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Ontology Browser

Term:
phosphorylation of RNA polymerase II C-terminal domain (GO:0070816)
Annotations: Rat: (13) Mouse: (12) Human: (12) Chinchilla: (5) Bonobo: (5) Dog: (11) Squirrel: (5) Pig: (11)
Parent Terms Term With Siblings Child Terms
actin phosphorylation +   
carbon catabolite regulation of transcription from RNA polymerase II promoter +   
common-partner SMAD protein phosphorylation  
dephosphorylation of RNA polymerase II C-terminal domain  
DNA damage induced protein phosphorylation  
histone phosphorylation +   
I-kappaB phosphorylation +   
inhibitory G protein-coupled receptor phosphorylation +   
JUN phosphorylation  
miRNA-mediated regulation of transcription by RNA polymerase II +  
negative regulation of protein kinase activity by protein phosphorylation  
negative regulation of protein phosphorylation +   
negative regulation of transcription by RNA polymerase II +   
nitrogen catabolite regulation of transcription from RNA polymerase II promoter +   
pathway-restricted SMAD protein phosphorylation +   
peptidyl-arginine phosphorylation 
peptidyl-aspartic acid phosphorylation +   
peptidyl-cysteine phosphorylation 
peptidyl-histidine phosphorylation  
peptidyl-serine phosphorylation +   
peptidyl-threonine phosphorylation +   
peptidyl-tyrosine phosphorylation +   
phosphorylation of RNA polymerase II C-terminal domain +   
The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
positive regulation of androgen receptor activity  
positive regulation of protein phosphorylation +   
positive regulation of transcription by RNA polymerase II +   
protein autophosphorylation +   
regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter 
regulation of mating-type specific transcription from RNA polymerase II promoter +  
regulation of nodal signaling pathway involved in determination of left/right asymmetry +   
regulation of phosphorylation of RNA polymerase II C-terminal domain +   
regulation of pri-miRNA transcription by RNA polymerase II +   
regulation of protein phosphorylation +   
regulation of ribosomal protein gene transcription by RNA polymerase II +  
regulation of snRNA transcription by RNA polymerase II +   
regulation of telomeric RNA transcription from RNA pol II promoter +   
regulation of transcription from RNA polymerase II promoter by pheromones +  
regulation of transcription from RNA polymerase II promoter in response to iron +   
regulation of transcription from RNA polymerase II promoter in response to stress +   
regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry +   
regulation of transcription from RNA polymerase II promoter involved in heart development +   
regulation of transcription from RNA polymerase II promoter involved in kidney development +   
regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle +  
regulation of transcription from RNA polymerase II promoter involved in spermatogenesis  
regulation of transcription initiation from RNA polymerase II promoter +   
regulation of transcription involved in anterior/posterior axis specification 
regulation of translational initiation by eIF2 alpha phosphorylation +   

Synonyms
Exact Synonyms: CTD domain phosphorylation of RNA polymerase II ;   generation of II(0) form of RNA polymerase II ;   generation of hyperphosphorylated CTD of RNA polymerase II ;   hyperphosphorylation of RNA polymerase II C-terminal domain
Alternate IDs: GO:0016245
Definition Sources: GOC:krc, GOC:mah, PMID:17079683

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