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Ontology Browser

endothelial tip cell fate specification (GO:0097102)
Annotations: Rat: (1) Mouse: (1) Human: (2) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1)
Parent Terms Term With Siblings Child Terms
angiogenic sprout fusion +   
blood vessel endothelial cell proliferation involved in sprouting angiogenesis +   
cell migration involved in sprouting angiogenesis +   
endothelial stalk cell fate specification 
endothelial tip cell fate specification  
The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels.
negative regulation of sprouting angiogenesis +   
positive regulation of sprouting angiogenesis  
regulation of sprouting angiogenesis +   

Exact Synonyms: angiogenic tip cell fate specification
Definition Sources: CL:0000704, GOC:dgh, PMID:21521739

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