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Term:
Notch receptor processing, ligand-dependent (GO:0035333)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0) Naked Mole-rat: (0) Green Monkey: (0)
Parent Terms Term With Siblings Child Terms
negative regulation of Notch signaling pathway +   
Notch receptor processing, ligand-dependent 
The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
Notch receptor processing, ligand-independent 
Notch signaling involved in heart development +   
Notch signaling pathway involved in arterial endothelial cell fate commitment  
Notch signaling pathway involved in camera-type eye photoreceptor fate commitment 
Notch signaling pathway involved in forebrain neuroblast division 
Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment 
Notch signaling pathway involved in somitogenesis +   
positive regulation of Notch signaling pathway  
positive regulation of transcription of Notch receptor target  
regulation of Notch signaling pathway +   

Synonyms
Narrow Synonyms: Notch S2 cleavage ;   Notch S3 cleavage
Definition Sources: GOC:bf, PMID:12651094

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