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NADP-retinol dehydrogenase activity (GO:0052650)
Annotations: Rat: (9) Mouse: (11) Human: (12) Chinchilla: (4) Bonobo: (5) Dog: (7) Squirrel: (3) Pig: (8)
Parent Terms Term With Siblings Child Terms
2-methylbutanol:NADP oxidoreductase activity 
3-methylbutanol:NADP oxidoreductase activity 
alditol:NADP+ 1-oxidoreductase activity +   
NADP-retinol dehydrogenase activity  
Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+.

Exact Synonyms: NADP(H)-dependent retinol dehydrogenase/reductase activity ;   retinol:NADP+ oxidoreductase activity
Broad Synonyms: all-trans retinal reductase activity ;   all-trans-retinol dehydrogenase activity
Xrefs: EC: ;   KEGG_REACTION:R08379 ;   MetaCyc:RXN-10841 ;   RHEA:25033 ;   Reactome:R-HSA-2466861 "Defective RDH12 does not reduce atRAL to atROL and causes LCA13" ;   Reactome:R-HSA-2471670 "Defective RDH12 does not reduce atRAL to atROL" ;   reactome:R-HSA-2464803 "RDH8 reduces atRAL to atROL" ;   reactome:R-HSA-2464822 "RDH12 reduces atRAL to atROL" ;   reactome:R-HSA-2465921 "11cRDH oxidises 11cROL to 11cRAL" ;   reactome:R-HSA-2465940 "atRAL is reduced to atROL" ;   reactome:R-HSA-5419165 "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL" ;   reactome:R-HSA-5615668 "AKR1C3 reduces atRAL to atROL" ;   reactome:R-HSA-5623643 "RDH13 reduces atRAL to atROL" ;   reactome:R-HSA-74872 "RDH10,11 oxidise 11cROL to 11cRAL"
Definition Sources: RHEA:25033

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.