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Ontology Browser

Term:
cytoplasm to vacuole transport by the NVT pathway (GO:0120113)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
cytoplasm to vacuole transport by the Cvt pathway +  
cytoplasm to vacuole transport by the NVT pathway 
A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.
protein targeting to lysosome +   
protein targeting to vacuolar membrane +   
protein targeting to vacuole involved in autophagy +   

Synonyms
Exact Synonyms: protein localization by the NVT pathway ;   protein localization by the Nbr1-mediated vacuolar targeting pathway
Broad Synonyms: cytoplasm to vacuole targeting
Definition Sources: PMID:26365378

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.