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NICOTINAMIDE ADENINE NUCLEOTIDE UTILIZATION PATHWAY (PW:0002581)

View Ontology Report

Description

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme of enzyme-catalyzed reduction-oxidation (redox) reactions. Its discovery and mechanistic understanding span more than a century and brought four Nobel prizes. NAD+ and its reduced form NADH, and the phosphorylated NADP/NADPH forms, serve as hydride acceptors or donors in over 2,000 redox reactions. In addition to its known role as a cofactor in redox reactions, NAD+ serves as a substrate for several classes of enzymes that include

Pathway Diagram:

Elsevier Inc. nicotinamide adenine dinucleotide biosynthetic pathway cyclic ADP-ribose Bst1 Cd38 NAD+ ---> target ribosylation MAR/PAR erasers MAR/PAR readers NAD+ ---> target deacetylation sirtuins ADP-ribosylation pathway, cyclic ribosylation ADP-ribosylation pathway, mono and poly-ribosylation sirtuin mediated pathway MAR/PAR writers (PARPs) NAD+ ---> cyclic ADP-ribose nicotinamide adenine dinucleotide biosynthetic pathway ---> NAD+ target deribosylation NAD+ target ribosylation ---> target deribosylation target ribosylation MAR/PAR readers ---- target ribosylation target deacetylation
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Genes in Pathway:


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ADP-ribosylation pathway, cyclic ribosylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bst1 bone marrow stromal cell antigen 1 ISO RGD PMID:23576305 RGD:11250406 NCBI chr14:71,466,179...71,482,671
Ensembl chr14:67,252,998...67,270,180
JBrowse link
G Cd38 CD38 molecule ISO RGD PMID:23576305 RGD:11250406 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986
JBrowse link
ADP-ribosylation pathway, mono and poly-ribosylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:120,070,471...120,122,633
JBrowse link
G Chfr checkpoint with forkhead and ring finger domains ISO RGD PMID:26091342 RGD:11100038 NCBI chr12:52,164,214...52,197,860
Ensembl chr12:46,504,497...46,538,014
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 1:213,675,413...213,831,571
Ensembl chr 1:204,246,166...204,389,716
JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 3:148,173,821...150,191,077
Ensembl chr 3:127,720,181...129,734,492
JBrowse link
G Oard1 O-acyl-ADP-ribose deacylase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 9:20,074,507...20,084,946
Ensembl chr 9:12,578,970...12,587,249
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase ISO RGD PMID:26091342 RGD:11100038 NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,436,476...7,544,273
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 7:109,829,721...109,839,054
Ensembl chr 7:107,949,043...107,958,304
JBrowse link
G Parp11 poly (ADP-ribose) polymerase family, member 11 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:160,298,040...160,344,369
Ensembl chr 4:160,304,905...160,341,946
JBrowse link
G Parp12 poly (ADP-ribose) polymerase family, member 12 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:68,793,411...68,851,214
Ensembl chr 4:67,839,237...67,883,685
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 ISO RGD PMID:26091342 RGD:11100038 NCBI chr11:78,408,134...78,440,201
Ensembl chr11:64,902,785...64,934,916
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 8:74,626,399...74,644,610
Ensembl chr 8:65,727,706...65,749,433
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr15:26,494,722...26,517,893
Ensembl chr15:24,034,106...24,044,338
JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 ISO RGD PMID:26091342 RGD:11100038 NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810
JBrowse link
G Parp6 poly (ADP-ribose) polymerase family, member 6 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 8:68,912,393...68,944,904
Ensembl chr 8:60,016,877...60,049,108
JBrowse link
G Parp8 poly (ADP-ribose) polymerase family, member 8 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 2:48,679,405...48,848,700
Ensembl chr 2:48,679,436...48,849,253
JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 ISO RGD PMID:26091342 RGD:11100038 NCBI chr11:78,286,282...78,320,409
Ensembl chr11:64,780,981...64,815,455
JBrowse link
G Rnf146 ring finger protein 146 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 1:30,286,680...30,304,367
Ensembl chr 1:28,458,887...28,475,923
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase ISO RGD PMID:26091342 RGD:11100038 NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:149,753,682...149,780,327
JBrowse link
G Tnks tankyrase ISO RGD PMID:26091342 RGD:11100038 NCBI chr16:63,922,969...64,073,972
Ensembl chr16:57,225,094...57,366,260
JBrowse link
G Tnks2 tankyrase 2 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 1:243,980,432...244,033,629
Ensembl chr 1:234,567,858...234,621,079
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 ISO RGD PMID:26091342 RGD:11100038 NCBI chr 4:67,979,055...68,029,353
Ensembl chr 4:67,012,185...67,062,428
JBrowse link
Sirtuin mediated pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 ISO RGD PMID:26785480 RGD:11100032 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt2 sirtuin 2 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
G Sirt3 sirtuin 3 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Sirt4 sirtuin 4 ISO RGD PMID:26785480 RGD:11100032 NCBI chr12:46,785,852...46,800,179
Ensembl chr12:41,131,262...41,139,439
JBrowse link
G Sirt5 sirtuin 5 ISO RGD PMID:26785480 RGD:11100032 NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101
JBrowse link
G Sirt6 sirtuin 6 ISO RGD PMID:26785480 RGD:11100032 NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,082,364...8,098,914
JBrowse link
G Sirt7 sirtuin 7 ISO RGD PMID:26785480 RGD:11100032 NCBI chr10:106,394,802...106,401,627
Ensembl chr10:105,896,476...105,903,172
JBrowse link

Pathway Gene Annotations

References Associated with the nicotinamide adenine nucleotide utilization pathway:

Ontology Path Diagram:

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paths to the root

Import into Pathway Studio: