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Ontology Browser

Term:
ATM and Rad3-related (ATR) signaling pathway (PW:0001362)
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Parent Terms Term With Siblings Child Terms
altered serine/threonine-specific kinase mediated signaling pathway +   
ataxia telangiectasia-mutated (ATM) signaling pathway   
ATM and Rad3-related (ATR) signaling pathway 
The ATM and Rad3-related (ATR) serine/threonine kinase mediated signaling responds to several kinds of DNA damage, of which single-stranded DNA (ssDNA) exerts a key role. ssDNAs are induced by stressed replication forks. ATR acting on its substrates prevents the cell from erroneous mitotic entry, plays a key role in interstrand cross link (ICL) repair pathway and also exerts important regulatory roles in homologous recombination pathway of double-strand break repair.
calcium/calmodulin dependent kinase signaling pathway +    
chromatin modification/remodeling pathway +     
DNA repair pathway +    
Hippo signaling pathway +  
mitogen activated protein kinase signaling pathway +     
phosphatidylinositol 3-kinase-Akt signaling pathway +    
protein kinase A (PKA) signaling pathway   
protein kinase C (PKC) signaling pathway   

Synonyms
Exact Synonyms: ATR signaling pathway
Definition Sources: PMID:20947357, PMID:21615334, PMID:22417748

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