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Ontology Browser

Term:
direct thrombin inhibitor drug pathway (PW:0002146)
Annotations: Rat: (20) Mouse: (20) Human: (20) Chinchilla: (20) Bonobo: (20) Dog: (20) Squirrel: (20) Pig: (20)
Parent Terms Term With Siblings Child Terms
direct factors Xa inhibitor drug pathway +  
direct thrombin inhibitor drug pathway +   
The pharmacokinetics and pharmacodynamics pathway of drugs that reduce or prevent the formation of blood clots by directly inhibiting thrombin. Thrombin is a serine protease involved in coagulation-related reactions. The drugs are further classified depending on how they interact with thrombin. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
heparin group drug pathway +   
vitamin K antagonist drug pathway +    

Synonyms
Definition Sources: wikipedia:https://en.wikipedia.org/wiki/Direct_thrombin_inhibitor

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.