any functional anomaly of the non-motile primary cilia found on renal epithelial cells and thought to act as a mechanical sensor to detect renal tubular fluid; impaired mechanical response of primary cilia to physiological fluid flow, or abnormalities in intracellular Ca2+ increase in response to fluid stress may alter renal (tubular) cell proliferation and differentiation and lead to renal cyst formation
abnormal kidney glutathione peroxidase activity +
abnormal podocyte physiology +
abnormal renal arterial blood pressure +
abnormal renal filtration +
abnormal renal plasma flow rate +
abnormal renal reabsorption +
abnormal renal sympathetic nerve activity +
abnormal renal transport +
abnormal renal vascular resistance +
abnormal renal water homeostasis +
abnormal susceptibility to kidney reperfusion injury +