Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.
7-methylguanosine RNA capping +
RNA (guanine-N7)-methylation +
rRNA methylation +
snoRNA 2,2,7-trimethylguanosine (TMG) capping +
snRNA 2,2,7-trimethylguanosine (TMG) capping
snRNA methylation +
tRNA methylation +
Synonyms
Exact Synonyms:
2,2,7-trimethylguanosine cap formation
;
TMG cap formation
;
conversion of m(7)G to m(3)G
;
m(7)G cap hypermethylation
Narrow Synonyms:
hypermethylation of snRNA cap
;
hypermethylation of snoRNA cap
;
snRNA capping
;
snoRNA capping