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Ontology Browser

Term:
hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)
Annotations: Rat: (7) Mouse: (7) Human: (7) Chinchilla: (7) Bonobo: (7) Dog: (7) Squirrel: (7) Pig: (7)
Parent Terms Term With Siblings Child Terms
apoptotic signaling pathway +   
bile acid signaling pathway +   
calmodulin dependent kinase signaling pathway +   
carbohydrate mediated signaling +   
cell surface receptor signaling pathway +   
chloroplast-nucleus signaling pathway 
dopamine receptor signaling pathway +   
endoplasmic reticulum unfolded protein response +   
ER-nucleus signaling pathway +   
extracellular ATP signaling 
G protein-coupled receptor signaling pathway +   
hormone-mediated signaling pathway +   
hydrogen peroxide mediated signaling pathway +  
hypoxia-inducible factor-1alpha signaling pathway +   
A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
immune response-regulating signaling pathway +   
intracellular receptor signaling pathway +   
intracellular signal transduction +   
intrinsic apoptotic signaling pathway in response to hypoxia +   
ligand-gated ion channel signaling pathway +  
lipoprotein particle mediated signaling +   
mitochondria-nucleus signaling pathway  
necroptotic signaling pathway  
negative regulation of cellular response to hypoxia +   
negative regulation of signal transduction +   
neuronal signal transduction +   
osmosensory signaling pathway +   
pattern recognition receptor signaling pathway +   
peptidoglycan recognition protein signaling pathway +  
phototransduction +   
positive regulation of cellular response to hypoxia +   
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
positive regulation of signal transduction +   
postsynaptic signal transduction +   
presynaptic signal transduction +   
red or far-red light signaling pathway +   
regulation of blood pressure by chemoreceptor signaling pathway 
regulation of cellular response to hypoxia +   
regulation of floral organ abscission by signal transduction +  
regulation of signal transduction +   
regulation of transcription from RNA polymerase II promoter in response to hypoxia +   
salicylic acid mediated signaling pathway +  
serotonin receptor signaling pathway +   
signal transduction by conformational transition 
signal transduction by protein phosphorylation +   
signal transduction in absence of ligand +   
signal transduction involved in cellular response to ammonium ion 
signal transduction involved in filamentous growth 
signal transduction involved in morphogenesis checkpoint 
signal transduction involved in positive regulation of conjugation with cellular fusion +  
signal transduction involved in regulation of gene expression  
SMAD protein signal transduction +   
sphingolipid mediated signaling pathway +   

Synonyms
Exact Synonyms: HIF1alpha pathway ;   hypoxia-inducible factor signaling ;   hypoxia-inducible factor-1alpha signalling pathway
Definition Sources: GOC:bf, GOC:jc, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.