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Pathways
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Ontology Browser
Term:
insulin signaling pathway (PW:0000143)
2 pathway diagrams for this term and its child terms. (View Interactive Pathway Diagram)     Standard Pathway Browser
Parent Terms Term With Siblings Child Terms
adenosine monophosphate-activated protein kinase (AMPK) signaling pathway  
altered energy homeostasis pathway +  
altered glucose homeostasis pathway +  
altered peptide and protein hormone signaling pathway +  
angiotensin signaling pathway +  
citric acid cycle pathway  
corticotropin-releasing hormone signaling pathway  
glucagon signaling pathway  
glucose biosynthesis pathway +  
glucose transport pathway +  
glucose utilization pathway +  
insulin secretion pathway +   
insulin signaling pathway +   
Insulin, the peptide hormone secreted by pancreatic beta cells, plays essential roles in glucose and energy homeostasis. Insulin signaling activates two main intracellular pathways to regulate carbohydrate and fat metabolism and to prompt glucose absorption in insulin sensitive tissues such as skeletal muscle and adipocytes. Deregulation of the pathway has been associated with a number of conditions, primarily diabetes.
View Interactive Diagram
leptin system pathway  
melanocortin system pathway  
mTOR signaling pathway  
parathyroid hormone family signaling pathway +  
vasopressin signaling pathway +   

Synonyms
Related Synonyms: Signaling by Insulin receptor ;   insulin receptor signaling pathway
Definition Sources: GO:0008286, KEGG:map4910, PID:200014, PMID:12169433, Reactome:R-HSA-74752, SMP:00391

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