maintenance of unfolded protein involved in ERAD pathway - Ontology Browser

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maintenance of unfolded protein involved in ERAD pathway (GO:1904378)
Annotations: Rat: (3) Mouse: (3) Human: (3) Chinchilla: (3) Bonobo: (3) Dog: (3) Squirrel: (3) Pig: (3)

Parent Terms

Term With Siblings

Child Terms

ERAD pathway + part-of

maintenance of unfolded protein + is-a

ER-associated misfolded protein catabolic process

maintenance of unfolded protein involved in ERAD pathway

Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome.

negative regulation of ERAD pathway +

positive regulation of ERAD pathway +

protein localization to cytosolic proteasome complex involved in ERAD pathway

regulation of ERAD pathway +

retrograde protein transport, ER to cytosol +

ubiquitin-dependent ERAD pathway +

Synonyms
Exact Synonyms:	maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation
Related Synonyms:	ERAD chaperone-like activity ; chaperone holdase activity ; holdase activity ; maintenance of unfolded protein during ERAD ; maintenance of unfolded protein involved in ER-associated degradation pathway ; maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway
Definition Sources:	GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303

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