INSULIN SIGNALING PATHWAY (PW:0000143)

View Ontology Report

Description

Insulin signaling pathway plays essential roles in glucose and energy homeostasis. Impairment of the pathway, such as decrease in insulin signaling can lead to insulin resistance, the risk of developing type-2 diabetes (T2D) and the complications associated with it. Insulin binding to its receptor InsR, the only receptor of the insulin pathway, results in conformational changes and subsequent autophosphorylation of distinct tyrosine residues on the juxtamembrane, kinase and C-terminal doma

Pathway Diagram:

Ariadne Genomics Inc. Irs1 Sh2b2 PY_multiple PY972 Socs1 Socs3 Socs6 Socs7 Insr --+> Shc1 Insr --+> Irs2 Shc1 Grb2 ---- Irs1 Grb2 Sos2 Sos1 Irs2 Socs7 ---| Insr Socs3 ---| Insr Socs6 ---| Insr Socs1 ---| Insr Grb2 ---- Sos1 insulin responsive facilitative sugar transporter mediated glucose transport pathway Ins2 ---- Insr Grb10 Grb14 Insr --+> Irs3 Irs3 Insr Insr --+> Irs4 Irs4 Pkcs Insr --+> Irs1 Ptpn1 Enpp1 Ptprf phosphatidylinositol 3-kinase-Akt signaling pathway Insr --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway Insr --+> Sh2b2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ptpn11 Ins2 Ptpn1 ---| Insr Ptprf ---| Insr Grb2 ---- Shc1 Grb2 ---- Sos2 Irs2 ---- Ptpn11 Grb2 ---- Irs2 Pik3r1 Pkcs ---| Irs1 Pkcs ---| Insr Enpp1 ---| Insr Grb10 ---| Insr Grb14 ---| Insr Irs2 ---- Pik3r1 Irs1 ---- Pik3r1 Ins1 ---- Insr Ins1 Irs2 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Irs1 --+> phosphatidylinositol 3-kinase-Akt signaling pathway Ptpn11 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway
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Genes in Pathway:

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insulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6907045
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:6907045
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
RGD:10402751
RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6484113
RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6907045
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6907045
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6907045
G Calml3 calmodulin-like 3 JBrowse link 17 70,070,458 70,073,697 RGD:6907045
G Calml5 calmodulin-like 5 JBrowse link 17 70,044,956 70,045,886 RGD:6907045
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6484113
RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Dok1 docking protein 1 JBrowse link 4 113,864,211 113,866,695 RGD:6484113
G Eif4e eukaryotic translation initiation factor 4E JBrowse link 2 243,819,616 243,853,987 RGD:6907045
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 JBrowse link 9 94,310,476 94,325,445 RGD:6907045
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6484113
RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:1625124
G Exoc2 exocyst complex component 2 JBrowse link 17 34,665,810 34,842,266 RGD:6484113
G Exoc3 exocyst complex component 3 JBrowse link 1 31,700,953 31,731,726 RGD:6484113
G Exoc4 exocyst complex component 4 JBrowse link 4 60,549,128 61,358,305 RGD:6484113
G Exoc5 exocyst complex component 5 JBrowse link 15 25,888,757 25,933,302 RGD:6484113
G Exoc6 exocyst complex component 6 JBrowse link 1 256,211,879 256,369,318 RGD:6484113
G Exoc7 exocyst complex component 7 JBrowse link 10 105,242,152 105,259,795 RGD:6484113
RGD:6907045
G F2rl2 coagulation factor II (thrombin) receptor-like 2 JBrowse link 2 26,240,385 26,245,533 RGD:6484113
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6907045
G Fbp1 fructose-bisphosphatase 1 JBrowse link 17 396,175 417,480 RGD:6907045
G Fbp2 fructose-bisphosphatase 2 JBrowse link 17 372,554 389,918 RGD:6907045
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:6907045
G Flot2 flotillin 2 JBrowse link 10 65,304,901 65,329,332 RGD:6907045
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6484113
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6907045
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6907045
G Grb10 growth factor receptor bound protein 10 JBrowse link 14 92,021,851 92,122,249 RGD:1625124
RGD:6484113
G Grb14 growth factor receptor bound protein 14 JBrowse link 3 50,937,403 51,054,447 RGD:1625124
RGD:6484113
RGD:61620
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:1299201
RGD:10402751
RGD:6907045
RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Gys1 glycogen synthase 1 JBrowse link 1 101,427,195 101,447,092 RGD:6907045
G Gys2 glycogen synthase 2 JBrowse link 4 176,638,632 176,679,805 RGD:6907045
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6907045
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6907045
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6484113
RGD:10402751
RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:6484113
RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:1625124
RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1625124
RGD:10402751
RGD:6907045
RGD:6484113
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1580595
RGD:10402751
RGD:6907045
RGD:6484113
RGD:1625124
RGD:1299201
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:1580595
RGD:10402751
RGD:7248547
RGD:6907045
RGD:6484113
RGD:1581310
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:1580595
RGD:10402751
RGD:7248547
RGD:6907045
RGD:1299201
G Irs3 insulin receptor substrate 3 JBrowse link 12 22,120,305 22,125,103 RGD:1581310
RGD:7248547
RGD:6907045
G Irs4 insulin receptor substrate 4 JBrowse link X 113,003,824 113,018,088 RGD:6907045
RGD:7248547
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Lipe lipase E, hormone sensitive type JBrowse link 1 82,248,031 82,266,727 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
RGD:10402751
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
RGD:10402751
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
RGD:10402751
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:6907045
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:6907045
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:6484113
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pard6a par-6 family cell polarity regulator alpha JBrowse link 19 37,668,133 37,670,450 RGD:6484113
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6907045
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) JBrowse link 15 34,216,735 34,224,357 RGD:6907045
G Pde3a phosphodiesterase 3A JBrowse link 4 175,431,904 175,703,844 RGD:6907045
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
RGD:10402751
RGD:6907045
G Phka1 phosphorylase kinase regulatory subunit alpha 1 JBrowse link X 72,377,020 72,515,385 RGD:6907045
G Phka2 phosphorylase kinase regulatory subunit alpha 2 JBrowse link X 35,970,650 36,926,616 RGD:6907045
G Phkb phosphorylase kinase regulatory subunit beta JBrowse link 19 22,031,684 22,281,788 RGD:6907045
G Phkg1 phosphorylase kinase catalytic subunit gamma 1 JBrowse link 12 30,450,431 30,464,314 RGD:6907045
G Phkg2 phosphorylase kinase catalytic subunit gamma 2 JBrowse link 1 199,019,298 199,032,053 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:10402751
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:1299201
RGD:6907045
RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 JBrowse link 10 55,085,269 55,135,069 RGD:10402751
G Pklr pyruvate kinase L/R JBrowse link 2 188,449,158 188,458,034 RGD:6907045
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6907045
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:6907045
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:6907045
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:6907045
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A JBrowse link 4 41,171,486 41,212,116 RGD:6907045
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B JBrowse link 16 60,415,192 60,427,498 RGD:6907045
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C JBrowse link 1 255,371,830 255,376,833 RGD:6907045
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D JBrowse link 3 173,950,613 173,953,684 RGD:6907045
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6907045
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6907045
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 JBrowse link 12 46,316,298 46,326,789 RGD:6907045
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 JBrowse link 2 199,831,990 199,847,623 RGD:6907045
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 JBrowse link 7 140,489,499 140,506,925 RGD:6907045
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:6907045
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 JBrowse link 9 81,999,368 82,008,620 RGD:6907045
G Prkar1a protein kinase cAMP-dependent type 1 regulatory subunit alpha JBrowse link 10 97,940,705 97,959,199 RGD:6907045
G Prkar2a protein kinase cAMP-dependent type 2 regulatory subunit alpha JBrowse link 8 117,486,085 117,548,768 RGD:6907045
G Prkar2b protein kinase cAMP-dependent type 2 regulatory subunit beta JBrowse link 6 51,265,509 51,356,383 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1625124
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:1625124
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:1625124
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
RGD:6907045
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:1625124
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
RGD:6907045
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1580595
RGD:6907045
RGD:6484113
RGD:2293185
RGD:1625124
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1299201
RGD:6484113
RGD:2293185
G Ptpra protein tyrosine phosphatase, receptor type, A JBrowse link 3 122,976,066 123,084,585 RGD:6484113
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:1625124
RGD:6907045
RGD:2293185
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:6907045
G Pygl glycogen phosphorylase L JBrowse link 6 92,597,759 92,643,734 RGD:6907045
G Pygm glycogen phosphorylase, muscle associated JBrowse link 1 221,756,325 221,771,142 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
RGD:10402751
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:6907045
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6484113
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:6907045
G Rhoq ras homolog family member Q JBrowse link 6 10,533,151 10,568,582 RGD:6484113
RGD:6907045
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6907045
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6484113
RGD:6907045
G Rps6kb2 ribosomal protein S6 kinase B2 JBrowse link 1 219,406,201 219,412,888 RGD:6907045
G Rptor regulatory associated protein of MTOR, complex 1 JBrowse link 10 108,750,620 109,058,691 RGD:6907045
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6484113
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:1625124
RGD:6907045
RGD:6484113
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1625124
RGD:10402751
RGD:6907045
RGD:6484113
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Shc3 SHC adaptor protein 3 JBrowse link 17 13,670,520 13,791,043 RGD:6907045
G Shc4 SHC adaptor protein 4 JBrowse link 3 117,897,738 117,990,289 RGD:6907045
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6907045
RGD:10402751
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1625125
RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:1625125
RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:6907045
G Socs6 suppressor of cytokine signaling 6 JBrowse link 18 85,962,729 85,981,125 RGD:1625125
G Socs7 suppressor of cytokine signaling 7 JBrowse link 10 85,301,797 85,337,971 RGD:1625125
G Sorbs1 sorbin and SH3 domain containing 1 JBrowse link 1 259,373,921 259,502,108 RGD:6484113
RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1299201
RGD:10402751
RGD:6907045
RGD:6484113
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:1299201
RGD:6907045
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6907045
G Trip10 thyroid hormone receptor interactor 10 JBrowse link 9 9,689,214 9,702,353 RGD:6484113
RGD:6907045
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:6907045
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:6907045
altered insulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayinsulin responsive facilitative sugar transporter mediated glucose transport pathwaySlc2a4 (Glut4) mediated uptake of glucose
Pathwaythe extracellular signal-regulated Raf/Mek/Erk signaling pathwaythe mitogen activated protein kinase (MAPK) cascade activated by insulin signaling
Pathwayphosphatidylinositol 3-kinase-Akt signaling pathwaythe PI3K, mostly the class IA lipid kinase acting downstream of receptor tyrosine kinases

Pathway Gene Annotations

Disease Annotations Associated with Genes in the insulin signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmCav1 , Gys1 , Mapk8
abdominal obesity-metabolic syndromePpargc1a , Prkci
Abdominal Obesity-Metabolic Syndrome 4Lipe
Aberrant Crypt FociGsk3b , Mapk1 , Mapk3
Acetyl-Coa Carboxylase DeficiencyAcaca
Acid-Base ImbalanceFbp1
acoustic neuromaCav1
acrodysostosisPrkar1a
Acrodysostosis 1, with or without Hormone ResistancePrkar1a
Acute Coronary SyndromeFasn
Acute HepatitisTsc2
acute kidney failureBad , Gsk3b , Ins2 , Mtor , Ppargc1a
Acute Liver FailureIns1 , Ins2 , Mapk8
Acute Lung InjuryCav1 , Pik3cg , Prkaa1
acute myeloid leukemiaCbl , Eif4ebp1 , Foxo1 , Hras , Kras , Nras , Ptpn11 , Sgk1 , Tsc2
acute myocardial infarctionGsk3b
acute promyelocytic leukemiaAkt1 , Nras , Prkar1a
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaKras , Mtor , Pik3ca , Ptpn11
adenoid cystic carcinomaFoxo3 , Hras , Kras , Map2k2 , Pik3ca , Pygb
adenomaIns2 , Kras
Adenosine Triphosphate, Elevated, of ErythrocytesPklr
adrenal carcinomaBraf , Nras , Pik3ca
Adrenal Cortex NeoplasmsPrkar1a
adrenal cortical adenomaPrkaca
Adrenal Gland NeoplasmsPrkaca
adrenocortical carcinomaBraf , Nras , Pik3ca
adult T-cell leukemiaNras , Prkcb
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS Dementia ComplexInsr , Irs1
AIDS-Associated NephropathyMtor
AlbuminuriaIns2 , Nck1 , Nck2 , Ppargc1a
Alcoholic Liver DiseasesCav1
allergic contact dermatitisSocs1 , Socs2
alveolar rhabdomyosarcomaFoxo1
Alzheimer's diseaseAkt1 , Bad , Calm1 , Calml5 , Cav1 , Elk1 , Foxo3 , Gsk3b , Hras , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pck1 , Pik3cg , Pik3r1 , Ppargc1a , Prkcb , Shc1 , Slc2a4 , Tsc2
amblyopiaPpargc1a
ameloblastomaBraf
amelogenesis imperfecta type 1GPrkar1a
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Bad , Gsk3b , Ppargc1a
amyotrophic lateral sclerosis type 1Shc1
anemiaHk1 , Kras
angiomyolipomaTsc2
angiosarcomaHras , Kras
Animal Disease ModelsAkt1 , Fasn , Hk1 , Hk2 , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg
Animal Mammary NeoplasmsHras , Pik3r1 , Rasa1 , Sgk1
anti-basement membrane glomerulonephritisMapk8 , Rapgef1
Aortic CalcificationEnpp1
aortic valve disease 1Enpp1
aortic valve stenosisPtpn11
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
apparent mineralocorticoid excess syndromePrkar1a
arrhythmogenic right ventricular dysplasia 9Prkag2
arterial calcification of infancyEnpp1
arteriosclerosisLipe , Mapk9
arteriovenous malformationRasa1
arteriovenous malformations of the brainKras
asthmaPik3cg
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Hras , Kras , Ptpn11 , Tsc1
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Cav1 , Pik3cg , Socs3
atopic dermatitisMapk8
atrial fibrillationCav1
Atrial Myxoma, FamilialPrkar1a
AtrophyMapk3 , Rps6kb1
autism spectrum disorderAcaca , Mapk3 , Prkab2 , Tsc1 , Tsc2
autistic disorderEif4e , Hras , Mapk1 , Pik3cg , Prkcb , Tsc1 , Tsc2
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Kras , Nras
autosomal dominant polycystic kidney diseaseMtor , Rps6kb1
autosomal recessive Alport syndromeHras
autosomal recessive hypophosphatemic ricketsEnpp1
autosomal recessive limb-girdle muscular dystrophy type 2NInsr
autosomal recessive polycystic kidney diseaseAkt1 , Mtor , Pik3ca , Tsc1
B-Cell Chronic Lymphocytic LeukemiaBraf , Cbl , Hras , Kras , Nras
B-cell lymphomaNras , Ptpn1
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeAkt3
basal cell carcinomaPik3ca , Rasa1
biliary tract benign neoplasmPrkacb
bipolar disorderAkt1 , Gsk3b , Ins2
bladder carcinomaHras
bladder diseaseIns2
bladder urothelial carcinomaAkt1 , Braf , Hras , Kras , Map2k1 , Nras , Pik3ca
Bone MetastasisEnpp1
Bowen's DiseasePpargc1a
Brachydactyly with HypertensionPde3a
brain diseaseTsc1 , Tsc2
Brain InjuriesAkt1 , Bad , Elk1 , Gsk3b , Ppargc1a
Brain Injuries, TraumaticBad
brain ischemiaAkt1 , Bad , Cav1 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Prkaca , Prkacb , Prkca
Brain NeoplasmsBraf , Hras , Nras , Pik3ca , Pik3r1 , Ptpn11 , Tsc2
branched-chain keto acid dehydrogenase kinase deficiencyPhkg2
breast adenocarcinomaAkt1 , Kras , Pik3ca
breast cancerAkt1 , Braf , Cav1 , Grb2 , Hras , Kras , Mtor , Pik3ca
Breast Cancer, FamilialPik3ca , Pik3r3
Breast NeoplasmsAkt1 , Akt2 , Bad , Braf , Cav1 , Crkl , Fasn , Hras , Ikbkb , Insr , Kras , Map2k1 , Map2k2 , Mapk1 , Mtor , Pdpk1 , Pik3ca , Pik3r1 , Prkaa1 , Prkca , Prkci , Raf1 , Rps6 , Rps6kb2 , Socs1 , Socs2 , Tsc1 , Tsc2
Breasts and/or Nipples, Aplasia or Hypoplasia of, 2Ptprf
bronchiolo-alveolar adenocarcinomaKras
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsBad , Gsk3b , Mtor , Pklr , Rps6kb1 , Socs3
Cafe au lait Spots, MultipleSos1
cancerBraf , Hras , Nras , Pik3ca , Pik3r1
cannabis abuseAkt1 , Calm1 , Calm2
capillary hemangiomaAkt3
Capillary Malformation-Arteriovenous MalformationRasa1
carbohydrate metabolic disorderPrkag3
CarcinogenesisBraf , Cav1 , Kras
carcinomaHras , Kras , Pik3r1 , Rasa1 , Sgk1
cardiac arrestAkt1 , Ins2
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Cav1 , Gsk3b , Mapk1 , Mapk8 , Mtor , Pik3cg , Ppargc1a , Prkaa2 , Prkca , Prkcb , Prkcz , Pygm , Raf1 , Rps6kb1 , Shc1 , Slc2a4
cardiomyopathyAkt1 , Insr , Kras , Mapk1 , Mapk3 , Ppargc1a , Prkaa2 , Prkag2
Cardiovascular AbnormalitiesMap2k1 , Ptpn11
cardiovascular system diseaseEnpp1 , Gys1 , Ppargc1a
Carney complexPrkar1a
Carotid Artery InjuriesCbl , Foxo3 , Ppargc1a
cataractMap2k1
catecholaminergic polymorphic ventricular tachycardiaCalm1
catecholaminergic polymorphic ventricular tachycardia 1Calm1
catecholaminergic polymorphic ventricular tachycardia 4Calm1
Cecal NeoplasmsKras
Cell Transformation, NeoplasticHras , Irs1 , Kras , Mapk8
Cerebral HemorrhageMtor
Charcot-Marie-Tooth disease dominant intermediate CPik3r3 , Ptprf
Charcot-Marie-Tooth disease type 4GHk1
Chemical and Drug Induced Liver InjuryBad , Fasn , Pygl , Rasa1 , Shc1
childhood pilocytic astrocytomaMapk1
cholangiocarcinomaKras , Prkaca , Prkacb
cholestasisPygm
chondrosarcomaMtor
choriocarcinomaInsr
choroid plexus carcinomaFoxo3
Choroidal NeovascularizationIkbkb
Chromosome 17, Trisomy 17p11 2Srebf1
chromosome 17q12 deletion syndromeAcaca
chromosome 1q21.1 deletion syndromePrkab2
Chronic Allograft DysfunctionMtor
Chronic HepatitisShc1
Chronic Intermittent HypoxiaHk1 , Hk2
chronic kidney diseaseInsr , Ppargc1a
chronic lymphocytic leukemiaBraf , Hras , Kras , Nras , Ptpn11
chronic myeloid leukemiaAkt1 , Braf , Crkl , Nras
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseFoxo3 , Mapk8 , Ppargc1a
Chronic PancreatitisBad
CLOVES syndromePik3ca
Cocaine-Related DisordersCalm1 , Calm2 , Mapk1 , Mapk3
cognitive disorderGsk3b , Ins2 , Tsc1
Cole DiseaseEnpp1
colitisIkbkb , Pik3cg , Ppargc1a
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3
colon cancerAkt1 , Braf , Nras , Pik3ca
colon carcinomaAkt1 , Braf , Nras , Pik3ca
Colonic NeoplasmsAkt2 , Akt3 , Bad , Braf , Crkl , Fbp1 , Gsk3b , Ikbkb , Kras , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Prkaa1
colorectal adenocarcinomaGsk3b , Mapk1 , Mapk3 , Mapk8 , Raf1
colorectal adenomaMapk8 , Raf1
colorectal cancerAkt1 , Braf , Nras , Pik3ca
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Hk1 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cd , Pik3cg , Pik3r1 , Pik3r3 , Prkcb , Ptpn11 , Raf1
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Mtor , Pik3ca
congenital adrenal hyperplasiaPrkar1a
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPtpn11
congenital diaphragmatic herniaCbl , Insr
congenital generalized lipodystrophy type 3Cav1
congenital heart diseasePtpn11
Congenital HyperinsulinismGck
congenital hypothyroidismPpargc1a
Congenital Myopathy, with Excess of Muscle SpindlesHras
congenital nonspherocytic hemolytic anemiaHk1 , Pklr
congestive heart failureAcaca , Cbl , Fasn , Foxo1 , Gsk3b , Ins2 , Mtor , Pck1 , Pdpk1 , Pik3cg , Ppargc1a , Ppp1ca , Ppp1cc , Prkaca , Prkar2a , Prkar2b , Prkca , Prkcb , Slc2a4
Contrast-Induced NephropathyMapk8
Cornelia De Lange Syndrome 5Phka1
coronary artery diseaseAkt1 , Gck , Irs1 , Prkag2
Coronary DiseaseIrs1 , Prkag2
coronary restenosisMapk1
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cowden diseaseAkt1 , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca
craniopharyngiomaBraf
crescentic glomerulonephritisMtor
cryptorchidismCbl
Currarino TriadPik3ca
Cushing syndromePrkar1a
cutaneous T cell lymphomaBraf , Prkcq
cystic kidney diseaseIns2
degenerative disc diseaseCrk , Gsk3b
demyelinating diseaseMapk1
Dermal FibrosisCav1
dermatitisIkbkb
dermoid cyst of ovaryFoxo3
Developmental DisabilitiesAkt3 , Braf , Cbl , Pik3r2
Diabetes ComplicationsEnpp1 , Prkaa1
diabetes mellitusCav1 , Gck , Ins1 , Ins2 , Insr , Irs1 , Ppp1r3a
Diabetes Mellitus, Experimental Akt1 , Bad , Cav1 , Foxo3 , G6pc , Gck , Hk1 , Hras , Ikbkb , Insr , Irs1 , Irs2 , Mapk1 , Mapk3 , Mtor , Pck1 , Pde3a , Phka1 , Pik3r1 , Pklr , Ppargc1a , Prkca , Prkcb , Prkci , Pygm , Slc2a4 , Socs3 , Srebf1 , Tsc2
Diabetes Mellitus, New-Onset after TransplantationMtor
Diabetic CardiomyopathiesBad , Ins2 , Mapk1 , Mapk3
Diabetic CystopathyBad
diabetic encephalopathyGsk3b
diabetic ketoacidosisIns2 , Insr
Diabetic NephropathiesEnpp1 , Gsk3b , Ins2 , Irs2 , Mapk1 , Mtor , Ppargc1a , Prkcb , Srebf1 , Trip10
diabetic neuropathyBad , Cav1 , Insr , Sgk1 , Srebf1
diabetic retinopathyHras , Ins2 , Ppargc1a
diffuse large B-cell lymphomaPdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Rps6kb1
DiGeorge syndromeCrkl
dilated cardiomyopathyFasn , Kras , Ppargc1a , Ppp1ca , Prkca , Prkcb , Ptpn11 , Raf1 , Rps6kb1
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationBraf , Fasn , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1
disease of metabolismIns2 , Ptpn11 , Srebf1
Disease ProgressionHras , Pik3ca , Prkab1 , Ptprf , Rps6
Diseases of the AgedPpargc1a
Donohue syndromeInsr
Drug-Induced DyskinesiaGsk3b , Mtor
ductal carcinoma in situPrkca , Socs1 , Socs2 , Socs3
dysembryoplastic neuroepithelial tumorBraf
dystoniaIns2
EdemaIns2
embryonal rhabdomyosarcomaPtpn11
end stage renal failureEnpp1 , Fasn , Irs1 , Mtor , Srebf1
endometrial adenocarcinomaMapk1 , Mapk3 , Pik3r1
endometrial cancerKras , Pik3cb , Pik3r1
endometrial carcinomaGsk3b , Hras , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Tsc2
endometrial hyperplasiaKras
Endometrial NeoplasmsAkt2 , Bad , Braf , Foxo3 , Grb2 , Gsk3b , Kras , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Prkca , Socs2 , Socs3
Endometrioid CarcinomasAkt1 , Kras , Mapk1 , Mapk3 , Pik3r2
endometriosisEnpp1 , Kras
EndotoxemiaIrs1 , Pck1 , Pck2 , Prkaa1 , Socs1 , Socs3
EpendymomaShc3
epidermal nevusHras , Kras , Nras , Pik3ca
epilepsyAkt1 , Tsc1 , Tsc2
esophageal carcinomaHras , Kras , Pik3ca
esophagus adenocarcinomaPik3ca
exfoliation syndromeCav1
Experimental ArthritisAkt1 , Cbl , Cblb , Gsk3b , Ikbkb , Mtor , Nras , Pik3cd , Pik3cg , Socs3
Experimental Autoimmune EncephalomyelitisCblb , Foxo3 , Pik3cg , Prkaa1
Experimental Autoimmune MyocarditisCav1 , Rps6
Experimental Autoimmune NeuritisCav1
Experimental ColitisMapk1 , Mapk3
Experimental LeukemiaCbl , Nras
Experimental Liver CirrhosisCav1 , G6pc , Gck , Inpp5d , Ins2 , Mapk1 , Mapk3 , Mtor , Pck1 , Pck2 , Pklr , Ppp1r3b , Ppp1r3c , Prkcb , Ptpn1 , Rhoq , Socs1 , Socs2 , Srebf1
Experimental Liver NeoplasmsHras , Kras , Map2k1 , Mapk1 , Mapk3 , Socs1
Experimental MelanomaIkbkb
Experimental NeoplasmsBraf , Hras , Kras , Nras
Experimental SarcomaKras , Nras
extrahepatic cholestasisMapk1 , Mapk3 , Mapk8 , Mapk9
Facial AsymmetryPik3ca
Failure to ThrivePtpn11
familial adenomatous polyposisAkt1
familial hyperinsulinemic hypoglycemia 3Gck
familial hyperinsulinemic hypoglycemia 5Insr
familial hyperlipidemiaIrs1 , Shc1
familial hypertrophic cardiomyopathyCalm3 , Kras , Prkag2 , Raf1 , Sos1
familial partial lipodystrophyAkt2 , Cav1 , Lipe
familial partial lipodystrophy type 3Ppp1r3a
familial partial lipodystrophy type 6Lipe
Familial Prostate CancerMap2k1
fatty liver diseaseAcaca , Acacb , Gck , Ins2 , Mapk8 , Ppargc1a , Prkaa1 , Shc1 , Socs1 , Socs3 , Srebf1
Female InfertilityMapk1 , Mapk3 , Tsc2
Fetal DiseasesPrkcb
Fetal Growth RetardationElk1 , G6pc , Irs1 , Irs2 , Pck1 , Ppargc1a , Ptpn11 , Srebf1
fibrillary astrocytomaKras
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Phkg2 , Pik3cg , Socs3
Focal Cortical Dysplasia of TaylorMtor , Tsc1 , Tsc2
Follicular Thyroid CancerBraf , Hras , Nras
follicular thyroid carcinomaBraf , Hras , Kras , Nras , Prkar1a
fructose-1,6-bisphosphatase deficiencyFbp1
gallbladder carcinomaPik3ca
Gallbladder NeoplasmsKras
gangliogliomaBraf
gastric adenocarcinomaAkt1 , Braf , Hras , Kras , Map2k1 , Map2k2 , Mtor , Nras , Pik3ca , Ptpn11 , Raf1
gastric ulcerBad , Mapk1 , Mapk3
Gastrointestinal NeoplasmsPik3ca
gastrointestinal stromal tumorBraf , Kras
Gaucher's diseasePklr
Generalized EpilepsyFasn , Mapk10
genetic diseaseAkt2 , Akt3 , Braf , Calm2 , Cav1 , Cbl , Gck , Gys2 , Hras , Kras , Map2k1 , Mapk1 , Mtor , Phka2 , Pik3ca , Pik3r1 , Pik3r2 , Prkcg , Ptpn11 , Pygm , Raf1 , Sos1 , Tsc1 , Tsc2
germinomaBraf
gestational diabetesG6pc , Gck , Ins2 , Insr
Giant Pigmented Hairy NevusHras , Nras
gingival fibromatosisSos1
glaucomaBad
glioblastoma multiformeAkt1 , Akt3 , Braf , Enpp1 , Hras , Kras , Map2k2 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1
GliosisMapk1 , Mapk3
glomerulonephritisMapk1
glucose intoleranceIns2 , Insr , Ppargc1a , Prkaa1 , Prkaa2
glycogen storage diseaseGys2 , Phka1 , Phka2 , Phkg2 , Prkag2 , Pygl , Pygm
Glycogen Storage Disease 0, LiverGys2
Glycogen Storage Disease 0, MuscleGys1
glycogen storage disease IG6pc
Glycogen Storage Disease IAG6pc
Glycogen Storage Disease IBG6pc
glycogen storage disease IXaPhka2
glycogen storage disease IXbPhkb
glycogen storage disease IXcPhkg2
glycogen storage disease IXdPhka1
glycogen storage disease VPygm
glycogen storage disease VIPygl
grade III astrocytomaKras
Graft vs Host DiseasePik3cg
granulosa cell tumorPrkar2b , Sgk1
Growth DisordersCbl , Pik3ca
growth hormone secreting pituitary adenomaPtpn11
hairy cell leukemiaMap2k1
HamartomaTsc2
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca
head and neck squamous cell carcinomaAkt1 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca
Hearing Loss, Cisplatin-InducedGsk3b
heart diseaseGsk3b , Lipe , Ppargc1a
Helicobacter InfectionsPrkaa1 , Socs3
hemangiomaTsc2
Hematologic NeoplasmsCbl
HemimegalencephalyMtor , Pik3ca , Rheb
Hemolytic Anemia, Nonspherocytic, due to Hexokinase DeficiencyHk1
HemorrhageCav1
hepatitisIns2
hepatocellular adenomaHras , Kras , Ptpn11
hepatocellular carcinomaAcaca , Akt1 , Akt2 , Braf , Fasn , Fbp1 , Hras , Irs1 , Irs2 , Kras , Mtor , Nras , Pck1 , Pik3ca , Pygl , Rps6 , Shc1 , Socs3 , Srebf1 , Tsc1
Hereditary Hyperferritinemia with Congenital CataractsGys1
hereditary multiple exostosesPtpn11
Hereditary Neoplastic SyndromesPik3ca , Prkar1a , Rasa1 , Tsc1 , Tsc2
Hirschsprung Disease 1Tsc2
Hodgkin's lymphomaPtpn1
human immunodeficiency virus infectious diseaseEif4ebp1 , Socs1 , Socs3
Huntington's diseaseElk1 , Ppargc1a , Prkaa1 , Trip10
HyperalgesiaInsr , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Prkcb , Prkcg , Prkcz , Raf1
HyperammonemiaPrkcq
HypercholesterolemiaSrebf1
hyperglycemiaCbl , Gck , Ins2 , Insr , Irs2 , Pck1 , Pklr , Ppargc1a , Prkcb , Prkcz , Shc1
hyperinsulinemic hypoglycemiaGck
hyperinsulinismGck , Ins2 , Insr , Irs1 , Pklr , Prkcq , Ptpn1 , Ptprf , Rps6kb1
HyperkalemiaIns2
Hyperphosphatasia with Mental Retardation Syndrome 5Acaca
HyperplasiaAkt1 , Cav1 , Ikbkb , Pik3ca
HyperproinsulinemiaIns1 , Ins2
hypertensionAkt1 , Akt2 , Bad , Cav1 , Gck , Gsk3b , Ikbkb , Ins2 , Kras , Lipe , Mapk8 , Mtor , Pik3r1 , Prkag2 , Prkca , Prkcb , Ptpn1 , Rps6kb1 , Sgk1
Hypertensive NephropathyShc1
hyperthyroidismPpargc1a
HypertriglyceridemiaIns2 , Lipe , Mtor , Socs1 , Socs3
hypertrophic cardiomyopathyCav1 , Fasn , Ins2 , Prkaca , Prkag2 , Ptpn11 , Raf1
hypertrophic cardiomyopathy 1Prkag2
hypertrophic cardiomyopathy 4Braf
hypertrophic cardiomyopathy 6Prkag2
HypertrophyMapk1 , Mapk3
hyperuricemiaIns2
Hypoglossal Nerve InjuriesPrkaca , Prkacb
hypoglycemiaAkt2 , G6pc , Gck , Ins2 , Pik3r1 , Ppp1r3a
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 7 with or without anosmiaNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypokalemiaIns2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
Hypophosphatemic Rickets, Autosomal Recessive, 2Enpp1
HypoproteinemiaRps6kb1
HypotensionIns2
hypothyroidismBad , Cav1 , Phka1
HypoxiaPck2
Hypoxia-Ischemia, BrainFoxo3
idiopathic interstitial pneumoniaMtor
immune system diseasePrkcb
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
impotenceAkt1 , Bad
in situ carcinomaAkt1
InflammationAkt1 , Eif4ebp1 , Mtor , Pik3cg , Ptpn1 , Tsc2
inflammatory bowel diseaseIkbkb
Insulin ResistanceAcaca , Acacb , Akt2 , Bad , Cblb , Enpp1 , Foxo1 , Gck , Gys1 , Ikbkb , Ins2 , Insr , Irs1 , Irs2 , Mapk3 , Pik3r1 , Pklr , Ppargc1a , Ppp1r3a , Prkaa1 , Prkaa2 , Prkcb , Prkcq , Prkcz , Ptpn1 , Ptprf , Shc1 , Slc2a4 , Socs1 , Socs3 , Sorbs1 , Srebf1 , Tsc1
Insulin-Resistant Diabetes Mellitus, with Acanthosis NigricansInsr
insulinomaIns2
intellectual disabilityFasn , Kras , Prkcg , Tsc1 , Tsc2
intermediate coronary syndromeAkt1
intermittent claudicationBad
interstitial cystitisMtor
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsGsk3b , Map2k1 , Map2k2 , Mapk8 , Prkca
Intimal HyperplasiaFoxo3
intrahepatic cholangiocarcinomaKras
invasive ductal carcinomaAkt1 , Crkl , Socs1 , Socs2 , Socs3
ischemiaAkt2 , Mapk9 , Prkca , Raf1
juvenile myelomonocytic leukemiaCbl , Kras , Nras , Ptpn11
juvenile rheumatoid arthritisKras , Mapk1
Kearns-Sayre syndromePpargc1a
keratoconusFoxo1 , Pik3cg
kidney angiomyolipomaMtor
kidney diseaseMapk1 , Srebf1
kidney failureIns2 , Ppargc1a , Tsc1
Kidney NeoplasmsAkt1 , Braf , Eif4ebp1 , Kras , Mapk1 , Mapk3 , Ppargc1a , Raf1 , Tsc1 , Tsc2
Kidney Reperfusion InjuryIkbkb , Ppargc1a
Klinefelter's syndromeNras
Kuhnt-Junius degenerationMapk8
L-2-hydroxyglutaric aciduriaSos2
Langerhans-cell histiocytosisBraf
large cell carcinomaPrkca
Left Ventricular HypertrophyEnpp1 , Foxo3 , Mtor , Pde3a , Ppargc1a , Prkag2 , Prkca , Prkcb , Prkcz , Rasa1 , Rps6kb1 , Shc1
leiomyomaCav1 , Tsc2
Lennox-Gastaut syndromeMapk10
LEOPARD syndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
lethal congenital glycogen storage disease of heartPrkag2
leukemiaBad , Nras , Prkcz , Ptpn11
LeukocytosisKras , Nras
Lewy body dementiaElk1 , Ins2 , Insr
limited sclerodermaCav1
lipid metabolism disorderPrkag3
lipid storage diseaseSrebf1
lipoatrophic diabetes mellitusInsr
lipodystrophyInsr
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
liposarcomaFasn
liver benign neoplasmBraf , Hras , Kras , Raf1
liver cancerAkt1 , Hras , Kras , Nras , Pik3ca
liver cirrhosisPhkg2
liver diseaseHk3 , Ins2 , Socs1 , Socs3
Liver FailureRps6
Liver InjuryGck
Liver Reperfusion InjuryBad , Gsk3b , Mapk8
long QT syndromeHk3 , Pik3cg , Prkag2 , Rheb
long QT syndrome 1Calm2 , Calm3
long QT syndrome 14Calm1
long QT syndrome 15Calm2
low tension glaucomaCav1
lung adenocarcinomaAkt1 , Braf , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
lung cancerBraf , Kras , Pik3ca
lung diseaseInsr
Lung InjuryMtor
Lung NeoplasmsAkt1 , Braf , Calml3 , Cav1 , Crkl , Dok1 , Hras , Kras , Mapk1 , Mapk3 , Mtor , Pik3ca , Raf1 , Tsc1
lung small cell carcinomaAkt1 , Mtor , Pik3ca , Pik3r1
lung squamous cell carcinomaAkt1 , Braf , Hras , Kras , Pik3ca , Ptpn11
lupus nephritisMtor
LymphangiectasisRaf1
lymphangioleiomyomatosisTsc1 , Tsc2
Lymphatic MetastasisCav1 , Pdpk1 , Pik3ca , Pik3cb , Socs2 , Socs3 , Tsc2
lymphomaKras , Nras , Ptpn11
lymphopeniaCbl
MacrocephalyAkt3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular degenerationBad , Ppargc1a
major depressive disorderCalm2
malariaPklr
male infertilityCbl
Malformations of Cortical Development, Group IIPhka2
malignant fibroxanthomaPpargc1a
malignant gliomaAkt2 , Bad , Braf , Cav1 , Hras , Kras , Map2k1 , Mapk3 , Mtor , Pik3ca , Pik3r3 , Prkca , Raf1
malignant mesotheliomaPtprf , Raf1
malignant ovarian germ cell neoplasmCbl
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Cav1 , Gsk3b , Hras , Mapk1 , Mapk3 , Mtor , Pik3r1 , Rasa1 , Sgk1 , Socs1 , Socs3
Mandibular NeoplasmsBraf
mantle cell lymphomaEif4e , Eif4ebp1 , Gsk3b , Mtor , Pik3cd
maturity-onset diabetes of the youngGck , Ins1 , Ins2
maturity-onset diabetes of the young type 10Ins1 , Ins2
maturity-onset diabetes of the young type 2Gck
Mauriac SyndromePhkg2
Meckel syndromeExoc4
Mediastinal NeoplasmsPtpn1
medulloblastomaFoxo3 , Irs2 , Nras , Pik3ca , Pik3cg , Prkar1a , Tsc2
Megakaryoblastic Leukemia of Down SyndromeNras
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Braf , Cav1 , Cbl , Fasn , Gys2 , Hras , Kras , Map2k1 , Map2k2 , Mtor , Nras , Pck1 , Pik3ca , Pik3r1 , Ppargc1a , Prkag2 , Raf1
Memory DisordersIns2
Meningeal NeoplasmsAkt1
meningiomaAkt1
mental depressionGsk3b
mesangial proliferative glomerulonephritisRapgef1
MesotheliomaMtor
Metabolic SyndromeIns2 , Irs1 , Ppargc1a
MetachondromatosisPtpn11
Micronuclei, Chromosome-DefectiveIns2
Microsatellite InstabilityBraf
middle cerebral artery infarctionBad , Gsk3b , Ikbkb , Mapk1 , Mapk3 , Mtor , Prkcg
migraineMap2k2
Monoclonal B-Cell LymphocytosisRapgef1
Mouth NeoplasmsHras , Kras , Nras , Pik3ca , Tsc1 , Tsc2
MPTP PoisoningIns2
mucinous cystadenocarcinomaSgk1
Multiple AbnormalitiesCav1 , Gsk3b , Kras , Mapk1 , Phka2 , Pik3r2
Multiple Hamartoma SyndromePik3ca
multiple myelomaBraf , Cbl , Hk1 , Hras , Kras , Nras , Pik3ca , Ptpn11
Multiple Organ FailureMapk1
multiple sclerosisCav1 , Cblb
muscular atrophyAkt1 , Gsk3b , Ikbkb , Mtor , Rps6kb1
muscular diseaseIns2 , Pygm
Muscular Dystrophy, AnimalMtor , Ppargc1a
myelodysplastic syndromeHras , Kras , Nras
myeloid neoplasmCbl , Kras , Nras
myeloid sarcomaKras
myocardial infarctionAkt1 , Gsk3b , Mapk1 , Mtor , Pde3a , Pik3cg , Ppargc1a , Rps6kb1 , Socs1
Myocardial IschemiaCrk , Eif4e , Eif4ebp1 , Hk1 , Hk2 , Ptpra , Pygb , Pygm , Socs3
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Cbl , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Pik3cg , Ppargc1a , Prkcb , Slc2a4
myofibrillar myopathy 1Prkag3
MyxomaPrkar1a
narcolepsySocs2
Nasopharyngeal NeoplasmsHras , Nras , Pik3ca
Nematode InfectionsPik3r1
neonatal diabetes mellitusGck , Ins1 , Ins2
Neonatal HyperbilirubinemiaIkbkb
Neoplasm InvasivenessEif4e , Hras , Mapk1 , Mapk3
Neoplasm MetastasisAkt2 , Braf , Cav1 , Kras , Mapk1 , Mapk3 , Mapk9 , Mtor , Pik3ca , Pik3r3
Neoplastic ProcessesHras
nephritisMtor
nephrogenic diabetes insipidusPrkca
Nephrogenic Fibrosing DermopathyCav1
nephrotic syndromeNck1 , Nck2 , Ppargc1a
Nerve DegenerationMapk1 , Mapk3 , Tsc2
neural tube defectIns2
neuroblastomaHras , Kras , Nras , Pik3ca , Ptpn11 , Tsc2
Neurocutaneous MelanosisNras
neurodegeneration with brain iron accumulation 3Gys1
Neurodevelopmental DisordersPtpn11
neuroendocrine tumorBraf
neurofibromaPtpn11
neurofibrosarcomaNras
neuronal ceroid lipofuscinosis 1Ppargc1a , Rps6kb1
neuronal ceroid lipofuscinosis 6Gsk3b , Mapk1 , Mapk3
neuropathyPhka1
NevusBraf
Nevus, PigmentedNras
non-Hodgkin lymphomaBraf , Map2k1 , Nras , Pik3ca
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Foxo3 , Hras , Kras , Map2k1 , Nras , Pdpk1 , Pik3ca , Prkcb , Raf1 , Rheb
nonalcoholic fatty liver diseaseIrs1 , Irs2 , Mapk8 , Ppargc1a , Prkaca , Prkca , Srebf1
Nonseminomatous Germ Cell TumorBraf
Noonan Like SyndromeCbl , Ptpn11 , Sos1
Noonan syndromeBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 1Braf , Map2k1 , Nras , Ptpn11 , Raf1
Noonan syndrome 3Hras , Kras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 4Sos1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 9Sos2
Noonan Syndrome-Like Disorder with Loose Anagen Hair 2Ppp1cb
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl , Ptpn11
obesityAcacb , Akt1 , Akt2 , Bad , Cav1 , Enpp1 , Fasn , Foxo3 , Gck , Hk1 , Hk2 , Ikbkb , Ins2 , Irs1 , Irs2 , Lipe , Mapk1 , Mapk3 , Mtor , Pck1 , Pde3a , Pik3cg , Pik3r1 , Pklr , Ppargc1a , Prkar2b , Prkcb , Prkci , Ptpn1 , Ptprf , Rps6kb1 , Socs1 , Socs3 , Sorbs1 , Srebf1 , Tsc1
obsessive-compulsive disorderHras
Occupational AsthmaPrkca
Ollier diseasePtpn11
open-angle glaucomaCav1
Ossification of Posterior Longitudinal LigamentEnpp1
ossification of the posterior longitudinal ligament of spineEnpp1
osteoarthritisBad , Cav1 , Enpp1 , Ins2 , Mtor
Osteoarthritis, ExperimentalMapk3
OsteochondromaPtpn11
osteoporosisIrs1 , Irs2
osteosarcomaAkt1 , Tsc2
ovarian cancerAkt1 , Kras , Pik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Cav1 , Crkl , Dok1 , Fasn , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Ppp1cc , Prkca , Prkci , Socs1 , Socs2
ovarian serous cystadenocarcinomaBraf , Hras , Nras , Pik3ca
Oxygen-Induced RetinopathyMapk8
Paget's disease of boneInpp5d
PainAkt1
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaHras , Kras , Map2k2 , Pik3ca
pancreatic cancerAkt1 , Akt2 , Akt3 , Bad , Braf , Ins2 , Kras , Mtor , Tsc2
pancreatic carcinomaKras , Mtor , Tsc1
pancreatic ductal carcinomaIns2 , Kras , Tsc2
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisIkbkb , Ins2
Pancreatitis, Experimental, Acute Kras
panic disorderIns2
papillary renal cell carcinomaBraf , Hras , Mtor , Nras , Pik3ca , Rheb
papillary thyroid carcinomaBraf
papillomaHras
ParalysisIns2 , Pygm
paraplegiaAkt1
Parasitic Liver DiseasesKras
ParesthesiaIns2
Parkinson's diseaseAkt1 , Fbp1 , Gsk3b , Ins2 , Insr , Ppargc1a
Parkinsonian DisordersBad , Mtor , Ppargc1a
penile neoplasmHras , Kras , Pik3ca
peripheral nervous system diseasePhka1
peritonitisGsk3b
permanent neonatal diabetes mellitusGck , Ins1 , Ins2
Phelan-McDermid syndromeIns2
phencyclidine abuseCalm1 , Calm2
phobic disorderHras
Phosphoenolpyruvate Carboxykinase 2 DeficiencyPck2
Phosphoenolpyruvate Carboxykinase DeficiencyPck1
Phosphoenolpyruvate Carboxykinase Deficiency, MitochondrialPck2
Pigmented Nodular Adrenocortical Disease, Primary, 1Prkar1a
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
pilocytic astrocytomaKras
Pituitary NeoplasmsPrkca
placental insufficiencyPpargc1a
plasmacytomaBraf , Hras , Kras , Nras , Pik3ca , Ptpn11
pleomorphic xanthoastrocytomaBraf , Cav1 , Exoc4 , Gck , Grb10 , Phkg1 , Pik3cg , Ppp1r3a , Prkar2b , Sh2b2 , Tsc1
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaIkbkb
PoisoningGsk3b
polycystic kidney diseaseMtor
polycystic ovary syndromeAkt2 , Ins2 , Pde3b
PolymicrogyriaAkt3
PolyuriaPrkca
Port-Wine StainRasa1
portal hypertensionMtor , Pik3r1
pre-malignant neoplasmAkt1 , Eif4ebp1 , Hras , Insr , Irs1 , Mapk8 , Mapk9 , Prkaa1 , Socs4 , Tsc2
precursor lymphoblastic lymphoma/leukemiaHk1 , Kras , Nras
precursor T-lymphoblastic lymphoma/leukemiaKras , Mtor , Ptpn11
prediabetes syndromePpargc1a
Premature AgingFoxo1
primary biliary cirrhosisPpargc1a , Rps6kb1
primary open angle glaucomaCav1
primary pigmented nodular adrenocortical diseasePrkaca , Prkar1a
primary pulmonary hypertensionCav1
Primary Pulmonary Hypertension, 3Cav1
progressive myoclonus epilepsyTsc1
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Ikbkb , Insr , Map2k1 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Raf1
prostate cancerAkt2 , Akt3 , Exoc2 , Grb2 , Ikbkb , Ins2 , Kras , Mapk10 , Pde3a , Pdpk1 , Pik3ca , Pik3cb , Pik3cg , Pik3r1 , Pik3r2 , Ppp1r3c , Raf1 , Sorbs1 , Sos1
prostate carcinomaAkt2
prostate carcinoma in situKras
prostatic hypertrophyBad
Prostatic NeoplasmsAkt1 , Bad , Braf , Cav1 , Crkl , Foxo1 , Foxo3 , Gsk3b , Hras , Ins2 , Insr , Irs1 , Kras , Map2k1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Prkacb , Prkca , Prkcq , Prkcz , Socs1
proteinuriaNck1 , Nck2
Proteus syndromeAkt1
psoriasisCav1 , Ikbkb
PTEN hamartoma tumor syndromePik3ca
pulmonary emphysemaPpargc1a
pulmonary fibrosisBad , Cav1
pulmonary hypertensionCav1 , Foxo1 , Hk1 , Mapk1 , Mapk3 , Mtor , Pde3a , Slc2a4
pulmonary valve stenosisBraf , Hras , Sos1
pyruvate kinase deficiency of red cellsPklr
Q feverFlot1
Radiation Injuries, ExperimentalMapk1 , Mapk3
RASopathiesBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
rectal neoplasmMapk8 , Nras , Pik3ca , Pik3cb
RecurrenceHras , Kras
renal carcinomaMtor , Nras , Pik3ca
renal cell carcinomaAkt1 , Akt3 , Bad , Cav1 , Insr , Kras , Map2k1 , Mapk1 , Mtor , Nras , Pik3ca , Pik3r1 , Rheb , Tsc1 , Tsc2
renal fibrosisKras , Mapk1 , Ppargc1a
Reperfusion InjuryAkt1 , Bad , Cav1 , Inpp5d , Mapk8 , Mapk9 , Pik3r1 , Pklr , Prkca , Socs1 , Socs3 , Socs4
Retina Reperfusion InjuryBad
retinal detachmentPrkcq
Retinal NeovascularizationMtor
retinitis pigmentosaAcacb , Hk1 , Prkcg
RETINITIS PIGMENTOSA 79Hk1
Rett syndromePtpn1
RhabdomyolysisIns2
rheumatoid arthritisFoxo3 , Prkcq
Right Ventricular HypertrophyAkt1 , Mtor , Ppargc1a , Prkca
Salivary Gland NeoplasmsPygb
sarcomaPik3ca
SarcopeniaCav1 , Ppargc1a
schizophreniaAkt1 , Crkl , Elk1 , Gsk3b , Mapk3 , Mtor , Pik3cb , Ppargc1a
Schnyder corneal dystrophyMtor
sciatic neuropathyCav1 , Gsk3b , Mtor , Ppargc1a
scoliosisPtpn11
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seborrheic keratosisPik3ca
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
seminomaHras , Insr , Kras
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
sensorineural hearing lossPrkcb
SepsisBad , Eif4e , Gsk3b , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3cg , Ppargc1a , Prkcq , Socs1 , Socs2 , Socs3
Septic PeritonitisPik3r1
serous cystadenocarcinomaSgk1
Severe Growth Restriction with Distinctive FaciesIns1
Sezary's diseaseBraf , Mapk1
ShockMapk1 , Mapk3
Shock, HemorrhagicBad , Mapk1 , Mtor
short bowel syndromeInsr
SHORT SyndromePik3r1
sickle cell anemiaHk1
silicosisPrkcb
Silver-Russell syndromeIns1
skin benign neoplasmHras
skin melanomaAkt1 , Braf , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Raf1
Skin NeoplasmsAkt1 , Crkl , Hras
Sleep Initiation and Maintenance DisordersPpargc1a
small cell carcinomaMtor
Small-For-Size SyndromeBad
Smith-Kingsmore SyndromeMtor
Smith-Magenis syndromeAcaca , Exoc7 , Fasn , Flot2 , G6pc , Grb2 , Map2k2 , Prkar1a , Prkca , Rps6kb1 , Rptor , Socs3 , Socs7 , Srebf1
spermatocytomaHras
Spinal Cord InjuriesAkt1 , Cav1 , Foxo3 , Mtor , Ppargc1a , Ppp1cc , Socs2
Spinal Cord Reperfusion InjuryBad
spinocerebellar ataxia type 14Prkcg
Spinocerebellar Ataxia, X-Linked 1Phka1
Spinocerebellar AtaxiasPrkcg
Splenic NeoplasmsHras
SplenomegalyKras , Nras
spondyloarthropathyEnpp1
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Hras , Mtor , Pik3ca , Rheb
squamous cell carcinomaAkt1 , Cav1 , Hras , Kras , Mapk1 , Mapk3 , Pik3ca , Ptpn11 , Rasa1 , Tsc1 , Tsc2
status epilepticusFoxo3 , Gsk3b , Mtor , Prkcb , Socs3
Stevens-Johnson syndromeCav1
stomach cancerKras , Pik3ca
stomach carcinomaKras
Stomach NeoplasmsCav1 , Fbp1 , Hras , Irs2 , Kras , Mapk1 , Mapk3 , Mapk8 , Nras , Pik3ca , Prkaa1 , Prkab1 , Prkcb , Ptprf , Rps6
StrokeAkt1 , Enpp1 , Mapk8 , Pde3a , Pik3ca , Pik3cg , Prkaa2 , Prkag2
Sturge-Weber SyndromeRasa1
Subarachnoid HemorrhageGsk3b
substance-induced psychosisAkt1
substance-related disorderGsk3b , Insr , Mknk1
systemic lupus erythematosusPik3cg
systemic sclerodermaCav1
T-Cell LymphomaAkt1
TachycardiaGsk3b , Ins2
Takotsubo CardiomyopathyPpargc1a
tauopathyGsk3b
temporal lobe epilepsyFoxo3 , Mtor
Temporomandibular Joint DisordersMtor
Testis Reperfusion InjuryMapk1 , Mapk3
tetralogy of FallotPtpn11
third ventricle chordoid gliomaPrkca
thrombosisPde3a , Pik3cb
thymomaHras
thyroid cancerMapk1
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Hras , Kras , Nras , Pik3ca
Tobacco Use DisorderRptor
Tongue NeoplasmsHras
toxic encephalopathyMtor
transient cerebral ischemiaBad , Cav1 , Cbl , Elk1 , Ikbkb , Rps6 , Sgk1
transient neonatal diabetes mellitusGck
transitional cell carcinomaAkt1 , Braf , Cav1 , Hras , Kras , Map2k1 , Mapk1 , Mtor , Nras , Pik3ca , Rheb
Transplant RejectionIkbkb
Trichilemmoma Hras
trigeminal neuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Prkcg
tuberous sclerosisEif4ebp1 , Tsc1 , Tsc2
tuberous sclerosis 1Tsc1 , Tsc2
tuberous sclerosis 2Tsc2
Tumor Predisposition SyndromeTsc1 , Tsc2
type 1 diabetes mellitusCbl , Cblb , Foxo1 , Ins2 , Ppargc1a , Prkcq
type 1 diabetes mellitus 2Ins1 , Ins2
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Braf , Calm1 , Enpp1 , Foxo1 , G6pc , Gck , Grb14 , Gsk3b , Hk1 , Hk2 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Lipe , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pck1 , Pik3cb , Pik3r1 , Pklr , Ppargc1a , Ppp1r3a , Ppp1r3c , Prkaa1 , Prkaa2 , Prkcb , Prkci , Prkcz , Ptpn1 , Slc2a4 , Socs3 , Sorbs1 , Srebf1
uremiaSgk1
ureteral obstructionAkt1 , Mapk1 , Mapk3 , Mtor
urethral obstructionMapk1
urinary bladder cancerAkt1 , Cav1 , Hk1 , Hras , Kras , Mtor , Prkca , Socs1 , Tsc1
Urinary Bladder NeoplasmHras , Kras , Tsc1
Urinary IncontinenceMapk1
uterine carcinosarcomaHras , Pik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Hras , Kras , Mapk1 , Mtor , Nras , Pik3ca , Sos1
uterine fibroidTsc2
Uterine NeoplasmsBraf , Hras , Kras , Map2k1 , Mtor , Nras , Pik3ca , Pik3r1 , Rheb , Sos1
vascular dementiaEif4e , Gsk3b , Mtor , Rps6
Vascular MalformationsPik3ca
vasculitisCbl
velocardiofacial syndromeCrkl , Mapk1
Ventilator-Induced Lung InjuryAkt1 , Pik3cg
Ventricular Dysfunction, LeftIns2
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
ventricular septal defectBraf
Ventricular TachycardiaPrkag2 , Raf1
visual epilepsyBad , Ins2 , Pik3ca , Tsc1 , Tsc2
vitiligoPik3r1
Weight GainCalm1 , Cav1 , Grb14 , Pik3ca
Weight LossIns2
Weissenbacher-Zweymuller syndromeMapk1 , Slc2a4
West syndromeTsc1 , Tsc2
withdrawal disorderMapk1 , Mapk3
Wolff-Parkinson-White syndromePrkag2
Pathway Annotations Associated with Genes in the insulin signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Eif4ebp1 , Grb2 , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rps6kb1 , Rps6kb2 , Sos1 , Sos2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1ca , Ppp1cb , Ppp1r3d , Prkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkag1 , Prkag2 , Prkag3
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Ikbkb , Map2k2 , Mapk1 , Mapk8 , Pard6a , Pdpk1 , Pik3ca , Prkacb , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
aldosterone signaling pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Prkcb , Prkcg , Sgk1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered galactose metabolic pathwayG6pc , Hk2
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin signaling pathwayIns2 , Insr
altered leptin system pathwayInsr
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
Alzheimer's disease pathwayBad , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Gsk3b , Mapk1 , Mapk3
amino sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
amiodarone pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
amlodipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
amyotrophic lateral sclerosis pathwayBad
angiotensin II signaling pathwayPdpk1 , Prkcz
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkacb , Prkar1a , Prkar2a , Prkar2b , Prkx
atenolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
autophagy pathwayIns1 , Ins2 , Prkaa1 , Prkaa2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Ikbkb , Inpp5d , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayGsk3b
betaxolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
bile acid transport pathwayPrkaca , Prkacb , Prkx
bisoprolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1 , Ppp1ca
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
bupranolol drug pathwayCalm1 , Prkaca , Prkar1a
bupranolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
butirosin and neomycin biosynthetic pathwayGck , Hk1 , Hk2 , Hk3
c-Jun N-terminal kinases MAPK signaling pathwayMapk10 , Mapk8 , Mapk9 , Rapgef1
calcium/calcium-mediated signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
calcium/calmodulin dependent kinase 2 signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1cc
carvedilol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
cell cycle pathway, mitoticGsk3b
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz , Raf1
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Foxo3 , Grb2 , Gsk3b , Hras , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkacb , Prkcb , Prkcz , Prkx , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Crk , Crkl , Grb2 , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
citric acid cycle pathwayPck1 , Pck2
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
congenital sucrase-isomaltase deficiency pathwayGck , Gys2 , Hk2 , Pygl
corticosteroid signaling pathwaySgk1
CRM1 export pathwayEif4e
cyclooxygenase mediated pathway of arachidonic acid metabolismMknk1
dilated cardiomyopathy pathwayPrkaca , Prkacb , Prkx
diltiazem pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
disopyramide pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
dobutamine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
dopamine signaling pathwayPpp1ca , Ppp1cb , Ppp1cc , Prkaca , Prkacb
dopamine signaling pathway via D1 family of receptorsPrkacb
E-cadherin signaling pathwayAkt1 , Akt2 , Crk , Exoc3 , Exoc4 , Nck1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Pik3cg , Pik3r5 , Pik3r6 , Prkaca , Prkca , Prkcg , Prkcq , Prkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPck1 , Pck2 , Pdpk1 , Sorbs1
endocytosis pathwayCav1 , Cbl , Cblb , Cblc , Hras , Pard6a , Prkci , Prkcz
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Elk1 , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Crk , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Prkca , Prkcg , Prkcq , Raf1
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
ephrin - ephrin receptor bidirectional signaling axisCbl , Crk , Crkl , Grb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Nck1 , Nck2 , Nras , Pik3ca , Pik3cg , Pik3r1 , Pik3r5 , Pik3r6 , Rasa1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Cblb , Cblc , Crk , Crkl , Eif4ebp1 , Elk1 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rasa1 , Rps6kb1 , Rps6kb2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
erythropoietin signaling pathwayCbl , Crkl , Grb2 , Hras , Inpp5d , Irs2 , Mapk8 , Pik3r1 , Ptpn11 , Shc1 , Socs3 , Sos1
esmolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
facilitative sugar transporter mediated glucose transport pathwaySlc2a4
Fanconi syndrome pathwayG6pc , Hk2 , Pklr
FasL mediated signaling pathwayAkt1 , Ikbkb , Mapk10 , Mapk8 , Mapk9 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
fatty acid biosynthetic pathwayAcaca , Acacb , Fasn
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Inpp5d , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Crk , Crkl , Inpp5d , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Rps6kb1 , Rps6kb2
fibroblast growth factor signaling pathwayAkt1 , Cbl , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Ptpn11 , Shc1 , Sos1
flecainde pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
follicle-stimulating hormone signaling pathwayPpp1ca , Prkacb
forkhead class A signaling pathwayAkt1 , G6pc , Gck , Ins2 , Pck1 , Pklr
fosphenytoin pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
french type sialuria pathwayHk1
fructose and mannose metabolic pathwayFbp1 , Fbp2 , Hk1 , Hk2 , Hk3
fructose-1,6-bisphosphatase deficiency pathwayFbp1 , G6pc , Hk2 , Pck1
fructosuria pathwayFbp1 , Hk1
galactokinase deficiency pathwayGck
galactose metabolic pathwayG6pc , Gck , Hk1 , Hk2 , Hk3
galactosemia pathwayG6pc , Gck , Hk1
GALE deficiency pathwayGck
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
gluconeogenesis pathwayFbp1 , Fbp2 , G6pc , Gck , Hk1 , Hk2 , Hk3 , Pck1 , Pck2 , Pklr
Glut1 deficiency syndrome pathwayG6pc
glutamate signaling pathwayMapk1 , Mapk3 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
glyburide pharmacodynamics pathwayIns2
glycogen biosynthetic pathwayGck , Gsk3b , Gys1 , Gys2 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d
glycogen degradation pathwayCalm1 , Calm2 , Calm3 , G6pc , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d , Pygb , Pygl , Pygm
glycogen metabolic pathwayG6pc , Gck , Gys2 , Pygl
glycogen storage disease type Ia pathwayFbp1 , G6pc , Hk2 , Pck1
glycogen storage disease type Ib pathwayFbp1 , G6pc , Hk2 , Pck1
glycogen storage disease type III pathwayGck , Gys2 , Hk2 , Pygl
glycogen storage disease type IV pathwayGck , Gys2 , Hk2 , Pygl
glycogen storage disease type VI pathwayGck , Gys2 , Hk2 , Pygl
glycogen storage disease type VII pathwayG6pc , Hk2 , Pklr
glycolysis pathwayFbp1 , Fbp2 , G6pc , Gck , Hk1 , Hk2 , Hk3 , Pck1 , Pck2 , Pklr
glycolysis/gluconeogenesis pathwayFbp1 , Fbp2 , G6pc , Gck , Hk1 , Hk2 , Hk3 , Pck1 , Pck2 , Pklr
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Elk1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Prkaca , Prkacb , Prkca , Prkcb , Prkx , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Ikbkb , Inpp5d , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Prkaca , Prkacb , Ptpn11 , Raf1 , Shc1 , Sos1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Grb2 , Gsk3b , Hras , Ikbkb , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Socs3 , Sos1 , Sos2
hereditary fructose intolerance syndrome pathwayFbp1 , Hk1
histamine signaling pathway, immunologicalPpp1ca , Prkacb
Huntington's disease pathwayPpargc1a
hypertrophic cardiomyopathy pathwayPrkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkag1 , Prkag2 , Prkag3
hypoxia inducible factor pathwayAkt1 , Elk1 , Gck , Hk1 , Hk2
ibutilide pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
inflammatory response pathwayMapk8
influenza A pathwayAkt1 , Akt2 , Akt3 , Gsk3b , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1 , Socs3
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Calm1 , Calm2 , Calm3 , Cbl , Crk , Gsk3b , Gys1 , Ins2 , Insr , Ppp1cc , Ppp1r3a , Prkci , Prkcz , Rapgef1 , Rhoq , Slc2a4 , Sorbs1 , Trip10
insulin secretion pathwayGck
insulin signaling pathwayAcaca , Acacb , Akt1 , Akt2 , Akt3 , Bad , Braf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Cav1 , Cbl , Cblb , Cblc , Crk , Crkl , Dok1 , Eif4e , Eif4e2 , Eif4ebp1 , Elk1 , Enpp1 , Exoc2 , Exoc3 , Exoc4 , Exoc5 , Exoc6 , Exoc7 , F2rl2 , Fasn , Fbp1 , Fbp2 , Flot1 , Flot2 , Foxo1 , Foxo3 , G6pc , Gck , Grb10 , Grb14 , Grb2 , Gsk3b , Gys1 , Gys2 , Hk1 , Hk2 , Hk3 , Hras , Ikbkb , Inpp5d , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Lipe , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mknk1 , Mknk2 , Mtor , Nck1 , Nck2 , Nras , Pard6a , Pck1 , Pck2 , Pde3a , Pde3b , Pdpk1 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pik3r6 , Pklr , Ppargc1a , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d , Prkaa1 , Prkaa2 , Prkab1 , Prkab2 , Prkaca , Prkacb , Prkag1 , Prkag2 , Prkag3 , Prkar1a , Prkar2a , Prkar2b , Prkca , Prkcb , Prkcg , Prkci , Prkcq , Prkcz , Prkx , Ptpn1 , Ptpn11 , Ptpra , Ptprf , Pygb , Pygl , Pygm , Raf1 , Rapgef1 , Rasa1 , Rheb , Rhoq , Rps6 , Rps6kb1 , Rps6kb2 , Rptor , Sgk1 , Sh2b2 , Shc1 , Shc2 , Shc3 , Shc4 , Slc2a4 , Socs1 , Socs2 , Socs3 , Socs4 , Socs6 , Socs7 , Sorbs1 , Sos1 , Sos2 , Srebf1 , Trip10 , Tsc1 , Tsc2
insulin-like growth factor signaling pathwayAkt1 , Bad , Crk , Crkl , Grb10 , Grb2 , Hras , Irs1 , Irs2 , Irs4 , Nck2 , Pdpk1 , Pik3ca , Pik3r1 , Prkcz , Ptpn1 , Ptpn11 , Raf1 , Rps6kb1 , Shc1 , Sos1
integrin mediated signaling pathwayNck2
interleukin-1 signaling pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkci , Prkcz
interleukin-12 signaling pathwayMtor , Socs1
interleukin-2 signaling pathwayGrb2 , Hras , Irs1 , Irs2 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3r1 , Prkcb , Ptpn11 , Raf1 , Rasa1 , Shc1 , Socs1 , Socs2 , Socs3 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1 , Socs3
interleukin-3 signaling pathwayGrb2 , Inpp5d , Pik3ca , Pik3r1 , Prkaca , Prkacb , Ptpn11 , Shc1
interleukin-4 signaling pathwayAkt1 , Cbl , Grb2 , Inpp5d , Irs1 , Irs2 , Mtor , Pik3ca , Pik3r1 , Rps6kb1 , Shc1 , Socs1 , Socs3
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-6 signaling pathwayAkt1 , Foxo1 , Grb2 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2
intrinsic apoptotic pathwayBad
isoprenaline pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
isradipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Socs1 , Socs2 , Socs3 , Socs4 , Socs6 , Socs7 , Sos1 , Sos2
lactose biosynthetic pathwayG6pc
Leigh disease pathwayAcaca , Pck1 , Pklr
Leishmaniasis pathwayElk1 , Mapk1 , Mapk3 , Prkcb
leptin system pathwayIrs1 , Irs2 , Ptpn1 , Ptpn11 , Socs3
levobunolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
lidocaine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
long term depressionBraf , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Ppp1ca , Ppp1cb , Ppp1cc , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , Raf1
luteinizing hormone signaling pathwayPpp1ca , Prkacb
malonic aciduria pathwayAcaca
maturity-onset diabetes of the young pathwayGck , Ins1 , Ins2 , Pklr
measles pathwayAkt1 , Akt2 , Akt3 , Cblb , Dok1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcq
melanocortin system pathwayPrkacb
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
methylmalonic aciduria, cobalamin-related pathwayAcaca
metoprolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
mexiletine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Elk1 , Grb2 , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mknk1 , Mknk2 , Nras , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , Raf1 , Rasa1 , Shc1 , Sos1 , Sos2 , Tsc2
monoterpenoid biosynthetic pathwayEnpp1
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4e , Eif4e2 , Eif4ebp1 , Hras , Ikbkb , Ins1 , Ins2 , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Raf1 , Rheb , Rps6 , Rps6kb1 , Rps6kb2 , Rptor , Sgk1 , Srebf1 , Tsc1 , Tsc2
myocarditis pathwayCav1
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3 , Mapk8 , Pik3ca , Pik3r1 , Ptpn1 , Ptpn11
nadolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nebivolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Crk , Crkl , Foxo3 , Grb2 , Gsk3b , Hras , Ikbkb , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Rapgef1 , Sh2b2 , Shc1 , Shc2 , Shc3 , Shc4 , Sos1 , Sos2
niacin metabolic pathwayEnpp1
nifedipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nimodipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nisoldipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
nitrendipine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
NOD-like receptor signaling pathwayIkbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2
Notch signaling pathwayCbl
nuclear factor kappa B signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b , Ikbkb
nucleotide sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
p38 MAPK signaling pathwayCalm1 , Calm2 , Calm3 , Mknk1 , Mknk2
p53 signaling pathwayAkt1 , Gsk3b , Mapk8 , Mapk9 , Tsc2
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
pantothenic acid metabolic pathwayEnpp1
penbutolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
pentose phosphate pathwayFbp1 , Fbp2
phenytoin pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Inpp5d , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pik3r6 , Sgk1
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo1 , Foxo3 , Gsk3b , Inpp5d , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Slc2a4
phosphoenolpyruvate carboxykinase deficiency pathwayFbp1 , G6pc , Hk2 , Pck1
phosphoinositide metabolic pathwayInpp5d , Pik3ca , Pik3cd , Pik3r1
pindolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
platelet-derived growth factor signaling pathwayBraf , Cav1 , Cbl , Crk , Crkl , Dok1 , Elk1 , Grb10 , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3cg , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pik3r6 , Prkca , Ptpn1 , Ptpn11 , Raf1 , Rasa1 , Shc1 , Sos1
potassium channel inhibitors pharmacodynamics pathwayIns2
primary hyperoxaluria type 2 pathwayAcaca , Pck1 , Pklr
prion disease pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkaca , Prkacb , Prkx
procainamide pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
propanoate metabolic pathwayAcaca , Acacb
propranolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
prostaglandin D2 signaling pathwayPrkacb
prostaglandin I2 signaling pathwayPrkacb
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo1 , Grb2 , Gsk3b , Hras , Ikbkb , Ins1 , Ins2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
protease mediated signaling via protease-activated receptor 3F2rl2
protein kinase A (PKA) signaling pathwayPde3a , Pde3b , Prkaca , Prkacb , Prkar1a , Prkar2a , Prkar2b
protein kinase C (PKC) signaling pathwayPard6a , Pdpk1 , Prkca , Prkcb , Prkcg , Prkci , Prkcq , Prkcz , Rasa1
purine metabolic pathwayEnpp1 , Pde3a , Pde3b , Pklr
pyruvate decarboxylase deficiency pathwayAcaca , Pck1 , Pklr
pyruvate dehydrogenase E1 deficiency pathwayAcaca , Pck1 , Pklr
pyruvate kinase deficiency of red cells pathwayAcaca , Pck1 , Pklr
pyruvate metabolic pathwayAcaca , Acacb , Pck1 , Pck2 , Pklr
quinidine pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Cbl , Crkl , Gsk3b , Mapk8 , Nck2 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Rapgef1 , Sos1 , Sos2
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb , Mapk10 , Mapk8 , Mapk9
reverse cholesterol transport pathwayCav1
Rheb mediated signaling pathwayRheb
Rho/Rac/Cdc42 mediated signaling pathwayCbl , Crk , Mapk8 , Rapgef1 , Rhoq , Sorbs1
riboflavin metabolic pathwayEnpp1
ribose 5-phosphate isomerase deficiency pathwayFbp1
ribosome biogenesis pathwayPrkcb
RNA transport pathwayEif4e , Eif4e2 , Eif4ebp1
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Grb2 , Pik3r1 , Ptpn11 , Shc1
serotonin signaling pathway via receptors engaging G alphas protein familyPpp1ca , Prkacb
sialic acid storage disease pathwayHk1
sleeping sickness pathwayPrkca , Prkcb , Prkcg
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
somatostatin signaling pathwayPtpn11
sotalol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Irs1 , Mapk1 , Mapk3 , Mapk8
starch and sucrose metabolic pathwayEnpp1 , G6pc , Gck , Gys1 , Gys2 , Hk1 , Hk2 , Hk3 , Pygb , Pygl , Pygm
sterol regulatory element-binding protein signaling pathwaySrebf1
syndecan signaling pathwayHras , Mapk1 , Mapk3 , Mapk8 , Prkaca , Prkca , Rasa1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Gsk3b , Hras , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapk9 , Nck1 , Nck2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Tay-Sachs disease pathwayHk1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Shc1 , Tsc2
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
timolol pharmacodynamics pathwayCalm1 , Prkaca , Prkar1a
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Bad , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1
Trail mediated signaling pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transaldolase deficiency pathwayFbp1
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayCav1 , Foxo1 , Foxo3 , Grb2 , Pard6a , Pdpk1 , Ppp1ca , Rps6kb1 , Shc1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathway