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Diffuse alveolar damage (HP:0033006)
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Parent Terms Term With Siblings Child Terms
Abnormal alveolar type II pneumocyte morphology +   
Abnormal pulmonary alveolar system development +   
Alveolar septal thickening 
Diffuse alveolar damage 
Diffuse alveolar damage (DAD) describes a comon histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis and crack cocaine inhalation.
Hyaline membranes  
Intraalveolar nodular calcifications  

Definition Sources: LMU:mgriese, PMID:28570160, PMID:32364264

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