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phospholipid-hydroperoxide glutathione peroxidase activity (GO:0047066)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (0) Squirrel: (1) Pig: (1)
Parent Terms Term With Siblings Child Terms
18-hydroxyoleate peroxygenase activity 
oleate peroxygenase activity 
peroxidase activity +   
peroxiredoxin activity +   
phospholipid-hydroperoxide glutathione peroxidase activity  
Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.
plant seed peroxidase activity 

Exact Synonyms: glutathione:lipid-hydroperoxide oxidoreductase activity ;   hydroperoxide glutathione peroxidase activity ;   peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)
Related Synonyms: PHGPX ;   peroxidation-inhibiting protein activity
Xrefs: EC: ;   MetaCyc: ;   reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE" ;   reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE" ;   reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA" ;   reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA"
Definition Sources: EC:, MetaCyc:

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.