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Ontology Browser
Term:
broad specificity oxidative DNA demethylase activity (GO:0035516)
Annotations: Rat: (5) Mouse: (5) Human: (5) Chinchilla: (5) Bonobo: (5) Dog: (5) Squirrel: (5) Pig: (5) Naked Mole-rat: (5) Green Monkey: (5)
Parent Terms Term With Siblings Child Terms
2'-deoxymugineic-acid 2'-dioxygenase activity 
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity 
2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity 
4-coumaroyl 2'-hydroxylase activity 
5-methylcytosine dioxygenase activity  
6-beta-hydroxyhyoscyamine epoxidase activity 
[protein]-asparagine 3-dioxygenase activity  
broad specificity oxidative DNA demethylase activity  
Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
clavaminate synthase activity 
codeine O-demethylase activity 
cytosine C-5 DNA demethylase activity  
deacetoxycephalosporin-C hydroxylase activity 
deoxyuridine 1'-dioxygenase activity 
deoxyuridine 2'-dioxygenase activity 
desacetoxyvindoline 4-hydroxylase activity 
DNA N6-methyladenine demethylase activity  
flavanone 3-dioxygenase activity 
flavone synthase activity 
flavonol synthase activity 
gamma-butyrobetaine dioxygenase activity  
gibberellin 2-beta-dioxygenase activity 
gibberellin 20-oxidase activity 
gibberellin 3-beta-dioxygenase activity 
glutarate dioxygenase activity 
histone H3K27me2/H3K27me3 demethylase activity  
histone H3K36 demethylase activity +   
histone H3K4me/H3K4me2/H3K4me3 demethylase activity  
histone H3K56me2/H3K56me3 demethylase activity 
histone H3K9me/H3K9me2 demethylase activity  
histone H3K9me2/H3K9me3 demethylase activity  
histone H3R2 demethylase activity  
histone H4K20 demethylase activity  
histone H4R3 demethylase activity  
hyoscyamine (6S)-dioxygenase activity 
L-gamma-glutamyl-L-propargylglycine hydroxylase activity 
leucocyanidin oxygenase activity 
mugineic-acid 3-dioxygenase activity 
oxidative RNA demethylase activity +   
peptidyl-arginine 3-dioxygenase activity  
peptidyl-aspartic acid 3-dioxygenase activity  
peptidyl-histidine dioxygenase activity  
peptidyl-lysine 3-dioxygenase activity  
peptidyl-lysine 4-dioxygenase activity  
peptidyl-lysine 5-dioxygenase activity +   
peptidyl-proline dioxygenase activity +   
phytanoyl-CoA dioxygenase activity  
proline 3-hydroxylase activity 
sulfonate dioxygenase activity 
taurine dioxygenase activity 
thebaine 6-O-demethylase activity 
thymine dioxygenase activity 
trimethyllysine dioxygenase activity  
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity  

Synonyms
Exact Synonyms: 2-oxoglutarate-dependent DNA demethylase
Narrow Synonyms: 1-ethyladenine demethylase activity ;   5-formylcytosine dioxygenase activity ;   5-hydroxymethylcytosine dioxygenase activity ;   5fC dioxygenase ;   5hmC dioxygenase ;   N1-methyladenine demethylase activity ;   N3-methylcytosine demethylase activity
Broad Synonyms: oxidative DNA demethylase activity
Alternate IDs: GO:0103051 ;   GO:0103052 ;   GO:0103053
Xrefs: EC:1.14.11.33 ;   MetaCyc:RXN-12353 ;   RHEA:30299 ;   Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2" ;   Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"
Definition Sources: PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299

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