EPIDERMAL GROWTH FACTOR/NEUREGULIN SIGNALING PATHWAY (PW:0000170)

View Ontology Report

Description

Epidermal growth factor/neuregulin signaling pathway plays a central role in the regulation of cell growth, differentiation, proliferation and survival. At least eleven ligands bind to four receptors to activate downstream signaling pathways, primarily the Raf/Mek/Erk MAPK and the phosphatidylinositol 3-Akt cascades (reports point to activation of Stat proteins in certain cancer cell lines). The ligands are type 1 transmembrane proteins whose extracellular domain must be cleaved in order to free

Pathway Diagram:

Ariadne Genomics Inc. Erbb3 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Erbb4 Erbb3 Sos1 Adams ---> Nrg ligands Adams ---> Egfr/Erbb4 ligands Adams ---> Egfr ligands Erbb4 ---- Nrg ligands Erbb3 ---- Nrg ligands Egfr/Erbb4 ligands ---- Erbb4 Egfr ---- Egfr/Erbb4 ligands Egfr ---- Egfr ligands the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell differentiation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> pro-growth the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> cell proliferation pro-growth phosphatidylinositol 3-kinase-Akt signaling pathway cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway ---> cell survival the extracellular signal-regulated Raf/Mek/Erk signaling pathway Egfr ---- Shc1 Erbb4 ---- Grb2 Erbb2 ---- Shc1 Egfr ---- Grb2 Grb2 ---- Shc1 Grb2 ---- Sos2 Grb2 Grb2 ---- Sos1 Pik3r1 Shc1 Erbb4 ---- Shc1 Egfr cell differentiation cell survival Erbb2 Erbb3 ---- Pik3r1 Ptprj ---| Egfr Cbl Cbl ---| Egfr Egfr ligands Egfr/Erbb4 ligands Adams Ptprj Sos2 Nrg ligands
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6907045
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:6907045
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:2317976
G Adam12 ADAM metallopeptidase domain 12 JBrowse link 1 205,951,840 206,286,294 RGD:2317976
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:2317976
G Adam19 ADAM metallopeptidase domain 19 JBrowse link 10 31,146,107 31,240,582 RGD:2317976
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:2317976
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:1578718
RGD:6907045
RGD:6484113
RGD:2317963
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Btc betacellulin JBrowse link 14 18,231,854 18,270,621 RGD:2317963
RGD:6907045
RGD:6484113
RGD:2324625
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6907045
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6907045
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:6907045
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:6907045
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:2317988
RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6907045
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:1626483
RGD:6907045
RGD:6484113
RGD:2317963
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1581898
RGD:6907045
RGD:6484113
RGD:1581908
RGD:2317963
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Epgn epithelial mitogen JBrowse link 14 18,627,103 18,635,135 RGD:2317963
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:2317963
RGD:6907045
RGD:6484113
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:1642700
RGD:2289958
RGD:6907045
RGD:6484113
RGD:2317988
RGD:2317965
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:2317965
RGD:6907045
G Ereg epiregulin JBrowse link 14 18,577,620 18,591,395 RGD:2317963
RGD:6907045
RGD:6484113
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
RGD:6907045
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6484113
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:2317988
RGD:6907045
RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:6484113
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:2317963
RGD:6907045
RGD:6484113
RGD:1581908
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6484113
RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:6484113
RGD:6907045
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6484113
RGD:6907045
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:2317965
RGD:6907045
G Nrg2 neuregulin 2 JBrowse link 18 28,835,391 29,015,552 RGD:1304015
RGD:6907045
RGD:6484113
RGD:2317965
G Nrg3 neuregulin 3 JBrowse link 16 15,763,031 16,932,208 RGD:2317965
RGD:6907045
RGD:6484113
G Nrg4 neuregulin 4 JBrowse link 8 59,782,789 59,849,433 RGD:2317965
RGD:6907045
RGD:6484113
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6484113
RGD:6907045
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6907045
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:6907045
G Pak4 p21 (RAC1) activated kinase 4 JBrowse link 1 85,162,462 85,201,746 RGD:6907045
G Pak6 p21 (RAC1) activated kinase 6 JBrowse link 3 110,442,175 110,486,317 RGD:6907045
G Pak7 p21 (RAC1) activated kinase 7 JBrowse link 3 129,042,232 129,357,512 RGD:6907045
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1642700
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:2317988
RGD:6907045
RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma JBrowse link 7 11,267,207 11,294,291 RGD:6484113
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6484113
RGD:6907045
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642700
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:6907045
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6484113
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:6484113
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:2317988
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6484113
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6907045
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:6907045
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:2317988
RGD:6907045
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Shc3 SHC adaptor protein 3 JBrowse link 17 13,670,520 13,791,043 RGD:6907045
G Shc4 SHC adaptor protein 4 JBrowse link 3 117,897,738 117,990,289 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1581110
RGD:6907045
RGD:6484113
RGD:2317988
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:2317988
RGD:6907045
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1581134
RGD:6907045
RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6484113
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6907045
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:2317963
RGD:6907045
RGD:6484113
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:6484113
G Wasl Wiskott-Aldrich syndrome-like JBrowse link 4 51,677,722 51,726,212 RGD:6484113
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:5490965
RGD:5133242
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:5133243
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAdamsAdam members
Functional ClassEgfr/Erbb4 ligandsepidermal growth factor receptor
Functional ClassNrg ligandsneuregulin ligands

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai1
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Eif4ebp1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rps6kb1 , Rps6kb2 , Sos1 , Sos2 , Stat3 , Stat5a , Stat5b
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Jun , Map2k2 , Map2k7 , Mapk1 , Mapk8 , Pak1 , Pik3ca , Prkcz
aldosterone signaling pathwayHsp90aa1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered Reelin signaling pathwaySrc
Alzheimer disease pathwayAdam10 , Adam17 , Bad , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPrkcz
angiotensin II signaling pathway via AT2 receptorErbb3 , Gnai3 , Ptpn6
antigen processing and presentation pathwayHsp90aa1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg2 , Prkcb , Ptpn6 , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayGsk3b
bladder cancer pathwayBraf , Cdkn1a , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9
calcium/calcium-mediated signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Egfr , Erbb2 , Erbb3 , Erbb4 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
calcium/calmodulin dependent kinase 2 signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g
cell cycle pathway, mitoticAbl1 , Cdkn1a , Cdkn1b , Gsk3b , Myc
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz , Raf1 , Stat1 , Stat3 , Tgfa
cetuximab pharmacodynamics pathwayEgfr
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gnai1 , Gnai3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Prkcz , Ptk2 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5b , Wasl
chronic myeloid leukemia pathwayAbl1 , Akt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Cdkn1a , Cdkn1b , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Stat5a , Stat5b
clathrin-dependent synaptic vesicle endocytosisPip5k1c
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
cortisol signaling pathwayHsp90aa1
cytokine mediated signaling pathwayEgf , Egfr
dopamine signaling pathwaySrc
E-cadherin signaling pathwayAkt1 , Akt2 , Crk , Egf , Egfr , Nck1 , Pik3ca , Pik3r1 , Pip5k1c , Plcg1 , Src
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Prkca , Prkcg , Prkcz , Src
endocytosis pathwayCbl , Cblb , Cblc , Egf , Egfr , Erbb3 , Erbb4 , Hras , Pip5k1c , Prkcz , Src
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1 , Map2k7 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Crk , Gnai1 , Gnai3 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Prkca , Prkcg , Raf1 , Src
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Ptk2
ephrin - ephrin receptor bidirectional signaling axisCbl , Crk , Crkl , Grb2 , Hras , Map2k1 , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Nck1 , Nck2 , Nras , Pak1 , Pik3ca , Pik3r1 , Pik3r5 , Plcg1 , Rasa1 , Src , Wasl
epidermal growth factor/neuregulin signaling pathwayAbl1 , Abl2 , Adam10 , Adam12 , Adam17 , Adam19 , Adam9 , Akt1 , Akt2 , Akt3 , Areg , Bad , Braf , Btc , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Cblb , Cblc , Cdkn1a , Cdkn1b , Crk , Crkl , Egf , Egfr , Eif4ebp1 , Elk1 , Epgn , Erbb2 , Erbb3 , Erbb4 , Ereg , Gab1 , Gnai1 , Gnai3 , Grb2 , Gsk3b , Gsn , Hbegf , Hras , Hsp90aa1 , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Myc , Nck1 , Nck2 , Nras , Nrg1 , Nrg2 , Nrg3 , Nrg4 , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn1 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Tgfa , Tln1 , Wasl
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayCbl , Crkl , Gab1 , Grb2 , Hras , Mapk8 , Pik3r1 , Plcg1 , Plcg2 , Ptpn11 , Ptpn6 , Shc1 , Sos1 , Stat1 , Stat5a , Stat5b
estrogen signaling pathwayHsp90aa1 , Src
FasL mediated signaling pathwayAkt1 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Crk , Crkl , Gsn , Map2k1 , Mapk1 , Mapk3 , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Rps6kb1 , Rps6kb2 , Wasl
fibroblast growth factor signaling pathwayAkt1 , Camk2a , Cbl , Gab1 , Grb2 , Jun , Mapk1 , Mapk3 , Pak4 , Pik3ca , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Sos1 , Src , Stat1 , Stat5b
forkhead class A signaling pathwayAkt1 , Cdkn1b , Jun
G protein mediated signaling pathway via Galphai familyGnai1 , Gnai3
G1/S transition pathwayCdkn1a , Cdkn1b
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Camk2a , Camk2b , Camk2d , Camk2g , Cdkn1a , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2 , Tgfa
glutamate signaling pathwayGnai1 , Gnai3 , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayMapk8 , Mapk9 , Nrg1 , Src
gonadotropin-releasing hormone signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Egfr , Elk1 , Grb2 , Hbegf , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Prkca , Prkcb , Raf1 , Sos1 , Sos2 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Shc1 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
Hedgehog signaling pathwayAkt1 , Gnai1 , Gnai3 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Egf , Egfr , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Stat1 , Stat3
hypoxia inducible factor pathwayAkt1 , Elk1 , Jun
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Gsk3b , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1 , Stat1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pip5k1c , Plcg1 , Plcg2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Cbl , Crk , Gsk3b , Pak1 , Prkcz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Crk , Crkl , Eif4ebp1 , Elk1 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Crk , Crkl , Grb2 , Hras , Nck2 , Pik3ca , Pik3r1 , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rps6kb1 , Shc1 , Sos1
integrin mediated signaling pathwayNck2 , Ptk2 , Tln1
interleukin-1 signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1 , Prkcz
Interleukin-10 signaling pathwayStat1 , Stat3
interleukin-12 signaling pathwayMtor , Stat1 , Stat3 , Stat5a
interleukin-2 signaling pathwayGrb2 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Nras , Pik3ca , Pik3r1 , Prkcb , Ptpn11 , Raf1 , Rasa1 , Shc1 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
interleukin-23 signaling pathwayPik3ca , Pik3r1 , Stat1 , Stat3 , Stat5a
interleukin-27 signaling pathwayStat1 , Stat3 , Stat5a
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11 , Shc1 , Stat5a , Stat5b
interleukin-4 signaling pathwayAkt1 , Cbl , Grb2 , Mtor , Pik3ca , Pik3r1 , Ptpn6 , Rps6kb1 , Shc1 , Stat5a , Stat5b
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11 , Stat5a , Stat5b
interleukin-6 signaling pathwayAdam10 , Adam17 , Akt1 , Gab1 , Grb2 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Sos2 , Stat1 , Stat3
intrinsic apoptotic pathwayBad
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Ptpn6 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5a , Stat5b
Leishmania infection pathwayElk1 , Jun , Mapk1 , Mapk3 , Prkcb , Ptpn6 , Stat1
leptin system pathwayPtpn1 , Ptpn11 , Stat3
long term depressionBraf , Gnai1 , Gnai3 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Camk2a , Camk2b , Camk2d , Camk2g , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Ptk2 , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Cblb , Cdkn1b , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3 , Stat5a , Stat5b
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Nras , Pak1 , Pak2 , Prkca , Prkcb , Prkcg , Raf1 , Rasa1 , Shc1 , Sos1 , Sos2
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1 , Rps6kb1 , Rps6kb2
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Camk2a , Camk2b , Camk2d , Camk2g , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Src , Stat1
myocarditis pathwayAbl1 , Abl2
N-cadherin signaling pathwayCamk2g , Gsn , Mapk8 , Pik3ca , Pik3r1 , Pip5k1c , Plcg1 , Ptpn1 , Ptpn11
nerve growth factor signaling pathwaySos1 , Src
neurotrophic factor signaling pathwayAbl1 , Akt1 , Akt2 , Akt3 , Bad , Braf , Camk2a , Camk2b , Camk2d , Camk2g , Crk , Crkl , Gab1 , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
NOD-like receptor signaling pathwayHsp90aa1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Tgfa
Notch signaling pathwayAdam10 , Adam12 , Adam17 , Cbl , Cdkn1a , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca , Src
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Gsk3b
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnai1
p38 MAPK signaling pathwayCamk2b
p53 signaling pathwayAbl1 , Akt1 , Cdkn1a , Gsk3b , Mapk8 , Mapk9
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Stat1 , Stat3 , Tgfa
panitumumab pharmacodynamics pathwayEgfr
phosphatidylinositol 3-kinase class I signaling pathwayHras , Hsp90aa1 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Src
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pip5k1c , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Gsk3b , Hsp90aa1 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Src
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayAbl1 , Braf , Cbl , Crk , Crkl , Elk1 , Gab1 , Grb2 , Hras , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Nck1 , Nck2 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Prkca , Ptpn1 , Ptpn11 , Ptprj , Raf1 , Rasa1 , Shc1 , Sos1 , Src , Stat1 , Stat3 , Stat5a , Stat5b , Wasl
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion diseases pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Cdkn1b , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
protein kinase C (PKC) signaling pathwayHsp90aa1 , Prkca , Prkcb , Prkcg , Prkcz , Rasa1
pyruvate metabolic pathwayPdk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Map2k7 , Mapk8 , Nck2 , Pik3ca , Pik3r1 , Src
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Sos1 , Sos2 , Tgfa
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk10 , Mapk8 , Mapk9
rheumatoid arthritis disease pathwayJun
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Crk , Jun , Map2k4 , Mapk8 , Pak1
ribosome biogenesis pathwayPrkcb
RNA transport pathwayEif4ebp1
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Cdkn1b , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptk2
somatostatin signaling pathwayPtpn11 , Ptprj , Src
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Gnai1 , Gnai3 , Jun , Mapk1 , Mapk3 , Mapk8 , Pak1 , Plcg1 , Src
syndecan signaling pathwayAdam12 , Egfr , Hras , Mapk1 , Mapk3 , Mapk8 , Prkca , Rasa1 , Src
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Gsk3b , Hras , Jun , Kras , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk3 , Mapk9 , Nck1 , Nck2 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Ptpn6 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Gnai1 , Gnai3 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pdk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Trail mediated signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayCamk2a , Grb2 , Rps6kb1 , Shc1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc , Rps6kb1 , Rps6kb2
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma brucei infection pathwayPrkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Gnai1 , Gnai3 , Jun , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
tumor necrosis factor mediated signaling pathwayAdam17 , Map2k7 , Prkcz , Stat1
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz
type II interferon signaling pathwayAkt1 , Camk2a , Camk2b , Camk2d , Camk2g , Cbl , Crkl , Map2k1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Ptpn11 , Stat1 , Stat3
ubiquitin/proteasome degradation pathwayCbl , Cblb , Cblc , Src
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Gab1 , Grb2 , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nck1 , Nck2 , Nras , Pak2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Shc2 , Src
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Gsk3b , Jun , Mapk10 , Mapk8 , Mapk9 , Myc , Prkca , Prkcb , Prkcg
Wnt signaling, canonical pathwayGsk3b
Wnt signaling, non-canonical pathwayCamk2a , Mapk10 , Mapk8 , Mapk9 , Prkcz
Phenotype Annotations Associated with Genes in the epidermal growth factor/neuregulin signaling pathway

References Associated with the epidermal growth factor/neuregulin signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: