Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Necklace skeletal muscle fibers (HP:0031238)
Annotations: Rat: (0) Mouse: (0) Human: (1) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
Abnormal muscle fiber protein expression +   
Abnormal muscle fiber-type distribution +   
Abnormal muscle glycogen content +   
Abnormal sarcomere morphology +   
Abnormality of skeletal muscle fiber size +   
Angulated muscle fibers  
Autophagic vacuoles  
Central core regions in muscle fibers  
Centrally nucleated skeletal muscle fibers  
Deposits immunoreactive to beta-amyloid protein  
Increased endomysial connective tissue  
Increased muscle lipid content +   
Motheaten muscle fibers 
Muscle fiber atrophy +   
Muscle fiber hypertrophy  
Muscle fiber inclusion bodies +   
Muscle fiber necrosis  
Muscle fiber splitting  
Myelin-like whorls in vacuolated fibers 
Necklace skeletal muscle fibers  
A histological alteration of muscle fibers that resembles a necklace (necklace fibers). A substantial proportion of fibers (4-20% in PMID:19084976) show internalized nuclei aligned in a basophilic ring (necklace) at 3 micrometers beneath the sarcolemma. Ultrastructurally, such necklaces consist of myofibrils of smaller diameter, in oblique orientation, surrounded by mitochondria, sarcoplasmic reticulum and glycogen granules.
Perifascicular muscle fiber atrophy 
Ragged-red muscle fibers  
Reduced muscle carnitine level  
Rimmed vacuoles  
Ring fibers 
Skeletal muscle autophagosome accumulation  

Exact Synonyms: Necklace skeletal muscle fibres
Definition Sources: PMID:19084976

paths to the root