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Pathways
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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
altered single-strand DNA repair pathway +    
base excision repair pathway  
mismatch repair pathway +    
nucleotide excision repair pathway +     
The nucleotide excision repair pathway is an important mechanism for the detection of helix-distorting base alterations. Unlike the base excision repair pathway that only removes the damaged bases, the NER pathway removes an entire lesion-containing segment. The single-strand gap thus introduced is filled in by DNA polymerase using the undamaged strand as a template. The pathway can be subdivided into two sub-pathways: transcription-coupled and global genome repair. They only differ in the lesion recognition step while the core repair component is shared.
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Synonyms
Related Synonyms: NER pathway ;   Nucleotide Excision Repair ;   nucleotide-excision repair
Definition Sources: GO:0006289, KEGG:map03420, OneLook:www.onelook.com, PMID:23046879, PMID:23085398, Reactome:R-HSA-5696398, SMP:00478

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