MITOGEN ACTIVATED PROTEIN KINASE SIGNALING PATHWAY (PW:0000007)

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Description

The mitogen activated protein kinase pathways (MAPKs) represent highly conserved cascades activated in response to effectors downstream of receptor tyrosine kinases (RTKs) or in some cases G-protein coupled receptors (GPCRs), and in response to inflammatory cytokines and stress. Together, they control many cellular processes. The hallmark of MAPK pathways is the shared architecture of a three-tier signaling core: MAP3K/MAP2K/MAPK. The downstream tier and main effectors MAPKs are activated by pho

Pathway Diagram:

Ariadne Genomics Inc. Erk5 MAPK signaling pathway p38 MAPK signaling pathway c-Jun N-terminal kinases MAPK signaling pathway The extracellular signal-regulated RAF/MEK/ERK pathway immune response motility apoptosis proliferation differentiation survival cytokine receptors RTK Rho Ras Traf effectors2 adapters effectors1 inflammatory cytokines GF stress conditions
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mitogen activated protein kinase signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:6907045
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6907045
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:6907045
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6907045
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6907045
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6907045
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6907045
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6907045
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6907045
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:6907045
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:6907045
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:6907045
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:6907045
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:6907045
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 4 15,706,974 16,130,848 RGD:6907045
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:6907045
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 JBrowse link 16 4,871,348 5,795,825 RGD:6907045
G Cacna2d4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 JBrowse link 4 151,298,548 151,409,263 RGD:6907045
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:6907045
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:6907045
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:6907045
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:6907045
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 JBrowse link 10 95,921,479 95,934,170 RGD:6907045
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:6907045
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 JBrowse link 1 192,613,766 192,708,371 RGD:6907045
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 JBrowse link 10 95,954,160 96,015,484 RGD:6907045
G Cacng5 calcium voltage-gated channel auxiliary subunit gamma 5 JBrowse link 10 96,122,240 96,166,606 RGD:6907045
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 JBrowse link 1 64,307,684 64,322,124 RGD:6907045
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 JBrowse link 1 64,374,547 64,405,380 RGD:6907045
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 JBrowse link 1 64,330,106 64,350,338 RGD:6907045
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Ccdc88b coiled-coil domain containing 88B JBrowse link 1 222,102,436 222,118,485 RGD:6907045
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6907045
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Chp1 calcineurin-like EF-hand protein 1 JBrowse link 3 111,354,506 111,389,998 RGD:6907045
G Chp2 calcineurin-like EF hand protein 2 JBrowse link 1 192,169,634 192,173,228 RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6907045
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6907045
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:6907045
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:6907045
G Dusp14 dual specificity phosphatase 14 JBrowse link 10 71,363,688 71,383,602 RGD:6907045
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:6907045
G Dusp2 dual specificity phosphatase 2 JBrowse link 3 119,776,925 119,779,110 RGD:6907045
G Dusp22 dual specificity phosphatase 22 JBrowse link 17 34,986,589 35,037,297 RGD:6907045
G Dusp3 dual specificity phosphatase 3 JBrowse link 10 89,904,578 89,918,296 RGD:6907045
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:6907045
G Dusp5 dual specificity phosphatase 5 JBrowse link 1 274,245,184 274,258,595 RGD:6907045
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:6907045
G Dusp7 dual specificity phosphatase 7 JBrowse link 8 115,069,095 115,076,130 RGD:6907045
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:6907045
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:6907045
G Ecsit ECSIT signalling integrator JBrowse link 8 23,085,598 23,099,064 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Elk4 ELK4, ETS transcription factor JBrowse link 13 48,788,262 48,813,267 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:1582137
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6907045
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6907045
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:6907045
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:6907045
G Fgf11 fibroblast growth factor 11 JBrowse link 10 56,403,320 56,410,816 RGD:6907045
G Fgf12 fibroblast growth factor 12 JBrowse link 11 75,606,360 76,171,078 RGD:6907045
G Fgf13 fibroblast growth factor 13 JBrowse link X 142,053,648 142,589,274 RGD:6907045
G Fgf14 fibroblast growth factor 14 JBrowse link 15 110,382,274 111,077,027 RGD:6907045
G Fgf16 fibroblast growth factor 16 JBrowse link X 76,786,728 76,796,311 RGD:6907045
G Fgf17 fibroblast growth factor 17 JBrowse link 15 52,326,758 52,337,360 RGD:6907045
G Fgf18 fibroblast growth factor 18 JBrowse link 10 18,047,109 18,082,290 RGD:6907045
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:6907045
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6907045
G Fgf20 fibroblast growth factor 20 JBrowse link 16 55,152,748 55,159,352 RGD:6907045
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:6907045
G Fgf22 fibroblast growth factor 22 JBrowse link 7 12,829,785 12,831,675 RGD:6907045
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:6907045
G Fgf3 fibroblast growth factor 3 JBrowse link 1 218,003,018 218,006,942 RGD:6907045
G Fgf4 fibroblast growth factor 4 JBrowse link 1 218,024,537 218,029,539 RGD:6907045
G Fgf5 fibroblast growth factor 5 JBrowse link 14 12,974,921 12,996,046 RGD:6907045
G Fgf6 fibroblast growth factor 6 JBrowse link 4 159,563,798 159,572,333 RGD:6907045
G Fgf7 fibroblast growth factor 7 JBrowse link 3 118,315,859 118,368,464 RGD:6907045
G Fgf8 fibroblast growth factor 8 JBrowse link 1 265,492,949 265,498,965 RGD:6907045
G Fgf9 fibroblast growth factor 9 JBrowse link 15 38,341,657 38,386,945 RGD:6907045
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:6907045
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6907045
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:6907045
G Fgfr4 fibroblast growth factor receptor 4 JBrowse link 17 9,990,072 10,004,339 RGD:6907045
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:6907045
G Flnb filamin B JBrowse link 15 18,750,152 18,883,019 RGD:6907045
G Flnc filamin C JBrowse link 4 56,710,934 56,738,779 RGD:6907045
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6907045
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6907045
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6907045
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6907045
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:6907045
G Gng12 G protein subunit gamma 12 JBrowse link 4 97,634,925 97,763,478 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:6907045
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:6907045
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:6907045
G Hspa2 heat shock protein family A member 2 JBrowse link 6 99,433,575 99,436,288 RGD:6907045
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6907045
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6907045
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6907045
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:6907045
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Jund JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 16 20,485,028 20,486,707 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6907045
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6907045
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:6907045
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6907045
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:6907045
G Map3k12 mitogen activated protein kinase kinase kinase 12 JBrowse link 7 144,102,275 144,120,306 RGD:6907045
G Map3k13 mitogen-activated protein kinase kinase kinase 13 JBrowse link 11 82,744,391 82,938,357 RGD:6907045
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:6907045
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:6907045
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:6907045
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6907045
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:6907045
G Map3k6 mitogen-activated protein kinase kinase kinase 6 JBrowse link 5 151,435,679 151,448,329 RGD:6907045
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:6907045
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:6907045
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 JBrowse link 1 87,937,126 87,959,514 RGD:6907045
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 JBrowse link 1 221,710,622 221,726,274 RGD:6907045
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 JBrowse link 6 3,276,732 3,444,519 RGD:6907045
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 9 46,657,444 46,782,545 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:6907045
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:6907045
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:6907045
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:6907045
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:6907045
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:6907045
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:6907045
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6907045
G Max MYC associated factor X JBrowse link 6 99,984,260 100,011,460 RGD:6907045
G Mecom MDS1 and EVI1 complex locus JBrowse link 2 117,396,084 117,993,604 RGD:6907045
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:6907045
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:6907045
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:6907045
G Mos MOS proto-oncogene, serine/threonine kinase JBrowse link 5 16,746,085 16,747,392 RGD:6907045
G Mras muscle RAS oncogene homolog JBrowse link 8 107,629,028 107,656,851 RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:6907045
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:6907045
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:6907045
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:6907045
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6907045
G Nlk nemo like kinase JBrowse link 10 65,840,052 65,963,932 RGD:6907045
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 7 142,899,358 142,920,216 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6907045
G Ntf4 neurotrophin 4 JBrowse link 1 101,405,314 101,408,145 RGD:6907045
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:6907045
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6907045
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:70317
RGD:6907045
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6907045
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6907045
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6907045
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6907045
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:6907045
G Pla2g10 phospholipase A2, group X JBrowse link 10 1,509,732 1,520,970 RGD:6907045
G Pla2g12a phospholipase A2, group XIIA JBrowse link 2 235,311,664 235,327,972 RGD:6907045
G Pla2g12b phospholipase A2, group XIIB JBrowse link 20 28,989,440 29,007,967 RGD:6907045
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:6907045
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:6907045
G Pla2g2c phospholipase A2, group IIC JBrowse link 5 157,163,672 157,187,654 RGD:6907045
G Pla2g2d phospholipase A2, group IID JBrowse link 5 157,222,636 157,228,795 RGD:6907045
G Pla2g2f phospholipase A2, group IIF JBrowse link 5 157,192,047 157,217,265 RGD:6907045
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:6907045
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6907045
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:6907045
G Pla2g4e phospholipase A2, group IVE JBrowse link 3 111,952,396 112,018,470 RGD:6907045
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:6907045
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:6907045
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6907045
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:6907045
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:6907045
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:6907045
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:6907045
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:6907045
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6907045
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta JBrowse link 5 64,945,583 64,946,578 RGD:6907045
G Ppp5c protein phosphatase 5, catalytic subunit JBrowse link 1 78,944,054 78,968,361 RGD:6907045
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:6907045
G Ptpn7 protein tyrosine phosphatase, non-receptor type 7 JBrowse link 13 51,958,023 51,971,431 RGD:6907045
G Ptprr protein tyrosine phosphatase, receptor type, R JBrowse link 7 59,039,717 59,325,925 RGD:6907045
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6907045
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:6907045
G Rapgef2 Rap guanine nucleotide exchange factor 2 JBrowse link 2 177,836,191 178,057,378 RGD:6907045
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:6907045
G Rasa2 RAS p21 protein activator 2 JBrowse link 8 104,417,827 104,542,313 RGD:6907045
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:6907045
G Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 JBrowse link 2 21,460,041 21,698,937 RGD:6907045
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:6907045
G Rasgrp2 RAS guanyl releasing protein 2 JBrowse link 1 221,771,238 221,788,765 RGD:6907045
G Rasgrp3 RAS guanyl releasing protein 3 JBrowse link 6 21,072,634 21,171,619 RGD:6907045
G Rasgrp4 RAS guanyl releasing protein 4 JBrowse link 1 88,078,350 88,094,331 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G RGD1564956 similar to calcium binding protein P22 JBrowse link 5 70,747,534 70,749,967 RGD:6907045
G RGD1565395 similar to stathmin 1/oncoprotein 18) JBrowse link 10 83,147,416 83,147,903 RGD:6907045
G RGD1565588 similar to calcium binding protein P22 JBrowse link 4 6,477,461 6,479,158 RGD:6907045
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:6907045
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:6907045
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:6907045
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:6907045
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:6907045
G Rras RAS related JBrowse link 1 101,012,822 101,016,720 RGD:6907045
G Rras2 RAS related 2 JBrowse link 1 178,940,515 179,010,257 RGD:6907045
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1304398
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:6907045
G Stk3 serine/threonine kinase 3 JBrowse link 7 73,617,926 73,883,896 RGD:6907045
G Stk4 serine/threonine kinase 4 JBrowse link 3 160,467,552 160,546,540 RGD:6907045
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6907045
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:6907045
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:6907045
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6907045
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6907045
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580517
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:2298532
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298532
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2293882
RGD:5133243
RGD:5133242
RGD:2298531
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:5490966
RGD:5490965
RGD:5133242
RGD:4143515
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:5133243
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:2293882
c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:2293876
RGD:2293879
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:2293881
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:2293881
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:2293881
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:2314491
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:2293881
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:2293875
RGD:2298708
RGD:2298577
RGD:2298561
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:2293875
RGD:2298577
RGD:2298567
RGD:2298561
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:2293879
RGD:2293875
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:2293875
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:2293876
RGD:2298577
RGD:2298567
RGD:2293875
G Map3k12 mitogen activated protein kinase kinase kinase 12 JBrowse link 7 144,102,275 144,120,306 RGD:2293875
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:2293879
RGD:2293875
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2293879
RGD:2293875
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:2293879
RGD:2293875
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:2293875
G Map3k9 mitogen-activated protein kinase kinase kinase 9 JBrowse link 6 105,455,461 105,518,974 RGD:2293875
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:2293875
RGD:2298567
RGD:2298561
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:2293875
RGD:2298577
RGD:2298561
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:2293880
RGD:1579811
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:2293880
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:2293880
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:2293875
RGD:2298577
RGD:2298561
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:2293876
RGD:2293879
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:11534984
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2296020
Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:2298532
RGD:1582263
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:2298532
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2298532
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298532
RGD:2298794
G Sh2d2a SH2 domain containing 2A JBrowse link 2 187,218,851 187,225,000 RGD:2298532
G Wnk1 WNK lysine deficient protein kinase 1 JBrowse link 4 152,452,211 152,578,469 RGD:2298532
p38 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1625329
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6484113
G Bnip2 BCL2 interacting protein 2 JBrowse link 8 76,400,333 76,426,307 RGD:7240533
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6484113
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6484113
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6484113
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6484113
G Ccm2 CCM2 scaffold protein JBrowse link 14 86,812,728 86,859,408 RGD:2293891
RGD:7240533
RGD:6484113
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:7240533
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:7240533
G Dlk1 delta like non-canonical Notch ligand 1 JBrowse link 6 133,576,513 133,583,751 RGD:7240533
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:7240533
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:7240533
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:7240533
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:7240533
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6484113
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6484113
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6484113
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128786
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:2293891
RGD:6484113
RGD:2298758
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:2293891
RGD:6484113
RGD:2298758
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:6484113
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:7240533
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:7240533
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2293891
RGD:7240533
RGD:6484113
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:6484113
RGD:7240533
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
RGD:7240533
G Map3k6 mitogen-activated protein kinase kinase kinase 6 JBrowse link 5 151,435,679 151,448,329 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:2293891
RGD:7240533
RGD:6484113
RGD:2298758
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:7240533
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:2293891
RGD:6484113
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:2293891
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:2293891
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1580544
RGD:6484113
RGD:2293891
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:2293891
RGD:2302280
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:2315047
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:2315047
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:2315047
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:7240533
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:2293891
RGD:6484113
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:7240533
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:6484113
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:6484113
RGD:7240533
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:6484113
RGD:7240533
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2296020
RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6484113
RGD:7240533
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6484113
the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Araf A-Raf proto-oncogene, serine/threonine kinase JBrowse link X 1,369,534 1,391,603 RGD:5686410
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:1580106
RGD:5686410
RGD:1626216
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:2293881
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:5686410
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:628557
RGD:5686410
G Ksr1 kinase suppressor of ras 1 JBrowse link 10 66,323,704 66,342,469 RGD:2293880
RGD:5686410
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:70317
RGD:1626216
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:729046
RGD:1626216
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:1357969
RGD:2293879
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:724475
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:628468
RGD:8553011
RGD:1626216
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:628468
RGD:8553011
RGD:1626216
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
RGD:8553011
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:5686410
G Pebp1 phosphatidylethanolamine binding protein 1 JBrowse link 12 45,026,948 45,031,148 RGD:2293882
RGD:2302807
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1642529
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642630
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:70317
RGD:5686410
RGD:1626216
RGD:1580106
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:2315047
G Rps6ka2 ribosomal protein S6 kinase A2 JBrowse link 1 53,219,346 53,499,445 RGD:2315047
G Rps6ka3 ribosomal protein S6 kinase A3 JBrowse link X 37,469,736 37,576,055 RGD:2315047
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Rps6ka6 ribosomal protein S6 kinase A6 JBrowse link X 82,641,679 82,743,771 RGD:2315047
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1304283
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1643182
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1643230
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1580097

Pathway Gene Annotations

Disease Annotations Associated with Genes in the mitogen activated protein kinase signaling pathway
Disease TermsGene Symbols
22q11 Deletion SyndromeFgf8
46 XY gonadal dysgenesisMap3k1
46,XY Sex Reversal 6Map3k1
abdominal aortic aneurysmMapk8
Aberrant Crypt FociFos , Mapk1 , Mapk3 , Myc , Tgfb2
Abortion, SpontaneousFgf7 , Il1b , Tgfb1 , Tgfbr1
acanthosis nigricansFgfr3
achondroplasiaFgfr3
Achondroplastic DwarfismFgfr3
acneTnf , Tnfrsf1a
Acneiform EruptionsFgfr2
acoustic neuromaBdnf , Fgfr1
acquired immunodeficiency syndromeTnf , Tnfrsf1a
acrocephalosyndactyliaFgfr1 , Fgfr2 , Fgfr3
Acromicric DysplasiaTgfb1
actinic keratosisTgfb1
Acute Coronary SyndromeHspa1a , Hspa8 , Tnf
Acute HepatitisTsc2
acute kidney failureDdit3 , Egf , Egfr , Fas , Hspa1a , Hspa8 , Il1a , Il1b , Myc , Nfkb1 , Tgfb1 , Tnf , Tnfrsf1a , Tp53
Acute Liver FailureCd14 , Fas , Faslg , Hspa8 , Mapk8 , Tnf
Acute Lung InjuryEgfr , Fas , Faslg , Il1b , Ngf , Pak1 , Pla2g2a , Tgfb1 , Tnf
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesFgfr1
acute myeloid leukemiaFas , Fgfr1 , Hras , Hspb1 , Il1a , Kras , Myc , Nf1 , Nras , Rasgrp1 , Tp53 , Tsc2
acute myocardial infarctionCacng4
acute promyelocytic leukemiaAkt1 , Myc , Nras
Acute-Phase ReactionDdit3
adenocarcinomaEgf , Egfr , Erbb2 , Fgf9 , Hspa8 , Il1b , Kras , Myc , Nfkb1 , Tgfb1 , Tnf , Tp53
adenoid cystic carcinomaFgf16 , Fgfr2 , Fgfr4 , Hras , Kras , Map2k2 , Mecom , Tp53
adenomaCacna1d , Kras , Nf1 , Tp53
adrenal carcinomaBraf , Nras , Tp53
adrenal cortical adenomaPrkaca
Adrenal Gland NeoplasmsCdc42 , Prkaca , Tp53
Adrenal InsufficiencyPla2g2a
adrenocortical carcinomaBraf , Daxx , Egfr , Nras , Tp53
adult respiratory distress syndromeFgfr4 , Il1b , Pla2g2a , Pla2g4a , Tnf , Tnfrsf1a
adult T-cell leukemiaFas , Nras , Prkcb , Tp53
aggressive periodontitisIl1r2
agranulocytosisIl1b
AIDS Dementia ComplexIl1b , Pdgfb
AIDS-Associated NephropathyEgf
Aland Island eye diseaseCacna1f
AlbuminuriaIl1b , Tnf
alcoholic hepatitisTnf
alcoholic liver cirrhosisRela , Tgfb1 , Tnf
Alcoholic Liver DiseasesIl1b
allergic bronchopulmonary aspergillosisIl1a , Tnf , Tnfrsf1a
allergic conjunctivitisIl1b , Pla2g2a , Tgfb1
allergic contact dermatitisIl1a , Tnf
allergic hypersensitivity diseaseCd14 , Il1b , Il1r1 , Il1r2 , Map2k6 , Tgfb1 , Tnf , Tnfrsf1a
allergic rhinitisIl1b
alopeciaBdnf
Alport syndromeIl1b
Alveolar Bone LossTnf
Alzheimer's diseaseAkt1 , Atf2 , Bdnf , Casp3 , Cdc42 , Egf , Egfr , Elk1 , Fas , Fgf1 , Fgfr1 , Hras , Hspa1a , Hspa1b , Hspb1 , Ikbkb , Il1a , Il1b , Mapk10 , Mapk14 , Mapk8 , Mapk9 , Mapt , Ngf , Ntf3 , Ntrk1 , Ntrk2 , Pak1 , Pdgfb , Ptpn5 , Shc1 , Tnf , Tp53 , Tsc2
ameloblastomaBraf
amnestic disorderBdnf , Il1a , Ngf
amphetamine abuseAkt1 , Arrb2 , Bdnf , Fos , Map2k5 , Rela
Amyloid NeuropathiesDusp1
amyloidosisTnf , Tnfrsf1a
amyotrophic lateral sclerosisAkt1 , Cacna1a , Casp3 , Mapk14 , Pla2g4a , Tnf , Tp53
amyotrophic lateral sclerosis type 1Fgf6 , Fos , Jund , Pdgfa , Shc1 , Tnf
Anaplastic Thyroid CarcinomaTp53
anemiaIl1b , Kras , Tnf , Tnfrsf1a
Anemia, RefractoryTnf
AnetodermaTgfb1
AneurysmFlna , Tgfbr2
Angina, StableTnf
angiomyolipomaTsc2
angiosarcomaHras , Jun , Kras , Myc , Tp53
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsAkt1 , Cacna1d , Erbb2 , Fas , Fos , Il1b , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mapt , Myc , Prkcg , Tnf , Tp53
ankylosing spondylitisIl1r2
ankylosisFgfr2
Anorectal MalformationsFgfr2
AnorexiaIl1a , Il1b , Tnf , Tnfrsf1a
anterior uveitisTnf
anthracosisIl1a , Il1b , Tnf
anti-basement membrane glomerulonephritisDusp1 , Il1b , Mapk14 , Mapk8 , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas , Tnf , Tnfrsf1a
Antley-Bixler syndromeFgfr2
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISFgfr2
anxiety disorderFos , Tnf
aortic aneurysmFlna , Tgfb2 , Tgfbr1 , Tgfbr2
aortic valve diseaseEgfr
aortic valve insufficiencyTgfb1 , Tgfb2
aortic valve stenosisEgfr , Ppp3cb
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Aplasia of Lacrimal and Salivary GlandsFgf10
aplastic anemiaFas , Faslg , Tgfb1 , Tnf
arrhythmogenic right ventricular cardiomyopathyTgfb3
arrhythmogenic right ventricular dysplasia 1Tgfb3
Arsenic PoisoningGadd45b , Hspa1b , Il1a , Il1b , Tnf , Tp53
Arterial ThrombosisFlna
arterial tortuosity syndromeFlna
arteriosclerosisDusp1 , Faslg , Il1b , Mapk9 , Rela , Tgfb1 , Tgfbr2 , Tnfrsf1a
Arteriovenous FistulaArrb1 , Arrb2 , Fgf2
arteriovenous malformationRasa1
arteriovenous malformations of the brainCacna1h , Egfr , Kras , Map4k4
asbestosisDdit3 , Tnf
AsphyxiaJun
asphyxiating thoracic dystrophyFgfr3
aspiration pneumoniaIl1a , Tnf
Aspirin-Induced AsthmaCacng6
asthmaBdnf , Cd14 , Chuk , Egfr , Fas , Il1a , Il1b , Ngf , Ntf3 , Ntf4 , Ntrk1 , Pdgfb , Pla2g4a , Tgfb1 , Tnf , Tnfrsf1a
Asthma, OccupationalPla2g4a , Prkca , Tgfb1 , Tnf
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Fgfr1 , Hras , Kras , Map2k3 , Nf1 , Ntrk2 , Tp53
AtaxiaBdnf , Cacna1a , Cacna2d2 , Cacnb4
atelosteogenesisFlnb
Atelosteogenesis Type 1Flnb
Atelosteogenesis Type 3Flnb
atherosclerosisAkt1 , Faslg , Fgf21 , Hspa1a , Hspa1b , Il1b , Ngf , Pdgfrb , Pla2g2a , Tnf
atopic dermatitisBdnf , Il1b , Mapk8 , Ngf , Ntrk1 , Tgfb1 , Tnf
atrial fibrillationTnf
atrial heart septal defect 1Ntf3
atrophic gastritisIl1b
AtrophyMapk3
attention deficit hyperactivity disorderBdnf , Ntrk2
atypical chronic myeloid leukemiaFgfr1
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autism spectrum disorderBdnf , Cacnb2 , Dusp14 , Mapk11 , Mapk12 , Mapk3 , Mapk8ip2 , Mef2c , Taok2 , Tsc2
autistic disorderBdnf , Cacna1c , Cacna1h , Egf , Hras , Mapk1 , Mef2c , Nf1 , Ntf3 , Ntf4 , Ntrk2 , Pla2g4a , Prkcb , Tnf , Tsc2
Autoimmune DiseasesFas , Tgfb2 , Tnfrsf1a
autoimmune hepatitisTgfb1
autoimmune lymphoproliferative syndromeFas , Faslg , Nras
autoimmune lymphoproliferative syndrome type 4Kras , Nras
Autoimmune Lymphoproliferative Syndrome, Type IAFas
autoimmune thrombocytopenic purpuraFas , Il1a , Tgfb1
autoimmune thyroiditisTnf
autosomal dominant diseaseFgfr3
autosomal dominant familial periodic feverTnfrsf1a
autosomal dominant hypophosphatemic ricketsFgf23
autosomal dominant mental retardation 20Mef2c
autosomal dominant mental retardation 48Rac1
autosomal dominant non-syndromic intellectual disability 10Cacng2
autosomal dominant polycystic kidney diseaseCd14 , Fos , Myc
autosomal recessive Alport syndromeHras
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive limb-girdle muscular dystrophy type 2AFlna
autosomal recessive limb-girdle muscular dystrophy type 2JPdgfra
autosomal recessive nonsyndromic deafness 4Fgfr1
autosomal recessive Parkinson's disease 14Pla2g6
autosomal recessive polycystic kidney diseaseAkt1 , Cd14 , Egfr , Myc
autosomal recessive pseudohypoaldosteronism type 1Tnfrsf1a
B-Cell LeukemiaMyc
B-cell lymphomaNras
background diabetic retinopathyPdgfb
BacteremiaMapkapk3
bacterial infectious diseaseCasp3
Bacterial KeratitisIl1r1
bacterial meningitisBdnf , Ngf , Ntrk2
bacterial pneumoniaCd14 , Chuk , Il1b , Tnf , Tnfrsf1a
Balkan nephropathyTp53
Bardet-Biedl syndromeAkt3
Barrett's esophagusFas , Rela
basal cell carcinomaErbb2 , Rasa1 , Tp53
basal ganglia calcificationPdgfb , Pdgfrb
basal ganglia diseasePdgfb , Pdgfrb
Beare-Stevenson cutis gyrata syndromeFgfr2
Behcet's diseaseFas , Ikbkg , Il1b , Tgfb1 , Tnf , Tnfrsf1a
Bent Bone Dysplasia SyndromeFgfr2
berylliosisTgfb1 , Tnf
beta thalassemiaIl1a , Tnf
Bile Duct NeoplasmsEgfr
biliary atresiaCd14
biliary tract diseaseFgf2
biliary tract neoplasmFaslg , Prkacb
bilirubin metabolic disorderTnf
bipolar disorderAkt1 , Bdnf , Cacna1c , Cacna1d , Cdc42 , Ntrk1 , Ntrk2
bladder carcinomaFgfr3 , Hras
bladder diseaseFgf2 , Ngf
bladder neck obstructionNgf
bladder urothelial carcinomaAkt1 , Braf , Erbb2 , Fgfr3 , Hras , Kras , Map2k1 , Nras , Tp53
blindnessNf1
Bloch-Sulzberger syndromeIkbkg
blood platelet diseasePla2g4a
Body WeightBdnf , Map2k5
bone development diseaseChuk , Fgfr3 , Flnb , Rps6ka3 , Tgfb2 , Tp53
bone diseaseFgf2 , Tgfbr2
Bone FracturesFgf2 , Tgfbr2
Bone Marrow NeoplasmsTp53
Bone NeoplasmsTgfbr2
Boomerang dysplasiaFlnb
BradycardiaCacna1d
Brain DeathMap2k4 , Map2k6
brain diseaseTgfb1 , Tsc2
brain edemaTnf
brain infarctionFgf2 , Il1b , Pdgfb
Brain InjuriesAkt1 , Bdnf , Casp3 , Cd14 , Dusp5 , Elk1 , Fas , Fgf2 , Fos , Hspa1a , Hspb1 , Il1a , Il1b , Il1r1 , Jun , Pdgfa , Pdgfb , Pdgfra , Pdgfrb , Ppp3ca , Rela , Tnf , Tnfrsf1a
brain ischemiaAkt1 , Bdnf , Casp3 , Ddit3 , Dusp6 , Fas , Faslg , Fgf1 , Hspa1b , Hspa8 , Il1a , Il1b , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapt , Nfkb1 , Pak1 , Pla2g4a , Prkaca , Prkacb , Prkca , Rela , Tgfb1 , Tnf , Tnfrsf1a , Tp53
Brain NeoplasmsBraf , Egfr , Hras , Nras , Rela , Tgfbr2 , Tp53 , Tsc2
breast adenocarcinomaAkt1 , Kras , Tp53
breast cancerAkt1 , Braf , Erbb2 , Fgfr2 , Fgfr4 , Grb2 , Hras , Kras , Myc , Nfkb1 , Tp53
Breast Cancer, FamilialTp53
breast ductal carcinomaCacna1c , Cacna1h
Breast NeoplasmsAkt1 , Akt2 , Braf , Casp3 , Cdc25b , Crkl , Ddit3 , Dusp1 , Dusp6 , Egf , Egfr , Erbb2 , Fas , Faslg , Fgf10 , Fgf2 , Fgf3 , Fgf4 , Fgf8 , Fgfr1 , Fgfr2 , Fgfr3 , Fgfr4 , Flna , Fos , Hras , Hspa1b , Ikbkb , Il1b , Jun , Kras , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k7 , Map3k1 , Mapk1 , Mapt , Mecom , Myc , Pak1 , Pak2 , Pdgfa , Pdgfra , Pdgfrb , Pla2g4a , Prkca , Raf1 , Rela , Stmn1 , Tgfb1 , Tnf , Tp53 , Tsc2
Bronchial HyperreactivityCd14 , Il1b , Ngf , Tnf
bronchiectasisIl1b , Tnf
Bronchiectasis with or without Elevated Sweat Chloride 1Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 2Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 3Tnfrsf1a
bronchiolitisIl1b
bronchiolo-alveolar adenocarcinomaEgfr , Kras , Tp53
Bronchopulmonary DysplasiaIl1b , Tnf
Brugada syndromeCacna1c , Cacna2d1 , Cacnb2
Brugada syndrome 3Cacna1c
Brugada syndrome 4Cacnb2
bulimia nervosaBdnf
Burkitt lymphomaMyc
BurnsCasp3 , Cd14 , Fgfr1 , Il1a , Il1b , Ngf , Pla2g4a , Tnf
Burns, ChemicalFgfr2 , Il1a , Il1b , Il1r1
CachexiaIl1b , Tgfb1 , Tnf , Tnfrsf1a
Cafe au lait Spots, MultipleNf1 , Sos1
Cafe-au-Lait SpotsNf1
CAKUTHspa1b
calcinosisCasp3 , Erbb2 , Fgf23 , Il1b , Pdgfb , Pdgfrb , Tgfb1
camptodactyly-tall stature-scoliosis-hearing loss syndromeFgfr3
Camurati-Engelmann diseaseTgfb1
cannabis abuseAkt1
capillary hemangiomaAkt3
Capillary Malformation-Arteriovenous MalformationRasa1
CarcinogenesisBraf , Erbb2 , Kras
carcinomaCdc42 , Dusp6 , Egfr , Fgfr3 , Hras , Kras , Myc , Pdgfa , Rasa1 , Rasgrf2 , Stmn1 , Tgfb1 , Tgfbr2 , Tp53
carcinosarcomaTgfb1
cardiac arrestAkt1 , Cacna2d1 , Cacnb2 , Tnf
Cardiac ArrhythmiasCacna1c , Cacna2d2 , Cacnb2 , Map2k4
Cardiac Complexes, PrematureCacna1c , Cacnb2
Cardiac Conduction Defect, NonspecificCacnb2
Cardiac FibrosisPak1 , Tgfb1
Cardiac Valvular Dysplasia, X-LinkedFlna
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Egfr , Fgf2 , Fgf21 , Il1b , Map2k5 , Map2k6 , Mapk1 , Mapk8 , Myc , Pak1 , Pdgfrb , Ppp3ca , Prkca , Prkcb , Rac1 , Raf1 , Rela , Shc1 , Srf , Tgfb1 , Tnf
cardiomyopathyAkt1 , Fas , Faslg , Flnc , Il1a , Il1b , Kras , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Mapt , Srf , Tnf , Tp53
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1 , Sos1
CardiotoxicityRac1
Cardiovascular AbnormalitiesFgf8 , Map2k1 , Srf
cardiovascular system diseaseHspa1a
Cardiovirus InfectionsTnf
carotid artery diseaseCd14 , Faslg , Mras , Tgfb1 , Tp53
Carotid Artery InjuriesDusp1 , Myc
Carotid AtherosclerosisFgf21
carotid stenosisFaslg
cartilage diseaseFgf14
cataractFas , Fgf2 , Map2k1 , Tp53
Cecal NeoplasmsKras , Tp53
celiac diseaseCd14
Cell Transformation, NeoplasticEgf , Fos , Hras , Jun , Kras , Mapk8 , Myc , Nfkb1 , Rac1 , Rela , Tgfb1 , Tp53
Central Nervous System NeoplasmsTp53
Centronuclear Myopathy 6, with fiber-type disproportionMap3k20
cerebellar ataxiaCacna1a
Cerebral HemorrhageBdnf , Casp3 , Cd14 , Nfkb1 , Nfkb2 , Rela
cerebral infarctionTnf
cervical cancerFgfr3 , Tp53
cervix carcinomaFgfr3 , Tp53
cervix uteri carcinoma in situFaslg , Rela
Charcot-Marie-Tooth diseaseHspb1 , Ntrk2
Charcot-Marie-Tooth disease axonal type 2FHspb1
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryCdc25b , Fas , Gadd45a , Hspa8 , Il1a , Il1b , Il1r2 , Rasa1 , Shc1 , Tgfbr1 , Tnf
Chemotherapy-Induced Febrile NeutropeniaTp53
Chest TraumaFas
childhood absence epilepsyCacna1a , Cacna1h , Cacna2d2 , Cacng2 , Cacng3 , Fgfr3
childhood electroclinical syndromeCacna1a
Childhood SchizophreniaRela
chlamydiaTnf
ChloracneEgfr , Gadd45a
cholangiocarcinomaEgfr , Erbb2 , Faslg , Fgf2 , Fgfr2 , Kras , Prkaca , Prkacb , Tgfb1 , Tgfbr2 , Tp53
cholangitisTgfb2
cholecystolithiasisPla2g2a
cholestasisCd14 , Il1a , Mapk13 , Mapk14 , Pdgfb , Rela , Tnf
cholesteatomaIl1a , Il1b
cholesteatoma of middle earFgf2 , Il1a , Il1r1 , Rela , Tnf , Tp53
chondrosarcomaFgfr3
choreatic diseaseCacna2d2
chorioamnionitisFas , Il1a , Tgfb1 , Tnf
choriocarcinomaFgf8 , Pdgfb , Pdgfrb
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Choroidal NeovascularizationFgf2 , Ikbkb
Chromosome 17 DeletionTp53
Chromosome 17, Trisomy 17p11 2Mapk7
chromosome 17q12 deletion syndromeDusp14
Chromosome BreakageMyc
Chronic Allograft DysfunctionTnf
Chronic Allograft NephropathyPdgfa , Pdgfb , Pdgfra , Pdgfrb
Chronic Cerebral HypoperfusionMapk14
chronic conjunctivitisFas
chronic kidney diseaseFgf21 , Fgf23 , Il1b , Ngf
chronic lymphocytic leukemiaBraf , Fgf16 , Hras , Kras , Myc , Nras , Tp53
Chronic Lymphocytic Leukemia, B-CellBraf , Fas , Fgf16 , Hras , Il1a , Il1b , Kras , Nras , Tnf , Tp53
chronic myeloid leukemiaAkt1 , Braf , Crkl , Fas , Faslg , Il1b , Mapk14 , Nras
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseEgfr , Il1b , Map2k4 , Mapk8 , Ntf3 , Ntrk1 , Tgfb1 , Tnf , Tnfrsf1a , Tp53
Chronic PainBdnf , Ntrk2
Chronic PeriodontitisRac2
chronic progressive external ophthalmoplegiaIl1a , Il1b
chronic ulcer of skinFgf2 , Ngf , Pdgfa , Pdgfra
Chronic UveitisFas
cicatricial pemphigoidTnf
clear cell adenocarcinomaDaxx , Tp53
clear cell renal cell carcinomaMyc , Pdgfb
cleft lipFgf1 , Fgf10 , Fgf2 , Fgf3 , Fgf7 , Fgf8 , Fgf9 , Fgfr1 , Fgfr2 , Fgfr3 , Myc
cleft palateChuk , Egf , Fgf10 , Fgf2 , Fgf3 , Fgf7 , Fgf8 , Fgf9 , Fgfr1 , Fgfr2 , Fgfr3 , Flna , Flnb , Myc , Pdgfra , Tgfb1 , Tgfb2 , Tgfb3
cleft soft palateTgfbr2
clonorchiasisFas , Faslg
clubfootFlnb
Cocaine-Related DisordersBdnf , Fgf2 , Fos , Jund , Mapk1 , Mapk3 , Ngf , Ntrk2 , Rps6ka5
cocoon syndromeChuk
Coffin-Lowry syndromeRps6ka3
Cognition DisordersBdnf , Fgf14 , Mapk14 , Mapt
cognitive disorderFgf2
Cognitive DysfunctionIl1b
colitisArrb1 , Bdnf , Chuk , Dusp1 , Fgf19 , Ikbkb , Il1b , Ntrk1 , Ntrk2 , Pla2g2a , Rela , Tnf
colon adenocarcinomaDaxx , Mapk1 , Mapk3 , Rac1 , Tgfb1
colon adenomaRac1
colon cancerAkt1 , Braf , Nras , Pla2g2a , Tgfb3 , Tgfbr2 , Tp53
colon carcinomaAkt1 , Braf , Fgfr3 , Nras , Tgfb1 , Tgfb2 , Tp53
Colonic NeoplasmsAkt2 , Akt3 , Braf , Cacna2d1 , Casp3 , Crkl , Egfr , Erbb2 , Fas , Fos , Hspa2 , Hspb1 , Ikbkb , Il1b , Jun , Kras , Map2k3 , Map2k6 , Mapk8 , Mapk9 , Mecom , Myc , Nfkb1 , Pdgfrb , Rela , Tgfbr2 , Tnf , Tnfrsf1a , Tp53
color blindnessBdnf
colorectal adenocarcinomaFos , Jun , Mapk1 , Mapk3 , Mapk8 , Raf1 , Tp53
colorectal adenomaFos , Jun , Mapk8 , Raf1 , Tnfrsf1a
colorectal cancerAkt1 , Braf , Fgfr3 , Nras , Rac1 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Egfr , Erbb2 , Fgfr3 , Flnc , Fos , Hras , Hspa8 , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pla2g2a , Prkcb , Raf1 , Tgfb1 , Tgfb2 , Tgfbr1 , Tnf , Tp53
Combined Oxidative Phosphorylation Deficiency 11Tp53
common coldIl1a , Il1b
common variable immunodeficiencyNfkb1 , Nfkb2
Common Variable Immunodeficiency 12Nfkb1
complex cortical dysplasia with other brain malformationsAkt3 , Hras
cone dystrophyCacna2d4
cone-rod dystrophyCacna2d4
cone-rod dystrophy 14Cacna2d4
congenital central hypoventilation syndromeBdnf
congenital diaphragmatic herniaFgf18 , Fgf2 , Pdgfra , Tgfb1 , Tnf
Congenital Foot DeformitiesFgfr1
Congenital Generalized FibromatosisPdgfrb
congenital heart diseaseTgfb2
Congenital Idiopathic Intestinal PseudoobstructionFlna
Congenital Limb DeformitiesCacna1c , Chuk , Fgfr2 , Tgfb2
congenital myasthenic syndrome 10Cacna1c
congenital myasthenic syndrome 4CNtrk1
Congenital Myopathy, with Excess of Muscle SpindlesHras
congenital stationary night blindnessCacna1f
congenital stationary night blindness 2ACacna1f
congestive heart failureArrb1 , Erbb2 , Fas , Fos , Hspb1 , Il1b , Map2k7 , Prkaca , Prkca , Prkcb , Rac1 , Srf , Tnf , Tnfrsf1a , Tp53
contact dermatitisDdit3 , Dusp1 , Hspb1
Contrast-Induced NephropathyIl1b
Copper-Overload CirrhosisCasp3 , Tgfb1
Cor pulmonaleTnf
corneal edemaIl1a
corneal neovascularizationFas , Fgf2
corneal ulcerNgf , Tnf
coronary artery diseaseAkt1 , Cd14 , Fgf2 , Il1b , Mras , Ngf , Tgfb1 , Tnf , Tnfrsf1a , Traf6
Coronary DiseaseCd14 , Fgf2 , Hspa1a , Il1b , Mras
Coronary OcclusionHspa1a
coronary restenosisMapk1 , Myc , Tnf , Tp53
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2
CoughTnf
Cowden diseaseAkt1 , Egfr
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1
Coxsackievirus InfectionsTnf
Craniocerebral TraumaIl1a
Craniofacial AbnormalitiesEgfr , Fgf3 , Fgf8 , Fgfr1 , Fgfr2 , Pdgfra , Tgfb2 , Tgfbr2 , Tp53
craniopharyngiomaBraf , Pdgfra
craniosynostosisFgfr1 , Fgfr2 , Fgfr3 , Flna
Craniosynostosis Syndrome, Autosomal RecessiveFgfr2
crescentic glomerulonephritisIl1b
Creutzfeldt-Jakob diseaseIl1a
Crohn's diseaseHspa1l , Tnf , Tnfrsf1a
Crouzon syndromeFgfr2 , Fgfr3
Crouzon syndrome-acanthosis nigricans syndromeFgfr3
cryoglobulinemiaTnf
cryptogenic organizing pneumoniaTnfrsf1a
cryptorchidismCasp3 , Rela
Currarino TriadMap3k13
cutaneous leishmaniasisIl1b , Tnf
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1 , Braf , Cacna1c , Cacna1s , Hras , Map2k1 , Map2k2 , Nf1 , Nras , Pdgfra , Rac1 , Raf1 , Tp53
cutaneous T cell lymphomaBraf , Fas , Nfkb2 , Tp53
CyanosisTgfb2
Cystadenoma, SerousDaxx
cystic fibrosisCd14 , Fas , Faslg , Hspa1a , Il1a , Il1b , Tgfb1 , Tnf , Tnfrsf1a
cystitisBdnf , Il1b , Ngf , Rela , Tnf
Cytomegalovirus InfectionsTnf
cytomegalovirus retinitisTnf , Tnfrsf1a
DeafnessBdnf , Cacna1d
Deafness, Congenital, with Inner Ear Agenesis, Microtia, and MicrodontiaFgf3
decubitus ulcerFgf2
degenerative disc diseaseCrk , Ngf , Tgfb1
dementiaEgfr , Mapt
demyelinating diseaseFgf2 , Fgfr1 , Fgfr3 , Myc , Tnf , Tp53
dermatitisEgf , Egfr , Fgf2 , Ikbkb , Pla2g4a , Tnf
dermatitis herpetiformisTnf
dermatofibrosarcoma protuberansPdgfb
dermatomyositisFas , Il1a , Il1b , Tnf
developmental coordination disorderFgfr2
Developmental DisabilitiesAkt3 , Braf , Cacna1a , Ntrk2 , Rps6ka3
diabetes mellitusRac1
diabetic angiopathyCasp3 , Fas , Faslg , Rela , Tnf
Diabetic CardiomyopathiesErbb2 , Tnf
diabetic encephalopathyDusp1 , Ngf
Diabetic FootHspa1b
Diabetic NephropathiesBdnf , Cacna1b , Casp3 , Egf , Fas , Faslg , Fgf2 , Fgf21 , Fgf23 , Hspa1a , Hspa1b , Hspa8 , Hspb1 , Il1b , Mapk1 , Mapk14 , Ntrk2 , Pdgfa , Pdgfb , Pdgfrb , Prkcb , Rela , Tgfb1 , Tgfbr2 , Tnf , Tnfrsf1a , Tp53
diabetic neuropathyBdnf , Casp3 , Fgf2 , Il1b , Mapk14 , Ngf , Ntf3 , Ntrk1 , Tgfb1 , Tgfb2 , Tgfb3 , Tnf
diabetic retinopathyBdnf , Casp3 , Egfr , Fgf2 , Hras , Il1a , Il1b , Ngf , Tnf
Diamond-Blackfan anemiaTp53
Diaphyseal Dysplasia 1, ProgressiveTgfb1
diarrheaCd14 , Il1a
diffuse large B-cell lymphomaFas , Tp53
DiGeorge syndromeCrkl , Fgf8 , Tgfbr2
Dilatation, PathologicTgfb1
dilated cardiomyopathyCacna1c , Cacnb2 , Cacnb4 , Cacng8 , Egfr , Erbb2 , Fas , Faslg , Flnc , Kras , Map2k5 , Mef2c , Nfatc4 , Ppp3ca , Ppp3r1 , Prkca , Prkcb , Rac1 , Raf1 , Srf , Tnf
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1HTnf
dilated cardiomyopathy 1NNRaf1
disease by infectious agentTnf
disease of cellular proliferationAtf2 , Braf , Erbb2 , Fgfr1 , Hras , Il1b , Kras , Map2k1 , Myc , Nras , Srf , Tp53
disease of metabolismHspa8
Disease ProgressionAtf2 , Egf , Egfr , Erbb2 , Fgf2 , Hras , Il1a , Myc
Dissecting AneurysmTgfbr1 , Tgfbr2
disseminated intravascular coagulationTnf
Distal Hereditary Motor Neuronopathy, Type IIBHspb1
Distal Hereditary Motor Neuropathy, Type IHspb1
distal muscular dystrophyFlnc
Down syndromeNtf3
drug allergyFaslg , Hspa1a , Hspa1l , Tnf
Drug EruptionsBdnf
Drug Hypersensitivity SyndromeHspa1l , Il1b
Drug-Induced AgranulocytosisIl1b
Drug-Induced DyskinesiaCacna1d , Rasgrf1 , Rela
Drug-Induced Immune ThrombocytopeniaIl1a , Il1b
Drug-induced NeutropeniaIl1a , Tp53
Drug-Related Side Effects and Adverse ReactionsTp53
dry eye syndromeIl1b , Tgfb1 , Tnf
Duchenne muscular dystrophyPla2g6 , Tgfb1
ductal carcinoma in situErbb2 , Pak2 , Prkca , Rela , Tp53
duodenal atresiaFgfr2
duodenal ulcerPla2g4a , Tgfb1
DwarfismFgfr3
DysarthriaCacna1a
dysembryoplastic neuroepithelial tumorBraf
dysgerminomaFgfr2
dyskeratosis congenitaTp53
DyskinesiasRasgrf1
dystoniaCacna1b
dystonia 12Pla2g6
dystonia 23Cacna1b
Eales DiseaseIl1b , Tnf
early infantile epileptic encephalopathyCacna2d2
Early Infantile Epileptic Encephalopathy, 42Cacna1a
Early Infantile Epileptic Encephalopathy, 47Fgf12
EczemaCd14
EdemaCasp3 , Il1b , Map2k6 , Tnf
Ehlers-Danlos syndromeTgfb1
Ehlers-Danlos Syndrome Classic TypeFlna
embryonal carcinomaFgf8
EmphysemaTnf , Tp53
encephalitisIl1b , Rela , Tnf
Encephalocraniocutaneous LipomatosisFgfr1
encephalomyelitisTnf
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsFlna , Ikbkg
End Stage Liver DiseaseTnfrsf1a
end stage renal failureIl1a , Il1b , Nfkb1 , Ngf , Rela , Tgfb1 , Tnf , Tnfrsf1a
Endocrine Bone DiseasesPdgfa
endodermal sinus tumorFgf8
endometrial cancerEgf , Fgfr2 , Tp53
endometrial carcinomaFgfr2 , Fgfr3 , Kras , Tsc2
Endometrial HyperplasiaCdc25b , Kras
Endometrial NeoplasmsAkt2 , Braf , Cdc25b , Egf , Erbb2 , Fgf1 , Fgf2 , Fgf7 , Fgfr2 , Grb2 , Jun , Kras , Map3k4 , Mapk1 , Mapk3 , Myc , Prkca , Tnfrsf1a , Tp53
Endometrioid CarcinomasAkt1 , Daxx , Egfr , Erbb2 , Fgfr2 , Kras , Pdgfra , Pdgfrb
endometriosisDusp1 , Egfr , Fgfr2 , Fos , Il1r1 , Kras , Nr4a1 , Ntrk1 , Pla2g2a , Rasgrp1 , Tgfb2 , Tnf
endometritisIl1a
endomyocardial fibrosisTgfb1
endophthalmitisFas , Il1b , Tnf
EndotoxemiaAtf2 , Casp3 , Cd14 , Fas , Il1a , Il1b , Mapk14 , Tnf
enlarged vestibular aqueductFgfr1
EntamoebiasisIl1b
EnterocolitisIl1a , Il1b
Enterovirus InfectionsTnfrsf1a
EosinophiliaPdgfra
eosinophilic esophagitisTgfb1
EpendymomaCacng2 , Map4k3
epidermal nevusFgfr3 , Hras , Kras , Nras
epilepsyAkt1 , Bdnf , Cacna1c , Cacna2d2 , Fgfr3 , Flna , Fos , Il1b , Mef2c , Ntrk2 , Rela , Tgfb1 , Tnf , Tsc2
epilepsy with generalized tonic-clonic seizuresBdnf , Fgf2 , Ngf , Ntf3
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOODPpp3ca
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1Ppp3ca
episodic ataxiaCacnb4
episodic ataxia type 2Cacna1a
episodic ataxia type 5Cacnb4
Erythema NodosumTnf
Escherichia Coli InfectionsNtrk2
esophageal cancerTgfbr2 , Tp53
esophageal carcinomaEgfr , Erbb2 , Fgfr2 , Hras , Kras , Myc , Tp53
Esophageal NeoplasmsEgfr , Erbb2 , Fas , Faslg , Fgfr2 , Hras , Kras , Map3k3 , Myc , Tgfbr2 , Tp53
esophagitisTnf
esophagus adenocarcinomaFas , Tp53
esophagus squamous cell carcinomaEgfr , Tp53
essential thrombocythemiaFgf2 , Pdgfa , Pdgfb , Tgfb1
essential tremorMapt
exfoliation syndromeCacna1a
Experimental ArthritisAkt1 , Arrb1 , Arrb2 , Cdc42 , Egfr , Faslg , Fgf8 , Fgfr1 , Ikbkb , Ikbkg , Il1a , Il1b , Nras , Tgfbr2 , Tnf , Tnfrsf1a
Experimental Autoimmune EncephalomyelitisBdnf , Cacna1b , Casp3 , Dusp10 , Faslg , Fgf2 , Mapt , Ngf , Ntrk1 , Pdgfb , Pdgfra , Pdgfrb , Tgfb1 , Tgfb2 , Tnf
Experimental Autoimmune NeuritisCd14 , Il1b , Tnf
Experimental Autoimmune UveitisFas
Experimental Autoimmune UveoretinitisTnfrsf1a
Experimental ColitisFas , Pdgfra , Pdgfrb , Tnf , Tnfrsf1a
Experimental Diabetes MellitusAkt1 , Bdnf , Cacng4 , Casp3 , Dusp1 , Egfr , Fas , Faslg , Fgf2 , Fgf21 , Hras , Ikbkb , Il1a , Il1b , Map2k3 , Map2k6 , Mapk1 , Mapk3 , Mef2c , Myc , Nfkb2 , Ngf , Ntrk1 , Pdgfb , Pdgfrb , Prkca , Prkcb , Rap1b , Rasgrf1 , Rela , Tgfb1 , Tgfb2 , Tnf , Tnfrsf1a , Tp53 , Tsc2
Experimental Liver CirrhosisArrb2 , Dusp16 , Dusp6 , Egf , Fas , Fgf2 , Flna , Fos , Il1b , Map3k8 , Myc , Pdgfa , Pdgfra , Pdgfrb , Pla2g12a , Pla2g4a , Prkcb , Rac2 , Rela , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tnf
Experimental NeoplasmsBraf , Erbb2 , Hras , Kras , Nras , Rela , Tnf , Tp53
Experimental SarcomaKras , Nras
Experimental SeizuresRasgrf1
extrahepatic cholestasisFos , Il1b , Jun , Map3k7 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pdgfrb , Rela , Tgfb1 , Tnf
extrinsic allergic alveolitisIl1a , Il1b , Tnf , Tnfrsf1a
Eye AbnormalitiesTgfb2 , Tgfbr2
Eye BurnsIl1b
eye diseaseCacna1f , Cacna2d4 , Tnf
Eye InjuriesFgf2
Eye Injuries, PenetratingFgf2
Fabry diseaseIl1a
Facial AsymmetryFgfr3
Facial Nerve InjuriesAtf2
facioscapulohumeral muscular dystrophyHspa1b