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Ontology Browser

Term:
reductive tricarboxylic acid cycle (GO:0019643)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
C4 photosynthesis +  
CAM photosynthesis 
carbon fixation by 3-hydroxypropionate cycle 
carbon fixation by acetyl-CoA pathway 
reductive pentose-phosphate cycle +  
reductive tricarboxylic acid cycle 
A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.

Synonyms
Exact Synonyms: reductive Kreb's cycle ;   reductive TCA cycle ;   reductive carboxylate cycle ;   reductive carboxylic acid cycle ;   reductive citric acid pathway
Alternate IDs: GO:0019644
Xrefs: MetaCyc:P23-PWY ;   MetaCyc:REDCITCYC
Definition Sources: GOC:jl, PMID:15838028

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.