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Ontology Browser

Term:
UBR1-RAD6 ubiquitin ligase complex (GO:1990303)
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Parent Terms Term With Siblings Child Terms
1,3-beta-D-glucan synthase complex 
4-aminobutyrate transaminase complex  
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex 
ABIN2-NFKB1-MAP3K8 complex 
acetate CoA-transferase complex +  
acetolactate synthase complex  
acetyltransferase complex +   
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) 
aminodeoxychorismate synthase complex 
aryl hydrocarbon receptor complex +   
aspartate carbamoyltransferase complex 
Atg12-Atg5-Atg16 complex  
ATP-dependent citrate lyase complex 
Bcl3-Bcl10 complex  
BRCA2-MAGE-D1 complex  
Bre1-Rad6 ubiquitin ligase complex 
CAAX-protein geranylgeranyltransferase complex  
calcium- and calmodulin-dependent protein kinase complex  
cAMP-dependent protein kinase complex  
CCR4-NOT complex +   
cellulose synthase complex +  
cysteine synthase complex 
Dbf4-dependent protein kinase complex  
DBIRD complex  
decaprenyl diphosphate synthase complex +  
dehydrodolichyl diphosphate synthase complex  
DNA polymerase complex +   
elongator holoenzyme complex  
endonuclease complex +  
enterobactin synthetase complex 
ethanolamine ammonia-lyase complex 
exodeoxyribonuclease V complex 
exodeoxyribonuclease VII complex 
fatty acid elongase complex  
fatty-acyl-CoA synthase complex 
ferredoxin hydrogenase complex 
G-protein alpha(13)-synembrin complex 
G-protein alpha(i)1-synembrin complex 
G-protein alpha(o)-synembrin complex 
G-protein alpha(q)-synembrin complex 
GCH1 complex 
Gemin3-Gemin4-Gemin5 complex 
Gemin6-Gemin7-unrip complex 
GID complex  
glucose-1-phosphate adenylyltransferase complex 
glutamate synthase complex +  
glutamyl-tRNA(Gln) amidotransferase complex  
glycosylphosphatidylinositol-mannosyltransferase I complex  
glycosylphosphatidylinositol-mannosyltransferase II complex 
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex  
guanyl-nucleotide exchange factor complex +   
Hedgehog signaling complex 
I-kappaB/NF-kappaB complex +   
imidazoleglycerol-phosphate synthase complex 
incipient cellular bud site 
inositol phosphoceramide synthase complex 
intracellular ferritin complex  
invertasome 
iron-sulfur cluster transfer complex 
magnesium-dependent protein serine/threonine phosphatase complex +   
mannosyltransferase complex +   
methionine adenosyltransferase complex  
methyl coenzyme M reductase complex 
methyltransferase complex +   
mRNA cap binding complex  
MUB1-RAD6-UBR2 ubiquitin ligase complex 
NAD(P)+ transhydrogenase complex (AB-specific) 
nitrogenase complex +  
nonhomologous end joining complex +   
nuclear cap binding complex  
nucleotide-activated protein kinase complex  
oligosaccharyltransferase complex +   
ornithine carbamoyltransferase complex 
oxoglutarate dehydrogenase complex +   
palmitoyltransferase complex +   
proteasome complex +   
protein acetyltransferase complex +   
protein farnesyltransferase complex  
protein kinase CK2 complex  
protein N-acetylglucosaminyltransferase complex  
Rab-protein geranylgeranyltransferase complex  
RAD6-UBR2 ubiquitin ligase complex 
riboflavin synthase complex 
ribonuclease H2 complex  
RNA polymerase complex +   
RPB4-RPB7 complex 
RSP5-BUL ubiquitin ligase complex 
serine-pyruvate aminotransferase complex  
SOD1-Bcl-2 complex 
SOD1-calcineurin complex 
sulfite reductase complex (NADPH) 
sulfurtransferase complex +  
SUMO ligase complex +   
TACC/TOG complex 
TOR complex +   
transferase complex, transferring phosphorus-containing groups +   
transnitrosylase complex +  
TRAPP complex +   
tRNA-specific adenosine-34 deaminase complex 
tRNA-splicing ligase complex  
ubiquitin activating enzyme complex 
ubiquitin conjugating enzyme complex +   
ubiquitin ligase complex +   
UBR1-RAD6 ubiquitin ligase complex 
A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.

Synonyms
Exact Synonyms: UBR1-RAD6 complex
Definition Sources: GOC:bhm, PMID:19531475

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