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Ontology Browser

Term:
negative regulation of molecular function, epigenetic (GO:0045857)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
modulation by host of viral molecular function +   
negative regulation of binding +   
negative regulation of catalytic activity +   
negative regulation of DNA-binding transcription factor activity +   
negative regulation of low-density lipoprotein receptor activity  
negative regulation of molecular function in other organism +   
negative regulation of molecular function, epigenetic 
Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
negative regulation of nuclear receptor transcription coactivator activity  
negative regulation of RNA binding transcription factor activity 
negative regulation of signaling receptor activity +   
negative regulation of transporter activity +   
positive regulation of molecular function in other organism +  
positive regulation of molecular function, epigenetic 

Synonyms
Exact Synonyms: down regulation of protein activity, epigenetic ;   downregulation of protein activity, epigenetic ;   negative regulation of protein activity, epigenetic
Narrow Synonyms: inhibition of protein activity, epigenetic
Definition Sources: GOC:dph, GOC:go_curators, GOC:tb

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.