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Ontology Browser

Term:
gene silencing by RNA-directed DNA methylation (GO:0080188)
Annotations: Rat: (0) Mouse: (1) Human: (1) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
gene silencing by RNA-directed DNA methylation  
A small RNA-based epigenetic gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism.
negative regulation of DNA methylation-dependent heterochromatin assembly  
positive regulation of DNA methylation-dependent heterochromatin assembly  
regulation of DNA methylation-dependent heterochromatin assembly +   
transfer RNA gene-mediated silencing 

Synonyms
Exact Synonyms: RdDM
Related Synonyms: RNA-directed DNA methylation
Definition Sources: PMID:21420348

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