STEROID HORMONE BIOSYNTHETIC PATHWAY (PW:0000040)

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Description

Steroid hormones play important roles in metabolism, growth and differentiation and in reproductive functions. The synthesis and release of steroid hormones are highly regulated by the hypothalamus-pituitary-adrenal axis. The precursor of all steroid hormones is cholesterol which is derived from diet or via de novo synthesis from acetyl-CoA. The chronic steroidogenic response involves the change in the expression of steroidogenic genes while the acute response involves the quick delivery of chol

Pathway Diagram:

Ariadne Genomics Inc. cortisol biosynthetic pathway testosterone biosynthetic pathway estradiol biosynthetic pathway e(3) e Cyp17a1 Cyp11a1 Fdx1 Fdxr NADPH(3) ---> NADP+(3) Hsd3b2 cholesterol Star aldosterone biosynthetic pathway estradiol cortisol pregnenolone ---> 17-hydroxypregnenolone NADP+ DHEA ---> estradiol NADPH cholesterol ---> pregnenolone pregnenolone ---> progesterone progesterone ---> aldosterone progesterone ---> cortisol 17-hydroxypregnenolone ---> cortisol DHEA progesterone 17-hydroxypregnenolone testosterone aldosterone pregnenolone Hsd3b1 Por Por ---> e NADP+(3) NADPH(3) NADPH(3) ---> e(3) NADPH ---> NADP+ 17-hydroxypregnenolone ---> DHEA
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Genes in Pathway:

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steroid hormone biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:10402751
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:6907045
RGD:10402751
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6907045
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:2325883
RGD:10402751
RGD:6907045
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:6907045
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:6907045
RGD:10402751
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:6907045
RGD:10402751
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:2325883
RGD:10402751
RGD:6907045
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:4889549
RGD:6907045
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6907045
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6907045
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:6907045
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 JBrowse link 12 10,636,294 10,684,273 RGD:6907045
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6907045
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6907045
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6907045
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:6907045
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 JBrowse link 2 102,701,903 102,871,257 RGD:6907045
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:6907045
RGD:10402751
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 19 37,476,083 37,481,326 RGD:6907045
RGD:10402751
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 JBrowse link 10 88,987,558 88,989,758 RGD:6907045
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 JBrowse link 3 82,924,699 83,048,465 RGD:6907045
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:6907045
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:6907045
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 JBrowse link 7 2,412,370 2,431,249 RGD:6907045
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 JBrowse link 13 88,288,116 88,308,019 RGD:6907045
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 JBrowse link 20 3,817,212 3,819,316 RGD:6907045
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
RGD:10402751
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:6907045
RGD:10402751
RGD:4889549
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 JBrowse link 2 200,615,910 200,633,317 RGD:6907045
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2325883
G Srd5a1 steroid 5 alpha-reductase 1 JBrowse link 1 36,320,504 36,354,694 RGD:6907045
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:6907045
G Srd5a3 steroid 5 alpha-reductase 3 JBrowse link 14 34,554,769 34,570,423 RGD:6907045
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6907045
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:6907045
G Sult2a2 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 JBrowse link 1 76,252,329 76,517,193 RGD:6907045
G Sult2b1 sulfotransferase family 2B member 1 JBrowse link 1 101,712,254 101,774,683 RGD:6907045
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6907045
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6907045
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 JBrowse link 9 95,274,707 95,302,822 RGD:6907045
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:6907045
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:6907045
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C JBrowse link 9 95,233,957 95,302,822 RGD:6907045
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:6907045
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6907045
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 JBrowse link 14 22,192,970 22,217,094 RGD:6907045
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 JBrowse link 14 22,251,507 22,267,899 RGD:6907045
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B RGD:6907045
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6907045
G Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 JBrowse link 14 22,495,084 22,534,865 RGD:6907045
aldosterone biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4889549
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:4889549
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:4889549
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
C21-steroid hormone biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:1299585
cortisol biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4889549
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:4892309
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:4889549
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
estradiol biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:4892309
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:2325883
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 JBrowse link 10 88,987,558 88,989,758 RGD:4889549
RGD:2325883
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:4889549
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6893583
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:6893583
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:2325883
testosterone biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:2325883
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:2325883
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:4889549
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2325883
G Srd5a1 steroid 5 alpha-reductase 1 JBrowse link 1 36,320,504 36,354,694 RGD:2325883
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:2325883
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6893583
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeDHEAdehydroepiandrosterone

Pathway Gene Annotations

Disease Annotations Associated with Genes in the steroid hormone biosynthetic pathway
Disease TermsGene Symbols
17,20-Lyase Deficiency, IsolatedCyp17a1
17-Hydroxysteroid Dehydrogenase DeficiencyHsd17b3
18-Hydroxylase DeficiencyCyp11b3
46 XY gonadal dysgenesisAkr1c1
46, XY Disorders of Sex DevelopmentCyp11a1
Abdominal ObesityHsd11b1
Abortion, SpontaneousCyp1a1 , Hsd17b1
acute kidney failureCyp1a1 , Cyp3a23/3a1 , Ugt1a1 , Ugt1a9
Acute Lung InjuryCyp1a1
acute myeloid leukemiaCyp1a1
Acute PainComt
adenocarcinomaCyp19a1 , Cyp7b1 , Ugt2b17
adenomaCyp1b1
adrenal cortical adenomaCyp11b1 , Cyp11b2
Adrenal Hyperplasia 2Hsd3b2
Adrenal Hyperplasia, Congenital, Type 5Cyp17a1
Adrenal InsufficiencyCyp11a1
AlbuminuriaCyp11b2
alcohol use disorderComt
alcoholic hepatitisSts , Sult1e1
alcoholic pancreatitisUgt1a7c
allergic contact dermatitisCyp1a1 , Hsd11b1
allergic hypersensitivity diseaseCyp1a1
alopeciaSrd5a2
Alzheimer's diseaseCyp19a1 , Hsd17b3 , Hsd3b1
amenorrheaCyp17a1 , Cyp19a1 , Por
amphetamine abuseComt
ankylosing spondylitisCyp1a1
ANTERIOR SEGMENT DYSGENESIS 6Cyp1b1
anterior segment mesenchymal dysgenesisCyp1b1
Antley-Bixler syndromePor
Antley-Bixler Syndrome with Genital Anomalies and Disordered SteroidogenesisPor
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISPor
anxiety disorderCyp3a2
apparent mineralocorticoid excessHsd11b2
apparent mineralocorticoid excess syndromeHsd11b2
aromatase excess syndromeCyp19a1
ArteritisCyp1a1
asthmaCyp1a1 , Hsd11b2
attention deficit hyperactivity disorderComt , Sts
AUDITORY NEUROPATHY AND OPTIC ATROPHYFdxr
autism spectrum disorderComt
autistic disorderComt , Cyp19a1
autosomal recessive congenital ichthyosis 1Sult2b1
autosomal recessive congenital ichthyosis 14Sult2b1
autosomal recessive congenital ichthyosis 2Sult2b1
Behcet's diseaseCyp1a1
bilirubin metabolic disorderUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
bipolar disorderAkr1c1 , Comt
Birth WeightCyp1a1
bladder neck obstructionCyp19a1
Bone Mineral Density Quantitative Trait Locus 12Ugt2b17
bone resorption diseaseCyp19a1
BradycardiaCyp1a1
Brain InjuriesComt , Cyp11a1
Breast NeoplasmsComt , Cyp17a1 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Cyp3a2 , Hsd17b1 , Srd5a1 , Srd5a2 , Sult1e1 , Ugt1a1
bronchitisCyp1a1
Bronchitis, ChronicCyp1a1
bulimia nervosaComt
buphthalmosCyp1b1
CardiomegalyCyp11a1 , Cyp11b2 , Cyp1a1 , Cyp1b1 , Srd5a1 , Star
Cardiomyopathy, Hypertrophic, FamilialComt
CatalepsyComt
Cell Transformation, NeoplasticPor
Chemical and Drug Induced Liver InjuryCyp3a23/3a1 , Sult1e1 , Sult2b1 , Ugt1a9
Chemotherapy-Induced Febrile NeutropeniaCyp3a9
Child Behavior DisordersComt
cholangiocarcinomaUgt1a9
cholecystolithiasisUgt1a1
cholelithiasisCyp17a1 , Ugt1a1
cholestasisCyp7a1 , Cyp7b1 , Sult2b1
chronic myeloid leukemiaCyp1a1 , Cyp3a9
chronic obstructive pulmonary diseaseCyp1a1
clubfootCyp1a1
Cocaine-Related DisordersComt
Cognition DisordersComt
colitisCyp1a1
colobomaCyp1b1
Colorectal NeoplasmsCyp1b1
congenital adrenal hyperplasiaCyp11a1 , Cyp11b1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Cyp21a1 , Hsd3b2 , Por , Star
Congenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase DeficiencyCyp11b2
congenital adrenal insufficiencyCyp11a1
congenital bile acid synthesis defectAkr1d1 , Cyp7b1
congenital bile acid synthesis defect 2Akr1d1
congenital bile acid synthesis defect 3Cyp7b1
congenital disorder of glycosylationSrd5a3
Congenital Disorder of Glycosylation Type 1QSrd5a3
congenital disorder of glycosylation type ISrd5a3
congestive heart failureCyp11b2
contact dermatitisCyp1a1 , Cyp1b1 , Ugt1a1 , Ugt1a6
cortisone reductase deficiencyHsd11b1
cortisone reductase deficiency 2Hsd11b1
Creutzfeldt-Jakob diseaseSrd5a3
Crigler Najjar Syndrome, Type 2Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Crigler-Najjar syndromeUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Critical IllnessCyp19a1
Crohn's diseaseUgt1a1
cryptorchidismHsd3b2 , Sts
Cutaneous Malignant Melanoma, Susceptibility To, 1Cyp17a1 , Cyp7b1 , Srd5a2
cystic fibrosisCyp1a1
diabetes mellitusCyp11b3 , Cyp1a1 , Srd5a2
Diabetic NephropathiesCyp11b2 , Cyp19a1
DiGeorge syndromeComt
Digestive System NeoplasmsCyp1a1
dilated cardiomyopathyComt
dilated cardiomyopathy 1HCyp11b3
disease of mental healthComt
Drug EruptionsCyp1a1
Drug-Induced DyskinesiaComt
Drug-Induced LeukopeniaCyp3a9
Drug-induced NeutropeniaCyp3a9 , Ugt1a1
Drug-Related Side Effects and Adverse ReactionsUgt1a1
end stage renal failureCyp1a1 , Cyp3a2
Endometrial NeoplasmsComt , Cyp11a1 , Cyp19a1 , Cyp1a1 , Hsd17b2 , Srd5a2 , Star , Sult1e1 , Sult2b1 , Ugt1a1
endometriosisCyp19a1 , Cyp1a1 , Hsd17b1 , Hsd17b2 , Srd5a1 , Srd5a2
EpendymomaHsd3b2
Esophageal NeoplasmsCyp19a1
esophagus squamous cell carcinomaCyp1b1
essential hypertensionCyp3a9
eumycotic mycetomaComt
Experimental Autoimmune EncephalomyelitisComt
Experimental Diabetes MellitusComt , Cyp11a1 , Cyp11b2 , Cyp19a1 , Cyp1a1 , Hsd11b1 , Star , Sts , Ugt2b17
Experimental Liver CirrhosisCyp17a1 , Cyp3a9 , Hsd17b2 , Hsd17b6 , Srd5a1 , Sult1e1 , Ugt2b
familial hyperlipidemiaHsd11b1
Familial Prostate CancerCyp3a2
FatigueComt
fatty liver diseaseCyp19a1 , Cyp1b1 , Cyp7b1 , Sts
Female Genital NeoplasmsUgt1a1
Female InfertilityCyp17a1 , Cyp19a1
Fetal Growth RetardationComt , Cyp11a1 , Cyp11b1 , Cyp11b2 , Cyp1a1 , Hsd11b2 , Star
FeverStar
fibromyalgiaComt
FibrosisCyp11b2 , Cyp19a1
Gallbladder NeoplasmsCyp17a1 , Cyp1a1
GallstonesUgt1a1
genetic diseaseCyp7b1 , Fdxr , Hsd17b3 , Srd5a3 , Sts , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
gestational diabetesCyp19a1
Gilbert syndromeUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
Glaucoma 1, Open Angle, ACyp1b1
Glaucoma 1, Open Angle, DCyp1b1
Glaucoma 1, Open Angle, FCyp1b1
Glaucoma 3, Primary Infantile, BCyp1b1
gliosarcomaPor
glucocorticoid-remediable aldosteronismCyp11b2 , Cyp11b3
glucose intoleranceCyp1b1
Gonadal Dysgenesis, XX Type, with DeafnessCyp17a1
Graft vs Host DiseaseUgt2b17
Gram-Negative Bacterial InfectionsUgt1a1
Graves' diseaseCyp1a1
HamartomaCyp1a1
Hearing Loss, Cisplatin-Induced, Susceptibility ToComt
heart diseaseCyp11b2 , Cyp1a1
hematopoietic system diseaseUgt1a1
hemochromatosisAkr1d1
hepatocellular adenomaCyp3a23/3a1
hepatocellular carcinomaComt , Cyp17a1 , Cyp1a1 , Hsd3b2
HepatomegalyCyp1a1 , Cyp1b1
hereditary spastic paraplegiaCyp7b1
hereditary spastic paraplegia 5ACyp7b1
Hodgkin's lymphomaUgt1a1
hydrophthalmosCyp1b1
HyperalgesiaComt
Hyperbilirubinemia, NeonatalUgt1a1
Hyperbilirubinemia, Transient Familial NeonatalUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a8 , Ugt1a9
HypercholesterolemiaCyp7a1
hyperglycemiaCyp11a1 , Hsd11b1
HyperkalemiaCyp17a1
HyperoxiaCyp1a1
Hyperoxic Lung InjuryCyp1a1
hyperprolactinemiaHsd3b1 , Hsd3b2 , Srd5a1 , Srd5a2
hypertensionComt , Cyp11a1 , Cyp11b1 , Cyp11b2 , Cyp11b3 , Cyp19a1 , Cyp1a1 , Hsd11b1 , Hsd11b2 , Hsd3b1 , Hsd3b2 , Sts
hyperthyroidismUgt1a1
Hypertrophy, Left VentricularCyp11b1 , Cyp11b2
HypoaldosteronismCyp11b2 , Cyp11b3
hypogonadismCyp11a1 , Cyp17a1 , Cyp19a1 , Hsd3b1 , Star
hypopituitarismCyp17a1 , Cyp19a1
hypospadiasCyp1a1 , Hsd3b1 , Hsd3b2 , Srd5a2
HypotensionPor
hypothyroidismCyp19a1 , Hsd3b1 , Srd5a1 , Star
InflammationCyp1a1 , Cyp3a2 , Cyp3a23/3a1 , Sts , Sult2b1 , Ugt1a1
inherited metabolic disorderHsd11b2
Insulin ResistanceHsd11b1 , Sts
intellectual disabilitySrd5a1 , Srd5a3
JaundiceCyp1a1 , Ugt1a1
Kahrizi syndromeSrd5a3
kernicterusUgt1a1
kidney diseaseCyp3a9
Kidney NeoplasmsCyp1a1
Kidney Reperfusion InjuryCyp19a1
learning disabilityPor
leiomyomaComt
Leukemia, Myeloid, Chronic-PhaseCyp3a9
lipid metabolism disorderCyp7b1
Lipoid Congenital Adrenal HyperplasiaCyp11a1 , Star
liver cirrhosisHsd11b2
liver diseaseCyp7b1 , Sult1e1
Liver Neoplasms, ExperimentalCyp1a1
Liver Reperfusion InjuryCyp1a1
long QT syndromeCyp1a1
Lung InjuryCyp1a1
Lung NeoplasmsCyp1a1 , Cyp1b1 , Ugt2b17
Lymphatic MetastasisComt
male infertilityCyp17a1 , Cyp1a1
Male Pseudohermaphroditism due to Deficiency of Testicular 17,20-DesmolaseAkr1c1
malignant hypertensionCyp17a1
Mammary Neoplasms, AnimalComt
melanomaCyp17a1 , Cyp1b1 , Cyp7b1 , Srd5a2
Memory DisordersComt
mental depressionCyp3a23/3a1
Metabolic SyndromeCyp11b2 , Hsd11b1
Micronuclei, Chromosome-DefectiveCyp1a1
Mouth NeoplasmsCyp1b1
multiple myelomaCyp1a1
Musculoskeletal AbnormalitiesPor
Musculoskeletal PainComt
myeloid leukemiaUgt1a1
myocardial infarctionCyp11b2 , Hsd11b2
myocarditisCyp11b2
Nematode InfectionsCyp1a1
Neoplasm MetastasisCyp19a1 , Sult1e1
nephritisCyp1a1
nephrosisCyp11a1 , Cyp3a18 , Cyp3a9 , Star
nephrotic syndromeHsd11b2
neural tube defectPor
NeuralgiaCyp17a1
neutropeniaUgt1a1
non-small cell lung carcinomaUgt1a1
nonalcoholic fatty liver diseaseCyp17a1
obesityAkr1c1 , Comt , Cyp1b1 , Hsd11b1 , Hsd11b2 , Srd5a1 , Sts
obsessive-compulsive disorderComt
Occupational DiseasesCyp1a1
OligomenorrheaCyp17a1
osteoporosisCyp17a1 , Cyp19a1
Osteoporosis, PostmenopausalCyp19a1
ovarian cystCyp17a1
ovarian diseaseCyp19a1
Ovarian NeoplasmsComt , Cyp19a1 , Cyp1b1 , Ugt1a1
PainComt
pancreatic cancerCyp17a1 , Ugt1a7c
pancreatitisFdx1
panic disorderComt
Paranoid DisordersAkr1c1 , Hsd3b2
paraplegiaCyp7b1
Parkinson's diseaseCyp1a1
Parkinsonian DisordersComt , Cyp1a1
Penis AgenesisSrd5a2
peripheral vascular diseaseCyp1a1
Peters anomalyCyp1b1
phaeochromocytomaComt
placental insufficiencyCyp19a1
pleomorphic xanthoastrocytomaAkr1d1 , Cyp3a18 , Cyp3a9 , Por
pneumoniaCyp1a1
polycystic ovary syndromeComt , Cyp17a1 , Cyp19a1 , Cyp1a1 , Hsd17b7 , Hsd3b1 , Hsd3b2 , Srd5a1 , Star
porphyria cutanea tardaCyp1a1
pre-eclampsiaComt , Cyp11b2
precursor B lymphoblastic lymphoma/leukemiaCyp3a9
precursor lymphoblastic lymphoma/leukemiaCyp1a1 , Cyp1b1 , Cyp3a9
Pregnancy ComplicationsHsd11b2
primary congenital glaucomaCyp1b1
primary hyperaldosteronismCyp11b1 , Cyp11b2 , Cyp11b3
primary immunodeficiency diseaseCyp3a9
primary open angle glaucomaCyp1b1
prostate carcinoma in situCyp19a1
prostatic hypertrophySrd5a1 , Srd5a2
Prostatic NeoplasmsComt , Cyp11b3 , Cyp17a1 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Cyp3a18 , Cyp3a9 , Cyp7b1 , Hsd17b1 , Hsd17b3 , Hsd3b1 , Hsd3b2 , Srd5a1 , Srd5a2 , Sult1e1 , Sult2b1 , Ugt2b17
prostatitisCyp19a1
protein-energy malnutritionCyp19a1
pseudohermaphroditismHsd17b3
Pseudovaginal Perineoscrotal HypospadiasCyp1b1 , Srd5a2
psoriasisComt , Cyp1a1
psoriatic arthritisCyp1a1
reactive arthritisCyp1a1
RecurrenceCyp19a1
renal cell carcinomaComt , Cyp1a1
renal tubular acidosisCyp11b2
Reperfusion InjuryCyp19a1 , Cyp3a9 , Sult1e1
rheumatoid arthritisHsd11b1 , Sts
schizophreniaComt , Sts , Ugt1a2
Schizophrenia Spectrum and Other Psychotic DisordersComt
sciatic neuropathyCyp11a1 , Cyp17a1 , Hsd3b1
SepsisCyp1a1
sex differentiation diseaseHsd17b3
sexual disorderCyp17a1
Sexual InfantilismCyp19a1
Sjogren's syndromeCyp19a1 , Cyp1a1
small cell carcinomaUgt1a1
Smith-Magenis syndromeFdxr , Hsd17b1
squamous cell carcinomaCyp1b1
StarvationUgt1a1
status epilepticusCyp11a1 , Hsd11b1
StrokeCyp11b2
systemic lupus erythematosusCyp1a1
Tachycardia, SinusCyp1a1
Temporomandibular Joint DisordersComt
thrombosisCyp3a9
Tissue AdhesionsCyp19a1
Toe Syndactyly, Telecanthus, and Anogenital and Renal MalformationsStar
toxic encephalopathyCyp3a9
type 1 diabetes mellitusHsd11b2 , Ugt1a1
type 2 diabetes mellitusCyp11a1 , Cyp11b2 , Cyp1a1 , Cyp3a2 , Cyp3a23/3a1 , Hsd11b1 , Hsd11b2 , Hsd17b3 , Hsd3b1 , Srd5a1 , Star , Ugt1a1 , Ugt1a6 , Ugt1a7c
uremiaComt
ureteral obstructionHsd11b2
urethral obstructionCyp19a1
urinary bladder cancerComt , Cyp19a1 , Cyp1a1 , Cyp1b1 , Por
Venous ThrombosisComt
visual epilepsyCyp11a1
vitiligoComt
Weight GainSts
X-linked ichthyosisSts
Pathway Annotations Associated with Genes in the steroid hormone biosynthetic pathway
Pathway TermsGene Symbols
11-beta-hydroxylase deficiency pathwayAkr1c1 , Akr1d1 , Cyp11a1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Hsd11b1 , Hsd11b2 , Hsd3b1 , Hsd3b2
17-alpha-hydroxylase deficiency pathwayAkr1c1 , Akr1d1 , Cyp11a1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Hsd11b1 , Hsd11b2 , Hsd3b1 , Hsd3b2
21-alpha-hydroxylase deficiency pathwayAkr1c1 , Akr1d1 , Cyp11a1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Hsd11b1 , Hsd11b2 , Hsd3b1 , Hsd3b2
aldosterone biosynthetic pathwayCyp11a1 , Cyp11b1 , Cyp11b2 , Cyp21a1 , Fdx1 , Fdxr , Por , Star
aldosterone signaling pathwayHsd11b1 , Hsd11b2
alendronate pharmacodynamics pathwayHsd17b7
alkaptonuria pathwayComt
apparent mineralocorticoid excess syndrome pathwayAkr1c1 , Akr1d1 , Cyp11a1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Hsd11b1 , Hsd11b2 , Hsd3b1 , Hsd3b2
aromatase inhibitor pathwayCyp19a1
artemether pharmacokinetics pathwayCyp3a9 , Ugt1a9
ascorbate and aldarate metabolic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
bile acid biosynthetic pathwayAkr1c1 , Akr1d1 , Cyp7a1 , Cyp7b1
bile acid transport pathwayCyp7a1
C21-steroid hormone biosynthetic pathwayCyp11b2 , Cyp11b3
carbamazepine pharmacokinetics pathwayCyp3a9
cerebrotendinous xanthomatosis pathwayAkr1c1 , Akr1d1 , Cyp7a1 , Cyp7b1
cholesterol biosynthetic pathwayHsd17b7
cholesterol ester storage disease pathwayHsd17b7
clopidogrel pharmacodynamics pathwayCyp3a9
clopidogrel pharmacokinetics pathwayCyp3a9
codeine and morphine pharmacodynamics pathwayUgt1a1 , Ugt1a2 , Ugt1a8
codeine and morphine pharmacokinetics pathwayUgt1a1 , Ugt1a2 , Ugt1a8
congenital bile acid synthesis defect pathwayAkr1c1 , Akr1d1 , Cyp7a1 , Cyp7b1
congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathwayHsd17b7
cortisol biosynthetic pathwayCyp11a1 , Cyp11b1 , Cyp17a1 , Cyp21a1 , Fdx1 , Fdxr , Hsd3b1 , Hsd3b2 , Por , Star
desmosterolosis pathwayHsd17b7
disulfiram pharmacodynamics pathwayComt
dopamine beta-hydroxylase deficiency pathwayComt
doxorubicin pharmacokinetics pathwayPor
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaCyp7a1
estradiol biosynthetic pathwayCyp11a1 , Cyp17a1 , Cyp19a1 , Fdx1 , Fdxr , Hsd17b1 , Hsd17b2 , Hsd17b3 , Hsd3b1 , Hsd3b2 , Por , Star , Sts , Sult1e1
etoposide pharmacodynamics pathwayCyp3a9 , Ugt1a1
etoposide pharmacokinetics pathwayCyp3a9 , Ugt1a1
familial hypercholanemia pathwayAkr1c1 , Akr1d1 , Cyp7a1 , Cyp7b1
fluoxetine pharmacodynamics pathwayCyp3a9
fluoxetine pharmacokinetics pathwayCyp3a9
hawkinsinuria pathwayComt
homocysteine metabolic pathwayComt
hypercholesterolemia pathwayHsd17b7
ibandronate pharmacodynamics pathwayHsd17b7
ibuprofen pharmacodynamics pathwayUgt1a1 , Ugt1a2 , Ugt1a9
ibuprofen pharmacokinetics pathwayUgt1a1 , Ugt1a2 , Ugt1a9
ifosfamide pharmacodynamics pathwayCyp3a9
ifosfamide pharmacokinetics pathwayCyp3a9
irinotecan pharmacodynamics pathwayCyp3a9 , Ugt1a1 , Ugt1a9
irinotecan pharmacokinetics pathwayCyp3a9 , Ugt1a1 , Ugt1a9
isoprenoid metabolic pathwayHsd3b5
linoleic acid metabolic pathwayCyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9
lipoid congenital adrenal hyperplasia pathwayAkr1c1 , Akr1d1 , Cyp11a1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Hsd11b1 , Hsd11b2 , Hsd3b1 , Hsd3b2
methionine cycle/metabolic pathwayComt
mevalonic aciduria pathwayHsd17b7
mitochondrial iron-sulfur cluster protein biogenesis pathwayFdx1 , Fdxr
mycophenolic acid pharmacokinetics pathwayCyp3a9 , Ugt1a8 , Ugt1a9
neviparine pharmacokinetics pathwayCyp3a9
nicotine pharmacodynamics pathwayUgt1a5 , Ugt1a9
nicotine pharmacokinetics pathwayUgt1a5 , Ugt1a9
nitrogenous bisphosphonate pharmacodynamics pathwayHsd17b7
O-linked glycan biosynthetic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
pamidronate pharmacodynamics pathwayHsd17b7
paracetamol pharmacokinetics pathwaySult1e1 , Ugt1a1 , Ugt1a6 , Ugt1a9
pentose and glucuronate interconversion pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
phase I biotransformation pathway via cytochrome P450Cyp1a1 , Cyp1b1 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
phenytoin pharmacodynamics pathwayComt , Ugt1a1 , Ugt1a5 , Ugt1a6 , Ugt1a9
porphyrin and chlorophyll metabolic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
primary bile acid biosynthetic pathwayAkr1d1 , Cyp7a1 , Cyp7b1
prostate cancer pathwaySrd5a2
retinol metabolic pathwayCyp1a1 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
risedronate pharmacodynamics pathwayHsd17b7
Smith-Lemli-Opitz Syndrome pathwayHsd17b7
sorafenib pharmacokinetics pathwayUgt1a1 , Ugt1a9
starch and sucrose metabolic pathwayUgt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
statin pharmacodynamics pathwayHsd17b7
steroid biosynthetic pathwayHsd17b7
steroid hormone biosynthetic pathwayAkr1c1 , Akr1d1 , Comt , Cyp11a1 , Cyp11b1 , Cyp11b2 , Cyp11b3 , Cyp17a1 , Cyp19a1 , Cyp1a1 , Cyp1b1 , Cyp21a1 , Cyp3a18 , Cyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Cyp7a1 , Cyp7b1 , Fdx1 , Fdxr , Hsd11b1 , Hsd11b2 , Hsd17b1 , Hsd17b12 , Hsd17b2 , Hsd17b3 , Hsd17b6 , Hsd17b7 , Hsd17b8 , Hsd3b1 , Hsd3b2 , Hsd3b5 , Por , Srd5a1 , Srd5a2 , Srd5a3 , Star , Sts , Sult1e1 , Sult2a2 , Sult2b1 , Ugt1a1 , Ugt1a2 , Ugt1a3 , Ugt1a5 , Ugt1a6 , Ugt1a7c , Ugt1a8 , Ugt1a9 , Ugt2a1 , Ugt2a3 , Ugt2b , Ugt2b17 , Ugt2b37
sulfite oxidase deficiency pathwaySult1e1 , Sult2b1
sulfur metabolic pathwaySult1e1 , Sult2a2 , Sult2b1
tamoxifen pharmacodynamics pathwayCyp3a9 , Ugt1a5
tamoxifen pharmacokinetics pathwayCyp3a2 , Cyp3a23/3a1 , Cyp3a9 , Ugt1a5
teniposide pharmacodynamics pathwayCyp3a9
teniposide pharmacokinetics pathwayCyp3a9
testosterone biosynthetic pathwayCyp11a1 , Cyp17a1 , Fdx1 , Fdxr , Hsd17b2 , Hsd17b3 , Hsd3b1 , Hsd3b2 , Por , Srd5a1 , Srd5a2 , Star , Sts
tramadol pharmacokinetics pathwayUgt1a8
tryptophan metabolic pathwayCyp1a1 , Cyp1b1
tyrosine metabolic pathwayComt
tyrosinemia type I pathwayComt
unsaturated fatty acid biosynthetic pathwayHsd17b12
valproic acid pharmacokinetics pathwayUgt1a2
vitamin A deficiency pathwayCyp3a18 , Cyp3a9 , Ugt1a1
Wolman disease pathwayHsd17b7
X-linked dominant chondrodysplasia punctata 2 pathwayHsd17b7
Zellweger syndrome pathwayAkr1c1 , Akr1d1 , Cyp7a1 , Cyp7b1
zoledronate pharmacodynamics pathwayHsd17b7
Phenotype Annotations Associated with Genes in the steroid hormone biosynthetic pathway

References Associated with the steroid hormone biosynthetic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: