Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
positive regulation of molecular function, epigenetic (GO:0045858)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
negative regulation of molecular function, epigenetic 
positive regulation of binding +   
positive regulation of catalytic activity +   
positive regulation of DNA-binding transcription factor activity +   
positive regulation of low-density lipoprotein receptor activity  
positive regulation of molecular function in other organism +  
positive regulation of molecular function, epigenetic 
Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
positive regulation of nuclear receptor transcription coactivator activity  
positive regulation of RNA binding transcription factor activity 
positive regulation of signaling receptor activity +   
positive regulation of transporter activity +   

Synonyms
Exact Synonyms: positive regulation of protein activity, epigenetic ;   up regulation of protein activity, epigenetic ;   upregulation of protein activity, epigenetic
Narrow Synonyms: activation of protein activity, epigenetic ;   stimulation of protein activity, epigenetic
Definition Sources: GOC:dph, GOC:go_curators, GOC:tb

paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.