Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
altered cardiovascular system homeostasis pathway +   
altered signaling pathway pertinent to immunity +   
auditory mechanotransduction pathway +    
chemokine mediated signaling pathway +   
cytokine mediated signaling pathway +    
epinephrine signaling pathway +    
fibrinolysis pathway +    
hematopoiesis pathway +    
hemostasis pathway +    
histamine signaling pathway, immunological  
Jak-Stat signaling pathway +    
kallikrein-kinin cascade pathway +     
The kallikrein-kinin system (KKS) cascade generates several bioactive kinins with roles in vasodilation, release of inflammatory mediators and stimulation of sensory neurons. Kinins also play a role in the renal handling of sodium and water metabolism. In the latter case, the system parallels renin-angiotensin (RAS); the two systems can cross-talk.

View Interactive Diagram
natriuretic peptide signaling pathway +   
natural anticoagulant pathway +    
nitric oxide mediated signaling pathway 
nuclear factor kappa B signaling pathway +    
peptide and protein hormone metabolic pathway +    
protein folding pathway +  
renin-angiotensin cascade pathway +     
signaling pathway in the adaptive immune response +   
signaling pathway in the innate immune response +    
vascular endothelial growth factor signaling pathway +    
vasopressin signaling pathway +     
visual phototransduction pathway +     

Synonyms
Related Synonyms: KKS system signaling pathway ;   tissue kallikrein-kinin cascade
Definition Sources: GO:0002255, PMID:12558525, PMID:12676165, PMID:12793984, PMID:16177542

paths to the root