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Pathways
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Ontology Browser
Term:
maintenance of unfolded protein involved in ERAD pathway (GO:1904378)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0) Naked Mole-rat: (0) Green Monkey: (0)
Parent Terms Term With Siblings Child Terms
maintenance of unfolded protein involved in ERAD pathway 
Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome.
negative regulation of ERAD pathway  
positive regulation of ERAD pathway  
regulation of ERAD pathway +   
retrograde protein transport, ER to cytosol +   
ubiquitin-dependent glycoprotein ERAD pathway +  

Synonyms
Exact Synonyms: maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation
Related Synonyms: ERAD chaperone-like activity ;   chaperone holdase activity ;   holdase activity ;   maintenance of unfolded protein during ERAD ;   maintenance of unfolded protein involved in ER-associated degradation pathway ;   maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway
Definition Sources: GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303

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