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Ontology Browser

Term:
methotrexate binding (GO:0051870)
Annotations: Rat: (3) Mouse: (3) Human: (4) Chinchilla: (2) Bonobo: (3) Dog: (2) Squirrel: (3) Pig: (4)
Parent Terms Term With Siblings Child Terms
(25S)-Delta(4)-dafachronate binding 
(25S)-Delta(7)-dafachronate binding 
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding  
3-sulfino-L-alanine binding 
5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding  
5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding  
5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding  
abscisic acid binding 
acyl-CoA binding +   
ADP-D-ribose binding +   
amino acid binding +   
arachidonic acid binding  
arginine binding  
aspartate binding  
biotin binding  
camalexin binding 
catecholamine binding +   
ceramide binding +   
chenodeoxycholic acid binding  
cocaine binding  
coenzyme F420 binding 
cyclosporin A binding  
dethiobiotin binding 
diazepam binding  
dibutyl phthalate binding 
dihydrofolic acid binding  
diphenyl phthalate binding 
ectoine binding 
epigallocatechin 3-gallate binding 
FK506 binding  
flavanol binding +  
flurbiprofen binding 
folic acid binding  
ganglioside GM1 binding  
ganglioside GM2 binding  
ganglioside GP1c binding  
ganglioside GT1b binding  
gibberellin binding 
glutamate binding  
glutamine binding 
glycine binding  
histamine binding  
hydroquinone binding 
hydroxyectoine binding 
icosanoid binding +   
isopentadecanoic acid binding 
L-ascorbic acid binding  
L-cysteine binding 
L-DOPA binding  
leptomycin B binding  
leucine binding  
linoleic acid binding  
lipoamide binding  
lipoic acid binding  
lithocholic acid binding  
macrolide binding +   
melatonin binding  
methotrexate binding  
Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
molybdopterin cofactor binding  
monocarboxylic acid binding +   
N-1-naphthylphthalamic acid binding 
nucleic acid binding +   
nucleobase binding +   
nucleoside binding +   
nucleoside phosphate binding +   
octanoic acid binding 
oleic acid binding  
penicillin binding 
peptide binding +   
phenylalkylamine binding 
phosphopantetheine binding  
phthalate binding 
polychlorinated biphenyl binding  
proline binding 
pyrroloquinoline quinone binding 
resveratrol binding  
retinoic acid binding  
riboflavin binding  
salicylic acid binding 
serine binding  
serotonin binding  
sialic acid binding  
stearic acid binding  
steroid binding +   
suramin binding  
taurine binding  
tetrahydrobiopterin binding +   
tetrapyrrole binding +   
thiamine binding  
thiamine pyrophosphate binding  
thienylcyclohexylpiperidine binding  
tryptophan binding +  
tyrosine binding +   
urea binding 
vitamin B6 binding +   
vitamin E binding  

Synonyms
Definition Sources: GOC:nln

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