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Pathways
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Ontology Browser
Term:
obsolete positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction (GO:0086094)
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Parent Terms Term With Siblings Child Terms
obsolete positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction 
OBSOLETE. An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction.

Synonyms
Narrow Synonyms: adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation
Definition Sources: GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118

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