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Ontology Browser

Term:
regulation of molecular function, epigenetic (GO:0040030)
Annotations: Rat: (2) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (2) Squirrel: (0) Pig: (1)
Parent Terms Term With Siblings Child Terms
modulation by symbiont of host molecular function +   
negative regulation of molecular function +   
positive regulation of molecular function +   
regulation of binding +   
regulation of catalytic activity +   
regulation of DNA-binding transcription factor activity +   
regulation of molecular function, epigenetic +   
Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
regulation of nuclear receptor transcription coactivator activity +   
regulation of RNA binding transcription factor activity +   
regulation of signaling receptor activity +   
regulation of transporter activity +   

Synonyms
Exact Synonyms: regulation of protein activity, epigenetic
Definition Sources: GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.