Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Parent Terms Term With Siblings Child Terms
apoptotic process +   
autophagic cell death +   
cornification +   
ferroptosis +   
A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.
granzyme-mediated programmed cell death signaling pathway +   
mitochondrial outer membrane permeabilization involved in programmed cell death +   
modulation by symbiont of host programmed cell death +   
negative regulation by symbiont of host programmed cell death +   
negative regulation of programmed cell death +   
positive regulation of programmed cell death +   
programmed cell death in response to reactive oxygen species +   
programmed cell death induced by symbiont +   
programmed cell death involved in cell development +   
programmed necrotic cell death +   
pyroptosis +   
regulation of programmed cell death +   

Related Synonyms: iron-dependent programmed cell death
Definition Sources: GOC:mtg_apoptosis, PMID:25236395, PMID:26794443

paths to the root