Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
sequestering of TGFbeta in extracellular matrix (GO:0035583)
Annotations: Rat: (4) Mouse: (4) Human: (4) Chinchilla: (4) Bonobo: (4) Dog: (4) Squirrel: (4) Pig: (4)
Parent Terms Term With Siblings Child Terms
negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation 
sequestering of BMP from receptor via BMP binding  
sequestering of BMP in extracellular matrix  
sequestering of nodal from receptor via nodal binding  
sequestering of TGFbeta from receptor via TGFbeta binding 
sequestering of TGFbeta in extracellular matrix  
Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.

Synonyms
Exact Synonyms: negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta ;   negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta ;   sequestering of TGFbeta LLC in extracellular matrix ;   sequestering of TGFbeta large latency complex in extracellular matrix
Definition Sources: GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508

paths to the root