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ATPase-coupled transmembrane transporter activity (GO:0042626)
Annotations: Rat: (107) Mouse: (101) Human: (108) Chinchilla: (98) Bonobo: (100) Dog: (91) Squirrel: (1) Pig: (98)
Parent Terms Term With Siblings Child Terms
ATPase-coupled transmembrane transporter activity +   
Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
decarboxylation-driven active transmembrane transporter activity 
light-driven active transmembrane transporter activity 
methyl transfer-driven active transmembrane transporter activity 
oxidoreduction-driven active transmembrane transporter activity  
P-P-bond-hydrolysis-driven protein transmembrane transporter activity  
pyrophosphate hydrolysis-driven proton transmembrane transporter activity +   

Exact Synonyms: ATP-coupled transmembrane transporter activity ;   ATP-dependent transmembrane transporter activity ;   ATPase activity, coupled to transmembrane movement of substances
Narrow Synonyms: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Broad Synonyms: P-P-bond-hydrolysis-driven transmembrane transporter activity ;   P-P-bond-hydrolysis-driven transporter
Alternate IDs: GO:0015405 ;   GO:0016820
Xrefs: EC:7.2.2 ;   MIPS_funcat:20.03.22 ;   Reactome:R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol" ;   reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1" ;   reactome:R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol" ;   reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol" ;   reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner"
Definition Sources: GOC:mtg_transport, ISBN:0815340729

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.