INTRINSIC APOPTOTIC PATHWAY (PW:0000104)

View Ontology Report

Description

Apoptosis, or programmed cell death, removes excess or damaged cells to maintain tissue homeostasis. The two major apoptotic pathways, the extrinsic, triggered by ligands activating the death receptors and the intrinsic (mitochondrial), triggered by intracellular stresses, converge on the activation of executioner caspases. In the intrinsic pathway, the Bcl-2 family of pro- and anti-apoptotic proteins controls the life-to-death switch. Structurally, they share the Bcl homology BH domain. Most pr

Pathway Diagram:

Ariadne Genomics Inc. caspase targets pro-survival Bcl BH3-only Bcl Bax Casp3 ---> caspase targets Casp7 ---> caspase targets Casp3 ---> caspase targets Casp7 ---> caspase targets Casp9 ---> Casp7 Casp9 ---> Casp3 Casp9 ---- Xiap Htra2 ---> released_Htra2 released_Diablo ---- Xiap Casp3 ---- Xiap Casp7 ---- Xiap BH3-only Bcl ---- pro-survival Bcl Apaf1 ---- released_Cycs Diablo ---> released_Diablo Apaf1 ---- Casp9 Cycs ---> released_Cycs released_Htra2 ---> Xiap intracellular stresses Bok ---- pro-survival Bcl Bax ---- pro-survival Bcl Bak1 ---- pro-survival Bcl released_Diablo released_Htra2 Bak1 Bok Htra2 Diablo Xiap Casp3 Casp7 intracellular stresses --+> BH3-only Bcl BH3-only Bcl ---| pro-survival Bcl pro-survival Bcl ---| Bak1 pro-survival Bcl ---| Bax pro-survival Bcl ---| Bok apoptosome --+> Casp9 released_Htra2 ---| Xiap released_Diablo ---| Xiap Xiap ---| Casp7 Xiap ---| Casp3 Casp9 --+> Casp3 Casp9 --+> Casp7 Xiap ---| Casp9 Apaf1 released_Cycs ATP dATP Cycs apoptosome Casp9
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
intrinsic apoptotic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:2313998
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1579966
RGD:2314029
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2313963
RGD:2313975
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1579966
RGD:2314140
RGD:2313998
RGD:2313975
RGD:2313963
G Bax_v1 BCL2 associated X, apoptosis regulator, variant 1 RGD:1579966
G Bax_v2 BCL2 associated X, apoptosis regulator, variant 2 RGD:1579966
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:2313994
RGD:2314029
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1579966
RGD:2314140
RGD:2313998
RGD:2313975
G Bcl2a1 BCL2-related protein A1 JBrowse link 8 96,551,424 96,559,527 RGD:2313975
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:1579966
RGD:2314140
RGD:2313975
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:2314029
G Bcl2l2 Bcl2-like 2 JBrowse link 15 33,543,774 33,549,165 RGD:2313963
RGD:2313975
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:2313998
RGD:2314029
RGD:2314002
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:2314029
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:2314029
G Bnip1 BCL2 interacting protein 1 JBrowse link 10 16,677,077 16,689,321 RGD:634759
RGD:2314029
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:2314028
RGD:2314029
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:2314029
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:70678
RGD:2313975
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:71121
RGD:2314390
RGD:2314187
RGD:2314002
RGD:2313998
RGD:2313963
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:2314187
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:2313963
RGD:2314390
RGD:2314187
RGD:2314002
RGD:2313998
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:2313963
RGD:2313998
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1626509
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:70327
RGD:2314029
RGD:2290488
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:2314385
G Mcl1 MCL1, BCL2 family apoptosis regulator JBrowse link 2 197,786,212 197,788,992 RGD:70678
RGD:2313975
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:2314029
RGD:2314140
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:2314390

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupcaspase targetsseveral genes identified as caspase substrates
Functional Classpro-survival Bclthe members of the Bcl family that are anti-apoptotic
Functional ClassBH3-only Bclthe members of the pro-apoptotic Bcl family with only the BH3 domain

Pathway Gene Annotations

Disease Annotations Associated with Genes in the intrinsic apoptotic pathway
Disease TermsGene Symbols
3-methylglutaconic aciduria type VIIIHtra2
abdominal obesity-metabolic syndrome 1Bax , Bcl2 , Fas
acute kidney failureBad , Bax , Bcl2 , Bcl2l1 , Fas
Acute Liver FailureCasp3 , Casp9 , Fas
Acute Lung InjuryBax , Bcl2 , Casp3 , Fas
acute myeloid leukemiaBcl2 , Bcl2l1 , Casp7 , Fas
acute myocardial infarctionCasp3 , Casp7
Acute Necrotizing PancreatitisCasp3
acute T cell leukemiaBax
adenocarcinomaBcl2
adenomaBcl2 , Bcl2l1
Adrenal InsufficiencyBax , Bcl2
adult T-cell leukemiaFas
AIDS-Related Kaposi SarcomaBcl2
alcoholic liver cirrhosisBcl2
allergic contact dermatitisBcl2
allergic hypersensitivity diseaseBcl2a1
allergic rhinitisBcl2
Alzheimer's diseaseBad , Bak1 , Bax , Bcl2 , Bcl2l1 , Casp3 , Casp7 , Casp9 , Fas , Htra2
amyotrophic lateral sclerosisBad , Bak1 , Bax , Bcl2 , Bcl2l1 , Bid , Bnip3l , Casp3 , Casp9 , Hrk
amyotrophic lateral sclerosis type 1Bcl2l1 , Xiap
Animal Disease ModelsFas
anti-basement membrane glomerulonephritisBax , Bcl2
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
aplastic anemiaFas
asphyxia neonatorumHtra2
asthmaBcl2 , Fas
atherosclerosisCasp3 , Fas
autistic disorderBcl2
Autoimmune DiseasesFas
autoimmune lymphoproliferative syndromeFas
Autoimmune Lymphoproliferative Syndrome, Type IAFas
autoimmune thrombocytopenic purpuraFas
azoospermiaBcl2
B-Cell Chronic Lymphocytic LeukemiaBcl2 , Bmf , Fas , Pmaip1
B-Cell CLL/Lymphoma 2Bcl2
bacterial infectious diseaseCasp3 , Casp9
Barrett's esophagusFas , Mcl1
Behcet's diseaseFas
bilirubin metabolic disorderBcl2
Brain ContusionCasp3
brain gliomaBax , Bcl2 , Casp3 , Fas
Brain InjuriesApaf1 , Bad , Bax , Bcl2 , Casp3 , Fas
Brain Injuries, TraumaticBad
brain ischemiaApaf1 , Bad , Bbc3 , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Cycs , Fas
breast ductal carcinomaHtra2
Breast NeoplasmsBad , Bax , Bcl2 , Bcl2a1 , Bcl2l1 , Casp3 , Casp7 , Casp9 , Fas , Xiap
Bronchopulmonary DysplasiaBax , Bid , Casp3 , Casp9
Burkitt lymphomaBbc3
BurnsBad , Bax , Bcl2 , Casp3
calcinosisCasp3
carcinomaBcl2 , Bcl2l1
CardiomegalyBad
cardiomyopathyFas , Htra2
cataractCasp3 , Casp9 , Fas
Cell Transformation, NeoplasticBcl2
Cerebral HemorrhageBax , Bcl2 , Bcl2l1 , Bnip3l , Casp3 , Casp9
cervix uteri carcinoma in situBcl2 , Xiap
Chemical and Drug Induced Liver InjuryBad , Bax , Fas
chemical colitisCasp3 , Casp7
Chest TraumaFas
ChloracneCycs
cholangiocarcinomaCycs
chorioamnionitisFas
Chronic Cerebral HypoperfusionBnip3l
chronic conjunctivitisFas
Chronic HepatitisCasp3
Chronic Intermittent HypoxiaBax , Bcl2 , Bnip3
chronic myeloid leukemiaBcl2l1 , Fas
chronic obstructive pulmonary diseaseBcl2l1 , Bnip3 , Casp3 , Fas
Chronic PancreatitisBad
Chronic UveitisFas
clear cell adenocarcinomaBcl2
clonorchiasisFas
colon cancerApaf1
colon carcinomaBax
Colonic NeoplasmsBad , Bak1 , Bax , Bcl2 , Casp3 , Casp7 , Fas
colorectal adenocarcinomaBcl2l1
Colorectal NeoplasmsBax , Bcl2 , Casp9
congestive heart failureBax , Bcl2 , Bnip3 , Casp3 , Fas
contact dermatitisBcl2
Contrast-Induced NephropathyCasp3
Copper-Overload CirrhosisCasp3
corneal neovascularizationFas
Craniofacial AbnormalitiesApaf1
cryptorchidismBcl2l1 , Casp3 , Fas , Htra2
cutaneous T cell lymphomaBax , Fas , Mcl1
cystic fibrosisFas
dementiaBax , Bcl2
Dementia, Multi-InfarctBax , Bcl2
dermatomyositisFas
Diabetes ComplicationsCasp9
Diabetes Mellitus, Experimental Bad , Bax , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Fas
diabetic angiopathyCasp3 , Fas
Diabetic CardiomyopathiesBad , Bcl2 , Casp3 , Casp9
Diabetic CystopathyBad
Diabetic NephropathiesCasp3 , Casp7 , Casp9 , Fas
diabetic neuropathyBad , Casp3
diabetic retinopathyCasp3 , Casp9
diffuse large B-cell lymphomaBcl2 , Fas
dilated cardiomyopathyBax , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Fas
disease by infectious agentXiap
Disease ProgressionBcl2
ductal carcinoma in situBcl2 , Bnip3
EdemaCasp3 , Casp9
end stage renal failureBcl2 , Bnip3
Endometrial NeoplasmsBad , Bcl2 , Bcl2l1 , Htra2
endometriosisBax , Bcl2 , Bcl2l1
endometritisCasp3 , Casp7 , Casp9
endophthalmitisFas
EndotoxemiaBax , Bcl2 , Casp3 , Casp7 , Casp9 , Fas
Esophageal NeoplasmsBax , Bbc3 , Bcl2 , Bcl2a1 , Fas , Xiap
esophagus adenocarcinomaFas
Experimental Allergic AsthmaBcl2 , Fas
Experimental ArthritisBax , Bcl2
Experimental Autoimmune EncephalomyelitisCasp3 , Casp9
Experimental Autoimmune MyocarditisCasp3 , Casp9
Experimental Autoimmune UveitisFas
Experimental ColitisFas
Experimental Liver CirrhosisApaf1 , Bak1 , Bcl2 , Bmf , Casp7 , Fas
Experimental Liver NeoplasmsBak1 , Bbc3 , Bcl2 , Bcl2l1
Eye AbnormalitiesApaf1
Familial Prostate CancerBcl2 , Bcl2l11
fatty liver diseaseCycs
Female InfertilityHtra2
Fetal Growth RetardationBax , Bcl2 , Casp3 , Fas
focal segmental glomerulosclerosisCasp9
follicular lymphomaBcl2
Gallbladder NeoplasmsBcl2
gastric ulcerBad , Bcl2 , Bcl2l1 , Casp3 , Fas
Gastrointestinal HemorrhageBax
genetic diseaseApaf1 , Fas
gestational diabetesBnip3l
glaucomaBad , Bax , Bcl2 , Fas
glomerulonephritisBcl2l11 , Fas
Graft vs Host DiseaseFas
Graves' diseaseFas
Hashimoto DiseaseFas
Head and Neck NeoplasmsBcl2 , Bcl2l1
Hearing LossBcl2l1
heart diseaseBax , Casp3 , Casp9
heart valve diseaseCasp3
hematopoietic system diseaseBcl2l1 , Fas
HemorrhageBnip3
hepatocellular carcinomaBcl2l1 , Bid , Casp3 , Casp9 , Fas
Hereditary PancreatitisCasp9
heroin dependenceFas
human immunodeficiency virus infectious diseaseBax , Fas
Huntington's diseaseBax , Bcl2 , Casp3 , Casp9 , Cycs , Fas , Htra2
hydrocephalusBok
HypercholesterolemiaCasp3 , Casp9
HyperoxiaBnip3 , Fas
HyperplasiaBax
hypersplenismFas
hypertensionBad , Bax , Bcl2 , Casp3 , Casp9
hypertrophic cardiomyopathyBcl2 , Casp3
HypothermiaBcl2 , Fas
hypothyroidismBad
HypoxiaCasp3
Hypoxia-Ischemia, BrainBax , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Fas
idiopathic pulmonary fibrosisFas
IgA glomerulonephritisFas
impotenceBad , Bax , Bcl2 , Bcl2l1 , Casp3
inclusion body myositisFas
infectious mononucleosisFas
Insulin ResistanceBad , Casp3 , Fas
intermittent claudicationBad , Bak1 , Bax , Bbc3 , Casp3
intestinal diseaseBax , Bcl2 , Casp3
Intestinal NeoplasmsBax , Bcl2
Intestinal Reperfusion InjuryCasp3 , Casp9
intracranial aneurysmBcl2
ischemiaBax , Cycs
Kashin-Beck DiseaseBax , Bcl2 , Fas
kidney diseaseCasp3 , Casp9
Kidney Reperfusion InjuryApaf1 , Bax , Bcl2 , Bnip3 , Casp3 , Casp7 , Fas
Knee OsteoarthritisBax , Bcl2
learning disabilityBcl2
Left Ventricular HypertrophyBak1
leiomyomaBak1 , Bax , Bcl2 , Bcl2l1
leishmaniasisMcl1
leukemiaBad
limited sclerodermaFas
liver cirrhosisCasp3 , Casp9
liver diseaseBcl2l1 , Fas
Liver Reperfusion InjuryBad , Bax , Bcl2 , Bcl2l1 , Casp9 , Fas
Lung NeoplasmsBcl2l1 , Casp7 , Fas , Mcl1
Lung Reperfusion InjuryBax , Bcl2 , Casp3
lung small cell carcinomaBcl2
lung squamous cell carcinomaCycs
Lymphatic MetastasisBcl2 , Casp9 , Cycs , Fas
lymphocytic leukemiaBcl2l1
Lymphoma, Extranodal NK-T-CellFas
lymphoproliferative syndromeFas , Xiap
macular degenerationBad , Bax , Fas
male infertilityBax , Bcl2 , Fas
malignant gliomaBad , Fas
malignant mesotheliomaBcl2
Mammary Neoplasms, ExperimentalApaf1 , Bad , Bak1 , Bax , Bcl2 , Bcl2l1 , Casp3 , Casp7 , Casp9 , Fas , Xiap
Manganese PoisoningBnip3
melanomaBcl2 , Bcl2l1 , Fas
Memory DisordersBcl2
mental depressionBax , Bcl2l1
mesenchymal chondrosarcomaBcl2
Metabolic Brain DiseasesFas
MetaplasiaBcl2
methylmalonic acidemiaCycs
Microsatellite InstabilityBax
middle cerebral artery infarctionApaf1 , Bad , Bax , Bcl2 , Bnip3 , Bnip3l , Casp3 , Casp9 , Htra2
mixed connective tissue diseaseFas
morphine dependenceBax , Bcl2
motor neuron diseaseHtra2
Moyamoya diseaseFas
multiple myelomaBcl2 , Bcl2l1 , Bnip3 , Mcl1
multiple sclerosisFas
multiple system atrophyFas
Multisystemic Smooth Muscle Dysfunction SyndromeFas
muscular atrophyApaf1
myasthenia gravisFas
Mycoplasma InfectionsCasp3
myelodysplastic syndromeFas
myocardial infarctionBax , Bcl2 , Bcl2l1 , Bnip3 , Casp3
Myocardial IschemiaBax , Bcl2
Myocardial Reperfusion InjuryBad , Bax , Bcl2 , Bcl2l1 , Bid , Bnip3 , Casp3 , Casp7 , Casp9 , Fas , Htra2 , Xiap
Nasal PolypsFas
nasopharynx carcinomaBcl2
NecrosisBcl2 , Fas
Neoplasm MetastasisBax , Bcl2 , Casp3 , Fas
Neoplasm MicrometastasisCycs
nephritisFas
nephroblastomaBcl2l1
Nephrosis, Puromycin AminonucleosideFas
Nerve DegenerationBak1 , Bax , Bcl2 , Casp3
nervous system diseaseCasp3 , Casp9
neural tube defectApaf1
non-Hodgkin lymphomaBcl2
non-small cell lung carcinomaApaf1 , Bad , Casp3 , Casp7 , Casp9 , Cycs
nonalcoholic fatty liver diseaseFas
Noonan syndromeApaf1
NSAID-EnteropathyCasp9
obesityBad , Bcl2 , Bnip3 , Cycs
ocular hypertensionBcl2l1 , Fas
oligomeganephroniaBcl2
Optic Nerve InjuriesBax , Bcl2
oral mucosa leukoplakiaBcl2
osteoarthritisBad , Bax , Bcl2 , Casp3 , Casp9
Osteoarthritis, ExperimentalCasp3 , Casp7
Osteoarthritis, Temporomandibular JointFas
osteochondrodysplasiaBcl2
osteoporosisBax , Bcl2
Ovarian NeoplasmsBcl2 , Bcl2l1 , Fas , Htra2 , Xiap
Oxygen-Induced RetinopathyFas
pancreatic cancerApaf1 , Bad , Bcl2l1 , Bid , Casp9 , Cycs
pancreatitisBnip3l , Casp3
Pancreatitis, Experimental, Acute Bcl2l1
Parkinson's diseaseApaf1 , Casp3 , Casp9 , Fas , Htra2
Parkinson's Disease 13Htra2
Parkinsonian DisordersApaf1 , Bad , Casp3 , Casp9 , Htra2
perinatal necrotizing enterocolitisBnip3
peripheral nervous system diseaseCasp9
peripheral vascular diseaseFas
plasma cell neoplasmBcl2l1
plasmacytomaBcl2
Plasmodium falciparum malariaFas
pleomorphic xanthoastrocytomaCycs
polycystic ovary syndromeBax , Bcl2
polycythemia veraBcl2l1
post-traumatic stress disorderBax , Bcl2 , Casp9
pre-eclampsiaFas
pre-malignant neoplasmBax , Bid , Casp3 , Casp9 , Fas
precursor B lymphoblastic lymphoma/leukemiaBcl2l1
precursor lymphoblastic lymphoma/leukemiaBcl2 , Bcl2l1 , Fas
precursor T-lymphoblastic lymphoma/leukemiaBax , Bcl2
Pregnancy Complications, CardiovascularFas
Premature AgingBax , Bcl2 , Htra2
priapismBcl2
prion diseaseBax
prostatic hypertrophyBad
Prostatic NeoplasmsBad , Bax , Bcl2 , Bcl2l1 , Bnip3 , Casp3 , Casp9 , Fas , Htra2 , Xiap
proteinuriaFas
pulmonary fibrosisBad
pulmonary hypertensionBcl2 , Bcl2l1
Radiation Injuries, ExperimentalCasp3 , Casp9 , Fas
relapsing-remitting multiple sclerosisFas
renal cell carcinomaApaf1 , Bad , Bak1 , Bcl2 , Bcl2l1 , Casp3 , Fas , Xiap
Renal IschemiaApaf1
Reperfusion InjuryApaf1 , Bad , Bax , Bcl2 , Bid , Casp3 , Casp9 , Fas
Retina Reperfusion InjuryApaf1 , Bad , Bax , Bcl2 , Bcl2l1 , Casp7
retinal degenerationBax , Bcl2
retinal detachmentApaf1 , Bnip3 , Casp3 , Casp9 , Fas
retinal diseaseCasp3
retinitis pigmentosaCasp7
retinoblastomaFas
rheumatoid arthritisBcl2a1 , Casp7 , Fas
salivary gland diseaseCasp3
sarcomaMcl1
SarcopeniaBax , Bcl2
sciatic neuropathyCasp3 , Casp7 , Fas
sclerosing cholangitisBcl2l11
scrapieBax , Casp3 , Casp9
seminomaFas
SepsisBad , Casp3 , Casp9 , Fas , Htra2
Shock, HemorrhagicBad , Bcl2 , Bcl2l1 , Casp3
Sjogren's syndromeFas
Skin AbnormalitiesApaf1
Small-For-Size SyndromeBad
Soft Tissue NeoplasmsBcl2
spermatic cord torsionCasp3
Spinal Cord CompressionFas
Spinal Cord InjuriesApaf1 , Bax , Bcl2 , Bnip3 , Bnip3l , Casp3 , Casp9 , Fas
Spinal Cord Reperfusion InjuryBad
Spinocerebellar AtaxiasCasp7
SplenomegalyFas , Htra2
squamous cell carcinomaBcl2 , Fas
status epilepticusBax , Bcl2 , Bcl2l1 , Casp3 , Htra2
stomach cancerHtra2
Stomach NeoplasmsBcl2l1 , Bid , Bnip3
StrokeBcl2l1 , Casp3
Subarachnoid HemorrhageBcl2 , Bnip3 , Casp3 , Casp9
substance-related disorderPmaip1
synovial sarcomaBcl2
systemic lupus erythematosusFas
Taste DisordersFas
teratomaBax
Testicular InjuryFas
Testis Reperfusion InjuryApaf1 , Bax , Bcl2 , Casp3 , Casp9
thoracic aortic aneurysmFas
thrombocytopeniaCycs
Thrombocytopenia 4Cycs
thyroiditisBax
Tongue NeoplasmsBcl2
toxic encephalopathyBcl2l1 , Casp3
toxoplasmosisBax
transient cerebral ischemiaBad , Bax , Bbc3 , Bcl2 , Bnip3 , Casp3 , Casp7 , Casp9 , Cycs , Fas , Htra2
transitional cell carcinomaApaf1 , Bcl2 , Bcl2l1 , Casp3 , Fas
type 1 diabetes mellitusCasp3 , Casp9 , Fas
type 2 diabetes mellitusBad , Bax , Bcl2 , Bcl2l1 , Bcl2l11 , Casp3 , Casp7 , Casp9 , Fas
ulcerative colitisCasp3 , Fas
ureteral obstructionCasp3 , Casp7 , Casp9
urinary bladder cancerBax , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Fas
Uterine Cervical NeoplasmsBak1 , Bax , Bcl2l1 , Casp3 , Xiap
Uterine NeoplasmsBcl2l1
varicoceleCasp9 , Fas
Ventricular Dysfunction, LeftFas
Viral MyocarditisCasp3
visual epilepsyApaf1 , Bad , Fas
vitiligoCasp7
X-linked lymphoproliferative syndrome 1Xiap
X-linked lymphoproliferative syndrome 2Xiap
Pathway Annotations Associated with Genes in the intrinsic apoptotic pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayBad
adenosine signaling pathwayBad
allograft rejection pathwayFas
Alzheimer's disease pathwayApaf1 , Bad , Bid , Casp3 , Casp7 , Casp9 , Cycs , Fas
amyotrophic lateral sclerosis pathwayApaf1 , Bad , Bax , Bcl2 , Bcl2l1 , Bid , Casp3 , Casp9 , Cycs
apoptotic cell death pathwayApaf1 , Bad , Bax , Bcl2 , Bcl2l1 , Bid , Casp3 , Casp7 , Casp9 , Cycs , Fas , Xiap
autoimmune thyroiditis pathwayFas
Bone morphogenetic proteins signaling pathwayXiap
cardiolipin metabolic pathwayCycs
ceramide signaling pathwayBad , Bax , Bcl2 , Bcl2l1 , Bid , Casp9 , Cycs
Chagas disease pathwayFas
chronic myeloid leukemia pathwayBad , Bcl2l1
colorectal cancer pathwayBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs
cytokine mediated signaling pathwayFas
electron transport chain pathwayCycs
endometrial cancer pathwayBad , Casp9
Endoplasmic Reticulum-associated degradation pathwayBak1 , Bax , Bcl2
Entamoebiasis pathwayCasp3
epidermal growth factor/neuregulin signaling pathwayBad
erythropoietin signaling pathwayBcl2 , Bcl2l1
extrinsic apoptotic pathwayCasp3 , Casp7 , Fas
FasL mediated signaling pathwayBid , Casp3 , Casp7 , Fas
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
graft-versus-host disease pathwayFas
hepatitis C pathwayBad
Huntington's disease pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp9 , Cycs
hypoxia inducible factor pathwayBnip3 , Mcl1
influenza A pathwayCasp9 , Cycs , Fas
insulin signaling pathwayBad
insulin-like growth factor signaling pathwayBad
interleukin-2 signaling pathwayBcl2
interleukin-3 signaling pathwayBcl2l1
interleukin-6 signaling pathwayMcl1
intrinsic apoptotic pathwayApaf1 , Bad , Bak1 , Bax , Bax_v1 , Bax_v2 , Bbc3 , Bcl2 , Bcl2a1 , Bcl2l1 , Bcl2l11 , Bcl2l2 , Bid , Bik , Bmf , Bnip1 , Bnip3 , Bnip3l , Bok , Casp3 , Casp7 , Casp9 , Cycs , Fas , Hrk , Htra2 , Mcl1 , Pmaip1 , Xiap
Jak-Stat signaling pathwayBcl2l1
measles pathwayBbc3 , Fas
melanoma pathwayBad
mitochondrial autophagy pathwayBnip3 , Bnip3l
mitogen activated protein kinase signaling pathwayCasp3 , Fas
mTOR signaling pathwayBnip3 , Cycs
myocarditis pathwayBid , Casp3 , Casp9 , Cycs
neurotrophic factor signaling pathwayBad , Bax , Bcl2
NOD-like receptor signaling pathwayXiap
non-small cell lung carcinoma pathwayBad , Casp9
p53 signaling pathwayApaf1 , Bax , Bbc3 , Bid , Casp3 , Casp9 , Cycs , Fas , Pmaip1
pancreatic cancer pathwayBad , Bcl2l1 , Casp9
Parkinson's disease pathwayApaf1 , Casp3 , Casp9 , Cycs , Htra2
phosphatidylinositol 3-kinase-Akt signaling pathwayBad , Casp9
prion disease pathwayBax
prostate cancer pathwayBad , Bcl2 , Casp9
sleeping sickness pathwayFas
small cell lung carcinoma pathwayApaf1 , Bcl2 , Bcl2l1 , Casp9 , Cycs , Xiap
syndecan signaling pathwayBax , Casp3
titanium dioxide nanoparticle response pathwayBax , Casp3 , Fas
toxoplasmosis pathwayBad , Bcl2 , Bcl2l1 , Casp3 , Casp9 , Cycs , Xiap
Trail mediated signaling pathwayBid , Casp3 , Casp7
transforming growth factor-beta Smad dependent signaling pathwayXiap
tuberculosis pathwayApaf1 , Bad , Bax , Bcl2 , Bid , Casp3 , Casp9 , Cycs
type 1 diabetes mellitus pathwayFas
ubiquitin/proteasome degradation pathwayXiap
vascular endothelial growth factor signaling pathwayBad , Casp9

References Associated with the intrinsic apoptotic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: