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Ontology Browser

Term:
cardiac endothelial to mesenchymal transition (GO:0140074)
Annotations: Rat: (2) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (1) Dog: (2) Squirrel: (2) Pig: (2)
Parent Terms Term With Siblings Child Terms
cardiac endothelial to mesenchymal transition +   
A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
epithelial to mesenchymal transition +   
mesenchymal cell development +   
mesenchymal cell differentiation involved in bone development  
mesenchymal cell differentiation involved in lung development  
mesenchymal cell differentiation involved in mammary gland development 
mesenchymal cell differentiation involved in renal system development +   
mesenchymal cell differentiation involved in salivary gland development 
mesenchymal cell fate commitment  
neural crest cell differentiation +   

Synonyms
Exact Synonyms: EndMT ;   EndoMT
Definition Sources: GOC:BHF, GOC:nc, PMID:16162442, PMID:26053665

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