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Ontology Browser

Parent Terms Term With Siblings Child Terms
MAPK cascade +     
ERK1 and ERK2 cascade +   
ERK5 cascade +   
An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
negative regulation of MAPK cascade +   
pheromone response MAPK cascade +  
positive regulation of MAPK cascade +   
regulation of MAPK cascade +   
stress-activated MAPK cascade +   

Exact Synonyms: BMK cascade ;   BMK signaling pathway ;   BMK signalling pathway ;   BMK1 cascade ;   ERK5 signaling pathway ;   MAPK7 cascade ;   big MAP kinase signaling cascade ;   extracellular signal-regulated kinase 5 cascade
Definition Sources: GOC:add, GOC:signaling, ISBN:0896039986, PMID:16376520, PMID:16880823, PMID:20811974, PMID:28903453

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