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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
tamoxifen pharmacodynamics pathway   
The pathway of tamoxifen-target interaction and of the biochemical or physiological responses to drug. In breast cancer cells, tamoxifen binding antagonizes estrogen binding and the subsequent conformational changes necessary for co-activators recruitment. It may also prompt the recruitment of co-repressor. Genetic variations can cause differences in the response of the organism to the drug.

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tamoxifen pharmacokinetics pathway   

Synonyms
Related Synonyms: SMP:00471
Definition Sources: PMID:19629072

paths to the root