THE EXTRACELLULAR SIGNAL-REGULATED RAF/MEK/ERK SIGNALING PATHWAY (PW:0000102)

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Description

The extracellular signal regulated MAP kinase pathway (Raf/Mek/Erk) couples signals reverberating from activated cell surface receptors via their downstream effectors, to many cytoplasmic and nuclear targets. Raf/Mek/Erk displays the characteristic three-tier core cascade MAPK architecture. The downstream and effector MAPK tier (here Erk represented by Mapk1 and 3) is activated by phosphorylation of threonine and tyrosine residues within the conserved TEY motif in the activation loop by d

Pathway Diagram:

Ariadne Genomics Inc. Mapk1 Pp2a Dusp6 Map2k2 Map2k1 Erk cytoplasmic/other targets Ksr1 Ksr2 Raf members upstream Ras RTK, others effectors/adapters Erk nuclear targets Erk activated MAPKAPK Pebp1 ---- Raf members Pebp1 ---| Raf members Pebp1 Raf members --+> Map2k2 Raf members --+> Map2k1 Pp2a --+> Raf members Pp2a ---| Map2k2 upstream Ras --+> Raf members effectors/adapters <--> upstream Ras Mapk3 Mapk1 ---> Erk nuclear targets Mapk3 ---> Erk cytoplasmic/other targets Mapk1 ---> Erk cytoplasmic/other targets Mapk3 ---> Erk nuclear targets effectors/adapters ---- RTK, others Ptprr ---| Mapk1 Map2k2 --+> Mapk3 Map2k1 --+> Mapk3 Map2k1 --+> Mapk1 Map2k2 --+> Mapk1 Pp2a ---| Map2k1 Pp2a ---| Mapk1 Pp2a ---| Mapk3 Dusp6 ---| Mapk1 Dusp6 ---| Mapk3 Ptprr ---| Mapk3 Mapk1 --+> Erk activated MAPKAPK Mapk3 --+> Erk activated MAPKAPK Ksr2 ---- Map2k1 Ksr1 ---- Map2k2 Ksr2 ---- Map2k2 Ksr1 ---- Raf members Ptprr
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Genes in Pathway:

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the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 1,369,534 1,391,603 RGD:5686410
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1580106
RGD:5686410
RGD:1626216
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:2293881
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:5686410
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:628557
RGD:5686410
G Ksr1 kinase suppressor of ras 1 JBrowse link 10 66,323,704 66,342,469 RGD:2293880
RGD:5686410
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:70317
RGD:1626216
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:729046
RGD:1626216
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:1357969
RGD:2293879
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:724475
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:628468
RGD:8553011
RGD:1626216
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:628468
RGD:8553011
RGD:1626216
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
RGD:8553011
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:5686410
G Pebp1 phosphatidylethanolamine binding protein 1 JBrowse link 12 45,026,948 45,031,148 RGD:2293882
RGD:2302807
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1642529
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642630
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:70317
RGD:5686410
RGD:1626216
RGD:1580106
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:2315047
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:2315047
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:2315047
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:2315047
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1304283
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1643182
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1643230
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580097
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2293882
RGD:2298531
RGD:5133242
RGD:5133243
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:5490966
RGD:5490965
RGD:5133242
RGD:4143515
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:5133243
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:2293882

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexPp2a complex
Functional Classupstream Ras
Functional ClassRaf members
Gene GroupErk nuclear targets
Gene GroupErk cytoplasmic/other targets
Functional ClassErk activated MAPKAPKadditional kinase tier that furthers the signal
Functional ClassRTK, othersupstream pathways that trigger Raf/Mek/Erk via receptor tyrosine kinases and other receptors

Pathway Gene Annotations

Disease Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway
Disease TermsGene Symbols
46 XY gonadal dysgenesisMap3k1
46,XY Sex Reversal 6Map3k1
Aberrant Crypt FociMapk1 , Mapk3
Acute HepatitisTsc2
acute kidney failureSpp1
acute myeloid leukemiaHras , Kras , Nras , Tsc2
acute promyelocytic leukemiaNras
adenocarcinomaKras , Spp1
adenoid cystic carcinomaHras , Kras , Map2k2
adenomaKras
adrenal carcinomaBraf , Nras
adrenocortical carcinomaBraf , Nras
adult T-cell leukemiaNras
AlbuminuriaSpp1
Alcoholic Liver DiseasesSpp1
allergic contact dermatitisSpp1
allergic hypersensitivity diseaseSpp1
Alzheimer's diseaseHras , Pebp1 , Shc1 , Tsc2
ameloblastomaBraf
amyotrophic lateral sclerosis type 1Shc1
anemiaKras
AneurysmSpp1
Angina PectorisSpp1
angiomyolipomaTsc2
angiosarcomaHras , Kras
Animal Disease ModelsKras , Mapk1 , Mapk3
anti-basement membrane glomerulonephritisPtk2b , Spp1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
arteriovenous malformations of the brainKras
asbestosisSpp1
astrocytomaBraf , Hras , Kras
AtrophyMapk3
autism spectrum disorderMapk3 , Tsc2
autistic disorderHras , Mapk1 , Tsc2
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 3Prkcd
autoimmune lymphoproliferative syndrome type 4Kras , Nras
autosomal dominant polycystic kidney diseaseSpp1
autosomal recessive Alport syndromeHras
B-cell lymphomaNras
biliary atresiaSpp1
bladder carcinomaHras
bladder urothelial carcinomaBraf , Hras , Kras , Map2k1 , Nras
bone development diseaseRps6ka3
brain diseaseTsc2
brain ischemiaDusp6 , Map2k1 , Mapk1 , Mapk3 , Prkcd , Ptk2b
Brain NeoplasmsBraf , Hras , Nras , Spp1 , Tsc2
breast adenocarcinomaKras
breast cancerBraf , Hras , Kras
Breast NeoplasmsAraf , Braf , Dusp6 , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Ptk2b , Raf1 , Spp1 , Tsc2
bronchiolo-alveolar adenocarcinomaKras
BurnsPrkcd
calcinosisSpp1
CarcinogenesisBraf , Kras
carcinomaDusp6 , Hras , Kras , Pebp1 , S1pr1
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyMapk1 , Prkcd , Raf1 , S1pr1 , Shc1 , Spp1
cardiomyopathyKras , Mapk1 , Mapk3
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1
Cardiovascular AbnormalitiesMap2k1
cataractMap2k1
Cecal NeoplasmsKras
Cell Transformation, NeoplasticHras , Kras
Cerebral HemorrhageSpp1
Charcot-Marie-Tooth disease type 2DSmad1
Chemical and Drug Induced Liver InjuryShc1 , Spp1
cholangiocarcinomaKras
chronic lymphocytic leukemiaBraf , Hras , Kras , Nras
Chronic Lymphocytic Leukemia, B-CellBraf , Hras , Kras , Nras
chronic myeloid leukemiaBraf , Nras
chronic myelomonocytic leukemiaNras
Cocaine-Related DisordersMapk1 , Mapk3 , Rps6ka5
Coffin-Lowry syndromeRps6ka3
colon adenocarcinomaMapk1 , Mapk3
colon cancerBraf , Nras
colon carcinomaBraf , Nras
Colonic NeoplasmsBraf , Kras
colorectal adenocarcinomaMapk1 , Mapk3 , Raf1
colorectal adenomaRaf1
colorectal cancerBraf , Nras
Colorectal NeoplasmsBraf , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Raf1
complex cortical dysplasia with other brain malformationsHras
congenital heart diseasePebp1
Congenital Myopathy, with Excess of Muscle SpindlesHras
congestive heart failurePebp1
coronary artery diseaseSpp1
coronary restenosisMapk1 , Spp1
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2
craniopharyngiomaBraf
Cutaneous Malignant Melanoma, Susceptibility To, 1Braf , Hras , Map2k1 , Map2k2 , Nras , Raf1
cutaneous T cell lymphomaBraf
Developmental DisabilitiesBraf , Rps6ka3
diabetic angiopathyPtk2b
Diabetic CardiomyopathiesSpp1
Diabetic NephropathiesMapk1 , Spp1
diabetic retinopathyHras
dilated cardiomyopathyKras , Raf1
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationBraf , Hras , Kras , Map2k1 , Nras , Spp1
Disease ProgressionHras
Drug-Related Side Effects and Adverse ReactionsSpp1
dysembryoplastic neuroepithelial tumorBraf
encephalomyelitisSpp1
endometrial carcinomaKras , Tsc2
Endometrial HyperplasiaKras
Endometrial NeoplasmsBraf , Kras , Mapk1 , Mapk3
Endometrioid CarcinomasKras , Spp1
endometriosisKras
epidermal nevusHras , Kras , Nras
epilepsyTsc2
esophageal carcinomaHras , Kras
Esophageal NeoplasmsHras , Kras
Experimental ArthritisNras
Experimental Autoimmune NeuritisSpp1
Experimental Diabetes MellitusHras , Mapk1 , Mapk3 , Prkcd , Smad1 , Spp1 , Tsc2
Experimental Liver CirrhosisDusp6 , Prkcd , S1pr1 , Smad1 , Spp1
Experimental NeoplasmsBraf , Hras , Kras , Nras , Spp1
Experimental SarcomaKras , Nras
extrahepatic cholestasisMapk1 , Mapk3
familial hyperlipidemiaShc1
fatty liver diseasePrkcd , Shc1
Female InfertilityMapk1 , Mapk3 , Tsc2
FibrosisSpp1
Focal Cortical Dysplasia of TaylorTsc2
focal segmental glomerulosclerosisSpp1
Follicular Thyroid CancerBraf , Hras , Nras
follicular thyroid carcinomaBraf , Hras , Kras , Nras
Foreign-Body ReactionSpp1
Gallbladder NeoplasmsKras
gastric adenocarcinomaBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1
gastrointestinal stromal tumorBraf , Kras
genetic diseaseBraf , Hras , Kras , Map2k1 , Map3k1 , Mapk1 , Raf1 , Rps6ka3 , Tsc2
germinomaBraf
Giant Pigmented Hairy NevusHras , Nras
glioblastoma multiformeBraf , Dusp6 , Hras , Nras
GliosisMapk1 , Mapk3
glomerulonephritisMapk1 , Ptk2b , Smad1 , Spp1
glomerulosclerosisSpp1
Gonadal Dysgenesis, XX Type, with DeafnessBraf
granulosa cell tumorSmad1
hairy cell leukemiaMap2k1
HamartomaTsc2
Head and Neck NeoplasmsMapk1 , Mapk3
head and neck squamous cell carcinomaBraf , Hras , Map2k1 , Map2k2 , Mapk1
heart diseaseSpp1
heart valve diseaseSpp1
hemangiomaTsc2
HepatitisSpp1
Hepatitis C, ChronicSpp1
Hepatitis, ChronicShc1
hepatocellular adenomaHras , Kras
hepatocellular carcinomaBraf , Hras , Kras , Nras , Rps6ka3 , Shc1 , Spp1
Hereditary Neoplastic SyndromesTsc2
Hirschsprung Disease 1Tsc2
HyperalgesiaDusp6 , Mapk1 , Mapk3 , Raf1
hyperglycemiaShc1
hyperinsulinismPrkcd
HypertelorismRps6ka3
hypertensionKras , Prkcd , Ptk2b
Hypertensive NephropathyShc1
hypertrophic cardiomyopathyRaf1
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularPrkcd , Ptk2b , Shc1
Hypertrophy, Right VentricularPrkcd
Hypoglossal Nerve InjuriesSmad1
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 19 with or without anosmiaDusp6
hypogonadotropic hypogonadism 7 with or without anosmiaDusp6 , Nras
InflammationSpp1 , Tsc2
Insulin ResistancePrkcd , Ptk2b , Shc1
intellectual disabilityKras , Rps6ka3 , Tsc2
Intestinal NeoplasmsMap2k1 , Map2k2 , Prkcd
intrahepatic cholangiocarcinomaKras
ischemiaRaf1
Joubert syndrome 9Braf
juvenile myelomonocytic leukemiaKras , Nras
juvenile rheumatoid arthritisKras , Mapk1
Kidney CalculiSpp1
kidney diseaseMapk1 , Spp1
kidney failureSpp1
Kidney NeoplasmsBraf , Kras , Mapk1 , Mapk3 , Raf1 , Tsc2
Klinefelter's syndromeNras
Language Development DisordersRps6ka3
Laryngeal NeoplasmsSpp1
leiomyomaTsc2
leishmaniasisDusp6
LEOPARD syndromeBraf , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaNras
Leukemia, ExperimentalNras
LeukocytosisKras , Nras
LeukoencephalopathiesSpp1
liver cancerHras , Kras , Nras
liver cirrhosisSpp1
liver neoplasmBraf , Hras , Kras , Raf1
Liver Neoplasms, ExperimentalHras , Kras , Map2k1 , Mapk1 , Mapk3 , Spp1
lung adenocarcinomaAraf , Braf , Hras , Kras , Map2k1 , Nras , Raf1
lung cancerBraf , Kras
Lung NeoplasmsBraf , Hras , Kras , Mapk1 , Mapk3 , Raf1 , Spp1
lung squamous cell carcinomaBraf , Hras , Kras
LymphangiectasisRaf1
lymphangioleiomyomatosisTsc2
Lymphatic MetastasisPebp1 , Tsc2
lymphomaKras , Nras
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveRps6ka3
malariaSpp1
male infertilitySmad1
malignant gliomaBraf , Hras , Raf1 , Spp1
malignant mesotheliomaRaf1
Mammary Neoplasms, AnimalDusp6 , Hras , Pebp1 , S1pr1
Mammary Neoplasms, ExperimentalDusp6 , Hras , Pebp1 , S1pr1 , Spp1
Mandibular NeoplasmsBraf
medulloblastomaNras , Tsc2
Megakaryoblastic Leukemia of Down SyndromeNras
MegalencephalyRps6ka3
melanomaAraf , Braf , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptk2b , Raf1 , Spp1
Mental Retardation, X-Linked 19Rps6ka3
MesotheliomaSpp1
MicrognathismRps6ka3
Microphthalmia, Syndromic 1Map3k1
Microsatellite InstabilityBraf
migraineMap2k2
Mouth NeoplasmsHras , Kras , Nras , Tsc2
Multiple AbnormalitiesKras , Mapk1
multiple myelomaBraf , Hras , Kras , Nras , Spp1
Multiple Organ FailureMapk1
multiple sclerosisSpp1
Muscle HypotoniaRps6ka3
muscular diseasePrkcd
myelodysplastic syndromeHras , Kras , Nras
myeloid neoplasmKras , Nras
myeloid sarcomaKras
myocardial infarctionMapk1 , Pebp1 , Spp1
Myocardial IschemiaDusp6 , Pebp1 , Prkcd
Myocardial Reperfusion InjuryMapk1 , Prkcd , Smad1 , Spp1
myocarditisSpp1
Nasopharyngeal NeoplasmsHras , Nras
nasopharynx carcinomaKras
NeointimaPtk2b
Neoplasm InvasivenessHras , Mapk1 , Mapk3 , Rps6ka3
Neoplasm MetastasisBraf , Kras , Mapk1 , Mapk3 , Pebp1 , Rps6ka3 , Spp1
Neoplasms, Cystic, Mucinous, and SerousSpp1
Neoplastic ProcessesHras
Neovascularization, PathologicSpp1
nephritisPtk2b
nephrotic syndromeSmad1
Nerve DegenerationMapk1 , Mapk3 , Tsc2
neuroblastomaHras , Kras , Nras , Tsc2
Neurocutaneous MelanosisNras
neuroendocrine tumorBraf
neurofibrosarcomaNras
neuronal ceroid lipofuscinosisBraf
neuronal ceroid lipofuscinosis 6Braf , Mapk1 , Mapk3
Neuronopathy, Distal Hereditary Motor, Type VSmad1
NevusBraf
Nevus, PigmentedNras
non-Hodgkin lymphomaBraf , Map2k1 , Nras
non-small cell lung carcinomaAraf , Braf , Hras , Kras , Map2k1 , Nras , Raf1 , Spp1
non-syndromic X-linked intellectual disabilityRps6ka3
Nonseminomatous Germ Cell TumorBraf
Noonan syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1
Noonan syndrome 1Braf , Map2k1 , Nras
Noonan syndrome 3Hras , Kras , Raf1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
obesityPrkcd
obsessive-compulsive disorderHras
OsteolysisSpp1
Osteoporosis, PostmenopausalPtk2b
osteosarcomaTsc2
ovarian cancerKras
Ovarian NeoplasmsBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pebp1 , Spp1
ovarian serous cystadenocarcinomaBraf , Hras , Nras
Pain, PostoperativeDusp6
pancreas diseaseSpp1
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaHras , Kras , Map2k2
pancreatic cancerBraf , Kras , Spp1 , Tsc2
pancreatic carcinomaKras
pancreatic ductal carcinomaKras , Tsc2
pancreatitisDusp6
Pancreatitis, Experimental, Acute Kras
Papillary Thyroid CancerBraf
papillary thyroid carcinomaBraf
papillomaHras
Parasitic Liver DiseasesKras
Parkinsonian DisordersPrkcd
penile neoplasmHras , Kras
phobic disorderHras
pilocytic astrocytomaKras
plasmacytomaBraf , Hras , Kras , Nras
pleomorphic xanthoastrocytomaBraf
Pleural NeoplasmsSpp1
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaSpp1
portal hypertensionPrkcd
pre-malignant neoplasmHras , Pebp1 , Tsc2
precursor lymphoblastic lymphoma/leukemiaKras , Nras
precursor T-lymphoblastic lymphoma/leukemiaKras
primary pulmonary hypertensionSmad1
Progressive Osseous HeteroplasiaSpp1
prostate adenocarcinomaBraf , Hras , Map2k1 , Mapk1 , Raf1
prostate cancerKras , Raf1
prostate carcinoma in situKras
Prostatic NeoplasmsBraf , Hras , Kras , Map2k1 , Map3k1 , Mapk3 , Nras , Pebp1 , Ptk2b , Spp1
proteinuriaSpp1
Psychomotor DisordersRps6ka3
pulmonary fibrosisSpp1
pulmonary hypertensionSmad1
pulmonary valve stenosisBraf , Hras
Radiation Injuries, ExperimentalMapk1 , Mapk3
radiculopathySpp1
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1
rectal neoplasmNras
RecurrenceHras , Kras
renal carcinomaNras
renal cell carcinomaKras , Map2k1 , Mapk1 , Nras , Pebp1 , Tsc2
renal fibrosisKras , Mapk1
renovascular hypertensionSpp1
Reperfusion InjuryPtk2b , S1pr1 , Spp1
restrictive cardiomyopathyPrkcd
rheumatoid arthritisSpp1
schizophreniaMapk3
scrapieSpp1
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seminomaHras , Kras
SepsisMapk1 , Mapk3
Sezary's diseaseBraf , Mapk1 , Rps6ka1
Shock, HemorrhagicMapk1
skin benign neoplasmHras
Skin NeoplasmsHras , Ptk2b
Smith-Magenis syndromeKsr1 , Map2k2
spermatocytomaHras
Spinal Cord InjuriesSpp1
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaAraf , Braf , Hras
squamous cell carcinomaHras , Kras , Mapk1 , Mapk3 , Tsc2
status epilepticusPtk2b
stomach cancerKras
Stomach NeoplasmsHras , Kras , Mapk1 , Mapk3 , Nras , Spp1
StrokePrkcd
substance-related disorderMknk1
Tachycardia, VentricularRaf1
Testicular NeoplasmsSmad1
thymomaHras
thyroid medullary carcinomaKras
Thyroid NeoplasmsBraf , Hras , Kras , Nras , Spp1
Tongue NeoplasmsHras
toxic encephalopathyPrkcd
transitional cell carcinomaBraf , Hras , Kras , Map2k1 , Mapk1 , Nras
Trauma, Nervous SystemSpp1
Trichilemmoma Hras
trigeminal neuralgiaMapk1 , Mapk3
tuberculosisSpp1
tuberous sclerosisTsc2
Tuberous Sclerosis 1Tsc2
Tuberous Sclerosis 2Tsc2
Tumor Predisposition SyndromeTsc2
type 2 diabetes mellitusBraf , Mapk1 , Mapk3
uremiaSpp1
urethral obstructionMapk1
urinary bladder cancerHras , Kras , Spp1
Urinary Bladder NeoplasmHras , Kras
Urinary CalculiSpp1
Urinary IncontinenceMapk1
uterine carcinosarcomaHras
Uterine Cervical NeoplasmsHras , Kras , Mapk1 , Nras
uterine fibroidTsc2
Uterine NeoplasmsBraf , Hras , Kras , Map2k1 , Nras
Vascular System InjuriesSpp1
velocardiofacial syndromeMapk1
ventricular septal defectBraf
visual epilepsyDusp6 , Prkcd , Spp1 , Tsc2
Weissenbacher-Zweymuller syndromeMapk1
West syndromeTsc2
withdrawal disorderMapk1 , Mapk3
Wounds and InjuriesSpp1
Pathway Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
adenosine signaling pathwayBraf , Hras , Map2k2 , Map3k1 , Mapk1 , Rps6ka1
aldosterone signaling pathwayKras , Mapk1 , Mapk3
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
Alzheimer's disease pathwayMapk1 , Mapk3
B cell receptor signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
Bone morphogenetic proteins signaling pathwayMapk1 , Smad1
brain-derived neurotrophic factor signaling pathwayShc1
c-Jun N-terminal kinases MAPK signaling pathwayMap3k1 , Map3k2 , Spp1
calcium/calcium-mediated signaling pathwayPtk2b
cell-extracellular matrix signaling pathwaySpp1
ceramide signaling pathwayBraf , Kras , Ksr1 , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Mapk3 , Prkcd , Raf1
Chagas disease pathwayMapk1 , Mapk3
chemokine mediated signaling pathwayBraf , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1 , Shc1
chronic myeloid leukemia pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
colorectal cancer pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
cyclooxygenase mediated pathway of arachidonic acid metabolismMknk1
diabetic nephropathy pathwaySpp1
eicosanoid signaling pathwayPrkcd
endocytosis pathwayHras
endometrial cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
endothelin signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkcd , Ptk2b , Raf1
ephrin - ephrin receptor bidirectional signaling axisHras , Map2k1 , Mapk1 , Mapk3 , Nras
epidermal growth factor/neuregulin signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
Erk5 MAPK signaling pathwayMap3k2
erythropoietin signaling pathwayHras , Shc1
FasL mediated signaling pathwayMap3k1
Fc epsilon receptor mediated signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1
Fc gamma receptor mediated signaling pathwayMap2k1 , Mapk1 , Mapk3 , Prkcd , Raf1
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Ptk2b , Rps6ka1 , Shc1 , Spp1
G protein mediated signaling pathway via Galphai familyS1pr1
glioma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
glutamate signaling pathwayMapk1 , Mapk3
gonadotropin-releasing hormone signaling pathwayHras , Kras , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
Hedgehog signaling pathwayMap2k1 , Prkcd
hepatitis C pathwayBraf , Hras , Kras , Mapk1 , Mapk3 , Nras , Raf1
influenza A pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
insulin signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Shc1 , Tsc2
insulin-like growth factor signaling pathwayHras , Prkcd , Raf1 , Shc1
interleukin-2 signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Ptk2b , Raf1 , Shc1
interleukin-3 signaling pathwayShc1
interleukin-4 signaling pathwayShc1
interleukin-6 signaling pathwayPrkcd
Jak-Stat signaling pathwayPtk2b
kidney disease pathwaySpp1
Leishmaniasis pathwayMapk1 , Mapk3
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6
melanoma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
mitogen activated protein kinase signaling pathwayBraf , Dusp6 , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka5 , Rps6ka6 , Shc1 , Tsc2
mTOR signaling pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
neurotrophic factor signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka5 , Rps6ka6 , Shc1
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung carcinoma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
p38 MAPK signaling pathwayMap3k1 , Mknk1 , Mknk2 , Rps6ka4 , Rps6ka5
p53 signaling pathwayPrkcd , Tsc2
pancreatic cancer pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras
phosphatidylinositol 3-kinase-Akt signaling pathwayRaf1
platelet-derived growth factor signaling pathwayBraf , Hras , Ksr1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1 , Rps6ka3 , S1pr1 , Shc1
prion disease pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
protein kinase C (PKC) signaling pathwayPrkcd
renal cell carcinoma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k1
Rho/Rac/Cdc42 mediated signaling pathwayPtk2b
scatter factor/hepatocyte growth factor signaling pathwayShc1
sphingosine 1-phosphate signaling pathwayMapk1 , Mapk3 , S1pr1
syndecan signaling pathwayHras , Mapk1 , Mapk3 , Prkcd
T cell receptor signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayAraf , Braf , Dusp6 , Hras , Kras , Ksr1 , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Pebp1 , Prkcd , Ptk2b , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka4 , Rps6ka5 , Rps6ka6 , S1pr1 , Shc1 , Smad1 , Spp1 , Tsc2
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
Toll-like receptor signaling pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Spp1
toxoplasmosis pathwayMapk1 , Mapk3
Trail mediated signaling pathwayMap3k1 , Mapk1 , Mapk3
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayShc1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Smad1
tuberculosis pathwayMapk1 , Mapk3 , Raf1
tumor necrosis factor mediated signaling pathwayMap3k1
type 2 diabetes mellitus pathwayMapk1 , Mapk3 , Prkcd
type II interferon signaling pathwayMap2k1 , Map3k1 , Mapk1 , Mapk3 , Prkcd
ubiquitin/proteasome degradation pathwayMap3k1
urinary bladder cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
vascular endothelial growth factor signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1
Wnt signaling, canonical pathwayTsc2
Phenotype Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway

References Associated with the the extracellular signal-regulated Raf/Mek/Erk signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: