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Term:
cholesterol 24-hydroxylase activity (GO:0033781)
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Parent Terms Term With Siblings Child Terms
(+)-abscisic acid 8'-hydroxylase activity 
(+)-delta-cadinene-8-hydroxylase activity 
(+)-menthofuran synthase activity 
(+)-taxifolin 5'-hydroxylase activity 
(-)-menthol monooxygenase activity 
(11Z)-eicosenoate 14-hydroxylase activity 
(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity 
(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity 
(22S)-22-hydroxy-campesterol C-23 hydroxylase activity 
(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity 
(5alpha)-campestan-3-one hydroxylase activity 
1,8-cineole 2-exo-monooxygenase activity  
1-deoxy-11-oxopentalenate oxygenase activity 
1-hydroxy-2-naphthoate hydroxylase activity 
1-hydroxy-2-oxolimonene 1,2-monooxygenase activity 
1-methylnaphthalene hydroxylase activity 
11-oxo-beta-amyrin 30-oxidase activity 
11alpha-hydroxy-beta-amyrin dehydrogenase activity 
17-hydroxyprogesterone 21-hydroxylase activity 
2,2',3-trihydroxybiphenyl monooxygenase activity 
2,2'-hydroxybiphenyl monooxygenase activity 
2,4-dichlorophenol 6-monooxygenase activity 
2,6-dihydroxypyridine 3-monooxygenase activity 
2-alpha-hydroxytaxusin 7-beta-hydroxylase activity 
2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity 
2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity 
2-hydroxy-phenylacetate hydroxylase activity 
2-hydroxybiphenyl 3-monooxygenase activity 
2-hydroxycyclohexanone 2-monooxygenase activity 
2-hydroxyisoflavanone synthase activity 
2-hydroxyquinoline 8-monooxygenase activity 
2-isopropylphenol monooxygenase activity 
2-methylbutyronitrile hydroxylase activity 
2-methylnaphthalene hydroxylase activity 
2-methylpropionitrile hydroxylase activity 
2-nitrophenol 2-monooxygenase activity 
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity 
2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity 
2-propylphenol monooxygenase activity 
24-ethylidenelophenol 4alpha-methyl oxidase activity 
24-hydroxycholesterol 7alpha-hydroxylase activity 
24-methylenecycloartanol 4alpha-methyl oxidase activity 
24-methylenelophenol methyl oxidase activity 
25-hydroxycholesterol 7alpha-hydroxylase activity  
27-hydroxycholesterol 7-alpha-monooxygenase activity  
3,5-xylenol methylhydroxylase activity 
3,9-dihydroxypterocarpan 6a-monooxygenase activity 
3-(3-hydroxyphenyl)propionate hydroxylase activity 
3-chlorotoluene monooxygenase activity 
3-epi-6-deoxocathasterone C-23 hydroxylase activity 
3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity 
3-HSA hydroxylase activity 
3-hydroxybenzoate 4-monooxygenase activity 
3-hydroxybenzoate 6-monooxygenase activity 
3-hydroxyindolin-2-one monooxygenase activity 
3-hydroxyphenylacetate 6-hydroxylase activity 
3-ketosteroid 9-alpha-monooxygenase activity 
3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity 
30-hydroxy-beta-amyrin 11-hydroxylase activity 
3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity 
3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity 
3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity 
4'-methoxyisoflavone 2'-hydroxylase activity 
4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity 
4-aminobenzoate 1-monooxygenase activity 
4-chlorobenzaldehyde oxidase activity 
4-hydroxyacetophenone monooxygenase activity 
4-hydroxybenzoate 1-hydroxylase activity 
4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity 
4-hydroxybenzoate 3-monooxygenase activity 
4-hydroxyphenylacetaldehyde oxime monooxygenase activity 
4-hydroxyphenylacetate 1-monooxygenase activity 
4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity 
4-hydroxypyridine-3-hydroxylase activity 
4-hydroxyquinoline 3-monooxygenase activity 
4-nitrophenol 2-monooxygenase activity  
4-nitrophenol 4-monooxygenase activity 
4-nitrotoluene monooxygenase activity 
4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity 
4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity 
4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity 
4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity 
4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity 
4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity 
4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity 
4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity 
4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity 
4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity 
5-epi-aristolochene-1,3-dihydroxylase activity 
5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity 
5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity  
6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity 
6-hydroxynicotinate 3-monooxygenase activity 
6-oxocampestanol hydroxylase activity 
6-oxocineole dehydrogenase activity 
7-beta-hydroxytaxusin 2-alpha-hydroxylase activity 
7-deoxyloganin 7-hydroxylase activity 
7-oxateasterone synthase activity 
7-oxatyphasterol synthase activity 
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity 
9,10-dihydroxystearate hydroxylase activity 
9,10-epoxystearate hydroxylase activity 
9-beta-stemod-13(17)-ene oxidase activity 
9beta-pimara-7,15-diene oxidase activity 
abieta-7,13-dien-18-ol hydroxylase activity 
abieta-7,13-diene hydroxylase activity 
abietadienal hydroxylase activity 
albendazole monooxygenase activity 
alkene monooxygenase activity 
allocryptopine 6-hydroxylase activity 
alpha-amyrin 28-monooxygenase activity 
alpha-humulene 10-hydroxylase activity 
alpha-pinene monooxygenase [NADH] activity 
anandamide epoxidase activity +   
angelicin synthase activity 
anhydrotetracycline monooxygenase activity 
antheraxanthin epoxidase activity 
anthranilate 3-monooxygenase (deaminating) activity 
anthraniloyl-CoA monooxygenase activity 
apigenin-7,4'-dimethyl ether 6-hydroxylase activity 
aurachin C monooxygenase activity 
benzoate 4-monooxygenase activity 
benzoyl-CoA 3-monooxygenase activity 
beta-amyrin 11-oxidase activity 
beta-amyrin 30-monooxygenase activity 
beta-amyrin monooxygenase activity 
beta-carotene 2,2'-beta-hydroxylase activity 
bisphenol A hydroxylase A activity 
branched-chain dodecylbenzene sulfonate monooxygenase activity 
brassinolide synthase activity 
C-4 methylsterol oxidase activity  
calcidiol 1-monooxygenase activity  
campest-4-en-3-one hydroxylase activity 
campestanol hydroxylase activity 
campesterol,NADPH:oxygen oxidoreductase activity 
caprate dehydroxylase activity 
carbon disulfide oxygenase activity 
chlorophenol 4-monooxygenase activity 
cholest-4-en-3-one 26-monooxygenase activity 
cholestanetriol 26-monooxygenase activity  
cholestanol hydroxylase activity 
cholesterol 24-hydroxylase activity  
Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
cholesterol 7-alpha-monooxygenase activity  
coniferyl aldehyde 5-hydroxylase activity 
costunolide 3beta-hydroxylase activity 
costunolide synthase activity 
cycloartenol 4alpha-methyl oxidase activity 
cyclohexanone monooxygenase activity 
cyclooctat-9-en-5,7-diol C18-monooxygenase activity 
cyclopentanone monooxygenase activity 
CYP79F1 dihomomethionine monooxygenase activity 
CYP79F1 tetrahomomethionine monooxygenase activity 
CYP79F1 trihomomethionine monooxygenase activity 
cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity 
cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity 
cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity 
cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity 
cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity 
dammarenediol 12-hydroxylase activity 
dehydroabietadienal hydroxylase activity 
dehydroabietadienol hydroxylase activity 
Delta12-linoleate epoxygenase activity 
deoxysarpagine hydroxylase activity 
dibenzothiophene monooxygenase activity 
dihydrochelirubine 12-monooxygenase activity 
dihydrosanguinarine 10-monooxygenase activity 
dimethyl sulfide monooxygenase activity 
dimethylsulfoxide oxygenase activity 
DMNT synthase activity 
emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity 
ent-7-alpha-hydroxykaurenoate oxidase activity 
ent-cassa-12,15-diene 11-hydroxylase activity 
ent-cassadiene-C2-hydroxylase activity 
ent-isokaurene C2-hydroxylase activity 
ent-kaur-16-en-19-al oxidase activity 
ent-kaur-16-en-19-ol oxidase activity 
ent-kaurene oxidase activity 
ent-kaurenoate oxidase activity 
eriodictyol 2-hydroxylase activity 
eriodictyol,NADPH:oxygen oxidoreductase activity 
FAD-dependent urate hydroxylase activity 
flaviolin monooxygenase activity 
flavonoid 3',5'-hydroxylase activity 
flavonoid 3'-monooxygenase activity  
fraxetin 5-hydroxylase activity 
genkwanin 6-hydroxylase activity 
geraniol 10-hydroxylase activity 
germacrene A acid 8beta-hydroxylase activity 
gibberellin 12-aldehyde oxidase activity 
glyceollin synthase activity 
hydroxyphenylacetonitrile 2-monooxygenase activity 
imidazoleacetate 4-monooxygenase activity 
indole-2-monooxygenase activity 
indole-3-carbonyl nitrile 4-hydroxylase activity 
indole-3-pyruvate monooxygenase activity 
indolin-2-one monooxygenase activity 
isobutylamine N-hydroxylase activity 
isoflavone 2'-hydroxylase activity 
isoflavone 3'-hydroxylase activity 
isofucosterol hydroxylase activity 
isoleucine N-monooxygenase (oxime forming) activity 
isopimaradienal hydroxylase activity 
isopimaradienol hydroxylase activity 
ketosteroid monooxygenase activity  
kynurenine 3-monooxygenase activity  
L-lysine 6-monooxygenase (NADPH) activity 
L-phenylalanine N-monooxygenase activity 
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) 
L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) 
laurate hydroxylase activity  
leukotriene-B4 20-monooxygenase activity  
leukotriene-E4 20-monooxygenase activity 
levopimaradienol hydroxylase activity 
licodione synthase activity 
limonene hydroxylase activity 
limonene monooxygenase activity +   
liquiritigenin,NADPH:oxygen oxidoreductase activity 
lithocholate 6beta-hydroxylase activity 
lupeol 28-monooxygenase activity 
lupeol 28-oxidase activity 
magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity 
melilotate 3-monooxygenase activity 
methane monooxygenase activity 
methanesulfonate monooxygenase activity 
methyltetrahydroprotoberberine 14-monooxygenase activity 
N,N-dimethylaniline monooxygenase activity  
N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) 
N-methylcoclaurine 3'-monooxygenase activity 
naringenin 2-hydroxylase activity 
naringenin,NADPH:oxygen oxidoreductase activity 
nitric-oxide synthase activity  
octat-9-en-7-ol 5-monooxygenase activity 
oleate 12-hydroxylase activity 
orcinol 2-monooxygenase activity 
parthenolide 3beta-hydroxylase activity 
parthenolide synthase activity 
paspalicine synthase activity 
paspalinine synthase activity 
pentachlorophenol monooxygenase activity 
phenanthrene 1,2-monooxygenase activity 
phenanthrene 3,4-monooxygenase activity 
phenanthrene 9,10-monooxygenase activity  
phenol 2-monooxygenase activity 
phenylacetate hydroxylase activity 
phenylacetone monooxygenase activity 
phenylacetyl-CoA 1,2-epoxidase activity 
phosphatidylcholine 12-monooxygenase activity 
pinocembrin 2-hydroxylase activity 
piperitol synthase activity 
precorrin-3B synthase activity 
protopanaxadiol 6-hydroxylase activity 
protopine 6-monooxygenase activity 
psoralen synthase activity 
pyocyanin hydroxylase activity 
questin monooxygenase activity 
quinine 3-monooxygenase activity  
sakuranetin 6-hydroxylase activity 
salicylate 1-monooxygenase activity 
salicylate 5-hydroxylase activity 
scopoletin 8-hydroxylase activity 
senecionine N-oxygenase activity 
sesamin synthase activity 
sitosterol hydroxylase activity 
sphingolipid long-chain base 4-hydroxylase activity 
sphingolipid very long chain fatty acid alpha-hydroxylase activity 
squalene monooxygenase activity  
sterol 14-demethylase activity  
styrene monooxygenase activity 
syn-pimaradiene 6beta-hydroxylase activity 
tabersonine 16-hydroxylase activity 
taurochenodeoxycholate 6alpha-hydroxylase activity 
taxane 10-beta-hydroxylase activity 
taxane 13-alpha-hydroxylase activity 
taxifolin 8-monooxygenase activity 
taxoid 14-beta-hydroxylase activity 
taxoid 7beta-hydroxylase activity 
taxusin 2-alpha-hydroxylase activity 
tetrahydrofuran hydroxylase activity 
tocopherol omega-hydroxylase activity +   
tocotrienol omega-hydroxylase activity  
toluene 2-monooxygenase activity 
toluene 3-monooxygenase activity 
toluene 4-monooxygenase activity 
toluene-4-sulfonate monooxygenase activity 
toluene-sulfonate methyl-monooxygenase activity 
trans-cinnamate 2-monooxygenase activity 
trans-cinnamate 4-monooxygenase activity 
tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity +  
tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity +  
trimethylamine monooxygenase activity  
trimethyluric acid monooxygenase activity 
tyrosine N-monooxygenase activity 
ursolic aldehyde 28-monooxygenase activity 
valine N-monooxygenase (oxime forming) activity 
vanillate monooxygenase activity 
very long chain fatty acid omega-hydroxylase activity 
vinorine hydroxylase activity 
xylene monooxygenase activity 
zeaxanthin 2,2'-beta-hydroxylase activity 
zeaxanthin 2-beta-hydroxylase activity 
zeaxanthin epoxidase [overall] activity 
zeaxanthin epoxidase activity 

Synonyms
Exact Synonyms: cholesterol 24-monooxygenase activity ;   cholesterol 24S-hydroxylase activity ;   cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity
Related Synonyms: CYP46 ;   CYP46A1 ;   cytochrome P450 46A1
Xrefs: EC:1.14.14.25 ;   KEGG_REACTION:R07207 ;   MetaCyc:1.14.13.98-RXN ;   RHEA:22716 ;   reactome:R-HSA-192061 "CYP46A1 24-hydroxylates CHOL"
Definition Sources: EC:1.14.14.25, RHEA:22716

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.