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cyclin-dependent protein kinase activating kinase holoenzyme complex (GO:0019907)
Annotations: Rat: (3) Mouse: (3) Human: (3) Chinchilla: (3) Bonobo: (3) Dog: (3) Squirrel: (3) Pig: (3)
Parent Terms Term With Siblings Child Terms
CKM complex 
cyclin-dependent protein kinase activating kinase holoenzyme complex  
A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
cyclin/CDK positive transcription elongation factor complex +   
DNA polymerase processivity factor complex +   
DNA recombinase auxiliary factor complex  
GTPase activator complex +   
transcription factor TFIIH holo complex +   
urease activator complex 

Exact Synonyms: CAK complex ;   CDK-activating kinase complex
Definition Sources: GOC:bhm, PMID:8752210

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