endothelial tip cell fate specification - Ontology Browser

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endothelial tip cell fate specification (GO:0097102)
Annotations: Rat: (1) Mouse: (1) Human: (2) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1)

Parent Terms

Term With Siblings

Child Terms

blood vessel endothelial cell fate specification + is-a

sprouting angiogenesis + part-of

angiogenic sprout fusion +

blood vessel endothelial cell proliferation involved in sprouting angiogenesis +

cell migration involved in sprouting angiogenesis +

endothelial stalk cell fate specification

endothelial tip cell fate specification

The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels.

negative regulation of sprouting angiogenesis +

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis +

Synonyms
Exact Synonyms:	angiogenic tip cell fate specification
Definition Sources:	CL:0000704, GOC:dgh, PMID:21521739

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