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Ontology Browser

interleukin-1 signaling pathway (PW:0000883)
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Parent Terms Term With Siblings Child Terms
interleukin-1 signaling pathway  
Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor, allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin 1alpha and beta.

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interleukin-6 signaling pathway  
tumor necrosis factor mediated signaling pathway  

Related Synonyms: Il-1 signaling pathway ;   PID:200089
Definition Sources: PMID:20081871, PMID:20303867, PMID:21219179

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.