abnormal professional antigen presenting cell physiology +
abnormal somatic hypermutation frequency
abnormal type I hypersensitivity reaction +
abnormal type II hypersensitivity reaction +
abnormal type III hypersensitivity reaction +
anomaly in the tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury