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GLUCAGON SIGNALING PATHWAY (PW:0000676)

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Description

In the pancreatic alpha cells of the islets of Langerhans, glucagon is processed from the precursor proglucagon by the prohormone convertase 2 (PC-2). In the intestinal L cells and brainstem neurons, prohormone convertase 1 (PC-1) processes the same precursor molecule into several peptides distinct from glucagon, including the glucagon-like peptides (GLP) 1 and 2. The resulting peptides bind to cognate G-protein coupled receptors (GPCR) to elicit distinct responses. When the levels of circulatin

Pathway Diagram:

Ariadne Genomics Inc. expression of gluconeogenic genes gluconeogenesis pathway glycogen degradation pathway glycogen biosynthetic pathway glycolysis pathway protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family Adcy6 Adcy5 protein kinase A (PKA) signaling pathway --+> expression of gluconeogenic genes reduced F2, 6P levels protein kinase A (PKA) signaling pathway --+> gluconeogenesis pathway protein kinase A (PKA) signaling pathway ---| glycolysis pathway ATP ---> cAMP Gnas --+> Adcy6 Gnas --+> Adcy5 cAMP --+> protein kinase A (PKA) signaling pathway cAMP ATP Gnas Gcg Gcgr ---- Gnas Gcg ---- Gcgr protein kinase A (PKA) signaling pathway --+> glycogen degradation pathway protein kinase A (PKA) signaling pathway ---| glycogen biosynthetic pathway Gcgr
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Genes in Pathway:

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glucagon signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy5 adenylate cyclase 5 IDA RGD PMID:17010343, PMID:10894801 RGD:2315004, RGD:2315006 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy6 adenylate cyclase 6 IDA RGD PMID:17010343, PMID:10894801 RGD:2315004, RGD:2315006 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Gcg glucagon ISO RGD PMID:16929363 RGD:2315015 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gcgr glucagon receptor IMP
IDA
RGD PMID:15687107, PMID:17010343 RGD:1625210, RGD:2315004 NCBI chr10:109,707,863...109,716,253
Ensembl chr10:109,707,962...109,716,128
JBrowse link
G Gnas GNAS complex locus IMP
IDA
RGD PMID:15687107, PMID:17010343 RGD:1625210, RGD:2315004 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaygluconeogenesis pathway
Pathwayglycogen biosynthetic pathway
Pathwayglycolysis pathway
Pathwayglycogen degradation pathway
PathwayG protein mediated signaling via Galphas familyBased on sequence similarity, the Galpha genes have been grouped into four classes. Effectors of activated Galphas are adenylyl cyclases that catalyzed the formation of cAMP
Small MoleculecAMPcAMP binding to the PKA complex leads to dissociation of the catalytic subunits
Pathwayprotein kinase A (PKA) signaling pathwayProtein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the second messenger cAMP signal

Pathway Gene Annotations

Disease Annotations Associated with Genes in the glucagon signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociGcg
acromegalyGnas
ACTH Syndrome, EctopicGnas
ACTH-independent macronodular adrenal hyperplasiaGnas
ACTH-independent macronodular adrenal hyperplasia 1Gcgr , Gnas
adrenal carcinomaGnas
adrenal gland hyperfunctionGnas
Adrenal Gland NeoplasmsGnas
adrenocortical carcinomaGnas
adult hepatocellular carcinomaGnas
Albright's hereditary osteodystrophyGnas
Alzheimer's diseaseGcg , Gnas
amyotrophic lateral sclerosis type 8Gnas
Animal Mammary NeoplasmsAdcy5
AnorexiaGcg
autistic disorderGcg
B-Cell Chronic Lymphocytic LeukemiaGnas
Birth WeightAdcy5
brachydactylyGnas
BradycardiaGcg
breast cancerGnas
Breast NeoplasmsGnas
Cafe-au-Lait SpotsGnas
carcinomaAdcy5
cardiomyopathyAdcy5
CatalepsyGcg
cholangiocarcinomaGnas
colitisGcg
Colonic NeoplasmsGcg
Colorectal NeoplasmsGnas
ComaGcg
congestive heart failureGcg
constipationGcg
Cushing SyndromeGnas
disease of cellular proliferationGnas
distal muscular dystrophy 4Adcy5
DysarthriaAdcy5
endocrine system diseaseGnas
Experimental Diabetes MellitusGcg
Familial Dyskinesia with Facial MyokymiaAdcy5
familial hyperlipidemiaGcg
FibrosisAdcy5
GallstonesGnas
gastric adenocarcinomaGnas
genetic diseaseAdcy5 , Gnas
growth hormone secreting pituitary adenomaGnas
head and neck squamous cell carcinomaGnas
heart diseaseGcg
hemorrhagic diseaseGnas
hepatocellular carcinomaGnas
Heterotopic OssificationGnas
hyperglycemiaGcg
hyperinsulinismGcg
HyperkinesisGcg
hypertensionAdcy5 , Gcg , Gnas
HypotensionGcg
HypothermiaGcg
HypoxiaGnas
Insulin ResistanceGnas
intellectual disabilityGnas
Lethal Congenital Contracture Syndrome 8Adcy6
liver cancerGnas
lung adenocarcinomaGnas
Mammary Neoplasms, ExperimentalAdcy5
McCune Albright syndromeGnas
melanomaGnas
Metabolic Bone DiseasesGnas
Myocardial Reperfusion InjuryGcg
neuroblastomaGnas
Neurodevelopmental DisordersAdcy5
obesityGcg , Gnas
Orthostatic HypotensionGnas
osteoporosisAdcy5
pancreatic adenocarcinomaGnas
pancreatic cancerGnas
Parasitic Liver DiseasesGnas
Parkinson's diseaseAdcy5
ParkinsonismAdcy5
pituitary adenoma 3Gnas
Pituitary NeoplasmsGnas
PoisoningGcg
polycystic kidney diseaseGnas
polycystic ovary syndromeGnas
Precocious PubertyGnas
prediabetes syndromeGcg
primary hyperaldosteronismGnas
Primary Pigmented Nodular Adrenocortical Disease, 1Gnas
progressive osseous heteroplasiaGnas
Prolonged Bleeding Time, Brachydactyly, and Mental RetardationGnas
pseudohypoaldosteronismGnas
pseudohypoparathyroidismGnas
pseudohypoparathyroidism type IBGnas
Pseudohypoparathyroidism Type ICGnas
pseudopseudohypoparathyroidismGnas
Respiration DisordersGnas
schizophreniaGnas
sex cord-gonadal stromal tumorGnas
skin melanomaGnas
SpasmGcg
stomach diseaseGcg
TachycardiaGcg , Gnas
Tachycardia, SinusGcg
Taste DisordersGcg
type 2 diabetes mellitusAdcy5 , Gcg , Gcgr
ureteral obstructionAdcy6
Uterine Cervical NeoplasmsGnas
vascular diseaseGcg
Ventricular Dysfunction, LeftAdcy5
withdrawal disorderGnas
Pathway Annotations Associated with Genes in the glucagon signaling pathway

References Associated with the glucagon signaling pathway:

Ontology Path Diagram:

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