abnormal professional antigen presenting cell physiology +
abnormal somatic hypermutation frequency
abnormal type I hypersensitivity reaction +
abnormal type II hypersensitivity reaction +
abnormal type III hypersensitivity reaction +
abnormal type IV hypersensitivity reaction +
anomaly in an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact