Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Ontology Browser
Term:
adenosine monophosphate-activated protein kinase (AMPK) signaling pathway (PW:0000542)
1 pathway diagrams for this term and its child terms. (View Interactive Pathway Diagram)     Standard Pathway Browser
Parent Terms Term With Siblings Child Terms
adenosine monophosphate-activated protein kinase (AMPK) signaling pathway  
AMPK senses changes in cellular energy as an ATP/AMP ratio. AMP binding allosterically activates AMPK; subsequent phosphorylation events lead to repression of energy consuming pathways. One target of AMPK is the mTOR signaling pathway. AMPK activates the inhibitory Tsc2 while inhibiting the mTorc1 complex.
View Interactive Diagram
altered energy homeostasis pathway +  
citric acid cycle pathway  
insulin signaling pathway +   
leptin system pathway  
melanocortin system pathway  
mTOR signaling pathway  
phosphatidylinositol 3-kinase signaling pathway +  
protein kinase A (PKA) signaling pathway  
protein kinase C (PKC) signaling pathway  

Synonyms
Related Synonyms: 5'AMP-activated protein kinase ;   AMPK signaling pathway
Definition Sources: PMID:15509864, PMID:16885148

paths to the root