THE EXTRACELLULAR SIGNAL-REGULATED RAF/MEK/ERK SIGNALING PATHWAY (PW:0000102)

View Ontology Report

Description

The extracellular signal regulated MAP kinase pathway (Raf/Mek/Erk) couples signals reverberating from activated cell surface receptors via their downstream effectors, to many cytoplasmic and nuclear targets. Raf/Mek/Erk displays the characteristic three-tier core cascade MAPK architecture. The downstream and effector MAPK tier (here Erk represented by Mapk1 and 3) is activated by phosphorylation of threonine and tyrosine residues within the conserved TEY motif in the activation loop by d

Pathway Diagram:

Ariadne Genomics Inc. Mapk1 Pp2a Dusp6 Map2k2 Map2k1 Erk cytoplasmic/other targets Ksr1 Ksr2 Raf members upstream Ras RTK, others effectors/adapters Erk nuclear targets Erk activated MAPKAPK Pebp1 ---- Raf members Pebp1 ---| Raf members Pebp1 Raf members --+> Map2k2 Raf members --+> Map2k1 Pp2a --+> Raf members Pp2a ---| Map2k2 upstream Ras --+> Raf members effectors/adapters <--> upstream Ras Mapk3 Mapk1 ---> Erk nuclear targets Mapk3 ---> Erk cytoplasmic/other targets Mapk1 ---> Erk cytoplasmic/other targets Mapk3 ---> Erk nuclear targets effectors/adapters ---- RTK, others Ptprr ---| Mapk1 Map2k2 --+> Mapk3 Map2k1 --+> Mapk3 Map2k1 --+> Mapk1 Map2k2 --+> Mapk1 Pp2a ---| Map2k1 Pp2a ---| Mapk1 Pp2a ---| Mapk3 Dusp6 ---| Mapk1 Dusp6 ---| Mapk3 Ptprr ---| Mapk3 Mapk1 --+> Erk activated MAPKAPK Mapk3 --+> Erk activated MAPKAPK Ksr2 ---- Map2k1 Ksr1 ---- Map2k2 Ksr2 ---- Map2k2 Ksr1 ---- Raf members Ptprr
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 1,369,534 1,391,603 RGD:5686410
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1580106
RGD:5686410
RGD:1626216
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:2293881
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:5686410
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:628557
RGD:5686410
G Ksr1 kinase suppressor of ras 1 JBrowse link 10 66,323,704 66,342,469 RGD:2293880
RGD:5686410
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:70317
RGD:1626216
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:729046
RGD:1626216
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:1357969
RGD:2293879
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:724475
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:628468
RGD:8553011
RGD:1626216
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:628468
RGD:8553011
RGD:1626216
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
RGD:8553011
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:5686410
G Pebp1 phosphatidylethanolamine binding protein 1 JBrowse link 12 45,026,948 45,031,148 RGD:2293882
RGD:2302807
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1642529
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642630
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:70317
RGD:5686410
RGD:1626216
RGD:1580106
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:2315047
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:2315047
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:2315047
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:2315047
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1304283
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1643182
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1643230
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580097
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2293882
RGD:2298531
RGD:5133242
RGD:5133243
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:5490966
RGD:5490965
RGD:5133242
RGD:4143515
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:5133243
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:2293882

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexPp2a complex
Functional Classupstream Ras
Functional ClassRaf members
Gene GroupErk nuclear targets
Gene GroupErk cytoplasmic/other targets
Functional ClassErk activated MAPKAPKadditional kinase tier that furthers the signal
Functional ClassRTK, othersupstream pathways that trigger Raf/Mek/Erk via receptor tyrosine kinases and other receptors

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
adenosine signaling pathwayBraf , Hras , Map2k2 , Map3k1 , Mapk1 , Rps6ka1
aldosterone signaling pathwayKras , Mapk1 , Mapk3
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
Alzheimer disease pathwayMapk1 , Mapk3
B cell receptor signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
bladder cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
Bone morphogenetic proteins signaling pathwayMapk1 , Smad1
brain-derived neurotrophic factor signaling pathwayShc1
c-Jun N-terminal kinases MAPK signaling pathwayMap3k1 , Map3k2 , Spp1
calcium/calcium-mediated signaling pathwayPtk2b
cell-extracellular matrix signaling pathwaySpp1
ceramide signaling pathwayBraf , Kras , Ksr1 , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Mapk3 , Prkcd , Raf1
chemokine mediated signaling pathwayBraf , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1 , Shc1
chronic myeloid leukemia pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
colorectal cancer pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
cyclooxygenase mediated pathway of arachidonic acid metabolismMknk1
diabetic nephropathy pathwaySpp1
eicosanoid signaling pathwayPrkcd
endocytosis pathwayHras
endometrial cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
endothelin signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkcd , Ptk2b , Raf1
ephrin - ephrin receptor bidirectional signaling axisHras , Map2k1 , Mapk1 , Mapk3 , Nras
epidermal growth factor/neuregulin signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
Erk5 MAPK signaling pathwayMap3k2
erythropoietin signaling pathwayHras , Shc1
FasL mediated signaling pathwayMap3k1
Fc epsilon receptor mediated signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1
Fc gamma receptor mediated signaling pathwayMap2k1 , Mapk1 , Mapk3 , Prkcd , Raf1
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Ptk2b , Rps6ka1 , Shc1 , Spp1
G protein mediated signaling pathway via Galphai familyS1pr1
glioma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
glutamate signaling pathwayMapk1 , Mapk3
gonadotropin-releasing hormone signaling pathwayHras , Kras , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Shc1
Hedgehog signaling pathwayMap2k1 , Prkcd
hepatitis C virus infection pathwayBraf , Hras , Kras , Mapk1 , Mapk3 , Nras , Raf1
influenza A virus infection pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
insulin signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Shc1 , Tsc2
insulin-like growth factor signaling pathwayHras , Prkcd , Raf1 , Shc1
interleukin-2 signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Ptk2b , Raf1 , Shc1
interleukin-3 signaling pathwayShc1
interleukin-4 signaling pathwayShc1
interleukin-6 signaling pathwayPrkcd
Jak-Stat signaling pathwayPtk2b
kidney disease pathwaySpp1
Leishmania infection pathwayMapk1 , Mapk3
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6
melanoma pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
mitogen activated protein kinase signaling pathwayBraf , Dusp6 , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka5 , Rps6ka6 , Shc1 , Tsc2
mTOR signaling pathwayBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
Mycobacterium tuberculosis infection pathwayMapk1 , Mapk3 , Raf1
neurotrophic factor signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Map3k1 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka5 , Rps6ka6 , Shc1
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
p38 MAPK signaling pathwayMap3k1 , Mknk1 , Mknk2 , Rps6ka4 , Rps6ka5
p53 signaling pathwayPrkcd , Tsc2
pancreatic cancer pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras
phosphatidylinositol 3-kinase-Akt signaling pathwayRaf1
platelet-derived growth factor signaling pathwayBraf , Hras , Ksr1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Raf1 , Rps6ka3 , S1pr1 , Shc1
prion diseases pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
protein kinase C (PKC) signaling pathwayPrkcd
renal cell cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k1
Rho/Rac/Cdc42 mediated signaling pathwayPtk2b
scatter factor/hepatocyte growth factor signaling pathwayShc1
sphingosine 1-phosphate signaling pathwayMapk1 , Mapk3 , S1pr1
syndecan signaling pathwayHras , Mapk1 , Mapk3 , Prkcd
T cell receptor signaling pathwayHras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayAraf , Braf , Dusp6 , Hras , Kras , Ksr1 , Map2k1 , Map2k2 , Map3k1 , Map3k2 , Mapk1 , Mapk3 , Mknk1 , Mknk2 , Nras , Pebp1 , Prkcd , Ptk2b , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka4 , Rps6ka5 , Rps6ka6 , S1pr1 , Shc1 , Smad1 , Spp1 , Tsc2
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
Toll-like receptor signaling pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Spp1
Toxoplasma gondii infection pathwayMapk1 , Mapk3
Trail mediated signaling pathwayMap3k1 , Mapk1 , Mapk3
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayShc1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Smad1
Trypanosoma cruzi infection pathwayMapk1 , Mapk3
tumor necrosis factor mediated signaling pathwayMap3k1
type 2 diabetes mellitus pathwayMapk1 , Mapk3 , Prkcd
type II interferon signaling pathwayMap2k1 , Map3k1 , Mapk1 , Mapk3 , Prkcd
ubiquitin/proteasome degradation pathwayMap3k1
vascular endothelial growth factor signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkcd , Ptk2b , Raf1
Wnt signaling, canonical pathwayTsc2
Phenotype Annotations Associated with Genes in the the extracellular signal-regulated Raf/Mek/Erk signaling pathway

References Associated with the the extracellular signal-regulated Raf/Mek/Erk signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: