblb
Multisystem Autoimmune Disease, Infantile-OnsetStat3
muscular atrophyAkt1 , Gsk3b , Mtor , Rps6kb1
Muscular Dystrophy, AnimalMtor
Musculoskeletal AbnormalitiesAbl1
Mycobacterium InfectionsStat1
myelodysplastic syndromeCdkn1b , Hras , Kras , Myc , Nras
myeloid neoplasmCbl , Kras , Nras
myeloid sarcomaKras
myocardial infarctionAkt1 , Cdkn1b , Gsk3b , Mapk1 , Mtor , Nrg1 , Rps6kb1
Myocardial IschemiaAreg , Camk2d , Crk , Eif4ebp1 , Erbb2 , Stat5a
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Cbl , Gsk3b , Mapk1 , Mapk8 , Prkcb , Stat1 , Stat3
Myoclonus, Familial CorticalMyc
Nasal PolypsJun , Stat3
Nasopharyngeal NeoplasmsEgfr , Hras , Nras , Pik3ca
nasopharynx carcinomaAkt2 , Erbb2 , Erbb3 , Kras , Pik3ca
Nematode InfectionsPik3r1
NeointimaErbb4 , Nrg1 , Pak1
Neonatal Inflammatory Skin and Bowel DiseaseAdam17
Neonatal Inflammatory Skin and Bowel Disease 1Adam17
Neonatal Inflammatory Skin and Bowel Disease 2Egfr
Neoplasm InvasivenessEgf , Egfr , Hras , Mapk1 , Mapk3 , Nrg1 , Ptk2 , Src , Tln1
Neoplasm MetastasisAkt2 , Braf , Cdkn1a , Egf , Egfr , Erbb2 , Erbb3 , Hsp90aa1 , Kras , Mapk1 , Mapk3 , Mapk9 , Mtor , Myc , Pik3ca , Pik3r3 , Ptk2 , Src , Stat1 , Stat3
Neoplasm Recurrence, LocalEgfr , Erbb2
Neoplastic ProcessesHras
nephritisMtor , Ptk2
nephroblastomaCdkn1b , Erbb2 , Myc , Pak1 , Stat1 , Stat3
nephrogenic diabetes insipidusPrkca
Nephrosis, Puromycin AminonucleosidePak2
nephrotic syndromeNck1 , Nck2
Nerve DegenerationMapk1 , Mapk3 , Tgfa
neuroblastomaHras , Kras , Map2k4 , Map2k7 , Myc , Nras , Pik3ca , Ptpn11
Neurocutaneous MelanosisNras
Neurodevelopmental DisordersPtpn11
neuroectodermal tumorMyc
neuroendocrine tumorBraf , Cdkn1b
neurofibromaPtpn11
neurofibrosarcomaNras
neuronal ceroid lipofuscinosisBraf
neuronal ceroid lipofuscinosis 1Rps6kb1
neuronal ceroid lipofuscinosis 6Braf , Gsk3b , Mapk1 , Mapk3
neutropeniaStat3
NevusBraf
Nevus, PigmentedNras
Niemann-Pick diseaseAbl1
Niemann-Pick disease type C1Abl1 , Stat3
non-Hodgkin lymphomaBraf , Map2k1 , Myc , Nras , Pik3ca
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Areg , Bad , Braf , Cbl , Cdkn1b , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Myc , Nras , Pik3ca , Prkcb , Raf1 , Stat3 , Tgfa
non-syndromic X-linked intellectual disabilityPak3
nonalcoholic fatty liver diseaseMapk8 , Stat3
Nonseminomatous Germ Cell TumorBraf
nonsyndromic deafnessTgfa
Nontuberculous Mycobacterium InfectionsStat1
Noonan Like SyndromeCbl , Ptpn11 , Sos1
Noonan syndromeBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 1Braf , Map2k1 , Nras , Ptpn11
Noonan syndrome 3Hras , Kras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 4Sos1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl , Ptpn11
obesityAkt1 , Akt2 , Bad , Cdkn1b , Egfr , Mtor , Myc , Pik3r1 , Prkcb , Ptpn1 , Rps6kb1 , Stat3
obsessive-compulsive disorderHras
ocular hypertensionCdkn1a
Ollier diseasePtpn11
Optic Nerve InjuriesJun
Oral Lichen PlanusCdkn1a
oral mucosa leukoplakiaCdkn1a
oral squamous cell carcinomaCdkn1a
osteoarthritisAdam12 , Bad , Mtor
Osteoarthritis, KneeHsp90aa1 , Tgfa
OsteochondromaPtpn11
osteopetrosisJun
osteoporosisAbl1 , Gsn , Myc , Tln1
osteosarcomaAkt1 , Egfr , Jun , Myc
otitis mediaBtc
ovarian cancerAkt1 , Egf , Erbb2 , Kras , Pik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Areg , Braf , Cdkn1a , Cdkn1b , Crkl , Egfr , Erbb2 , Erbb3 , Erbb4 , Ereg , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk3 , Mtor , Myc , Pak1 , Pik3ca , Pik3r1 , Prkca , Ptk2 , Stat3
ovarian serous cystadenocarcinomaBraf , Erbb2 , Hras , Nras , Pik3ca
ovary adenocarcinomaErbb2
Overactive Urinary BladderNrg1
Oxygen-Induced RetinopathyMapk8 , Stat3
PainAkt1 , Nrg1
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaErbb2 , Hras , Kras , Map2k2 , Pik3ca
pancreatic cancerAdam9 , Akt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Kras , Map2k4 , Mtor , Myc , Stat3 , Tgfa
pancreatic carcinomaCdkn1a , Kras , Mtor , Myc
pancreatic ductal carcinomaAdam9 , Cdkn1a , Egf , Kras
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisEgf
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Cdkn1a , Kras
Papillary Thyroid CancerBraf
papillary thyroid carcinomaBraf
papillomaCdkn1a , Egfr , Erbb2 , Hras , Map2k4 , Tgfa
paraplegiaAkt1
Parasitic Liver DiseasesKras
ParatuberculosisGsn
Parkinson's diseaseAbl1 , Akt1 , Egf , Egfr , Erbb2 , Gsk3b
Parkinsonian DisordersBad , Egfr , Mtor , Src
penile neoplasmHras , Kras , Pik3ca
peptic esophagitisEgfr
perinatal necrotizing enterocolitisEgf , Hbegf
peripartum cardiomyopathyStat3
peripheral nervous system diseaseErbb4 , Jun
peritonitisGsk3b
phencyclidine abuseCamk2b
phobic disorderHras
Phyllodes TumorCdkn1a , Egfr , Erbb3 , Erbb4
pilocytic astrocytomaKras
Pituitary NeoplasmsCdkn1a , Cdkn1b , Prkca
plasmacytomaBraf , Hras , Kras , Nras , Pik3ca
pleomorphic xanthoastrocytomaBraf , Camk2b , Egfr , Gnai1 , Wasl
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaEgf
PoisoningGsk3b
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMtor , Myc , Plcg1
polycystic ovary syndromeAkt2 , Camk2d , Gab1 , Nrg1
PolymicrogyriaAkt3
PolyuriaPrkca
Port-Wine StainRasa1
portal hypertensionHsp90aa1 , Mtor , Pik3r1
pre-eclampsiaErbb2
pre-malignant neoplasmAbl1 , Akt1 , Egf , Eif4ebp1 , Hras , Map2k7 , Mapk8 , Mapk9 , Stat3 , Stat5a
precursor B lymphoblastic lymphoma/leukemiaAbl1 , Stat3
precursor lymphoblastic lymphoma/leukemiaAbl1 , Kras , Myc , Nras
precursor T-lymphoblastic lymphoma/leukemiaKras , Mtor , Ptpn11 , Stat1
Premature AgingCdkn1a
primary biliary cirrhosisCdkn1a , Rps6kb1
primary hyperparathyroidismCdkn1b
primary hypomagnesemiaEgf
primary open angle glaucomaCdkn1a
prolactinomaMyc
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Erbb2 , Grb2 , Hras , Map2k1 , Mapk1 , Pik3ca , Pik3cb , Raf1
prostate cancerAkt2 , Akt3 , Erbb2 , Erbb3 , Grb2 , Kras , Mapk10 , Pak4 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Raf1 , Sos1
prostate carcinomaAkt2
prostate carcinoma in situAreg , Cdkn1b , Kras , Map2k4 , Map2k7 , Myc
prostatic hypertrophyBad , Myc
Prostatic NeoplasmsAdam9 , Akt1 , Areg , Bad , Braf , Cdkn1a , Cdkn1b , Crkl , Egf , Egfr , Erbb2 , Erbb3 , Erbb4 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k4 , Map2k7 , Mapk3 , Mtor , Myc , Nras , Pak6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Prkca , Prkcz , Ptk2 , Src , Stat1 , Stat3 , Stat5b , Tgfa
proteinuriaNck1 , Nck2 , Pak1 , Pak2
Proteus syndromeAkt1
psoriasisAreg , Cdkn1a , Stat3 , Tgfa
psoriatic arthritisStat3
psychotic disorderNrg1
PTEN hamartoma tumor syndromePik3ca
pulmonary edemaTgfa
pulmonary emphysemaJun
pulmonary fibrosisAreg , Bad , Egf , Egfr , Stat1 , Stat3 , Tgfa
pulmonary hypertensionCdkn1a , Cdkn1b , Egfr , Mtor , Myc , Ptk2 , Tgfa
pulmonary tuberculosisJun
pulmonary valve stenosisBraf , Hras , Sos1
Radiation Injuries, ExperimentalMapk1 , Mapk3
radiculopathyErbb4
RASopathiesBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
rectal neoplasmCdkn1b , Egfr , Mapk8 , Nras , Pik3ca , Pik3cb
RecurrenceErbb2 , Erbb3 , Hras , Kras
renal carcinomaMtor , Nras , Pik3ca
renal cell carcinomaAkt1 , Akt3 , Bad , Cdkn1b , Egfr , Erbb2 , Erbb4 , Jun , Kras , Map2k1 , Mapk1 , Mtor , Myc , Nras , Pak1 , Pik3ca , Pik3r1 , Stat3
renal fibrosisKras , Mapk1 , Myc
renal hypertensionCdkn1a
renal hypomagnesemia 3Egf
renal hypomagnesemia 4Egf
renal hypomagnesemia 5 with ocular involvementEgf
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Bad , Cdkn1a , Cdkn1b , Egf , Gnai3 , Hbegf , Jun , Mapk8 , Mapk9 , Pik3r1 , Prkca , Ptk2 , Src , Stat1 , Stat3 , Stat5a , Stat5b
respiratory allergyPtpn6
reticulate acropigmentation of KitamuraAdam10
Retina Reperfusion InjuryBad , Map2k4 , Stat3
retinal degenerationPak3 , Pak4
Retinal NeovascularizationMtor
retinitis pigmentosaAdam9 , Prkcg
Rett syndromePtpn1
rhabdoid cancerMyc
rheumatoid arthritisHsp90aa1 , Ptk2 , Stat1 , Stat3
Salivary Gland NeoplasmsCdkn1a
sarcoidosisCdkn1a
sarcomaPik3ca
SarcopeniaCdkn1a
schizophreniaAkt1 , Camk2b , Crkl , Egf , Egfr , Elk1 , Gsk3b , Map2k7 , Mapk3 , Mtor , Nrg1 , Nrg3 , Pak1 , Pak2 , Pik3cb
schizophrenia 6Nrg1
Schnyder corneal dystrophyMtor
sciatic neuropathyCdkn1b , Mtor , Nrg1
scoliosisPtpn11
scrapieStat1 , Stat3
sebaceous gland neoplasmCdkn1a
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seborrheic keratosisPik3ca
seminomaHras , Kras
senile cataractCdkn1b
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
sensorineural hearing lossPrkcb
SepsisBad , Cdkn1a , Gsk3b , Mapk1 , Mapk3 , Mtor , Stat1 , Stat3
Sepsis-Associated EncephalopathyStat3
Septic PeritonitisPik3r1
serous cystadenocarcinomaCdkn1a
Sezary's diseaseBraf , Cdkn1b , Mapk1 , Plcg1
Shock, HemorrhagicBad , Mapk1 , Mtor , Myc
SHORT SyndromePik3r1
silicosisPrkcb
Sinonasal NeoplasmsCdkn1a
skin benign neoplasmHras
skin melanomaStat3
Skin NeoplasmsAkt1 , Cdkn1a , Crkl , Erbb4 , Hras , Map2k4 , Stat3
Sleep DeprivationMap2k4
small cell carcinomaMtor
Small-For-Size SyndromeBad
Smith-Kingsmore SyndromeMtor
Smith-Magenis syndromeErbb2 , Grb2 , Map2k2 , Prkca , Rps6kb1 , Stat3 , Stat5a , Stat5b
spermatocytomaHras
Spinal Cord InjuriesAkt1 , Cdkn1b , Egfr , Erbb3 , Jun , Mtor
Spinal Cord Reperfusion InjuryBad
spinocerebellar ataxia type 14Prkcg
Spinocerebellar AtaxiasPrkcg
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Erbb2 , Hras , Mtor , Myc , Pik3ca
squamous cell carcinomaAkt1 , Areg , Cdkn1a , Egfr , Hras , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Ptk2 , Ptpn11 , Rasa1 , Stat3
status epilepticusAdam10 , Adam9 , Gsk3b , Jun , Mtor , Prkcb , Src
stomach cancerErbb2 , Kras , Pik3ca
Stomach NeoplasmsAreg , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Hbegf , Hras , Jun , Kras , Mapk1 , Mapk3 , Mapk8 , Myc , Nras , Pik3ca , Prkcb , Stat3 , Tgfa
StrokeAkt1 , Erbb4 , Mapk8 , Pak1 , Pik3ca , Src , Tgfa
Sturge-Weber SyndromeRasa1
Subarachnoid HemorrhageStat3
substance-induced psychosisAkt1 , Camk2b
systemic lupus erythematosusCdkn1a
T-cell large granular lymphocyte leukemiaStat5b
T-cell leukemiaStat3
T-Cell LymphomaAkt1 , Cdkn1a , Stat3 , Stat5b
T-LymphocytopeniaStat5b
Tachycardia, VentricularRaf1
tauopathyGsk3b
temporal lobe epilepsyMtor
Temporomandibular Joint DisordersMtor
Testicular NeoplasmsCdkn1b
tetralogy of FallotPtpn11
thoracic aortic aneurysmAdam10 , Adam17
THROMBOCYTOPENIA 6Src
thrombosisPik3cb
thymomaHras
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Cdkn1a , Hras , Kras , Nras , Pik3ca
Tobacco Use DisorderEgfr
Tongue NeoplasmsCdkn1a , Hras , Stat3
tongue squamous cell carcinomaCdkn1a , Egfr
toxic encephalopathyMtor
transient cerebral ischemiaBad , Camk2a , Cbl , Elk1 , Map2k4 , Stat3
transitional cell carcinomaAkt1 , Areg , Braf , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Map2k1 , Mapk1 , Mtor , Nras , Pak1 , Pik3ca
Transplant RejectionMyc
Trauma, Nervous SystemStat1
Trichilemmoma Hras
trigeminal neuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg
tuberous sclerosisEif4ebp1
type 1 diabetes mellitusBtc , Cbl , Cblb , Egfr , Stat3
type 2 diabetes mellitusAdam17 , Akt1 , Akt2 , Bad , Braf , Btc , Egfr , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3cb , Pik3r1 , Prkcb , Prkcz , Ptpn1 , Src , Stat3
ulcerative colitisCdkn1a , Stat3
uremiaPtk2
ureteral obstructionAbl1 , Akt1 , Mtor , Pak2
urethral obstructionMapk1
urinary bladder cancerAkt1 , Areg , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Map2k4 , Mtor , Myc , Prkca , Src
Urinary Bladder NeoplasmHras , Kras
Urinary IncontinenceMapk1
Urologic NeoplasmsErbb2
uterine carcinosarcomaErbb2 , Erbb3 , Hras , Pik3ca , Pik3r1
Uterine Cervical NeoplasmsAdam9 , Akt1 , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Erbb3 , Erbb4 , Hras , Kras , Mapk1 , Mtor , Myc , Nras , Pik3ca , Ptk2 , Sos1 , Stat3
Uterine NeoplasmsBraf , Cdkn1b , Erbb2 , Erbb3 , Hras , Kras , Map2k1 , Mtor , Nras , Pik3ca , Pik3r1 , Sos1
vascular dementiaMtor
Vascular MalformationsPik3ca
vasculitisCbl
velocardiofacial syndromeCrkl , Mapk1
Ventilator-Induced Lung InjuryAkt1
ventricular septal defectBraf
visual epilepsyBad , Camk2d , Erbb4 , Gnai1 , Nrg1 , Pik3ca
vitiligoPik3r1
Wallerian DegenerationErbb2 , Erbb3
Weight GainGsn , Pik3ca
Weissenbacher-Zweymuller syndromeMapk1
Williams-Beuren syndromeSrc
Wilson diseaseCamk2a
withdrawal disorderGnai1 , Mapk1 , Mapk3
Wounds and InjuriesEgf
Zollinger-Ellison syndromeEgf
Pathway Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai1
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Eif4ebp1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rps6kb1 , Rps6kb2 , Sos1 , Sos2 , Stat3 , Stat5a , Stat5b
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Jun , Map2k2 , Map2k7 , Mapk1 , Mapk8 , Pak1 , Pik3ca , Prkcz
aldosterone signaling pathwayHsp90aa1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered Reelin signaling pathwaySrc
Alzheimer's disease pathwayAdam10 , Adam17 , Bad , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayBad
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPrkcz
angiotensin II signaling pathway via AT2 receptorErbb3 , Gnai3 , Ptpn6
antigen processing and presentation pathwayHsp90aa1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg2 , Prkcb , Ptpn6 , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayGsk3b
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9
calcium/calcium-mediated signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Egfr , Erbb2 , Erbb3 , Erbb4 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
calcium/calmodulin dependent kinase 2 signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g
cell cycle pathway, mitoticAbl1 , Cdkn1a , Cdkn1b , Gsk3b , Myc
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz , Raf1 , Stat1 , Stat3 , Tgfa
cetuximab pharmacodynamics pathwayEgfr
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Gnai1 , Gnai3 , Jun , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gnai1 , Gnai3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Prkcz , Ptk2 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5b , Wasl
chronic myeloid leukemia pathwayAbl1 , Akt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Cdkn1a , Cdkn1b , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Stat5a , Stat5b
clathrin-dependent synaptic vesicle endocytosisPip5k1c
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
cortisol signaling pathwayHsp90aa1
cytokine mediated signaling pathwayEgf , Egfr
dopamine signaling pathwaySrc
E-cadherin signaling pathwayAkt1 , Akt2 , Crk , Egf , Egfr , Nck1 , Pik3ca , Pik3r1 , Pip5k1c , Plcg1 , Src
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Prkca , Prkcg , Prkcz , Src
endocytosis pathwayCbl , Cblb , Cblc , Egf , Egfr , Erbb3 , Erbb4 , Hras , Pip5k1c , Prkcz , Src
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1 , Map2k7 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Crk , Gnai1 , Gnai3 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Prkca , Prkcg , Raf1 , Src
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Ptk2
ephrin - ephrin receptor bidirectional signaling axisCbl , Crk , Crkl , Grb2 , Hras , Map2k1 , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Nck1 , Nck2 , Nras , Pak1 , Pik3ca , Pik3r1 , Pik3r5 , Plcg1 , Rasa1 , Src , Wasl
epidermal growth factor/neuregulin signaling pathwayAbl1 , Abl2 , Adam10 , Adam12 , Adam17 , Adam19 , Adam9 , Akt1 , Akt2 , Akt3 , Areg , Bad , Braf , Btc , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Cblb , Cblc , Cdkn1a , Cdkn1b , Crk , Crkl , Egf , Egfr , Eif4ebp1 , Elk1 , Epgn , Erbb2 , Erbb3 , Erbb4 , Ereg , Gab1 , Gnai1 , Gnai3 , Grb2 , Gsk3b , Gsn , Hbegf , Hras , Hsp90aa1 , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Myc , Nck1 , Nck2 , Nras , Nrg1 , Nrg2 , Nrg3 , Nrg4 , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn1 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Tgfa , Tln1 , Wasl
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayCbl , Crkl , Gab1 , Grb2 , Hras , Mapk8 , Pik3r1 , Plcg1 , Plcg2 , Ptpn11 , Ptpn6 , Shc1 , Sos1 , Stat1 , Stat5a , Stat5b
estrogen signaling pathwayHsp90aa1 , Src
FasL mediated signaling pathwayAkt1 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Crk , Crkl , Gsn , Map2k1 , Mapk1 , Mapk3 , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Rps6kb1 , Rps6kb2 , Wasl
fibroblast growth factor signaling pathwayAkt1 , Camk2a , Cbl , Gab1 , Grb2 , Jun , Mapk1 , Mapk3 , Pak4 , Pik3ca , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Sos1 , Src , Stat1 , Stat5b
forkhead class A signaling pathwayAkt1 , Cdkn1b , Jun
G protein mediated signaling pathway via Galphai familyGnai1 , Gnai3
G1/S transition pathwayCdkn1a , Cdkn1b
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Camk2a , Camk2b , Camk2d , Camk2g , Cdkn1a , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Tgfa
glutamate signaling pathwayGnai1 , Gnai3 , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayMapk8 , Mapk9 , Nrg1 , Src
gonadotropin-releasing hormone signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Egfr , Elk1 , Grb2 , Hbegf , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Prkca , Prkcb , Raf1 , Sos1 , Sos2 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Shc1 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
Hedgehog signaling pathwayAkt1 , Gnai1 , Gnai3 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Egf , Egfr , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Stat1 , Stat3
hypoxia inducible factor pathwayAkt1 , Elk1 , Jun
inflammatory response pathwayMapk8
influenza A pathwayAkt1 , Akt2 , Akt3 , Gsk3b , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1 , Stat1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pip5k1c , Plcg1 , Plcg2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Cbl , Crk , Gsk3b , Pak1 , Prkcz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Crk , Crkl , Eif4ebp1 , Elk1 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Crk , Crkl , Grb2 , Hras , Nck2 , Pik3ca , Pik3r1 , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rps6kb1 , Shc1 , Sos1
integrin mediated signaling pathwayNck2 , Ptk2 , Tln1
interleukin-1 signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1 , Prkcz
Interleukin-10 signaling pathwayStat1 , Stat3
interleukin-12 signaling pathwayMtor , Stat1 , Stat3 , Stat5a
interleukin-2 signaling pathwayGrb2 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Nras , Pik3ca , Pik3r1 , Prkcb , Ptpn11 , Raf1 , Rasa1 , Shc1 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
interleukin-23 signaling pathwayPik3ca , Pik3r1 , Stat1 , Stat3 , Stat5a
interleukin-27 signaling pathwayStat1 , Stat3 , Stat5a
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11 , Shc1 , Stat5a , Stat5b
interleukin-4 signaling pathwayAkt1 , Cbl , Grb2 , Mtor , Pik3ca , Pik3r1 , Ptpn6 , Rps6kb1 , Shc1 , Stat5a , Stat5b
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11 , Stat5a , Stat5b
interleukin-6 signaling pathwayAdam10 , Adam17 , Akt1 , Gab1 , Grb2 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Sos2 , Stat1 , Stat3
intrinsic apoptotic pathwayBad
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Ptpn6 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5a , Stat5b
Leishmaniasis pathwayElk1 , Jun , Mapk1 , Mapk3 , Prkcb , Ptpn6 , Stat1
leptin system pathwayPtpn1 , Ptpn11 , Stat3
long term depressionBraf , Gnai1 , Gnai3 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Camk2a , Camk2b , Camk2d , Camk2g , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Ptk2 , Raf1
measles pathwayAkt1 , Akt2 , Akt3 , Cblb , Cdkn1b , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3 , Stat5a , Stat5b
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Nras , Pak1 , Pak2 , Prkca , Prkcb , Prkcg , Raf1 , Rasa1 , Shc1 , Sos1 , Sos2
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1 , Rps6kb1 , Rps6kb2
myocarditis pathwayAbl1 , Abl2
N-cadherin signaling pathwayCamk2g , Gsn , Mapk8 , Pik3ca , Pik3r1 , Pip5k1c , Plcg1 , Ptpn1 , Ptpn11
nerve growth factor signaling pathwaySos1 , Src
neurotrophic factor signaling pathwayAbl1 , Akt1 , Akt2 , Akt3 , Bad , Braf , Camk2a , Camk2b , Camk2d , Camk2g , Crk , Crkl , Gab1 , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
NOD-like receptor signaling pathwayHsp90aa1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Tgfa
Notch signaling pathwayAdam10 , Adam12 , Adam17 , Cbl , Cdkn1a , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca , Src
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Gsk3b
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnai1
p38 MAPK signaling pathwayCamk2b
p53 signaling pathwayAbl1 , Akt1 , Cdkn1a , Gsk3b , Mapk8 , Mapk9
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Stat1 , Stat3 , Tgfa
panitumumab pharmacodynamics pathwayEgfr
phosphatidylinositol 3-kinase class I signaling pathwayHras , Hsp90aa1 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Src
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Gsk3b , Hsp90aa1 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Src
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayAbl1 , Braf , Cbl , Crk , Crkl , Elk1 , Gab1 , Grb2 , Hras , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Nck1 , Nck2 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Prkca , Ptpn1 , Ptpn11 , Ptprj , Raf1 , Rasa1 , Shc1 , Sos1 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Wasl
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion disease pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Cdkn1b , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
protein kinase C (PKC) signaling pathwayHsp90aa1 , Prkca , Prkcb , Prkcg , Prkcz , Rasa1
pyruvate metabolic pathwayPdk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Map2k7 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Src
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Sos1 , Sos2 , Tgfa
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk10 , Mapk8 , Mapk9
rheumatoid arthritis pathwayJun
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Crk , Jun , Map2k4 , Mapk8 , Pak1
ribosome biogenesis pathwayPrkcb
RNA transport pathwayEif4ebp1
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
sleeping sickness pathwayPrkca , Prkcb , Prkcg
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Cdkn1b , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptk2
somatostatin signaling pathwayPtpn11 , Ptprj , Src
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Gnai1 , Gnai3 , Jun , Mapk1 , Mapk3 , Mapk8 , Pak1 , Plcg1 , Src
syndecan signaling pathwayAdam12 , Egfr , Hras , Mapk1 , Mapk3 , Mapk8 , Prkca , Rasa1 , Src
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk3 , Mapk9 , Nck1 , Nck2 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Ptpn6 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Bad , Gnai1 , Gnai3 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Trail mediated signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayCamk2a , Grb2 , Rps6kb1 , Shc1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc , Rps6kb1 , Rps6kb2
trastuzumab pharmacodynamics pathwayEgfr
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Bad , Camk2a , Camk2b , Camk2d , Camk2g , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Src , Stat1
tumor necrosis factor mediated signaling pathwayAdam17 , Map2k7 , Prkcz , Stat1
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz
type II interferon signaling pathwayAkt1 , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Crkl , Map2k1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Ptpn11 , Stat1 , Stat3
ubiquitin/proteasome degradation pathwayCbl , Cblb , Cblc , Src
urinary bladder cancer pathwayBraf , Cdkn1a , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Gab1 , Grb2 , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nck1 , Nck2 , Nras , Pak2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Shc2 , Src
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Gsk3b , Jun , Mapk10 , Mapk8 , Mapk9 , Myc , Prkca , Prkcb , Prkcg
Wnt signaling, canonical pathwayGsk3b
Wnt signaling, non-canonical pathwayCamk2a , Mapk10 , Mapk8 , Mapk9 , Prkcz
Phenotype Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway

References Associated with the epidermal growth factor/neuregulin signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: