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Ontology Browser

Term:
abnormal glomerular filtration barrier function (MP:0011856)
Annotations: Rat: (4) Mouse: (7) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
abnormal glomerular filtration barrier function  
anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine
abnormal renal glomerular filtration rate +   

Synonyms
Exact Synonyms: abnormal GFB permeability
Definition Sources: MGI:anna, PMCID:PMC2895306

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