abnormal neural crest cell delamination - Ontology Browser

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abnormal neural crest cell delamination (MP:0012746)
Annotations: Rat: (0) Mouse: (6) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)

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Child Terms

abnormal neural crest cell physiology + is-a

abnormal melanoblast physiology +

abnormal neural crest cell apoptosis +

abnormal neural crest cell delamination

any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate

abnormal neural crest cell migration +

abnormal neural crest cell proliferation +

Synonyms
Exact Synonyms:	abnormal NCC delamination ; abnormal NCC emigration ; abnormal NCC individualization ; abnormal NCC segregation ; abnormal neural crest cell emigration ; abnormal neural crest cell individualization ; abnormal neural crest cell segregation
Definition Sources:	MGI:anna

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