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Ontology Browser

Term:
Central nervous system axonal spheroid (HP:0034381)
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Parent Terms Term With Siblings Child Terms
Abnormal cerebrospinal fluid morphology +   
Abnormal CNS myelination +   
Abnormal glial cell morphology +   
Abnormal meningeal morphology +   
Abnormal neural tube morphology +   
Abnormal subarachnoid space morphology +   
Abnormality of brain morphology +   
Abnormality of neuronal migration +   
Abnormality of the spinal cord +   
Alzheimer disease  
Aplasia/Hypoplasia involving the central nervous system +   
Atrophy/Degeneration affecting the central nervous system +   
Central nervous system axonal spheroid  
Axonal spheroids are bubble-like biological features that form on most degenerating axons. During neurodegeneration, bubble-like swellings form along the length of the axon, a primary and early effect of dynamic axonal deformation. These varicosities, spheroids, or swellings have been described as beads on a string and branches bearing fruit, and they frequently appear on degenerating axons. The focal swellings on degenerating axons, axonal spheroids, are often filled with cellular debris such as organelles, pathological proteins, and disorganized cytoskeletal elements.
Central nervous system cyst +   
Morphological abnormality of the pyramidal tract +   
Neoplasm of the central nervous system +   
Unusual CNS infection +   

Synonyms
Exact Synonyms: CNS axonal spheroid
Definition Sources: PMID:27423618, PMID:34678457

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